The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study

Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kanemitsu, Yukihide [verfasserIn] Komori, Koji [verfasserIn] Ishiguro, Seiji [verfasserIn] Watanabe, Toshiaki [verfasserIn] Sugihara, Kenichi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Lymph Node Colorectal Cancer Rectal Cancer Intermediate Lymph Node Rectal Cancer Patient

Übergeordnetes Werk:	Enthalten in: Annals of surgical oncology - Berlin [u.a.] : Springer, 1994, 19(2012), 7 vom: 01. Feb., Seite 2169-2177
Übergeordnetes Werk:	volume:19 ; year:2012 ; number:7 ; day:01 ; month:02 ; pages:2169-2177

Links:	Volltext

DOI / URN:	10.1245/s10434-012-2223-8

Katalog-ID:	SPR009951172

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520			\|a Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance.
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700	1		\|a Sugihara, Kenichi \|e verfasserin \|4 aut
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matchkey_str	article:15344681:2012----::hrltosiolmhoevlainnclrcacnesriaatruaieee
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publishDate	2012
allfields	10.1245/s10434-012-2223-8 doi (DE-627)SPR009951172 (SPR)s10434-012-2223-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kanemitsu, Yukihide verfasserin aut The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance. Lymph Node (dpeaa)DE-He213 Colorectal Cancer (dpeaa)DE-He213 Rectal Cancer (dpeaa)DE-He213 Intermediate Lymph Node (dpeaa)DE-He213 Rectal Cancer Patient (dpeaa)DE-He213 Komori, Koji verfasserin aut Ishiguro, Seiji verfasserin aut Watanabe, Toshiaki verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 7 vom: 01. Feb., Seite 2169-2177 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:7 day:01 month:02 pages:2169-2177 https://dx.doi.org/10.1245/s10434-012-2223-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 7 01 02 2169-2177
spelling	10.1245/s10434-012-2223-8 doi (DE-627)SPR009951172 (SPR)s10434-012-2223-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kanemitsu, Yukihide verfasserin aut The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance. Lymph Node (dpeaa)DE-He213 Colorectal Cancer (dpeaa)DE-He213 Rectal Cancer (dpeaa)DE-He213 Intermediate Lymph Node (dpeaa)DE-He213 Rectal Cancer Patient (dpeaa)DE-He213 Komori, Koji verfasserin aut Ishiguro, Seiji verfasserin aut Watanabe, Toshiaki verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 7 vom: 01. Feb., Seite 2169-2177 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:7 day:01 month:02 pages:2169-2177 https://dx.doi.org/10.1245/s10434-012-2223-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 7 01 02 2169-2177
allfields_unstemmed	10.1245/s10434-012-2223-8 doi (DE-627)SPR009951172 (SPR)s10434-012-2223-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kanemitsu, Yukihide verfasserin aut The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance. Lymph Node (dpeaa)DE-He213 Colorectal Cancer (dpeaa)DE-He213 Rectal Cancer (dpeaa)DE-He213 Intermediate Lymph Node (dpeaa)DE-He213 Rectal Cancer Patient (dpeaa)DE-He213 Komori, Koji verfasserin aut Ishiguro, Seiji verfasserin aut Watanabe, Toshiaki verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 7 vom: 01. Feb., Seite 2169-2177 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:7 day:01 month:02 pages:2169-2177 https://dx.doi.org/10.1245/s10434-012-2223-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 7 01 02 2169-2177
allfieldsGer	10.1245/s10434-012-2223-8 doi (DE-627)SPR009951172 (SPR)s10434-012-2223-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kanemitsu, Yukihide verfasserin aut The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance. Lymph Node (dpeaa)DE-He213 Colorectal Cancer (dpeaa)DE-He213 Rectal Cancer (dpeaa)DE-He213 Intermediate Lymph Node (dpeaa)DE-He213 Rectal Cancer Patient (dpeaa)DE-He213 Komori, Koji verfasserin aut Ishiguro, Seiji verfasserin aut Watanabe, Toshiaki verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 7 vom: 01. Feb., Seite 2169-2177 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:7 day:01 month:02 pages:2169-2177 https://dx.doi.org/10.1245/s10434-012-2223-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 7 01 02 2169-2177
allfieldsSound	10.1245/s10434-012-2223-8 doi (DE-627)SPR009951172 (SPR)s10434-012-2223-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kanemitsu, Yukihide verfasserin aut The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance. Lymph Node (dpeaa)DE-He213 Colorectal Cancer (dpeaa)DE-He213 Rectal Cancer (dpeaa)DE-He213 Intermediate Lymph Node (dpeaa)DE-He213 Rectal Cancer Patient (dpeaa)DE-He213 Komori, Koji verfasserin aut Ishiguro, Seiji verfasserin aut Watanabe, Toshiaki verfasserin aut Sugihara, Kenichi verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 19(2012), 7 vom: 01. Feb., Seite 2169-2177 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:19 year:2012 number:7 day:01 month:02 pages:2169-2177 https://dx.doi.org/10.1245/s10434-012-2223-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 19 2012 7 01 02 2169-2177
language	English
source	Enthalten in Annals of surgical oncology 19(2012), 7 vom: 01. Feb., Seite 2169-2177 volume:19 year:2012 number:7 day:01 month:02 pages:2169-2177
sourceStr	Enthalten in Annals of surgical oncology 19(2012), 7 vom: 01. Feb., Seite 2169-2177 volume:19 year:2012 number:7 day:01 month:02 pages:2169-2177
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Lymph Node Colorectal Cancer Rectal Cancer Intermediate Lymph Node Rectal Cancer Patient
dewey-raw	610
isfreeaccess_bool	false
container_title	Annals of surgical oncology
authorswithroles_txt_mv	Kanemitsu, Yukihide @@aut@@ Komori, Koji @@aut@@ Ishiguro, Seiji @@aut@@ Watanabe, Toshiaki @@aut@@ Sugihara, Kenichi @@aut@@
publishDateDaySort_date	2012-02-01T00:00:00Z
hierarchy_top_id	343969947
dewey-sort	3610
id	SPR009951172
language_de	englisch
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author	Kanemitsu, Yukihide
spellingShingle	Kanemitsu, Yukihide ddc 610 bkl 44.81 bkl 44.65 misc Lymph Node misc Colorectal Cancer misc Rectal Cancer misc Intermediate Lymph Node misc Rectal Cancer Patient The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study
authorStr	Kanemitsu, Yukihide
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topic_title	610 ASE 44.81 bkl 44.65 bkl The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study Lymph Node (dpeaa)DE-He213 Colorectal Cancer (dpeaa)DE-He213 Rectal Cancer (dpeaa)DE-He213 Intermediate Lymph Node (dpeaa)DE-He213 Rectal Cancer Patient (dpeaa)DE-He213
topic	ddc 610 bkl 44.81 bkl 44.65 misc Lymph Node misc Colorectal Cancer misc Rectal Cancer misc Intermediate Lymph Node misc Rectal Cancer Patient
topic_unstemmed	ddc 610 bkl 44.81 bkl 44.65 misc Lymph Node misc Colorectal Cancer misc Rectal Cancer misc Intermediate Lymph Node misc Rectal Cancer Patient
topic_browse	ddc 610 bkl 44.81 bkl 44.65 misc Lymph Node misc Colorectal Cancer misc Rectal Cancer misc Intermediate Lymph Node misc Rectal Cancer Patient
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hierarchy_parent_title	Annals of surgical oncology
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title	The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study
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title_full	The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study
author_sort	Kanemitsu, Yukihide
journal	Annals of surgical oncology
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author_browse	Kanemitsu, Yukihide Komori, Koji Ishiguro, Seiji Watanabe, Toshiaki Sugihara, Kenichi
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title_sort	relationship of lymph node evaluation and colorectal cancer survival after curative resection: a multi-institutional study
title_auth	The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study
abstract	Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance.
abstractGer	Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance.
abstract_unstemmed	Purpose This multicenter retrospective study aimed to clarify whether the number of lymph nodes retrieved influenced staging and survival in colorectal cancer. Methods We evaluated a total of 4538 patients who underwent curative resection for colorectal cancer with stage I, stage II, and stage III. Results The median number of lymph nodes retrieved was 19. The 5-year actuarial disease-specific survival of colon cancer patients with stage I, stage II, and stage III was 99.0%, 94.1%, and 79.1%, respectively, and that for rectal cancer patients with stage I, stage II, and stage III was 98.2%, 88.3%, and 69.1%, respectively. After adjustment for confounders, the number of lymph nodes retrieved and the number of positive nodes were both significant in prognosis for patients with colon cancer and rectal cancer. Survival improved with an increasing number of nodes in stage II patients. In stage III, patients within strata of retrieval of fewer than 12 nodes with a cutoff based on quartiles had lower discriminative ability (c-index 0.683). Patients who were treated at the hospitals with higher average node counts (>23.4 nodes) and higher 12-node measure compliance (>80%) experienced better survival than those treated at the hospitals with lower average node counts for advanced T-stage. Conclusion This study found that the number of lymph nodes retrieved and the number of positive nodes are both important prognostic factors. At least a 12-node threshold may be supported as a measure to improve a predictive capacity within individual patients and as a quality control parameter of hospital performance.
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container_issue	7
title_short	The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study
url	https://dx.doi.org/10.1245/s10434-012-2223-8
remote_bool	true
author2	Komori, Koji Ishiguro, Seiji Watanabe, Toshiaki Sugihara, Kenichi
author2Str	Komori, Koji Ishiguro, Seiji Watanabe, Toshiaki Sugihara, Kenichi
ppnlink	343969947
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1245/s10434-012-2223-8
up_date	2024-07-04T03:38:48.011Z
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The Relationship of Lymph Node Evaluation and Colorectal Cancer Survival After Curative Resection: A Multi-Institutional Study

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