Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism

Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and o...
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Autor*in:	Kuo, Lindsay E. [verfasserIn] Wachtel, Heather [verfasserIn] Roses, Robert E. [verfasserIn] Fraker, Douglas L. [verfasserIn] Kelz, Rachel R. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Hyperaldosteronism Antihypertensive Medication Hypokalemia Primary Hyperaldosteronism Adrenal Mass

Übergeordnetes Werk:	Enthalten in: Annals of surgical oncology - Berlin [u.a.] : Springer, 1994, 22(2015), Suppl 3 vom: 21. Juli, Seite 734-741
Übergeordnetes Werk:	volume:22 ; year:2015 ; number:Suppl 3 ; day:21 ; month:07 ; pages:734-741

Links:	Volltext

DOI / URN:	10.1245/s10434-015-4729-3

Katalog-ID:	SPR009974377

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520			\|a Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure.
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650		4	\|a Antihypertensive Medication \|7 (dpeaa)DE-He213
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650		4	\|a Primary Hyperaldosteronism \|7 (dpeaa)DE-He213
650		4	\|a Adrenal Mass \|7 (dpeaa)DE-He213
700	1		\|a Wachtel, Heather \|e verfasserin \|4 aut
700	1		\|a Roses, Robert E. \|e verfasserin \|4 aut
700	1		\|a Fraker, Douglas L. \|e verfasserin \|4 aut
700	1		\|a Kelz, Rachel R. \|e verfasserin \|4 aut
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Indexfelder

author_variant	l e k le lek h w hw r e r re rer d l f dl dlf r r k rr rrk
matchkey_str	article:15344681:2015----::nietlnitninleiiecivsmlreutipia
hierarchy_sort_str	2015
bklnumber	44.81 44.65
publishDate	2015
allfields	10.1245/s10434-015-4729-3 doi (DE-627)SPR009974377 (SPR)s10434-015-4729-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kuo, Lindsay E. verfasserin aut Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure. Hyperaldosteronism (dpeaa)DE-He213 Antihypertensive Medication (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Primary Hyperaldosteronism (dpeaa)DE-He213 Adrenal Mass (dpeaa)DE-He213 Wachtel, Heather verfasserin aut Roses, Robert E. verfasserin aut Fraker, Douglas L. verfasserin aut Kelz, Rachel R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 22(2015), Suppl 3 vom: 21. Juli, Seite 734-741 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:22 year:2015 number:Suppl 3 day:21 month:07 pages:734-741 https://dx.doi.org/10.1245/s10434-015-4729-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 22 2015 Suppl 3 21 07 734-741
spelling	10.1245/s10434-015-4729-3 doi (DE-627)SPR009974377 (SPR)s10434-015-4729-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kuo, Lindsay E. verfasserin aut Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure. Hyperaldosteronism (dpeaa)DE-He213 Antihypertensive Medication (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Primary Hyperaldosteronism (dpeaa)DE-He213 Adrenal Mass (dpeaa)DE-He213 Wachtel, Heather verfasserin aut Roses, Robert E. verfasserin aut Fraker, Douglas L. verfasserin aut Kelz, Rachel R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 22(2015), Suppl 3 vom: 21. Juli, Seite 734-741 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:22 year:2015 number:Suppl 3 day:21 month:07 pages:734-741 https://dx.doi.org/10.1245/s10434-015-4729-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 22 2015 Suppl 3 21 07 734-741
allfields_unstemmed	10.1245/s10434-015-4729-3 doi (DE-627)SPR009974377 (SPR)s10434-015-4729-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kuo, Lindsay E. verfasserin aut Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure. Hyperaldosteronism (dpeaa)DE-He213 Antihypertensive Medication (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Primary Hyperaldosteronism (dpeaa)DE-He213 Adrenal Mass (dpeaa)DE-He213 Wachtel, Heather verfasserin aut Roses, Robert E. verfasserin aut Fraker, Douglas L. verfasserin aut Kelz, Rachel R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 22(2015), Suppl 3 vom: 21. Juli, Seite 734-741 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:22 year:2015 number:Suppl 3 day:21 month:07 pages:734-741 https://dx.doi.org/10.1245/s10434-015-4729-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 22 2015 Suppl 3 21 07 734-741
allfieldsGer	10.1245/s10434-015-4729-3 doi (DE-627)SPR009974377 (SPR)s10434-015-4729-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kuo, Lindsay E. verfasserin aut Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure. Hyperaldosteronism (dpeaa)DE-He213 Antihypertensive Medication (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Primary Hyperaldosteronism (dpeaa)DE-He213 Adrenal Mass (dpeaa)DE-He213 Wachtel, Heather verfasserin aut Roses, Robert E. verfasserin aut Fraker, Douglas L. verfasserin aut Kelz, Rachel R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 22(2015), Suppl 3 vom: 21. Juli, Seite 734-741 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:22 year:2015 number:Suppl 3 day:21 month:07 pages:734-741 https://dx.doi.org/10.1245/s10434-015-4729-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 22 2015 Suppl 3 21 07 734-741
allfieldsSound	10.1245/s10434-015-4729-3 doi (DE-627)SPR009974377 (SPR)s10434-015-4729-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Kuo, Lindsay E. verfasserin aut Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure. Hyperaldosteronism (dpeaa)DE-He213 Antihypertensive Medication (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Primary Hyperaldosteronism (dpeaa)DE-He213 Adrenal Mass (dpeaa)DE-He213 Wachtel, Heather verfasserin aut Roses, Robert E. verfasserin aut Fraker, Douglas L. verfasserin aut Kelz, Rachel R. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 22(2015), Suppl 3 vom: 21. Juli, Seite 734-741 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:22 year:2015 number:Suppl 3 day:21 month:07 pages:734-741 https://dx.doi.org/10.1245/s10434-015-4729-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 22 2015 Suppl 3 21 07 734-741
language	English
source	Enthalten in Annals of surgical oncology 22(2015), Suppl 3 vom: 21. Juli, Seite 734-741 volume:22 year:2015 number:Suppl 3 day:21 month:07 pages:734-741
sourceStr	Enthalten in Annals of surgical oncology 22(2015), Suppl 3 vom: 21. Juli, Seite 734-741 volume:22 year:2015 number:Suppl 3 day:21 month:07 pages:734-741
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Hyperaldosteronism Antihypertensive Medication Hypokalemia Primary Hyperaldosteronism Adrenal Mass
dewey-raw	610
isfreeaccess_bool	false
container_title	Annals of surgical oncology
authorswithroles_txt_mv	Kuo, Lindsay E. @@aut@@ Wachtel, Heather @@aut@@ Roses, Robert E. @@aut@@ Fraker, Douglas L. @@aut@@ Kelz, Rachel R. @@aut@@
publishDateDaySort_date	2015-07-21T00:00:00Z
hierarchy_top_id	343969947
dewey-sort	3610
id	SPR009974377
language_de	englisch
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Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. 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author	Kuo, Lindsay E.
spellingShingle	Kuo, Lindsay E. ddc 610 bkl 44.81 bkl 44.65 misc Hyperaldosteronism misc Antihypertensive Medication misc Hypokalemia misc Primary Hyperaldosteronism misc Adrenal Mass Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism
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topic_title	610 ASE 44.81 bkl 44.65 bkl Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism Hyperaldosteronism (dpeaa)DE-He213 Antihypertensive Medication (dpeaa)DE-He213 Hypokalemia (dpeaa)DE-He213 Primary Hyperaldosteronism (dpeaa)DE-He213 Adrenal Mass (dpeaa)DE-He213
topic	ddc 610 bkl 44.81 bkl 44.65 misc Hyperaldosteronism misc Antihypertensive Medication misc Hypokalemia misc Primary Hyperaldosteronism misc Adrenal Mass
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title	Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism
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title_full	Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism
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author_browse	Kuo, Lindsay E. Wachtel, Heather Roses, Robert E. Fraker, Douglas L. Kelz, Rachel R.
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title_sort	incidental and intentional medicine achieve similar results in primary hyperaldosteronism
title_auth	Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism
abstract	Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure.
abstractGer	Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure.
abstract_unstemmed	Background Primary hyperaldosteronism is a common cause of hypertension, with significant cardiovascular, renal, and metabolic sequelae. Delayed diagnosis of primary hyperaldosteronism can lead to severe disease and lower cure rates after adrenalectomy. This study investigated the presentation and outcomes of patients who had primary hyperaldosteronism diagnosed after incidental discovery of an adrenal mass. Methods A retrospective cohort study investigated patients receiving adrenalectomy for primary hyperaldosteronism at the authors’ institution from 2001 to 2014. Patients were classified as nonincidental if the aldosteronoma was identified on imaging performed for a hypertension or hypokalemia workup or after a biochemical diagnosis or as incidental if the aldosteronoma was identified on imaging performed for any other reason. Nonincidental and incidental patients were compared in terms of patient demographics, clinical history, preoperative test results, surgical pathology findings, and postoperative course. Results The study included 210 patients, 17 (8.1 %) of whom were incidental. At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. Increased adherence to guidelines for screening of primary hyperaldosteronism will lead to a more timely diagnosis for all patients and a higher potential for surgical cure.
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container_issue	Suppl 3
title_short	Incidental and Intentional Medicine Achieve Similar Results in Primary Hyperaldosteronism
url	https://dx.doi.org/10.1245/s10434-015-4729-3
remote_bool	true
author2	Wachtel, Heather Roses, Robert E. Fraker, Douglas L. Kelz, Rachel R.
author2Str	Wachtel, Heather Roses, Robert E. Fraker, Douglas L. Kelz, Rachel R.
ppnlink	343969947
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1245/s10434-015-4729-3
up_date	2024-07-04T03:44:47.445Z
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At the time of surgical evaluation, 88 % of the incidental patients met the criteria for primary hyperaldosteronism screening based on hypokalemia or the degree of hypertension. The incidental patients were younger than the nonincidental patients, but the two groups were otherwise demographically and clinically similar. The incidental patients had larger aldosteronomas than the nonincidental patients. The nonincidental and incidental patients had similar rates of postoperative cure and failure. Conclusions Nonincidental and incidental patients have comparable disease severity before surgical evaluation and similar rates of postoperative cure. 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