Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins
Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with com...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Merrill, Andrea L. [verfasserIn] Tang, Rong [verfasserIn] Plichta, Jennifer K. [verfasserIn] Rai, Upahvan [verfasserIn] Coopey, Suzanne B. [verfasserIn] McEvoy, Maureen P. [verfasserIn] Hughes, Kevin S. [verfasserIn] Specht, Michelle C. [verfasserIn] Gadd, Michele A. [verfasserIn] Smith, Barbara L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Übergeordnetes Werk: |
Enthalten in: Annals of surgical oncology - Berlin [u.a.] : Springer, 1994, 23(2016), 11 vom: 20. Mai, Seite 3453-3458 |
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| Übergeordnetes Werk: |
volume:23 ; year:2016 ; number:11 ; day:20 ; month:05 ; pages:3453-3458 |
| Links: |
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| DOI / URN: |
10.1245/s10434-016-5251-y |
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| Katalog-ID: |
SPR009976329 |
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| 245 | 1 | 0 | |a Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins |
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| 520 | |a Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. | ||
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| 650 | 4 | |a Margin Width |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ipsilateral Breast Tumor Recurrence |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Shave Cavity Margin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Comedo Necrosis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Tang, Rong |e verfasserin |4 aut | |
| 700 | 1 | |a Plichta, Jennifer K. |e verfasserin |4 aut | |
| 700 | 1 | |a Rai, Upahvan |e verfasserin |4 aut | |
| 700 | 1 | |a Coopey, Suzanne B. |e verfasserin |4 aut | |
| 700 | 1 | |a McEvoy, Maureen P. |e verfasserin |4 aut | |
| 700 | 1 | |a Hughes, Kevin S. |e verfasserin |4 aut | |
| 700 | 1 | |a Specht, Michelle C. |e verfasserin |4 aut | |
| 700 | 1 | |a Gadd, Michele A. |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Barbara L. |e verfasserin |4 aut | |
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10.1245/s10434-016-5251-y doi (DE-627)SPR009976329 (SPR)s10434-016-5251-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Merrill, Andrea L. verfasserin aut Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. Residual Disease (dpeaa)DE-He213 Margin Width (dpeaa)DE-He213 Ipsilateral Breast Tumor Recurrence (dpeaa)DE-He213 Shave Cavity Margin (dpeaa)DE-He213 Comedo Necrosis (dpeaa)DE-He213 Tang, Rong verfasserin aut Plichta, Jennifer K. verfasserin aut Rai, Upahvan verfasserin aut Coopey, Suzanne B. verfasserin aut McEvoy, Maureen P. verfasserin aut Hughes, Kevin S. verfasserin aut Specht, Michelle C. verfasserin aut Gadd, Michele A. verfasserin aut Smith, Barbara L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 23(2016), 11 vom: 20. Mai, Seite 3453-3458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:23 year:2016 number:11 day:20 month:05 pages:3453-3458 https://dx.doi.org/10.1245/s10434-016-5251-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 23 2016 11 20 05 3453-3458 |
| spelling |
10.1245/s10434-016-5251-y doi (DE-627)SPR009976329 (SPR)s10434-016-5251-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Merrill, Andrea L. verfasserin aut Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. Residual Disease (dpeaa)DE-He213 Margin Width (dpeaa)DE-He213 Ipsilateral Breast Tumor Recurrence (dpeaa)DE-He213 Shave Cavity Margin (dpeaa)DE-He213 Comedo Necrosis (dpeaa)DE-He213 Tang, Rong verfasserin aut Plichta, Jennifer K. verfasserin aut Rai, Upahvan verfasserin aut Coopey, Suzanne B. verfasserin aut McEvoy, Maureen P. verfasserin aut Hughes, Kevin S. verfasserin aut Specht, Michelle C. verfasserin aut Gadd, Michele A. verfasserin aut Smith, Barbara L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 23(2016), 11 vom: 20. Mai, Seite 3453-3458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:23 year:2016 number:11 day:20 month:05 pages:3453-3458 https://dx.doi.org/10.1245/s10434-016-5251-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 23 2016 11 20 05 3453-3458 |
| allfields_unstemmed |
10.1245/s10434-016-5251-y doi (DE-627)SPR009976329 (SPR)s10434-016-5251-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Merrill, Andrea L. verfasserin aut Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. Residual Disease (dpeaa)DE-He213 Margin Width (dpeaa)DE-He213 Ipsilateral Breast Tumor Recurrence (dpeaa)DE-He213 Shave Cavity Margin (dpeaa)DE-He213 Comedo Necrosis (dpeaa)DE-He213 Tang, Rong verfasserin aut Plichta, Jennifer K. verfasserin aut Rai, Upahvan verfasserin aut Coopey, Suzanne B. verfasserin aut McEvoy, Maureen P. verfasserin aut Hughes, Kevin S. verfasserin aut Specht, Michelle C. verfasserin aut Gadd, Michele A. verfasserin aut Smith, Barbara L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 23(2016), 11 vom: 20. Mai, Seite 3453-3458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:23 year:2016 number:11 day:20 month:05 pages:3453-3458 https://dx.doi.org/10.1245/s10434-016-5251-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 23 2016 11 20 05 3453-3458 |
| allfieldsGer |
10.1245/s10434-016-5251-y doi (DE-627)SPR009976329 (SPR)s10434-016-5251-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Merrill, Andrea L. verfasserin aut Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. Residual Disease (dpeaa)DE-He213 Margin Width (dpeaa)DE-He213 Ipsilateral Breast Tumor Recurrence (dpeaa)DE-He213 Shave Cavity Margin (dpeaa)DE-He213 Comedo Necrosis (dpeaa)DE-He213 Tang, Rong verfasserin aut Plichta, Jennifer K. verfasserin aut Rai, Upahvan verfasserin aut Coopey, Suzanne B. verfasserin aut McEvoy, Maureen P. verfasserin aut Hughes, Kevin S. verfasserin aut Specht, Michelle C. verfasserin aut Gadd, Michele A. verfasserin aut Smith, Barbara L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 23(2016), 11 vom: 20. Mai, Seite 3453-3458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:23 year:2016 number:11 day:20 month:05 pages:3453-3458 https://dx.doi.org/10.1245/s10434-016-5251-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 23 2016 11 20 05 3453-3458 |
| allfieldsSound |
10.1245/s10434-016-5251-y doi (DE-627)SPR009976329 (SPR)s10434-016-5251-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.65 bkl Merrill, Andrea L. verfasserin aut Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. Residual Disease (dpeaa)DE-He213 Margin Width (dpeaa)DE-He213 Ipsilateral Breast Tumor Recurrence (dpeaa)DE-He213 Shave Cavity Margin (dpeaa)DE-He213 Comedo Necrosis (dpeaa)DE-He213 Tang, Rong verfasserin aut Plichta, Jennifer K. verfasserin aut Rai, Upahvan verfasserin aut Coopey, Suzanne B. verfasserin aut McEvoy, Maureen P. verfasserin aut Hughes, Kevin S. verfasserin aut Specht, Michelle C. verfasserin aut Gadd, Michele A. verfasserin aut Smith, Barbara L. verfasserin aut Enthalten in Annals of surgical oncology Berlin [u.a.] : Springer, 1994 23(2016), 11 vom: 20. Mai, Seite 3453-3458 (DE-627)343969947 (DE-600)2074021-9 1534-4681 nnns volume:23 year:2016 number:11 day:20 month:05 pages:3453-3458 https://dx.doi.org/10.1245/s10434-016-5251-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.65 ASE AR 23 2016 11 20 05 3453-3458 |
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Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. 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Merrill, Andrea L. |
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Merrill, Andrea L. ddc 610 bkl 44.81 bkl 44.65 misc Residual Disease misc Margin Width misc Ipsilateral Breast Tumor Recurrence misc Shave Cavity Margin misc Comedo Necrosis Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins |
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610 ASE 44.81 bkl 44.65 bkl Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins Residual Disease (dpeaa)DE-He213 Margin Width (dpeaa)DE-He213 Ipsilateral Breast Tumor Recurrence (dpeaa)DE-He213 Shave Cavity Margin (dpeaa)DE-He213 Comedo Necrosis (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 bkl 44.65 misc Residual Disease misc Margin Width misc Ipsilateral Breast Tumor Recurrence misc Shave Cavity Margin misc Comedo Necrosis |
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ddc 610 bkl 44.81 bkl 44.65 misc Residual Disease misc Margin Width misc Ipsilateral Breast Tumor Recurrence misc Shave Cavity Margin misc Comedo Necrosis |
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Annals of surgical oncology |
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Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins |
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Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins |
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Merrill, Andrea L. |
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Merrill, Andrea L. Tang, Rong Plichta, Jennifer K. Rai, Upahvan Coopey, Suzanne B. McEvoy, Maureen P. Hughes, Kevin S. Specht, Michelle C. Gadd, Michele A. Smith, Barbara L. |
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Merrill, Andrea L. |
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should new “no ink on tumor” lumpectomy margin guidelines be applied to ductal carcinoma in situ (dcis)? a retrospective review using shaved cavity margins |
| title_auth |
Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins |
| abstract |
Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. |
| abstractGer |
Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. |
| abstract_unstemmed |
Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. Use of narrower margins may have important implications for use of adjuvant therapy. |
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Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR009976329</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519081116.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201005s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1245/s10434-016-5251-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR009976329</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10434-016-5251-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.81</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.65</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Merrill, Andrea L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Should New “No Ink On Tumor” Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a “no ink on tumor” standard for pure DCIS by correlating clear margin width with rates of residual disease. Methods Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded. Rates of residual disease in shaved margins were determined based on margin status of the main lumpectomy specimen using margin widths of “ink on tumor,” ≤1, >1 to <2, and ≥2 mm. Results Overall, 182 women undergoing lumpectomy for pure DCIS met eligibility criteria. In patients with “ink on tumor” in the main lumpectomy specimen, 88 % had residual disease in the SCMs. Rates of residual disease in SCMs for lumpectomies with margins of <2 mm (but not on ink) were 52 % compared with 13 % for lumpectomies with margins ≥2 mm (p < 0.0005). Multivariate analyses confirmed the association of lumpectomy margin width and residual tumor in shaved cavity margins. Odds of residual disease in the SCM for postmenopausal patients were 74 % less than for pre/perimenopausal women (odds ratio 0.26; confidence interval 0.08–0.82). Conclusions Application of a “no ink on tumor” lumpectomy margin standard to patients with DCIS results in a significant increase in the rates of residual disease in cavity margins compared with use of a ≥2-mm margin standard. 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