Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach
Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are inf...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
David, Laurent [verfasserIn] Yun, Jay [verfasserIn] Nicoud, Roger-Marc [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Adsorption - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1995, 23(2017), 4 vom: 14. März, Seite 577-591 |
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| Übergeordnetes Werk: |
volume:23 ; year:2017 ; number:4 ; day:14 ; month:03 ; pages:577-591 |
| Links: |
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| DOI / URN: |
10.1007/s10450-017-9878-1 |
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| Katalog-ID: |
SPR010129332 |
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| 520 | |a Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. | ||
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| 700 | 1 | |a Nicoud, Roger-Marc |e verfasserin |4 aut | |
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10.1007/s10450-017-9878-1 doi (DE-627)SPR010129332 (SPR)s10450-017-9878-1-e DE-627 ger DE-627 rakwb eng 540 ASE 33.68 bkl 35.18 bkl 58.13 bkl David, Laurent verfasserin aut Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. Sugars (dpeaa)DE-He213 Chromatography (dpeaa)DE-He213 Simulation (dpeaa)DE-He213 Simulated Moving Bed (dpeaa)DE-He213 Ion exchange (dpeaa)DE-He213 Yun, Jay verfasserin aut Nicoud, Roger-Marc verfasserin aut Enthalten in Adsorption Dordrecht [u.a.] : Springer Science + Business Media B.V, 1995 23(2017), 4 vom: 14. März, Seite 577-591 (DE-627)30089516X (DE-600)1483298-7 1572-8757 nnns volume:23 year:2017 number:4 day:14 month:03 pages:577-591 https://dx.doi.org/10.1007/s10450-017-9878-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.68 ASE 35.18 ASE 58.13 ASE AR 23 2017 4 14 03 577-591 |
| spelling |
10.1007/s10450-017-9878-1 doi (DE-627)SPR010129332 (SPR)s10450-017-9878-1-e DE-627 ger DE-627 rakwb eng 540 ASE 33.68 bkl 35.18 bkl 58.13 bkl David, Laurent verfasserin aut Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. Sugars (dpeaa)DE-He213 Chromatography (dpeaa)DE-He213 Simulation (dpeaa)DE-He213 Simulated Moving Bed (dpeaa)DE-He213 Ion exchange (dpeaa)DE-He213 Yun, Jay verfasserin aut Nicoud, Roger-Marc verfasserin aut Enthalten in Adsorption Dordrecht [u.a.] : Springer Science + Business Media B.V, 1995 23(2017), 4 vom: 14. März, Seite 577-591 (DE-627)30089516X (DE-600)1483298-7 1572-8757 nnns volume:23 year:2017 number:4 day:14 month:03 pages:577-591 https://dx.doi.org/10.1007/s10450-017-9878-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.68 ASE 35.18 ASE 58.13 ASE AR 23 2017 4 14 03 577-591 |
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10.1007/s10450-017-9878-1 doi (DE-627)SPR010129332 (SPR)s10450-017-9878-1-e DE-627 ger DE-627 rakwb eng 540 ASE 33.68 bkl 35.18 bkl 58.13 bkl David, Laurent verfasserin aut Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. Sugars (dpeaa)DE-He213 Chromatography (dpeaa)DE-He213 Simulation (dpeaa)DE-He213 Simulated Moving Bed (dpeaa)DE-He213 Ion exchange (dpeaa)DE-He213 Yun, Jay verfasserin aut Nicoud, Roger-Marc verfasserin aut Enthalten in Adsorption Dordrecht [u.a.] : Springer Science + Business Media B.V, 1995 23(2017), 4 vom: 14. März, Seite 577-591 (DE-627)30089516X (DE-600)1483298-7 1572-8757 nnns volume:23 year:2017 number:4 day:14 month:03 pages:577-591 https://dx.doi.org/10.1007/s10450-017-9878-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.68 ASE 35.18 ASE 58.13 ASE AR 23 2017 4 14 03 577-591 |
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10.1007/s10450-017-9878-1 doi (DE-627)SPR010129332 (SPR)s10450-017-9878-1-e DE-627 ger DE-627 rakwb eng 540 ASE 33.68 bkl 35.18 bkl 58.13 bkl David, Laurent verfasserin aut Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. Sugars (dpeaa)DE-He213 Chromatography (dpeaa)DE-He213 Simulation (dpeaa)DE-He213 Simulated Moving Bed (dpeaa)DE-He213 Ion exchange (dpeaa)DE-He213 Yun, Jay verfasserin aut Nicoud, Roger-Marc verfasserin aut Enthalten in Adsorption Dordrecht [u.a.] : Springer Science + Business Media B.V, 1995 23(2017), 4 vom: 14. März, Seite 577-591 (DE-627)30089516X (DE-600)1483298-7 1572-8757 nnns volume:23 year:2017 number:4 day:14 month:03 pages:577-591 https://dx.doi.org/10.1007/s10450-017-9878-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.68 ASE 35.18 ASE 58.13 ASE AR 23 2017 4 14 03 577-591 |
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10.1007/s10450-017-9878-1 doi (DE-627)SPR010129332 (SPR)s10450-017-9878-1-e DE-627 ger DE-627 rakwb eng 540 ASE 33.68 bkl 35.18 bkl 58.13 bkl David, Laurent verfasserin aut Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. Sugars (dpeaa)DE-He213 Chromatography (dpeaa)DE-He213 Simulation (dpeaa)DE-He213 Simulated Moving Bed (dpeaa)DE-He213 Ion exchange (dpeaa)DE-He213 Yun, Jay verfasserin aut Nicoud, Roger-Marc verfasserin aut Enthalten in Adsorption Dordrecht [u.a.] : Springer Science + Business Media B.V, 1995 23(2017), 4 vom: 14. März, Seite 577-591 (DE-627)30089516X (DE-600)1483298-7 1572-8757 nnns volume:23 year:2017 number:4 day:14 month:03 pages:577-591 https://dx.doi.org/10.1007/s10450-017-9878-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 33.68 ASE 35.18 ASE 58.13 ASE AR 23 2017 4 14 03 577-591 |
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Enthalten in Adsorption 23(2017), 4 vom: 14. März, Seite 577-591 volume:23 year:2017 number:4 day:14 month:03 pages:577-591 |
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540 ASE 33.68 bkl 35.18 bkl 58.13 bkl Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach Sugars (dpeaa)DE-He213 Chromatography (dpeaa)DE-He213 Simulation (dpeaa)DE-He213 Simulated Moving Bed (dpeaa)DE-He213 Ion exchange (dpeaa)DE-He213 |
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comparing multi-column chromatographic processes for purifying monosaccharides part i: a simplified approach |
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Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach |
| abstract |
Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. |
| abstractGer |
Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. |
| abstract_unstemmed |
Abstract This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB. |
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Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach |
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https://dx.doi.org/10.1007/s10450-017-9878-1 |
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Yun, Jay Nicoud, Roger-Marc |
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10.1007/s10450-017-9878-1 |
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2024-07-03T14:06:56.462Z |
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|
| score |
7.401865 |