Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway
Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Rea...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pushpavalli, Sreerangam N. C. V. L. [verfasserIn] Sarkar, Arpita [verfasserIn] Ramaiah, M. Janaki [verfasserIn] Koteswara Rao, G. [verfasserIn] Bag, Indira [verfasserIn] Bhadra, Utpal [verfasserIn] Pal-Bhadra, Manika [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Apoptosis - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1996, 21(2015), 3 vom: 28. Dez., Seite 269-282 |
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| Übergeordnetes Werk: |
volume:21 ; year:2015 ; number:3 ; day:28 ; month:12 ; pages:269-282 |
| Links: |
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| DOI / URN: |
10.1007/s10495-015-1206-1 |
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| Katalog-ID: |
SPR010503587 |
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| 245 | 1 | 0 | |a Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway |
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| 520 | |a Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. | ||
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| 650 | 4 | |a Diap1 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Apoptosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Diap1 promoter |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hid |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Reaper |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Grim |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Sarkar, Arpita |e verfasserin |4 aut | |
| 700 | 1 | |a Ramaiah, M. Janaki |e verfasserin |4 aut | |
| 700 | 1 | |a Koteswara Rao, G. |e verfasserin |4 aut | |
| 700 | 1 | |a Bag, Indira |e verfasserin |4 aut | |
| 700 | 1 | |a Bhadra, Utpal |e verfasserin |4 aut | |
| 700 | 1 | |a Pal-Bhadra, Manika |e verfasserin |4 aut | |
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10.1007/s10495-015-1206-1 doi (DE-627)SPR010503587 (SPR)s10495-015-1206-1-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Pushpavalli, Sreerangam N. C. V. L. verfasserin aut Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. Mof (dpeaa)DE-He213 H4K16Ac (dpeaa)DE-He213 Diap1 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Diap1 promoter (dpeaa)DE-He213 Hid (dpeaa)DE-He213 Reaper (dpeaa)DE-He213 Grim (dpeaa)DE-He213 Sarkar, Arpita verfasserin aut Ramaiah, M. Janaki verfasserin aut Koteswara Rao, G. verfasserin aut Bag, Indira verfasserin aut Bhadra, Utpal verfasserin aut Pal-Bhadra, Manika verfasserin aut Enthalten in Apoptosis Dordrecht [u.a.] : Springer Science + Business Media B.V, 1996 21(2015), 3 vom: 28. Dez., Seite 269-282 (DE-627)306311577 (DE-600)1495863-6 1573-675X nnns volume:21 year:2015 number:3 day:28 month:12 pages:269-282 https://dx.doi.org/10.1007/s10495-015-1206-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 21 2015 3 28 12 269-282 |
| spelling |
10.1007/s10495-015-1206-1 doi (DE-627)SPR010503587 (SPR)s10495-015-1206-1-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Pushpavalli, Sreerangam N. C. V. L. verfasserin aut Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. Mof (dpeaa)DE-He213 H4K16Ac (dpeaa)DE-He213 Diap1 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Diap1 promoter (dpeaa)DE-He213 Hid (dpeaa)DE-He213 Reaper (dpeaa)DE-He213 Grim (dpeaa)DE-He213 Sarkar, Arpita verfasserin aut Ramaiah, M. Janaki verfasserin aut Koteswara Rao, G. verfasserin aut Bag, Indira verfasserin aut Bhadra, Utpal verfasserin aut Pal-Bhadra, Manika verfasserin aut Enthalten in Apoptosis Dordrecht [u.a.] : Springer Science + Business Media B.V, 1996 21(2015), 3 vom: 28. Dez., Seite 269-282 (DE-627)306311577 (DE-600)1495863-6 1573-675X nnns volume:21 year:2015 number:3 day:28 month:12 pages:269-282 https://dx.doi.org/10.1007/s10495-015-1206-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 21 2015 3 28 12 269-282 |
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10.1007/s10495-015-1206-1 doi (DE-627)SPR010503587 (SPR)s10495-015-1206-1-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Pushpavalli, Sreerangam N. C. V. L. verfasserin aut Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. Mof (dpeaa)DE-He213 H4K16Ac (dpeaa)DE-He213 Diap1 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Diap1 promoter (dpeaa)DE-He213 Hid (dpeaa)DE-He213 Reaper (dpeaa)DE-He213 Grim (dpeaa)DE-He213 Sarkar, Arpita verfasserin aut Ramaiah, M. Janaki verfasserin aut Koteswara Rao, G. verfasserin aut Bag, Indira verfasserin aut Bhadra, Utpal verfasserin aut Pal-Bhadra, Manika verfasserin aut Enthalten in Apoptosis Dordrecht [u.a.] : Springer Science + Business Media B.V, 1996 21(2015), 3 vom: 28. Dez., Seite 269-282 (DE-627)306311577 (DE-600)1495863-6 1573-675X nnns volume:21 year:2015 number:3 day:28 month:12 pages:269-282 https://dx.doi.org/10.1007/s10495-015-1206-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 21 2015 3 28 12 269-282 |
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10.1007/s10495-015-1206-1 doi (DE-627)SPR010503587 (SPR)s10495-015-1206-1-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Pushpavalli, Sreerangam N. C. V. L. verfasserin aut Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. Mof (dpeaa)DE-He213 H4K16Ac (dpeaa)DE-He213 Diap1 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Diap1 promoter (dpeaa)DE-He213 Hid (dpeaa)DE-He213 Reaper (dpeaa)DE-He213 Grim (dpeaa)DE-He213 Sarkar, Arpita verfasserin aut Ramaiah, M. Janaki verfasserin aut Koteswara Rao, G. verfasserin aut Bag, Indira verfasserin aut Bhadra, Utpal verfasserin aut Pal-Bhadra, Manika verfasserin aut Enthalten in Apoptosis Dordrecht [u.a.] : Springer Science + Business Media B.V, 1996 21(2015), 3 vom: 28. Dez., Seite 269-282 (DE-627)306311577 (DE-600)1495863-6 1573-675X nnns volume:21 year:2015 number:3 day:28 month:12 pages:269-282 https://dx.doi.org/10.1007/s10495-015-1206-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 21 2015 3 28 12 269-282 |
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10.1007/s10495-015-1206-1 doi (DE-627)SPR010503587 (SPR)s10495-015-1206-1-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Pushpavalli, Sreerangam N. C. V. L. verfasserin aut Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. Mof (dpeaa)DE-He213 H4K16Ac (dpeaa)DE-He213 Diap1 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Diap1 promoter (dpeaa)DE-He213 Hid (dpeaa)DE-He213 Reaper (dpeaa)DE-He213 Grim (dpeaa)DE-He213 Sarkar, Arpita verfasserin aut Ramaiah, M. Janaki verfasserin aut Koteswara Rao, G. verfasserin aut Bag, Indira verfasserin aut Bhadra, Utpal verfasserin aut Pal-Bhadra, Manika verfasserin aut Enthalten in Apoptosis Dordrecht [u.a.] : Springer Science + Business Media B.V, 1996 21(2015), 3 vom: 28. Dez., Seite 269-282 (DE-627)306311577 (DE-600)1495863-6 1573-675X nnns volume:21 year:2015 number:3 day:28 month:12 pages:269-282 https://dx.doi.org/10.1007/s10495-015-1206-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 21 2015 3 28 12 269-282 |
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Pushpavalli, Sreerangam N. C. V. L. @@aut@@ Sarkar, Arpita @@aut@@ Ramaiah, M. Janaki @@aut@@ Koteswara Rao, G. @@aut@@ Bag, Indira @@aut@@ Bhadra, Utpal @@aut@@ Pal-Bhadra, Manika @@aut@@ |
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Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. 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Pushpavalli, Sreerangam N. C. V. L. |
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Pushpavalli, Sreerangam N. C. V. L. ddc 570 bkl 44.00 misc Mof misc H4K16Ac misc Diap1 misc Apoptosis misc Diap1 promoter misc Hid misc Reaper misc Grim Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway |
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570 ASE 44.00 bkl Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway Mof (dpeaa)DE-He213 H4K16Ac (dpeaa)DE-He213 Diap1 (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Diap1 promoter (dpeaa)DE-He213 Hid (dpeaa)DE-He213 Reaper (dpeaa)DE-He213 Grim (dpeaa)DE-He213 |
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Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway |
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Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway |
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Pushpavalli, Sreerangam N. C. V. L. |
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Pushpavalli, Sreerangam N. C. V. L. Sarkar, Arpita Ramaiah, M. Janaki Koteswara Rao, G. Bag, Indira Bhadra, Utpal Pal-Bhadra, Manika |
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drosophila mof regulates diap1 and induces apoptosis in a jnk dependent pathway |
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Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway |
| abstract |
Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. |
| abstractGer |
Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. |
| abstract_unstemmed |
Abstract Histone modulations have been implicated in various cellular and developmental processes where in Drosophila Mof is involved in acetylation of H4K16. Reduction in the size of larval imaginal discs is observed in the null mutants of mof with increased apoptosis. Deficiency involving Hid, Reaper and Grim [H99] alleviated mofRNAi induced apoptosis in the eye discs. mofRNAi induced apoptosis leads to activation of caspases which is suppressed by over expression of caspase inhibitors like P35 and Diap1clearly depicting the role of caspases in programmed cell death. Also apoptosis induced by knockdown of mof is rescued by JNK mutants of bsk and tak1 indicating the role of JNK in mofRNAi induced apoptosis. The adult eye ablation phenotype produced by ectopic expression of Hid, Rpr and Grim, was restored by over expression of Mof. Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof1 mutants. This enrichment coincides with modification of histone H4K16Ac indicating an induction of direct transcriptional up regulation of Diap1 by Mof. Based on these results we propose that apoptosis triggered by mofRNAi proceeds through a caspase-dependent and JNK mediated pathway. |
| collection_details |
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| container_issue |
3 |
| title_short |
Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway |
| url |
https://dx.doi.org/10.1007/s10495-015-1206-1 |
| remote_bool |
true |
| author2 |
Sarkar, Arpita Ramaiah, M. Janaki Koteswara Rao, G. Bag, Indira Bhadra, Utpal Pal-Bhadra, Manika |
| author2Str |
Sarkar, Arpita Ramaiah, M. Janaki Koteswara Rao, G. Bag, Indira Bhadra, Utpal Pal-Bhadra, Manika |
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| doi_str |
10.1007/s10495-015-1206-1 |
| up_date |
2024-07-03T16:33:14.126Z |
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| score |
7.399148 |