Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination
We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of mel...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Litvinenko, G. I. [verfasserIn] Shurlygina, A. V. [verfasserIn] Gritsyk, O. B. [verfasserIn] Mel’nikova, E. V. [verfasserIn] Tenditnik, M. V. [verfasserIn] Avrorov, P. A. [verfasserIn] Trufakin, V. A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
Enthalten in: Bulletin of experimental biology and medicine - Dordrecht [u.a.] : Springer Science + Business Media B. V., 1956, 159(2015), 6 vom: Okt., Seite 732-735 |
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| Übergeordnetes Werk: |
volume:159 ; year:2015 ; number:6 ; month:10 ; pages:732-735 |
| Links: |
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| DOI / URN: |
10.1007/s10517-015-3061-z |
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| Katalog-ID: |
SPR010735097 |
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| 100 | 1 | |a Litvinenko, G. I. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination |
| 264 | 1 | |c 2015 | |
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| 520 | |a We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. | ||
| 700 | 1 | |a Shurlygina, A. V. |e verfasserin |4 aut | |
| 700 | 1 | |a Gritsyk, O. B. |e verfasserin |4 aut | |
| 700 | 1 | |a Mel’nikova, E. V. |e verfasserin |4 aut | |
| 700 | 1 | |a Tenditnik, M. V. |e verfasserin |4 aut | |
| 700 | 1 | |a Avrorov, P. A. |e verfasserin |4 aut | |
| 700 | 1 | |a Trufakin, V. A. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Bulletin of experimental biology and medicine |d Dordrecht [u.a.] : Springer Science + Business Media B. V., 1956 |g 159(2015), 6 vom: Okt., Seite 732-735 |w (DE-627)325568383 |w (DE-600)2037110-X |x 1573-8221 |7 nnns |
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10.1007/s10517-015-3061-z doi (DE-627)SPR010735097 (SPR)s10517-015-3061-z-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Litvinenko, G. I. verfasserin aut Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. Shurlygina, A. V. verfasserin aut Gritsyk, O. B. verfasserin aut Mel’nikova, E. V. verfasserin aut Tenditnik, M. V. verfasserin aut Avrorov, P. A. verfasserin aut Trufakin, V. A. verfasserin aut Enthalten in Bulletin of experimental biology and medicine Dordrecht [u.a.] : Springer Science + Business Media B. V., 1956 159(2015), 6 vom: Okt., Seite 732-735 (DE-627)325568383 (DE-600)2037110-X 1573-8221 nnns volume:159 year:2015 number:6 month:10 pages:732-735 https://dx.doi.org/10.1007/s10517-015-3061-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 159 2015 6 10 732-735 |
| spelling |
10.1007/s10517-015-3061-z doi (DE-627)SPR010735097 (SPR)s10517-015-3061-z-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Litvinenko, G. I. verfasserin aut Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. Shurlygina, A. V. verfasserin aut Gritsyk, O. B. verfasserin aut Mel’nikova, E. V. verfasserin aut Tenditnik, M. V. verfasserin aut Avrorov, P. A. verfasserin aut Trufakin, V. A. verfasserin aut Enthalten in Bulletin of experimental biology and medicine Dordrecht [u.a.] : Springer Science + Business Media B. V., 1956 159(2015), 6 vom: Okt., Seite 732-735 (DE-627)325568383 (DE-600)2037110-X 1573-8221 nnns volume:159 year:2015 number:6 month:10 pages:732-735 https://dx.doi.org/10.1007/s10517-015-3061-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 159 2015 6 10 732-735 |
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10.1007/s10517-015-3061-z doi (DE-627)SPR010735097 (SPR)s10517-015-3061-z-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Litvinenko, G. I. verfasserin aut Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. Shurlygina, A. V. verfasserin aut Gritsyk, O. B. verfasserin aut Mel’nikova, E. V. verfasserin aut Tenditnik, M. V. verfasserin aut Avrorov, P. A. verfasserin aut Trufakin, V. A. verfasserin aut Enthalten in Bulletin of experimental biology and medicine Dordrecht [u.a.] : Springer Science + Business Media B. V., 1956 159(2015), 6 vom: Okt., Seite 732-735 (DE-627)325568383 (DE-600)2037110-X 1573-8221 nnns volume:159 year:2015 number:6 month:10 pages:732-735 https://dx.doi.org/10.1007/s10517-015-3061-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 159 2015 6 10 732-735 |
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10.1007/s10517-015-3061-z doi (DE-627)SPR010735097 (SPR)s10517-015-3061-z-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Litvinenko, G. I. verfasserin aut Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. Shurlygina, A. V. verfasserin aut Gritsyk, O. B. verfasserin aut Mel’nikova, E. V. verfasserin aut Tenditnik, M. V. verfasserin aut Avrorov, P. A. verfasserin aut Trufakin, V. A. verfasserin aut Enthalten in Bulletin of experimental biology and medicine Dordrecht [u.a.] : Springer Science + Business Media B. V., 1956 159(2015), 6 vom: Okt., Seite 732-735 (DE-627)325568383 (DE-600)2037110-X 1573-8221 nnns volume:159 year:2015 number:6 month:10 pages:732-735 https://dx.doi.org/10.1007/s10517-015-3061-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 159 2015 6 10 732-735 |
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10.1007/s10517-015-3061-z doi (DE-627)SPR010735097 (SPR)s10517-015-3061-z-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Litvinenko, G. I. verfasserin aut Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. Shurlygina, A. V. verfasserin aut Gritsyk, O. B. verfasserin aut Mel’nikova, E. V. verfasserin aut Tenditnik, M. V. verfasserin aut Avrorov, P. A. verfasserin aut Trufakin, V. A. verfasserin aut Enthalten in Bulletin of experimental biology and medicine Dordrecht [u.a.] : Springer Science + Business Media B. V., 1956 159(2015), 6 vom: Okt., Seite 732-735 (DE-627)325568383 (DE-600)2037110-X 1573-8221 nnns volume:159 year:2015 number:6 month:10 pages:732-735 https://dx.doi.org/10.1007/s10517-015-3061-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 159 2015 6 10 732-735 |
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Litvinenko, G. I. @@aut@@ Shurlygina, A. V. @@aut@@ Gritsyk, O. B. @@aut@@ Mel’nikova, E. V. @@aut@@ Tenditnik, M. V. @@aut@@ Avrorov, P. A. @@aut@@ Trufakin, V. A. @@aut@@ |
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Litvinenko, G. I. |
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Litvinenko, G. I. ddc 570 bkl 42.00 Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination |
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570 ASE 42.00 bkl Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination |
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Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination |
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Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination |
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Litvinenko, G. I. |
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Litvinenko, G. I. Shurlygina, A. V. Gritsyk, O. B. Mel’nikova, E. V. Tenditnik, M. V. Avrorov, P. A. Trufakin, V. A. |
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effects of melatonin on morphological and functional parameters of the pineal gland and organs of immune system in rats during natural light cycle and constant illumination |
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Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination |
| abstract |
We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. |
| abstractGer |
We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. |
| abstract_unstemmed |
We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of $ CD4^{+} %$ 8^{+} $ splenocytes and $ CD4^{–} %$ 8^{+} $ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of $ CD4^{+} %$ 8^{+} $ cells in the spleen, and a decrease in percent rate of CD11b/c and $ CD4^{–} %$ 8^{+} $ splenocytes. In the thymus amount of $ CD4^{–} %$ 8^{+} $ cells increased, and absolute number of $ CD4^{+} %$ 25^{+} $ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. |
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| title_short |
Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination |
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https://dx.doi.org/10.1007/s10517-015-3061-z |
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| author2 |
Shurlygina, A. V. Gritsyk, O. B. Mel’nikova, E. V. Tenditnik, M. V. Avrorov, P. A. Trufakin, V. A. |
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Shurlygina, A. V. Gritsyk, O. B. Mel’nikova, E. V. Tenditnik, M. V. Avrorov, P. A. Trufakin, V. A. |
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10.1007/s10517-015-3061-z |
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2024-07-03T17:57:36.730Z |
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| score |
7.402235 |