Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory
Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed eff...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Behavior genetics - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1970, 44(2014), 4 vom: 15. Mai, Seite 295-313 |
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| Übergeordnetes Werk: |
volume:44 ; year:2014 ; number:4 ; day:15 ; month:05 ; pages:295-313 |
| Links: |
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| DOI / URN: |
10.1007/s10519-014-9654-x |
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SPR010775897 |
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| 100 | 1 | |a van den Berg, Stéphanie M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory |
| 264 | 1 | |c 2014 | |
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| 520 | |a Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. | ||
| 650 | 4 | |a Personality |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Item-Response Theory |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Measurement |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Genome-wide association studies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Consortium |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Meta-analysis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a de Moor, Marleen H. M. |e verfasserin |4 aut | |
| 700 | 1 | |a McGue, Matt |e verfasserin |4 aut | |
| 700 | 1 | |a Pettersson, Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Terracciano, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Verweij, Karin J. H. |e verfasserin |4 aut | |
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10.1007/s10519-014-9654-x doi (DE-627)SPR010775897 (SPR)s10519-014-9654-x-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl van den Berg, Stéphanie M. verfasserin aut Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. Personality (dpeaa)DE-He213 Item-Response Theory (dpeaa)DE-He213 Measurement (dpeaa)DE-He213 Genome-wide association studies (dpeaa)DE-He213 Consortium (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 de Moor, Marleen H. M. verfasserin aut McGue, Matt verfasserin aut Pettersson, Erik verfasserin aut Terracciano, Antonio verfasserin aut Verweij, Karin J. H. verfasserin aut Amin, Najaf verfasserin aut Derringer, Jaime verfasserin aut Esko, Tõnu verfasserin aut van Grootheest, Gerard verfasserin aut Hansell, Narelle K. verfasserin aut Huffman, Jennifer verfasserin aut Konte, Bettina verfasserin aut Lahti, Jari verfasserin aut Luciano, Michelle verfasserin aut Matteson, Lindsay K. verfasserin aut Viktorin, Alexander verfasserin aut Wouda, Jasper verfasserin aut Agrawal, Arpana verfasserin aut Allik, Jüri verfasserin aut Bierut, Laura verfasserin aut Broms, Ulla verfasserin aut Campbell, Harry verfasserin aut Smith, George Davey verfasserin aut Eriksson, Johan G. verfasserin aut Ferrucci, Luigi verfasserin aut Franke, Barbera verfasserin aut Fox, Jean-Paul verfasserin aut de Geus, Eco J. C. verfasserin aut Giegling, Ina verfasserin aut Gow, Alan J. verfasserin aut Grucza, Richard verfasserin aut Hartmann, Annette M. verfasserin aut Heath, Andrew C. verfasserin aut Heikkilä, Kauko verfasserin aut Iacono, William G. verfasserin aut Janzing, Joost verfasserin aut Jokela, Markus verfasserin aut Kiemeney, Lambertus verfasserin aut Lehtimäki, Terho verfasserin aut Madden, Pamela A. F. verfasserin aut Magnusson, Patrik K. E. verfasserin aut Northstone, Kate verfasserin aut Nutile, Teresa verfasserin aut Ouwens, Klaasjan G. verfasserin aut Palotie, Aarno verfasserin aut Pattie, Alison verfasserin aut Pesonen, Anu-Katriina verfasserin aut Polasek, Ozren verfasserin aut Pulkkinen, Lea verfasserin aut Pulkki-Råback, Laura verfasserin aut Raitakari, Olli T. verfasserin aut Realo, Anu verfasserin aut Rose, Richard J. verfasserin aut Ruggiero, Daniela verfasserin aut Seppälä, Ilkka verfasserin aut Slutske, Wendy S. verfasserin aut Smyth, David C. verfasserin aut Sorice, Rossella verfasserin aut Starr, John M. verfasserin aut Sutin, Angelina R. verfasserin aut Tanaka, Toshiko verfasserin aut Verhagen, Josine verfasserin aut Vermeulen, Sita verfasserin aut Vuoksimaa, Eero verfasserin aut Widen, Elisabeth verfasserin aut Willemsen, Gonneke verfasserin aut Wright, Margaret J. verfasserin aut Zgaga, Lina verfasserin aut Rujescu, Dan verfasserin aut Metspalu, Andres verfasserin aut Wilson, James F. verfasserin aut Ciullo, Marina verfasserin aut Hayward, Caroline verfasserin aut Rudan, Igor verfasserin aut Deary, Ian J. verfasserin aut Räikkönen, Katri verfasserin aut Arias Vasquez, Alejandro verfasserin aut Costa, Paul T. verfasserin aut Keltikangas-Järvinen, Liisa verfasserin aut van Duijn, Cornelia M. verfasserin aut Penninx, Brenda W. J. H. verfasserin aut Krueger, Robert F. verfasserin aut Evans, David M. verfasserin aut Kaprio, Jaakko verfasserin aut Pedersen, Nancy L. verfasserin aut Martin, Nicholas G. verfasserin aut Boomsma, Dorret I. verfasserin aut Enthalten in Behavior genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1970 44(2014), 4 vom: 15. Mai, Seite 295-313 (DE-627)320524345 (DE-600)2014974-8 1573-3297 nnns volume:44 year:2014 number:4 day:15 month:05 pages:295-313 https://dx.doi.org/10.1007/s10519-014-9654-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 44 2014 4 15 05 295-313 |
| spelling |
10.1007/s10519-014-9654-x doi (DE-627)SPR010775897 (SPR)s10519-014-9654-x-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl van den Berg, Stéphanie M. verfasserin aut Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. Personality (dpeaa)DE-He213 Item-Response Theory (dpeaa)DE-He213 Measurement (dpeaa)DE-He213 Genome-wide association studies (dpeaa)DE-He213 Consortium (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 de Moor, Marleen H. M. verfasserin aut McGue, Matt verfasserin aut Pettersson, Erik verfasserin aut Terracciano, Antonio verfasserin aut Verweij, Karin J. H. verfasserin aut Amin, Najaf verfasserin aut Derringer, Jaime verfasserin aut Esko, Tõnu verfasserin aut van Grootheest, Gerard verfasserin aut Hansell, Narelle K. verfasserin aut Huffman, Jennifer verfasserin aut Konte, Bettina verfasserin aut Lahti, Jari verfasserin aut Luciano, Michelle verfasserin aut Matteson, Lindsay K. verfasserin aut Viktorin, Alexander verfasserin aut Wouda, Jasper verfasserin aut Agrawal, Arpana verfasserin aut Allik, Jüri verfasserin aut Bierut, Laura verfasserin aut Broms, Ulla verfasserin aut Campbell, Harry verfasserin aut Smith, George Davey verfasserin aut Eriksson, Johan G. verfasserin aut Ferrucci, Luigi verfasserin aut Franke, Barbera verfasserin aut Fox, Jean-Paul verfasserin aut de Geus, Eco J. C. verfasserin aut Giegling, Ina verfasserin aut Gow, Alan J. verfasserin aut Grucza, Richard verfasserin aut Hartmann, Annette M. verfasserin aut Heath, Andrew C. verfasserin aut Heikkilä, Kauko verfasserin aut Iacono, William G. verfasserin aut Janzing, Joost verfasserin aut Jokela, Markus verfasserin aut Kiemeney, Lambertus verfasserin aut Lehtimäki, Terho verfasserin aut Madden, Pamela A. F. verfasserin aut Magnusson, Patrik K. E. verfasserin aut Northstone, Kate verfasserin aut Nutile, Teresa verfasserin aut Ouwens, Klaasjan G. verfasserin aut Palotie, Aarno verfasserin aut Pattie, Alison verfasserin aut Pesonen, Anu-Katriina verfasserin aut Polasek, Ozren verfasserin aut Pulkkinen, Lea verfasserin aut Pulkki-Råback, Laura verfasserin aut Raitakari, Olli T. verfasserin aut Realo, Anu verfasserin aut Rose, Richard J. verfasserin aut Ruggiero, Daniela verfasserin aut Seppälä, Ilkka verfasserin aut Slutske, Wendy S. verfasserin aut Smyth, David C. verfasserin aut Sorice, Rossella verfasserin aut Starr, John M. verfasserin aut Sutin, Angelina R. verfasserin aut Tanaka, Toshiko verfasserin aut Verhagen, Josine verfasserin aut Vermeulen, Sita verfasserin aut Vuoksimaa, Eero verfasserin aut Widen, Elisabeth verfasserin aut Willemsen, Gonneke verfasserin aut Wright, Margaret J. verfasserin aut Zgaga, Lina verfasserin aut Rujescu, Dan verfasserin aut Metspalu, Andres verfasserin aut Wilson, James F. verfasserin aut Ciullo, Marina verfasserin aut Hayward, Caroline verfasserin aut Rudan, Igor verfasserin aut Deary, Ian J. verfasserin aut Räikkönen, Katri verfasserin aut Arias Vasquez, Alejandro verfasserin aut Costa, Paul T. verfasserin aut Keltikangas-Järvinen, Liisa verfasserin aut van Duijn, Cornelia M. verfasserin aut Penninx, Brenda W. J. H. verfasserin aut Krueger, Robert F. verfasserin aut Evans, David M. verfasserin aut Kaprio, Jaakko verfasserin aut Pedersen, Nancy L. verfasserin aut Martin, Nicholas G. verfasserin aut Boomsma, Dorret I. verfasserin aut Enthalten in Behavior genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1970 44(2014), 4 vom: 15. Mai, Seite 295-313 (DE-627)320524345 (DE-600)2014974-8 1573-3297 nnns volume:44 year:2014 number:4 day:15 month:05 pages:295-313 https://dx.doi.org/10.1007/s10519-014-9654-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 44 2014 4 15 05 295-313 |
| allfields_unstemmed |
10.1007/s10519-014-9654-x doi (DE-627)SPR010775897 (SPR)s10519-014-9654-x-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl van den Berg, Stéphanie M. verfasserin aut Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. Personality (dpeaa)DE-He213 Item-Response Theory (dpeaa)DE-He213 Measurement (dpeaa)DE-He213 Genome-wide association studies (dpeaa)DE-He213 Consortium (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 de Moor, Marleen H. M. verfasserin aut McGue, Matt verfasserin aut Pettersson, Erik verfasserin aut Terracciano, Antonio verfasserin aut Verweij, Karin J. H. verfasserin aut Amin, Najaf verfasserin aut Derringer, Jaime verfasserin aut Esko, Tõnu verfasserin aut van Grootheest, Gerard verfasserin aut Hansell, Narelle K. verfasserin aut Huffman, Jennifer verfasserin aut Konte, Bettina verfasserin aut Lahti, Jari verfasserin aut Luciano, Michelle verfasserin aut Matteson, Lindsay K. verfasserin aut Viktorin, Alexander verfasserin aut Wouda, Jasper verfasserin aut Agrawal, Arpana verfasserin aut Allik, Jüri verfasserin aut Bierut, Laura verfasserin aut Broms, Ulla verfasserin aut Campbell, Harry verfasserin aut Smith, George Davey verfasserin aut Eriksson, Johan G. verfasserin aut Ferrucci, Luigi verfasserin aut Franke, Barbera verfasserin aut Fox, Jean-Paul verfasserin aut de Geus, Eco J. C. verfasserin aut Giegling, Ina verfasserin aut Gow, Alan J. verfasserin aut Grucza, Richard verfasserin aut Hartmann, Annette M. verfasserin aut Heath, Andrew C. verfasserin aut Heikkilä, Kauko verfasserin aut Iacono, William G. verfasserin aut Janzing, Joost verfasserin aut Jokela, Markus verfasserin aut Kiemeney, Lambertus verfasserin aut Lehtimäki, Terho verfasserin aut Madden, Pamela A. F. verfasserin aut Magnusson, Patrik K. E. verfasserin aut Northstone, Kate verfasserin aut Nutile, Teresa verfasserin aut Ouwens, Klaasjan G. verfasserin aut Palotie, Aarno verfasserin aut Pattie, Alison verfasserin aut Pesonen, Anu-Katriina verfasserin aut Polasek, Ozren verfasserin aut Pulkkinen, Lea verfasserin aut Pulkki-Råback, Laura verfasserin aut Raitakari, Olli T. verfasserin aut Realo, Anu verfasserin aut Rose, Richard J. verfasserin aut Ruggiero, Daniela verfasserin aut Seppälä, Ilkka verfasserin aut Slutske, Wendy S. verfasserin aut Smyth, David C. verfasserin aut Sorice, Rossella verfasserin aut Starr, John M. verfasserin aut Sutin, Angelina R. verfasserin aut Tanaka, Toshiko verfasserin aut Verhagen, Josine verfasserin aut Vermeulen, Sita verfasserin aut Vuoksimaa, Eero verfasserin aut Widen, Elisabeth verfasserin aut Willemsen, Gonneke verfasserin aut Wright, Margaret J. verfasserin aut Zgaga, Lina verfasserin aut Rujescu, Dan verfasserin aut Metspalu, Andres verfasserin aut Wilson, James F. verfasserin aut Ciullo, Marina verfasserin aut Hayward, Caroline verfasserin aut Rudan, Igor verfasserin aut Deary, Ian J. verfasserin aut Räikkönen, Katri verfasserin aut Arias Vasquez, Alejandro verfasserin aut Costa, Paul T. verfasserin aut Keltikangas-Järvinen, Liisa verfasserin aut van Duijn, Cornelia M. verfasserin aut Penninx, Brenda W. J. H. verfasserin aut Krueger, Robert F. verfasserin aut Evans, David M. verfasserin aut Kaprio, Jaakko verfasserin aut Pedersen, Nancy L. verfasserin aut Martin, Nicholas G. verfasserin aut Boomsma, Dorret I. verfasserin aut Enthalten in Behavior genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1970 44(2014), 4 vom: 15. Mai, Seite 295-313 (DE-627)320524345 (DE-600)2014974-8 1573-3297 nnns volume:44 year:2014 number:4 day:15 month:05 pages:295-313 https://dx.doi.org/10.1007/s10519-014-9654-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 44 2014 4 15 05 295-313 |
| allfieldsGer |
10.1007/s10519-014-9654-x doi (DE-627)SPR010775897 (SPR)s10519-014-9654-x-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl van den Berg, Stéphanie M. verfasserin aut Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. Personality (dpeaa)DE-He213 Item-Response Theory (dpeaa)DE-He213 Measurement (dpeaa)DE-He213 Genome-wide association studies (dpeaa)DE-He213 Consortium (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 de Moor, Marleen H. M. verfasserin aut McGue, Matt verfasserin aut Pettersson, Erik verfasserin aut Terracciano, Antonio verfasserin aut Verweij, Karin J. H. verfasserin aut Amin, Najaf verfasserin aut Derringer, Jaime verfasserin aut Esko, Tõnu verfasserin aut van Grootheest, Gerard verfasserin aut Hansell, Narelle K. verfasserin aut Huffman, Jennifer verfasserin aut Konte, Bettina verfasserin aut Lahti, Jari verfasserin aut Luciano, Michelle verfasserin aut Matteson, Lindsay K. verfasserin aut Viktorin, Alexander verfasserin aut Wouda, Jasper verfasserin aut Agrawal, Arpana verfasserin aut Allik, Jüri verfasserin aut Bierut, Laura verfasserin aut Broms, Ulla verfasserin aut Campbell, Harry verfasserin aut Smith, George Davey verfasserin aut Eriksson, Johan G. verfasserin aut Ferrucci, Luigi verfasserin aut Franke, Barbera verfasserin aut Fox, Jean-Paul verfasserin aut de Geus, Eco J. C. verfasserin aut Giegling, Ina verfasserin aut Gow, Alan J. verfasserin aut Grucza, Richard verfasserin aut Hartmann, Annette M. verfasserin aut Heath, Andrew C. verfasserin aut Heikkilä, Kauko verfasserin aut Iacono, William G. verfasserin aut Janzing, Joost verfasserin aut Jokela, Markus verfasserin aut Kiemeney, Lambertus verfasserin aut Lehtimäki, Terho verfasserin aut Madden, Pamela A. F. verfasserin aut Magnusson, Patrik K. E. verfasserin aut Northstone, Kate verfasserin aut Nutile, Teresa verfasserin aut Ouwens, Klaasjan G. verfasserin aut Palotie, Aarno verfasserin aut Pattie, Alison verfasserin aut Pesonen, Anu-Katriina verfasserin aut Polasek, Ozren verfasserin aut Pulkkinen, Lea verfasserin aut Pulkki-Råback, Laura verfasserin aut Raitakari, Olli T. verfasserin aut Realo, Anu verfasserin aut Rose, Richard J. verfasserin aut Ruggiero, Daniela verfasserin aut Seppälä, Ilkka verfasserin aut Slutske, Wendy S. verfasserin aut Smyth, David C. verfasserin aut Sorice, Rossella verfasserin aut Starr, John M. verfasserin aut Sutin, Angelina R. verfasserin aut Tanaka, Toshiko verfasserin aut Verhagen, Josine verfasserin aut Vermeulen, Sita verfasserin aut Vuoksimaa, Eero verfasserin aut Widen, Elisabeth verfasserin aut Willemsen, Gonneke verfasserin aut Wright, Margaret J. verfasserin aut Zgaga, Lina verfasserin aut Rujescu, Dan verfasserin aut Metspalu, Andres verfasserin aut Wilson, James F. verfasserin aut Ciullo, Marina verfasserin aut Hayward, Caroline verfasserin aut Rudan, Igor verfasserin aut Deary, Ian J. verfasserin aut Räikkönen, Katri verfasserin aut Arias Vasquez, Alejandro verfasserin aut Costa, Paul T. verfasserin aut Keltikangas-Järvinen, Liisa verfasserin aut van Duijn, Cornelia M. verfasserin aut Penninx, Brenda W. J. H. verfasserin aut Krueger, Robert F. verfasserin aut Evans, David M. verfasserin aut Kaprio, Jaakko verfasserin aut Pedersen, Nancy L. verfasserin aut Martin, Nicholas G. verfasserin aut Boomsma, Dorret I. verfasserin aut Enthalten in Behavior genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1970 44(2014), 4 vom: 15. Mai, Seite 295-313 (DE-627)320524345 (DE-600)2014974-8 1573-3297 nnns volume:44 year:2014 number:4 day:15 month:05 pages:295-313 https://dx.doi.org/10.1007/s10519-014-9654-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 44 2014 4 15 05 295-313 |
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10.1007/s10519-014-9654-x doi (DE-627)SPR010775897 (SPR)s10519-014-9654-x-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl van den Berg, Stéphanie M. verfasserin aut Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. Personality (dpeaa)DE-He213 Item-Response Theory (dpeaa)DE-He213 Measurement (dpeaa)DE-He213 Genome-wide association studies (dpeaa)DE-He213 Consortium (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 de Moor, Marleen H. M. verfasserin aut McGue, Matt verfasserin aut Pettersson, Erik verfasserin aut Terracciano, Antonio verfasserin aut Verweij, Karin J. H. verfasserin aut Amin, Najaf verfasserin aut Derringer, Jaime verfasserin aut Esko, Tõnu verfasserin aut van Grootheest, Gerard verfasserin aut Hansell, Narelle K. verfasserin aut Huffman, Jennifer verfasserin aut Konte, Bettina verfasserin aut Lahti, Jari verfasserin aut Luciano, Michelle verfasserin aut Matteson, Lindsay K. verfasserin aut Viktorin, Alexander verfasserin aut Wouda, Jasper verfasserin aut Agrawal, Arpana verfasserin aut Allik, Jüri verfasserin aut Bierut, Laura verfasserin aut Broms, Ulla verfasserin aut Campbell, Harry verfasserin aut Smith, George Davey verfasserin aut Eriksson, Johan G. verfasserin aut Ferrucci, Luigi verfasserin aut Franke, Barbera verfasserin aut Fox, Jean-Paul verfasserin aut de Geus, Eco J. C. verfasserin aut Giegling, Ina verfasserin aut Gow, Alan J. verfasserin aut Grucza, Richard verfasserin aut Hartmann, Annette M. verfasserin aut Heath, Andrew C. verfasserin aut Heikkilä, Kauko verfasserin aut Iacono, William G. verfasserin aut Janzing, Joost verfasserin aut Jokela, Markus verfasserin aut Kiemeney, Lambertus verfasserin aut Lehtimäki, Terho verfasserin aut Madden, Pamela A. F. verfasserin aut Magnusson, Patrik K. E. verfasserin aut Northstone, Kate verfasserin aut Nutile, Teresa verfasserin aut Ouwens, Klaasjan G. verfasserin aut Palotie, Aarno verfasserin aut Pattie, Alison verfasserin aut Pesonen, Anu-Katriina verfasserin aut Polasek, Ozren verfasserin aut Pulkkinen, Lea verfasserin aut Pulkki-Råback, Laura verfasserin aut Raitakari, Olli T. verfasserin aut Realo, Anu verfasserin aut Rose, Richard J. verfasserin aut Ruggiero, Daniela verfasserin aut Seppälä, Ilkka verfasserin aut Slutske, Wendy S. verfasserin aut Smyth, David C. verfasserin aut Sorice, Rossella verfasserin aut Starr, John M. verfasserin aut Sutin, Angelina R. verfasserin aut Tanaka, Toshiko verfasserin aut Verhagen, Josine verfasserin aut Vermeulen, Sita verfasserin aut Vuoksimaa, Eero verfasserin aut Widen, Elisabeth verfasserin aut Willemsen, Gonneke verfasserin aut Wright, Margaret J. verfasserin aut Zgaga, Lina verfasserin aut Rujescu, Dan verfasserin aut Metspalu, Andres verfasserin aut Wilson, James F. verfasserin aut Ciullo, Marina verfasserin aut Hayward, Caroline verfasserin aut Rudan, Igor verfasserin aut Deary, Ian J. verfasserin aut Räikkönen, Katri verfasserin aut Arias Vasquez, Alejandro verfasserin aut Costa, Paul T. verfasserin aut Keltikangas-Järvinen, Liisa verfasserin aut van Duijn, Cornelia M. verfasserin aut Penninx, Brenda W. J. H. verfasserin aut Krueger, Robert F. verfasserin aut Evans, David M. verfasserin aut Kaprio, Jaakko verfasserin aut Pedersen, Nancy L. verfasserin aut Martin, Nicholas G. verfasserin aut Boomsma, Dorret I. verfasserin aut Enthalten in Behavior genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1970 44(2014), 4 vom: 15. Mai, Seite 295-313 (DE-627)320524345 (DE-600)2014974-8 1573-3297 nnns volume:44 year:2014 number:4 day:15 month:05 pages:295-313 https://dx.doi.org/10.1007/s10519-014-9654-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 44 2014 4 15 05 295-313 |
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van den Berg, Stéphanie M. @@aut@@ de Moor, Marleen H. M. @@aut@@ McGue, Matt @@aut@@ Pettersson, Erik @@aut@@ Terracciano, Antonio @@aut@@ Verweij, Karin J. H. @@aut@@ Amin, Najaf @@aut@@ Derringer, Jaime @@aut@@ Esko, Tõnu @@aut@@ van Grootheest, Gerard @@aut@@ Hansell, Narelle K. @@aut@@ Huffman, Jennifer @@aut@@ Konte, Bettina @@aut@@ Lahti, Jari @@aut@@ Luciano, Michelle @@aut@@ Matteson, Lindsay K. @@aut@@ Viktorin, Alexander @@aut@@ Wouda, Jasper @@aut@@ Agrawal, Arpana @@aut@@ Allik, Jüri @@aut@@ Bierut, Laura @@aut@@ Broms, Ulla @@aut@@ Campbell, Harry @@aut@@ Smith, George Davey @@aut@@ Eriksson, Johan G. @@aut@@ Ferrucci, Luigi @@aut@@ Franke, Barbera @@aut@@ Fox, Jean-Paul @@aut@@ de Geus, Eco J. C. @@aut@@ Giegling, Ina @@aut@@ Gow, Alan J. @@aut@@ Grucza, Richard @@aut@@ Hartmann, Annette M. @@aut@@ Heath, Andrew C. @@aut@@ Heikkilä, Kauko @@aut@@ Iacono, William G. @@aut@@ Janzing, Joost @@aut@@ Jokela, Markus @@aut@@ Kiemeney, Lambertus @@aut@@ Lehtimäki, Terho @@aut@@ Madden, Pamela A. F. @@aut@@ Magnusson, Patrik K. E. @@aut@@ Northstone, Kate @@aut@@ Nutile, Teresa @@aut@@ Ouwens, Klaasjan G. @@aut@@ Palotie, Aarno @@aut@@ Pattie, Alison @@aut@@ Pesonen, Anu-Katriina @@aut@@ Polasek, Ozren @@aut@@ Pulkkinen, Lea @@aut@@ Pulkki-Råback, Laura @@aut@@ Raitakari, Olli T. @@aut@@ Realo, Anu @@aut@@ Rose, Richard J. @@aut@@ Ruggiero, Daniela @@aut@@ Seppälä, Ilkka @@aut@@ Slutske, Wendy S. @@aut@@ Smyth, David C. @@aut@@ Sorice, Rossella @@aut@@ Starr, John M. @@aut@@ Sutin, Angelina R. @@aut@@ Tanaka, Toshiko @@aut@@ Verhagen, Josine @@aut@@ Vermeulen, Sita @@aut@@ Vuoksimaa, Eero @@aut@@ Widen, Elisabeth @@aut@@ Willemsen, Gonneke @@aut@@ Wright, Margaret J. @@aut@@ Zgaga, Lina @@aut@@ Rujescu, Dan @@aut@@ Metspalu, Andres @@aut@@ Wilson, James F. @@aut@@ Ciullo, Marina @@aut@@ Hayward, Caroline @@aut@@ Rudan, Igor @@aut@@ Deary, Ian J. @@aut@@ Räikkönen, Katri @@aut@@ Arias Vasquez, Alejandro @@aut@@ Costa, Paul T. @@aut@@ Keltikangas-Järvinen, Liisa @@aut@@ van Duijn, Cornelia M. @@aut@@ Penninx, Brenda W. J. H. @@aut@@ Krueger, Robert F. @@aut@@ Evans, David M. @@aut@@ Kaprio, Jaakko @@aut@@ Pedersen, Nancy L. @@aut@@ Martin, Nicholas G. @@aut@@ Boomsma, Dorret I. @@aut@@ |
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van den Berg, Stéphanie M. |
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van den Berg, Stéphanie M. ddc 570 bkl 42.00 misc Personality misc Item-Response Theory misc Measurement misc Genome-wide association studies misc Consortium misc Meta-analysis Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory |
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570 ASE 42.00 bkl Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory Personality (dpeaa)DE-He213 Item-Response Theory (dpeaa)DE-He213 Measurement (dpeaa)DE-He213 Genome-wide association studies (dpeaa)DE-He213 Consortium (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 |
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ddc 570 bkl 42.00 misc Personality misc Item-Response Theory misc Measurement misc Genome-wide association studies misc Consortium misc Meta-analysis |
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Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory |
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(DE-627)SPR010775897 (SPR)s10519-014-9654-x-e |
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Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory |
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van den Berg, Stéphanie M. |
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Behavior genetics |
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van den Berg, Stéphanie M. de Moor, Marleen H. M. McGue, Matt Pettersson, Erik Terracciano, Antonio Verweij, Karin J. H. Amin, Najaf Derringer, Jaime Esko, Tõnu van Grootheest, Gerard Hansell, Narelle K. Huffman, Jennifer Konte, Bettina Lahti, Jari Luciano, Michelle Matteson, Lindsay K. Viktorin, Alexander Wouda, Jasper Agrawal, Arpana Allik, Jüri Bierut, Laura Broms, Ulla Campbell, Harry Smith, George Davey Eriksson, Johan G. Ferrucci, Luigi Franke, Barbera Fox, Jean-Paul de Geus, Eco J. C. Giegling, Ina Gow, Alan J. Grucza, Richard Hartmann, Annette M. Heath, Andrew C. Heikkilä, Kauko Iacono, William G. Janzing, Joost Jokela, Markus Kiemeney, Lambertus Lehtimäki, Terho Madden, Pamela A. F. Magnusson, Patrik K. E. Northstone, Kate Nutile, Teresa Ouwens, Klaasjan G. Palotie, Aarno Pattie, Alison Pesonen, Anu-Katriina Polasek, Ozren Pulkkinen, Lea Pulkki-Råback, Laura Raitakari, Olli T. Realo, Anu Rose, Richard J. Ruggiero, Daniela Seppälä, Ilkka Slutske, Wendy S. Smyth, David C. Sorice, Rossella Starr, John M. Sutin, Angelina R. Tanaka, Toshiko Verhagen, Josine Vermeulen, Sita Vuoksimaa, Eero Widen, Elisabeth Willemsen, Gonneke Wright, Margaret J. Zgaga, Lina Rujescu, Dan Metspalu, Andres Wilson, James F. Ciullo, Marina Hayward, Caroline Rudan, Igor Deary, Ian J. Räikkönen, Katri Arias Vasquez, Alejandro Costa, Paul T. Keltikangas-Järvinen, Liisa van Duijn, Cornelia M. Penninx, Brenda W. J. H. Krueger, Robert F. Evans, David M. Kaprio, Jaakko Pedersen, Nancy L. Martin, Nicholas G. Boomsma, Dorret I. |
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van den Berg, Stéphanie M. |
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10.1007/s10519-014-9654-x |
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harmonization of neuroticism and extraversion phenotypes across inventories and cohorts in the genetics of personality consortium: an application of item response theory |
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Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory |
| abstract |
Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. |
| abstractGer |
Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. |
| abstract_unstemmed |
Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. |
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Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory |
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de Moor, Marleen H. M. McGue, Matt Pettersson, Erik Terracciano, Antonio Verweij, Karin J. H. Amin, Najaf Derringer, Jaime Esko, Tõnu van Grootheest, Gerard Hansell, Narelle K. Huffman, Jennifer Konte, Bettina Lahti, Jari Luciano, Michelle Matteson, Lindsay K. Viktorin, Alexander Wouda, Jasper Agrawal, Arpana Allik, Jüri Bierut, Laura Broms, Ulla Campbell, Harry Smith, George Davey Eriksson, Johan G. Ferrucci, Luigi Franke, Barbera Fox, Jean-Paul de Geus, Eco J. C. Giegling, Ina Gow, Alan J. Grucza, Richard Hartmann, Annette M. Heath, Andrew C. Heikkilä, Kauko Iacono, William G. Janzing, Joost Jokela, Markus Kiemeney, Lambertus Lehtimäki, Terho Madden, Pamela A. F. Magnusson, Patrik K. E. Northstone, Kate Nutile, Teresa Ouwens, Klaasjan G. Palotie, Aarno Pattie, Alison Pesonen, Anu-Katriina Polasek, Ozren Pulkkinen, Lea Pulkki-Råback, Laura Raitakari, Olli T. Realo, Anu Rose, Richard J. Ruggiero, Daniela Seppälä, Ilkka Slutske, Wendy S. Smyth, David C. Sorice, Rossella Starr, John M. Sutin, Angelina R. Tanaka, Toshiko Verhagen, Josine Vermeulen, Sita Vuoksimaa, Eero Widen, Elisabeth Willemsen, Gonneke Wright, Margaret J. Zgaga, Lina Rujescu, Dan Metspalu, Andres Wilson, James F. Ciullo, Marina Hayward, Caroline Rudan, Igor Deary, Ian J. Räikkönen, Katri Arias Vasquez, Alejandro Costa, Paul T. Keltikangas-Järvinen, Liisa van Duijn, Cornelia M. Penninx, Brenda W. J. H. Krueger, Robert F. Evans, David M. Kaprio, Jaakko Pedersen, Nancy L. Martin, Nicholas G. Boomsma, Dorret I. |
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de Moor, Marleen H. M. McGue, Matt Pettersson, Erik Terracciano, Antonio Verweij, Karin J. H. Amin, Najaf Derringer, Jaime Esko, Tõnu van Grootheest, Gerard Hansell, Narelle K. Huffman, Jennifer Konte, Bettina Lahti, Jari Luciano, Michelle Matteson, Lindsay K. Viktorin, Alexander Wouda, Jasper Agrawal, Arpana Allik, Jüri Bierut, Laura Broms, Ulla Campbell, Harry Smith, George Davey Eriksson, Johan G. Ferrucci, Luigi Franke, Barbera Fox, Jean-Paul de Geus, Eco J. C. Giegling, Ina Gow, Alan J. Grucza, Richard Hartmann, Annette M. Heath, Andrew C. Heikkilä, Kauko Iacono, William G. Janzing, Joost Jokela, Markus Kiemeney, Lambertus Lehtimäki, Terho Madden, Pamela A. F. Magnusson, Patrik K. E. Northstone, Kate Nutile, Teresa Ouwens, Klaasjan G. Palotie, Aarno Pattie, Alison Pesonen, Anu-Katriina Polasek, Ozren Pulkkinen, Lea Pulkki-Råback, Laura Raitakari, Olli T. Realo, Anu Rose, Richard J. Ruggiero, Daniela Seppälä, Ilkka Slutske, Wendy S. Smyth, David C. Sorice, Rossella Starr, John M. Sutin, Angelina R. Tanaka, Toshiko Verhagen, Josine Vermeulen, Sita Vuoksimaa, Eero Widen, Elisabeth Willemsen, Gonneke Wright, Margaret J. Zgaga, Lina Rujescu, Dan Metspalu, Andres Wilson, James F. Ciullo, Marina Hayward, Caroline Rudan, Igor Deary, Ian J. Räikkönen, Katri Arias Vasquez, Alejandro Costa, Paul T. Keltikangas-Järvinen, Liisa van Duijn, Cornelia M. Penninx, Brenda W. J. H. Krueger, Robert F. Evans, David M. Kaprio, Jaakko Pedersen, Nancy L. Martin, Nicholas G. Boomsma, Dorret I. |
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10.1007/s10519-014-9654-x |
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2024-07-03T18:13:58.310Z |
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