Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase
Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed b...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bose, Tanushree [verfasserIn] Saroja Voruganti, V. [verfasserIn] Elizabeth Tejero, M. [verfasserIn] Michael Proffit, J. [verfasserIn] Cox, Laura A. [verfasserIn] VandeBerg, John L. [verfasserIn] Mahaney, Michael C. [verfasserIn] Rogers, Jeffrey [verfasserIn] Freeland-Graves, Jeanne H. [verfasserIn] Cole, Shelley A. [verfasserIn] Comuzzie, Anthony G. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Biochemical genetics - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967, 48(2010), 5-6 vom: 14. Apr., Seite 538-547 |
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| Übergeordnetes Werk: |
volume:48 ; year:2010 ; number:5-6 ; day:14 ; month:04 ; pages:538-547 |
| Links: |
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| DOI / URN: |
10.1007/s10528-010-9337-0 |
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| Katalog-ID: |
SPR010827838 |
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| 245 | 1 | 0 | |a Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase |
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| 520 | |a Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. | ||
| 650 | 4 | |a Nonalcoholic fatty liver disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Obesity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adipocyte size |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Genome scan |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a QTL |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Aspartate aminotransferase |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Saroja Voruganti, V. |e verfasserin |4 aut | |
| 700 | 1 | |a Elizabeth Tejero, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Michael Proffit, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Cox, Laura A. |e verfasserin |4 aut | |
| 700 | 1 | |a VandeBerg, John L. |e verfasserin |4 aut | |
| 700 | 1 | |a Mahaney, Michael C. |e verfasserin |4 aut | |
| 700 | 1 | |a Rogers, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Freeland-Graves, Jeanne H. |e verfasserin |4 aut | |
| 700 | 1 | |a Cole, Shelley A. |e verfasserin |4 aut | |
| 700 | 1 | |a Comuzzie, Anthony G. |e verfasserin |4 aut | |
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10.1007/s10528-010-9337-0 doi (DE-627)SPR010827838 (SPR)s10528-010-9337-0-e DE-627 ger DE-627 rakwb eng 570 540 ASE 44.00 bkl 42.00 bkl Bose, Tanushree verfasserin aut Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. Nonalcoholic fatty liver disease (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Adipocyte size (dpeaa)DE-He213 Genome scan (dpeaa)DE-He213 QTL (dpeaa)DE-He213 Aspartate aminotransferase (dpeaa)DE-He213 Saroja Voruganti, V. verfasserin aut Elizabeth Tejero, M. verfasserin aut Michael Proffit, J. verfasserin aut Cox, Laura A. verfasserin aut VandeBerg, John L. verfasserin aut Mahaney, Michael C. verfasserin aut Rogers, Jeffrey verfasserin aut Freeland-Graves, Jeanne H. verfasserin aut Cole, Shelley A. verfasserin aut Comuzzie, Anthony G. verfasserin aut Enthalten in Biochemical genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 48(2010), 5-6 vom: 14. Apr., Seite 538-547 (DE-627)306317737 (DE-600)1496197-0 1573-4927 nnns volume:48 year:2010 number:5-6 day:14 month:04 pages:538-547 https://dx.doi.org/10.1007/s10528-010-9337-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 42.00 ASE AR 48 2010 5-6 14 04 538-547 |
| spelling |
10.1007/s10528-010-9337-0 doi (DE-627)SPR010827838 (SPR)s10528-010-9337-0-e DE-627 ger DE-627 rakwb eng 570 540 ASE 44.00 bkl 42.00 bkl Bose, Tanushree verfasserin aut Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. Nonalcoholic fatty liver disease (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Adipocyte size (dpeaa)DE-He213 Genome scan (dpeaa)DE-He213 QTL (dpeaa)DE-He213 Aspartate aminotransferase (dpeaa)DE-He213 Saroja Voruganti, V. verfasserin aut Elizabeth Tejero, M. verfasserin aut Michael Proffit, J. verfasserin aut Cox, Laura A. verfasserin aut VandeBerg, John L. verfasserin aut Mahaney, Michael C. verfasserin aut Rogers, Jeffrey verfasserin aut Freeland-Graves, Jeanne H. verfasserin aut Cole, Shelley A. verfasserin aut Comuzzie, Anthony G. verfasserin aut Enthalten in Biochemical genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 48(2010), 5-6 vom: 14. Apr., Seite 538-547 (DE-627)306317737 (DE-600)1496197-0 1573-4927 nnns volume:48 year:2010 number:5-6 day:14 month:04 pages:538-547 https://dx.doi.org/10.1007/s10528-010-9337-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 42.00 ASE AR 48 2010 5-6 14 04 538-547 |
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10.1007/s10528-010-9337-0 doi (DE-627)SPR010827838 (SPR)s10528-010-9337-0-e DE-627 ger DE-627 rakwb eng 570 540 ASE 44.00 bkl 42.00 bkl Bose, Tanushree verfasserin aut Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. Nonalcoholic fatty liver disease (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Adipocyte size (dpeaa)DE-He213 Genome scan (dpeaa)DE-He213 QTL (dpeaa)DE-He213 Aspartate aminotransferase (dpeaa)DE-He213 Saroja Voruganti, V. verfasserin aut Elizabeth Tejero, M. verfasserin aut Michael Proffit, J. verfasserin aut Cox, Laura A. verfasserin aut VandeBerg, John L. verfasserin aut Mahaney, Michael C. verfasserin aut Rogers, Jeffrey verfasserin aut Freeland-Graves, Jeanne H. verfasserin aut Cole, Shelley A. verfasserin aut Comuzzie, Anthony G. verfasserin aut Enthalten in Biochemical genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 48(2010), 5-6 vom: 14. Apr., Seite 538-547 (DE-627)306317737 (DE-600)1496197-0 1573-4927 nnns volume:48 year:2010 number:5-6 day:14 month:04 pages:538-547 https://dx.doi.org/10.1007/s10528-010-9337-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 42.00 ASE AR 48 2010 5-6 14 04 538-547 |
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10.1007/s10528-010-9337-0 doi (DE-627)SPR010827838 (SPR)s10528-010-9337-0-e DE-627 ger DE-627 rakwb eng 570 540 ASE 44.00 bkl 42.00 bkl Bose, Tanushree verfasserin aut Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. Nonalcoholic fatty liver disease (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Adipocyte size (dpeaa)DE-He213 Genome scan (dpeaa)DE-He213 QTL (dpeaa)DE-He213 Aspartate aminotransferase (dpeaa)DE-He213 Saroja Voruganti, V. verfasserin aut Elizabeth Tejero, M. verfasserin aut Michael Proffit, J. verfasserin aut Cox, Laura A. verfasserin aut VandeBerg, John L. verfasserin aut Mahaney, Michael C. verfasserin aut Rogers, Jeffrey verfasserin aut Freeland-Graves, Jeanne H. verfasserin aut Cole, Shelley A. verfasserin aut Comuzzie, Anthony G. verfasserin aut Enthalten in Biochemical genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 48(2010), 5-6 vom: 14. Apr., Seite 538-547 (DE-627)306317737 (DE-600)1496197-0 1573-4927 nnns volume:48 year:2010 number:5-6 day:14 month:04 pages:538-547 https://dx.doi.org/10.1007/s10528-010-9337-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 42.00 ASE AR 48 2010 5-6 14 04 538-547 |
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10.1007/s10528-010-9337-0 doi (DE-627)SPR010827838 (SPR)s10528-010-9337-0-e DE-627 ger DE-627 rakwb eng 570 540 ASE 44.00 bkl 42.00 bkl Bose, Tanushree verfasserin aut Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. Nonalcoholic fatty liver disease (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Adipocyte size (dpeaa)DE-He213 Genome scan (dpeaa)DE-He213 QTL (dpeaa)DE-He213 Aspartate aminotransferase (dpeaa)DE-He213 Saroja Voruganti, V. verfasserin aut Elizabeth Tejero, M. verfasserin aut Michael Proffit, J. verfasserin aut Cox, Laura A. verfasserin aut VandeBerg, John L. verfasserin aut Mahaney, Michael C. verfasserin aut Rogers, Jeffrey verfasserin aut Freeland-Graves, Jeanne H. verfasserin aut Cole, Shelley A. verfasserin aut Comuzzie, Anthony G. verfasserin aut Enthalten in Biochemical genetics Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 48(2010), 5-6 vom: 14. Apr., Seite 538-547 (DE-627)306317737 (DE-600)1496197-0 1573-4927 nnns volume:48 year:2010 number:5-6 day:14 month:04 pages:538-547 https://dx.doi.org/10.1007/s10528-010-9337-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE 42.00 ASE AR 48 2010 5-6 14 04 538-547 |
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English |
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Enthalten in Biochemical genetics 48(2010), 5-6 vom: 14. Apr., Seite 538-547 volume:48 year:2010 number:5-6 day:14 month:04 pages:538-547 |
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Enthalten in Biochemical genetics 48(2010), 5-6 vom: 14. Apr., Seite 538-547 volume:48 year:2010 number:5-6 day:14 month:04 pages:538-547 |
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Nonalcoholic fatty liver disease Obesity Adipocyte size Genome scan QTL Aspartate aminotransferase |
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Biochemical genetics |
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Bose, Tanushree @@aut@@ Saroja Voruganti, V. @@aut@@ Elizabeth Tejero, M. @@aut@@ Michael Proffit, J. @@aut@@ Cox, Laura A. @@aut@@ VandeBerg, John L. @@aut@@ Mahaney, Michael C. @@aut@@ Rogers, Jeffrey @@aut@@ Freeland-Graves, Jeanne H. @@aut@@ Cole, Shelley A. @@aut@@ Comuzzie, Anthony G. @@aut@@ |
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2010-04-14T00:00:00Z |
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| author |
Bose, Tanushree |
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Bose, Tanushree ddc 570 bkl 44.00 bkl 42.00 misc Nonalcoholic fatty liver disease misc Obesity misc Adipocyte size misc Genome scan misc QTL misc Aspartate aminotransferase Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase |
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570 540 ASE 44.00 bkl 42.00 bkl Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase Nonalcoholic fatty liver disease (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Adipocyte size (dpeaa)DE-He213 Genome scan (dpeaa)DE-He213 QTL (dpeaa)DE-He213 Aspartate aminotransferase (dpeaa)DE-He213 |
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ddc 570 bkl 44.00 bkl 42.00 misc Nonalcoholic fatty liver disease misc Obesity misc Adipocyte size misc Genome scan misc QTL misc Aspartate aminotransferase |
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ddc 570 bkl 44.00 bkl 42.00 misc Nonalcoholic fatty liver disease misc Obesity misc Adipocyte size misc Genome scan misc QTL misc Aspartate aminotransferase |
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ddc 570 bkl 44.00 bkl 42.00 misc Nonalcoholic fatty liver disease misc Obesity misc Adipocyte size misc Genome scan misc QTL misc Aspartate aminotransferase |
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Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase |
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| title_full |
Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase |
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Bose, Tanushree |
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Biochemical genetics |
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Biochemical genetics |
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Bose, Tanushree Saroja Voruganti, V. Elizabeth Tejero, M. Michael Proffit, J. Cox, Laura A. VandeBerg, John L. Mahaney, Michael C. Rogers, Jeffrey Freeland-Graves, Jeanne H. Cole, Shelley A. Comuzzie, Anthony G. |
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identification of a qtl for adipocyte volume and of shared genetic effects with aspartate aminotransferase |
| title_auth |
Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase |
| abstract |
Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. |
| abstractGer |
Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. |
| abstract_unstemmed |
Abstract Plasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST. |
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Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase |
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Saroja Voruganti, V. Elizabeth Tejero, M. Michael Proffit, J. Cox, Laura A. VandeBerg, John L. Mahaney, Michael C. Rogers, Jeffrey Freeland-Graves, Jeanne H. Cole, Shelley A. Comuzzie, Anthony G. |
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| score |
7.398162 |