A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk
Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Furu [verfasserIn] Hu, Zhibin [verfasserIn] Yang, Rongxi [verfasserIn] Tang, Jinhai [verfasserIn] Liu, Yao [verfasserIn] Hemminki, Kari [verfasserIn] Sutter, Christian [verfasserIn] Wappenschmidt, Barbara [verfasserIn] Niederacher, Dieter [verfasserIn] Arnold, Norbert [verfasserIn] Meindl, Alfons [verfasserIn] Bartram, Claus R. [verfasserIn] Schmutzler, Rita K. [verfasserIn] Burwinkel, Barbara [verfasserIn] Shen, Hongbing [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Breast cancer research and treatment - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981, 127(2010), 3 vom: 08. Dez., Seite 769-775 |
|---|---|
| Übergeordnetes Werk: |
volume:127 ; year:2010 ; number:3 ; day:08 ; month:12 ; pages:769-775 |
| Links: |
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| DOI / URN: |
10.1007/s10549-010-1157-8 |
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| Katalog-ID: |
SPR011078332 |
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| 245 | 1 | 2 | |a A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk |
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| 520 | |a Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. | ||
| 650 | 4 | |a miRNAs |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a SNPs |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Breast cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Molecular epidemiology |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hu, Zhibin |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Rongxi |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Jinhai |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Hemminki, Kari |e verfasserin |4 aut | |
| 700 | 1 | |a Sutter, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Wappenschmidt, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Niederacher, Dieter |e verfasserin |4 aut | |
| 700 | 1 | |a Arnold, Norbert |e verfasserin |4 aut | |
| 700 | 1 | |a Meindl, Alfons |e verfasserin |4 aut | |
| 700 | 1 | |a Bartram, Claus R. |e verfasserin |4 aut | |
| 700 | 1 | |a Schmutzler, Rita K. |e verfasserin |4 aut | |
| 700 | 1 | |a Burwinkel, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Hongbing |e verfasserin |4 aut | |
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10.1007/s10549-010-1157-8 doi (DE-627)SPR011078332 (SPR)s10549-010-1157-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Wang, Furu verfasserin aut A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. miRNAs (dpeaa)DE-He213 SNPs (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Molecular epidemiology (dpeaa)DE-He213 Hu, Zhibin verfasserin aut Yang, Rongxi verfasserin aut Tang, Jinhai verfasserin aut Liu, Yao verfasserin aut Hemminki, Kari verfasserin aut Sutter, Christian verfasserin aut Wappenschmidt, Barbara verfasserin aut Niederacher, Dieter verfasserin aut Arnold, Norbert verfasserin aut Meindl, Alfons verfasserin aut Bartram, Claus R. verfasserin aut Schmutzler, Rita K. verfasserin aut Burwinkel, Barbara verfasserin aut Shen, Hongbing verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 127(2010), 3 vom: 08. Dez., Seite 769-775 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:127 year:2010 number:3 day:08 month:12 pages:769-775 https://dx.doi.org/10.1007/s10549-010-1157-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 127 2010 3 08 12 769-775 |
| spelling |
10.1007/s10549-010-1157-8 doi (DE-627)SPR011078332 (SPR)s10549-010-1157-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Wang, Furu verfasserin aut A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. miRNAs (dpeaa)DE-He213 SNPs (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Molecular epidemiology (dpeaa)DE-He213 Hu, Zhibin verfasserin aut Yang, Rongxi verfasserin aut Tang, Jinhai verfasserin aut Liu, Yao verfasserin aut Hemminki, Kari verfasserin aut Sutter, Christian verfasserin aut Wappenschmidt, Barbara verfasserin aut Niederacher, Dieter verfasserin aut Arnold, Norbert verfasserin aut Meindl, Alfons verfasserin aut Bartram, Claus R. verfasserin aut Schmutzler, Rita K. verfasserin aut Burwinkel, Barbara verfasserin aut Shen, Hongbing verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 127(2010), 3 vom: 08. Dez., Seite 769-775 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:127 year:2010 number:3 day:08 month:12 pages:769-775 https://dx.doi.org/10.1007/s10549-010-1157-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 127 2010 3 08 12 769-775 |
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10.1007/s10549-010-1157-8 doi (DE-627)SPR011078332 (SPR)s10549-010-1157-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Wang, Furu verfasserin aut A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. miRNAs (dpeaa)DE-He213 SNPs (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Molecular epidemiology (dpeaa)DE-He213 Hu, Zhibin verfasserin aut Yang, Rongxi verfasserin aut Tang, Jinhai verfasserin aut Liu, Yao verfasserin aut Hemminki, Kari verfasserin aut Sutter, Christian verfasserin aut Wappenschmidt, Barbara verfasserin aut Niederacher, Dieter verfasserin aut Arnold, Norbert verfasserin aut Meindl, Alfons verfasserin aut Bartram, Claus R. verfasserin aut Schmutzler, Rita K. verfasserin aut Burwinkel, Barbara verfasserin aut Shen, Hongbing verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 127(2010), 3 vom: 08. Dez., Seite 769-775 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:127 year:2010 number:3 day:08 month:12 pages:769-775 https://dx.doi.org/10.1007/s10549-010-1157-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 127 2010 3 08 12 769-775 |
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10.1007/s10549-010-1157-8 doi (DE-627)SPR011078332 (SPR)s10549-010-1157-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Wang, Furu verfasserin aut A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. miRNAs (dpeaa)DE-He213 SNPs (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Molecular epidemiology (dpeaa)DE-He213 Hu, Zhibin verfasserin aut Yang, Rongxi verfasserin aut Tang, Jinhai verfasserin aut Liu, Yao verfasserin aut Hemminki, Kari verfasserin aut Sutter, Christian verfasserin aut Wappenschmidt, Barbara verfasserin aut Niederacher, Dieter verfasserin aut Arnold, Norbert verfasserin aut Meindl, Alfons verfasserin aut Bartram, Claus R. verfasserin aut Schmutzler, Rita K. verfasserin aut Burwinkel, Barbara verfasserin aut Shen, Hongbing verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 127(2010), 3 vom: 08. Dez., Seite 769-775 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:127 year:2010 number:3 day:08 month:12 pages:769-775 https://dx.doi.org/10.1007/s10549-010-1157-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 127 2010 3 08 12 769-775 |
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10.1007/s10549-010-1157-8 doi (DE-627)SPR011078332 (SPR)s10549-010-1157-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Wang, Furu verfasserin aut A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. miRNAs (dpeaa)DE-He213 SNPs (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Molecular epidemiology (dpeaa)DE-He213 Hu, Zhibin verfasserin aut Yang, Rongxi verfasserin aut Tang, Jinhai verfasserin aut Liu, Yao verfasserin aut Hemminki, Kari verfasserin aut Sutter, Christian verfasserin aut Wappenschmidt, Barbara verfasserin aut Niederacher, Dieter verfasserin aut Arnold, Norbert verfasserin aut Meindl, Alfons verfasserin aut Bartram, Claus R. verfasserin aut Schmutzler, Rita K. verfasserin aut Burwinkel, Barbara verfasserin aut Shen, Hongbing verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 127(2010), 3 vom: 08. Dez., Seite 769-775 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:127 year:2010 number:3 day:08 month:12 pages:769-775 https://dx.doi.org/10.1007/s10549-010-1157-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 127 2010 3 08 12 769-775 |
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Enthalten in Breast cancer research and treatment 127(2010), 3 vom: 08. Dez., Seite 769-775 volume:127 year:2010 number:3 day:08 month:12 pages:769-775 |
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Enthalten in Breast cancer research and treatment 127(2010), 3 vom: 08. Dez., Seite 769-775 volume:127 year:2010 number:3 day:08 month:12 pages:769-775 |
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Breast cancer research and treatment |
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Wang, Furu @@aut@@ Hu, Zhibin @@aut@@ Yang, Rongxi @@aut@@ Tang, Jinhai @@aut@@ Liu, Yao @@aut@@ Hemminki, Kari @@aut@@ Sutter, Christian @@aut@@ Wappenschmidt, Barbara @@aut@@ Niederacher, Dieter @@aut@@ Arnold, Norbert @@aut@@ Meindl, Alfons @@aut@@ Bartram, Claus R. @@aut@@ Schmutzler, Rita K. @@aut@@ Burwinkel, Barbara @@aut@@ Shen, Hongbing @@aut@@ |
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2010-12-08T00:00:00Z |
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A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). 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|
| author |
Wang, Furu |
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Wang, Furu ddc 610 bkl 44.92 misc miRNAs misc SNPs misc Breast cancer misc Molecular epidemiology A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk |
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610 ASE 44.92 bkl A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk miRNAs (dpeaa)DE-He213 SNPs (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Molecular epidemiology (dpeaa)DE-He213 |
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ddc 610 bkl 44.92 misc miRNAs misc SNPs misc Breast cancer misc Molecular epidemiology |
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ddc 610 bkl 44.92 misc miRNAs misc SNPs misc Breast cancer misc Molecular epidemiology |
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ddc 610 bkl 44.92 misc miRNAs misc SNPs misc Breast cancer misc Molecular epidemiology |
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A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk |
| ctrlnum |
(DE-627)SPR011078332 (SPR)s10549-010-1157-8-e |
| title_full |
A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk |
| author_sort |
Wang, Furu |
| journal |
Breast cancer research and treatment |
| journalStr |
Breast cancer research and treatment |
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eng |
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600 - Technology |
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marc |
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2010 |
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Wang, Furu Hu, Zhibin Yang, Rongxi Tang, Jinhai Liu, Yao Hemminki, Kari Sutter, Christian Wappenschmidt, Barbara Niederacher, Dieter Arnold, Norbert Meindl, Alfons Bartram, Claus R. Schmutzler, Rita K. Burwinkel, Barbara Shen, Hongbing |
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127 |
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610 ASE 44.92 bkl |
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Elektronische Aufsätze |
| author-letter |
Wang, Furu |
| doi_str_mv |
10.1007/s10549-010-1157-8 |
| dewey-full |
610 |
| author2-role |
verfasserin |
| title_sort |
variant affecting mirnas binding in the circadian gene neuronal pas domain protein 2 (npas2) is not associated with breast cancer risk |
| title_auth |
A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk |
| abstract |
Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. |
| abstractGer |
Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. |
| abstract_unstemmed |
Abstract Disruption of the circadian rhythm has been reported to increase the risk of breast cancer. A single nucleotide polymorphism (SNP) rs2305160 in Neuronal PAS domain protein 2 (NPAS2), the largest circadian gene, was identified as a breast cancer susceptibility locus. In the current study, we found a novel functional SNP (rs3739008) located at 3′UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3′UTR of NPAS2. We then typed this SNP in case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer risk. However, we failed to find any significant associations by different genetic models (dominant genetic model, adjusted OR = 1.13, 95% CI = 0.95–1.35 for the Chinese population and adjusted OR = 0.99, 95% CI = 0.85–1.16 for the Germany population). Although we did not find significant associations at population levels from both Chinese and Germany case–control studies, due to the functional relevance of rs3739008 on NASP2 expression, it will be promising to investigate the influence of this variant on clinical characteristics of breast cancer and breast cancer survival. |
| collection_details |
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| container_issue |
3 |
| title_short |
A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk |
| url |
https://dx.doi.org/10.1007/s10549-010-1157-8 |
| remote_bool |
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| author2 |
Hu, Zhibin Yang, Rongxi Tang, Jinhai Liu, Yao Hemminki, Kari Sutter, Christian Wappenschmidt, Barbara Niederacher, Dieter Arnold, Norbert Meindl, Alfons Bartram, Claus R. Schmutzler, Rita K. Burwinkel, Barbara Shen, Hongbing |
| author2Str |
Hu, Zhibin Yang, Rongxi Tang, Jinhai Liu, Yao Hemminki, Kari Sutter, Christian Wappenschmidt, Barbara Niederacher, Dieter Arnold, Norbert Meindl, Alfons Bartram, Claus R. Schmutzler, Rita K. Burwinkel, Barbara Shen, Hongbing |
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| up_date |
2024-07-03T20:16:30.578Z |
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| score |
7.4003267 |