Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer
Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantifi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mu, Zhaomei [verfasserIn] Wang, Chun [verfasserIn] Ye, Zhong [verfasserIn] Austin, Laura [verfasserIn] Civan, Jesse [verfasserIn] Hyslop, Terry [verfasserIn] Palazzo, Juan P. [verfasserIn] Jaslow, Rebecca [verfasserIn] Li, Bingshan [verfasserIn] Myers, Ronald E. [verfasserIn] Jiang, Juntao [verfasserIn] Xing, Jinliang [verfasserIn] Yang, Hushan [verfasserIn] Cristofanilli, Massimo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
Circulating tumor cells (CTCs) |
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| Übergeordnetes Werk: |
Enthalten in: Breast cancer research and treatment - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981, 154(2015), 3 vom: 16. Nov., Seite 563-571 |
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| Übergeordnetes Werk: |
volume:154 ; year:2015 ; number:3 ; day:16 ; month:11 ; pages:563-571 |
| Links: |
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| DOI / URN: |
10.1007/s10549-015-3636-4 |
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| Katalog-ID: |
SPR011102284 |
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| 245 | 1 | 0 | |a Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer |
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| 520 | |a Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. | ||
| 650 | 4 | |a Circulating tumor cells (CTCs) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Circulating tumor cell clusters (CTC-clusters) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Inflammatory breast cancer (IBC) |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Wang, Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Zhong |e verfasserin |4 aut | |
| 700 | 1 | |a Austin, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Civan, Jesse |e verfasserin |4 aut | |
| 700 | 1 | |a Hyslop, Terry |e verfasserin |4 aut | |
| 700 | 1 | |a Palazzo, Juan P. |e verfasserin |4 aut | |
| 700 | 1 | |a Jaslow, Rebecca |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Bingshan |e verfasserin |4 aut | |
| 700 | 1 | |a Myers, Ronald E. |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Juntao |e verfasserin |4 aut | |
| 700 | 1 | |a Xing, Jinliang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Hushan |e verfasserin |4 aut | |
| 700 | 1 | |a Cristofanilli, Massimo |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:154 |g year:2015 |g number:3 |g day:16 |g month:11 |g pages:563-571 |
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10.1007/s10549-015-3636-4 doi (DE-627)SPR011102284 (SPR)s10549-015-3636-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Mu, Zhaomei verfasserin aut Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. Circulating tumor cells (CTCs) (dpeaa)DE-He213 Circulating tumor cell clusters (CTC-clusters) (dpeaa)DE-He213 Inflammatory breast cancer (IBC) (dpeaa)DE-He213 Wang, Chun verfasserin aut Ye, Zhong verfasserin aut Austin, Laura verfasserin aut Civan, Jesse verfasserin aut Hyslop, Terry verfasserin aut Palazzo, Juan P. verfasserin aut Jaslow, Rebecca verfasserin aut Li, Bingshan verfasserin aut Myers, Ronald E. verfasserin aut Jiang, Juntao verfasserin aut Xing, Jinliang verfasserin aut Yang, Hushan verfasserin aut Cristofanilli, Massimo verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 154(2015), 3 vom: 16. Nov., Seite 563-571 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:154 year:2015 number:3 day:16 month:11 pages:563-571 https://dx.doi.org/10.1007/s10549-015-3636-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 154 2015 3 16 11 563-571 |
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10.1007/s10549-015-3636-4 doi (DE-627)SPR011102284 (SPR)s10549-015-3636-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Mu, Zhaomei verfasserin aut Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. Circulating tumor cells (CTCs) (dpeaa)DE-He213 Circulating tumor cell clusters (CTC-clusters) (dpeaa)DE-He213 Inflammatory breast cancer (IBC) (dpeaa)DE-He213 Wang, Chun verfasserin aut Ye, Zhong verfasserin aut Austin, Laura verfasserin aut Civan, Jesse verfasserin aut Hyslop, Terry verfasserin aut Palazzo, Juan P. verfasserin aut Jaslow, Rebecca verfasserin aut Li, Bingshan verfasserin aut Myers, Ronald E. verfasserin aut Jiang, Juntao verfasserin aut Xing, Jinliang verfasserin aut Yang, Hushan verfasserin aut Cristofanilli, Massimo verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 154(2015), 3 vom: 16. Nov., Seite 563-571 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:154 year:2015 number:3 day:16 month:11 pages:563-571 https://dx.doi.org/10.1007/s10549-015-3636-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 154 2015 3 16 11 563-571 |
| allfields_unstemmed |
10.1007/s10549-015-3636-4 doi (DE-627)SPR011102284 (SPR)s10549-015-3636-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Mu, Zhaomei verfasserin aut Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. Circulating tumor cells (CTCs) (dpeaa)DE-He213 Circulating tumor cell clusters (CTC-clusters) (dpeaa)DE-He213 Inflammatory breast cancer (IBC) (dpeaa)DE-He213 Wang, Chun verfasserin aut Ye, Zhong verfasserin aut Austin, Laura verfasserin aut Civan, Jesse verfasserin aut Hyslop, Terry verfasserin aut Palazzo, Juan P. verfasserin aut Jaslow, Rebecca verfasserin aut Li, Bingshan verfasserin aut Myers, Ronald E. verfasserin aut Jiang, Juntao verfasserin aut Xing, Jinliang verfasserin aut Yang, Hushan verfasserin aut Cristofanilli, Massimo verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 154(2015), 3 vom: 16. Nov., Seite 563-571 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:154 year:2015 number:3 day:16 month:11 pages:563-571 https://dx.doi.org/10.1007/s10549-015-3636-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 154 2015 3 16 11 563-571 |
| allfieldsGer |
10.1007/s10549-015-3636-4 doi (DE-627)SPR011102284 (SPR)s10549-015-3636-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Mu, Zhaomei verfasserin aut Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. Circulating tumor cells (CTCs) (dpeaa)DE-He213 Circulating tumor cell clusters (CTC-clusters) (dpeaa)DE-He213 Inflammatory breast cancer (IBC) (dpeaa)DE-He213 Wang, Chun verfasserin aut Ye, Zhong verfasserin aut Austin, Laura verfasserin aut Civan, Jesse verfasserin aut Hyslop, Terry verfasserin aut Palazzo, Juan P. verfasserin aut Jaslow, Rebecca verfasserin aut Li, Bingshan verfasserin aut Myers, Ronald E. verfasserin aut Jiang, Juntao verfasserin aut Xing, Jinliang verfasserin aut Yang, Hushan verfasserin aut Cristofanilli, Massimo verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 154(2015), 3 vom: 16. Nov., Seite 563-571 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:154 year:2015 number:3 day:16 month:11 pages:563-571 https://dx.doi.org/10.1007/s10549-015-3636-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 154 2015 3 16 11 563-571 |
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10.1007/s10549-015-3636-4 doi (DE-627)SPR011102284 (SPR)s10549-015-3636-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Mu, Zhaomei verfasserin aut Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. Circulating tumor cells (CTCs) (dpeaa)DE-He213 Circulating tumor cell clusters (CTC-clusters) (dpeaa)DE-He213 Inflammatory breast cancer (IBC) (dpeaa)DE-He213 Wang, Chun verfasserin aut Ye, Zhong verfasserin aut Austin, Laura verfasserin aut Civan, Jesse verfasserin aut Hyslop, Terry verfasserin aut Palazzo, Juan P. verfasserin aut Jaslow, Rebecca verfasserin aut Li, Bingshan verfasserin aut Myers, Ronald E. verfasserin aut Jiang, Juntao verfasserin aut Xing, Jinliang verfasserin aut Yang, Hushan verfasserin aut Cristofanilli, Massimo verfasserin aut Enthalten in Breast cancer research and treatment Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 154(2015), 3 vom: 16. Nov., Seite 563-571 (DE-627)320433722 (DE-600)2004077-5 1573-7217 nnns volume:154 year:2015 number:3 day:16 month:11 pages:563-571 https://dx.doi.org/10.1007/s10549-015-3636-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 154 2015 3 16 11 563-571 |
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Enthalten in Breast cancer research and treatment 154(2015), 3 vom: 16. Nov., Seite 563-571 volume:154 year:2015 number:3 day:16 month:11 pages:563-571 |
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Enthalten in Breast cancer research and treatment 154(2015), 3 vom: 16. Nov., Seite 563-571 volume:154 year:2015 number:3 day:16 month:11 pages:563-571 |
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Circulating tumor cells (CTCs) Circulating tumor cell clusters (CTC-clusters) Inflammatory breast cancer (IBC) |
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Mu, Zhaomei @@aut@@ Wang, Chun @@aut@@ Ye, Zhong @@aut@@ Austin, Laura @@aut@@ Civan, Jesse @@aut@@ Hyslop, Terry @@aut@@ Palazzo, Juan P. @@aut@@ Jaslow, Rebecca @@aut@@ Li, Bingshan @@aut@@ Myers, Ronald E. @@aut@@ Jiang, Juntao @@aut@@ Xing, Jinliang @@aut@@ Yang, Hushan @@aut@@ Cristofanilli, Massimo @@aut@@ |
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2015-11-16T00:00:00Z |
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|
| author |
Mu, Zhaomei |
| spellingShingle |
Mu, Zhaomei ddc 610 bkl 44.92 misc Circulating tumor cells (CTCs) misc Circulating tumor cell clusters (CTC-clusters) misc Inflammatory breast cancer (IBC) Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer |
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Mu, Zhaomei |
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610 - Medicine & health |
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1573-7217 |
| topic_title |
610 ASE 44.92 bkl Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer Circulating tumor cells (CTCs) (dpeaa)DE-He213 Circulating tumor cell clusters (CTC-clusters) (dpeaa)DE-He213 Inflammatory breast cancer (IBC) (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.92 misc Circulating tumor cells (CTCs) misc Circulating tumor cell clusters (CTC-clusters) misc Inflammatory breast cancer (IBC) |
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ddc 610 bkl 44.92 misc Circulating tumor cells (CTCs) misc Circulating tumor cell clusters (CTC-clusters) misc Inflammatory breast cancer (IBC) |
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ddc 610 bkl 44.92 misc Circulating tumor cells (CTCs) misc Circulating tumor cell clusters (CTC-clusters) misc Inflammatory breast cancer (IBC) |
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Breast cancer research and treatment |
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320433722 |
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610 - Medicine & health |
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Breast cancer research and treatment |
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(DE-627)320433722 (DE-600)2004077-5 |
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Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer |
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(DE-627)SPR011102284 (SPR)s10549-015-3636-4-e |
| title_full |
Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer |
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Mu, Zhaomei |
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Breast cancer research and treatment |
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Breast cancer research and treatment |
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eng |
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600 - Technology |
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2015 |
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Mu, Zhaomei Wang, Chun Ye, Zhong Austin, Laura Civan, Jesse Hyslop, Terry Palazzo, Juan P. Jaslow, Rebecca Li, Bingshan Myers, Ronald E. Jiang, Juntao Xing, Jinliang Yang, Hushan Cristofanilli, Massimo |
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154 |
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610 ASE 44.92 bkl |
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Mu, Zhaomei |
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10.1007/s10549-015-3636-4 |
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610 |
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verfasserin |
| title_sort |
prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer |
| title_auth |
Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer |
| abstract |
Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. |
| abstractGer |
Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. |
| abstract_unstemmed |
Abstract The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-clusters play an important role in tumor metastasis. We aimed to assess whether quantification of CTC-clusters provides additional prognostic value over quantification of individual CTCs alone. In 115 prospectively enrolled advanced-stage (III and IV) breast cancer patients, CTCs and CTC-clusters were counted in 7.5 ml whole blood using the $ CellSearch^{®} $ system at baseline before first-line therapy. The individual and joint effects of CTC and CTC cluster counts on patients’ progression-free survival (PFS) were analyzed using Cox proportional hazards modeling. Of the 115 patients, 36 (31.3 %) had elevated baseline CTCs (≥5 CTCs/7.5 ml) and 20 (17.4 %) had CTC-clusters (≥2 CTCs/7.5 ml). Patients with elevated CTCs and CTC-clusters both had worse PFS with a hazard ratio (HR) of 2.76 [95 % confidence interval (CI) 1.57–4.86, Plog-rank = 0.0005] and 2.83 (1.48–5.39, Plog-rank = 0.001), respectively. In joint analysis, compared with patients with <5 CTCs and without CTC-clusters, patients with elevated CTCs but without clusters, and patients with elevated CTCs and with clusters, had an increasing trend of progression risk, with an HR of 2.21 (1.02–4.78) and 3.32 (1.68–6.55), respectively (Plog-rank = 0.0006, Ptrend = 0.0002). The additional prognostic value of CTC-clusters appeared to be more pronounced in patients with inflammatory breast cancer (IBC), the most aggressive form of breast cancer with the poorest survival. Baseline counts of both individual CTCs and CTC-clusters were associated with PFS in advanced-stage breast cancer patients. CTC-clusters might provide additional prognostic value compared with CTC enumeration alone, in patients with elevated CTCs. |
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Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer |
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https://dx.doi.org/10.1007/s10549-015-3636-4 |
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Wang, Chun Ye, Zhong Austin, Laura Civan, Jesse Hyslop, Terry Palazzo, Juan P. Jaslow, Rebecca Li, Bingshan Myers, Ronald E. Jiang, Juntao Xing, Jinliang Yang, Hushan Cristofanilli, Massimo |
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Wang, Chun Ye, Zhong Austin, Laura Civan, Jesse Hyslop, Terry Palazzo, Juan P. Jaslow, Rebecca Li, Bingshan Myers, Ronald E. Jiang, Juntao Xing, Jinliang Yang, Hushan Cristofanilli, Massimo |
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10.1007/s10549-015-3636-4 |
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2024-07-03T20:27:40.898Z |
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| score |
7.400714 |