Combinatorial targeting and nanotechnology applications
Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on mul...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Souza, Glauco R. [verfasserIn] Staquicini, Fernanda I. [verfasserIn] Christianson, Dawn R. [verfasserIn] Ozawa, Michael G. [verfasserIn] Miller, J. Houston [verfasserIn] Pasqualini, Renata [verfasserIn] Arap, Wadih [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Biomedical microdevices - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1998, 12(2009), 4 vom: 11. Aug., Seite 597-606 |
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| Übergeordnetes Werk: |
volume:12 ; year:2009 ; number:4 ; day:11 ; month:08 ; pages:597-606 |
| Links: |
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| DOI / URN: |
10.1007/s10544-009-9340-6 |
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| Katalog-ID: |
SPR011194324 |
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| 520 | |a Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. | ||
| 650 | 4 | |a Combinatorial targeting |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nanotechnology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nanoshuttles |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Multimodal detection |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gold nanoparticle |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Phage |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Peptide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Fractal |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Fluorescence |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Scattering |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Direct assembly |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Angle-dependent |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Light scattering |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Au-phage |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a ELISA |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Staquicini, Fernanda I. |e verfasserin |4 aut | |
| 700 | 1 | |a Christianson, Dawn R. |e verfasserin |4 aut | |
| 700 | 1 | |a Ozawa, Michael G. |e verfasserin |4 aut | |
| 700 | 1 | |a Miller, J. Houston |e verfasserin |4 aut | |
| 700 | 1 | |a Pasqualini, Renata |e verfasserin |4 aut | |
| 700 | 1 | |a Arap, Wadih |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomedical microdevices |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1998 |g 12(2009), 4 vom: 11. Aug., Seite 597-606 |w (DE-627)320433269 |w (DE-600)2004019-2 |x 1572-8781 |7 nnns |
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10.1007/s10544-009-9340-6 doi (DE-627)SPR011194324 (SPR)s10544-009-9340-6-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Souza, Glauco R. verfasserin aut Combinatorial targeting and nanotechnology applications 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. Combinatorial targeting (dpeaa)DE-He213 Nanotechnology (dpeaa)DE-He213 Nanoshuttles (dpeaa)DE-He213 Multimodal detection (dpeaa)DE-He213 Gold nanoparticle (dpeaa)DE-He213 Phage (dpeaa)DE-He213 Peptide (dpeaa)DE-He213 Fractal (dpeaa)DE-He213 Fluorescence (dpeaa)DE-He213 Scattering (dpeaa)DE-He213 Direct assembly (dpeaa)DE-He213 Angle-dependent (dpeaa)DE-He213 Light scattering (dpeaa)DE-He213 Au-phage (dpeaa)DE-He213 ELISA (dpeaa)DE-He213 Staquicini, Fernanda I. verfasserin aut Christianson, Dawn R. verfasserin aut Ozawa, Michael G. verfasserin aut Miller, J. Houston verfasserin aut Pasqualini, Renata verfasserin aut Arap, Wadih verfasserin aut Enthalten in Biomedical microdevices Dordrecht [u.a.] : Springer Science + Business Media B.V, 1998 12(2009), 4 vom: 11. Aug., Seite 597-606 (DE-627)320433269 (DE-600)2004019-2 1572-8781 nnns volume:12 year:2009 number:4 day:11 month:08 pages:597-606 https://dx.doi.org/10.1007/s10544-009-9340-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 12 2009 4 11 08 597-606 |
| spelling |
10.1007/s10544-009-9340-6 doi (DE-627)SPR011194324 (SPR)s10544-009-9340-6-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Souza, Glauco R. verfasserin aut Combinatorial targeting and nanotechnology applications 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. Combinatorial targeting (dpeaa)DE-He213 Nanotechnology (dpeaa)DE-He213 Nanoshuttles (dpeaa)DE-He213 Multimodal detection (dpeaa)DE-He213 Gold nanoparticle (dpeaa)DE-He213 Phage (dpeaa)DE-He213 Peptide (dpeaa)DE-He213 Fractal (dpeaa)DE-He213 Fluorescence (dpeaa)DE-He213 Scattering (dpeaa)DE-He213 Direct assembly (dpeaa)DE-He213 Angle-dependent (dpeaa)DE-He213 Light scattering (dpeaa)DE-He213 Au-phage (dpeaa)DE-He213 ELISA (dpeaa)DE-He213 Staquicini, Fernanda I. verfasserin aut Christianson, Dawn R. verfasserin aut Ozawa, Michael G. verfasserin aut Miller, J. Houston verfasserin aut Pasqualini, Renata verfasserin aut Arap, Wadih verfasserin aut Enthalten in Biomedical microdevices Dordrecht [u.a.] : Springer Science + Business Media B.V, 1998 12(2009), 4 vom: 11. Aug., Seite 597-606 (DE-627)320433269 (DE-600)2004019-2 1572-8781 nnns volume:12 year:2009 number:4 day:11 month:08 pages:597-606 https://dx.doi.org/10.1007/s10544-009-9340-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 12 2009 4 11 08 597-606 |
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10.1007/s10544-009-9340-6 doi (DE-627)SPR011194324 (SPR)s10544-009-9340-6-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Souza, Glauco R. verfasserin aut Combinatorial targeting and nanotechnology applications 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. Combinatorial targeting (dpeaa)DE-He213 Nanotechnology (dpeaa)DE-He213 Nanoshuttles (dpeaa)DE-He213 Multimodal detection (dpeaa)DE-He213 Gold nanoparticle (dpeaa)DE-He213 Phage (dpeaa)DE-He213 Peptide (dpeaa)DE-He213 Fractal (dpeaa)DE-He213 Fluorescence (dpeaa)DE-He213 Scattering (dpeaa)DE-He213 Direct assembly (dpeaa)DE-He213 Angle-dependent (dpeaa)DE-He213 Light scattering (dpeaa)DE-He213 Au-phage (dpeaa)DE-He213 ELISA (dpeaa)DE-He213 Staquicini, Fernanda I. verfasserin aut Christianson, Dawn R. verfasserin aut Ozawa, Michael G. verfasserin aut Miller, J. Houston verfasserin aut Pasqualini, Renata verfasserin aut Arap, Wadih verfasserin aut Enthalten in Biomedical microdevices Dordrecht [u.a.] : Springer Science + Business Media B.V, 1998 12(2009), 4 vom: 11. Aug., Seite 597-606 (DE-627)320433269 (DE-600)2004019-2 1572-8781 nnns volume:12 year:2009 number:4 day:11 month:08 pages:597-606 https://dx.doi.org/10.1007/s10544-009-9340-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 12 2009 4 11 08 597-606 |
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10.1007/s10544-009-9340-6 doi (DE-627)SPR011194324 (SPR)s10544-009-9340-6-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Souza, Glauco R. verfasserin aut Combinatorial targeting and nanotechnology applications 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. Combinatorial targeting (dpeaa)DE-He213 Nanotechnology (dpeaa)DE-He213 Nanoshuttles (dpeaa)DE-He213 Multimodal detection (dpeaa)DE-He213 Gold nanoparticle (dpeaa)DE-He213 Phage (dpeaa)DE-He213 Peptide (dpeaa)DE-He213 Fractal (dpeaa)DE-He213 Fluorescence (dpeaa)DE-He213 Scattering (dpeaa)DE-He213 Direct assembly (dpeaa)DE-He213 Angle-dependent (dpeaa)DE-He213 Light scattering (dpeaa)DE-He213 Au-phage (dpeaa)DE-He213 ELISA (dpeaa)DE-He213 Staquicini, Fernanda I. verfasserin aut Christianson, Dawn R. verfasserin aut Ozawa, Michael G. verfasserin aut Miller, J. Houston verfasserin aut Pasqualini, Renata verfasserin aut Arap, Wadih verfasserin aut Enthalten in Biomedical microdevices Dordrecht [u.a.] : Springer Science + Business Media B.V, 1998 12(2009), 4 vom: 11. Aug., Seite 597-606 (DE-627)320433269 (DE-600)2004019-2 1572-8781 nnns volume:12 year:2009 number:4 day:11 month:08 pages:597-606 https://dx.doi.org/10.1007/s10544-009-9340-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 12 2009 4 11 08 597-606 |
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10.1007/s10544-009-9340-6 doi (DE-627)SPR011194324 (SPR)s10544-009-9340-6-e DE-627 ger DE-627 rakwb eng 570 ASE 44.00 bkl Souza, Glauco R. verfasserin aut Combinatorial targeting and nanotechnology applications 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. Combinatorial targeting (dpeaa)DE-He213 Nanotechnology (dpeaa)DE-He213 Nanoshuttles (dpeaa)DE-He213 Multimodal detection (dpeaa)DE-He213 Gold nanoparticle (dpeaa)DE-He213 Phage (dpeaa)DE-He213 Peptide (dpeaa)DE-He213 Fractal (dpeaa)DE-He213 Fluorescence (dpeaa)DE-He213 Scattering (dpeaa)DE-He213 Direct assembly (dpeaa)DE-He213 Angle-dependent (dpeaa)DE-He213 Light scattering (dpeaa)DE-He213 Au-phage (dpeaa)DE-He213 ELISA (dpeaa)DE-He213 Staquicini, Fernanda I. verfasserin aut Christianson, Dawn R. verfasserin aut Ozawa, Michael G. verfasserin aut Miller, J. Houston verfasserin aut Pasqualini, Renata verfasserin aut Arap, Wadih verfasserin aut Enthalten in Biomedical microdevices Dordrecht [u.a.] : Springer Science + Business Media B.V, 1998 12(2009), 4 vom: 11. Aug., Seite 597-606 (DE-627)320433269 (DE-600)2004019-2 1572-8781 nnns volume:12 year:2009 number:4 day:11 month:08 pages:597-606 https://dx.doi.org/10.1007/s10544-009-9340-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.00 ASE AR 12 2009 4 11 08 597-606 |
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Enthalten in Biomedical microdevices 12(2009), 4 vom: 11. Aug., Seite 597-606 volume:12 year:2009 number:4 day:11 month:08 pages:597-606 |
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Combinatorial targeting Nanotechnology Nanoshuttles Multimodal detection Gold nanoparticle Phage Peptide Fractal Fluorescence Scattering Direct assembly Angle-dependent Light scattering Au-phage ELISA |
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Souza, Glauco R. @@aut@@ Staquicini, Fernanda I. @@aut@@ Christianson, Dawn R. @@aut@@ Ozawa, Michael G. @@aut@@ Miller, J. Houston @@aut@@ Pasqualini, Renata @@aut@@ Arap, Wadih @@aut@@ |
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There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Combinatorial targeting</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nanotechnology</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nanoshuttles</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Multimodal detection</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gold nanoparticle</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phage</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Peptide</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fractal</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluorescence</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Scattering</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Direct assembly</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Angle-dependent</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Light scattering</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Au-phage</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ELISA</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Staquicini, Fernanda I.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Christianson, Dawn R.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ozawa, Michael G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Miller, J. 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|
| author |
Souza, Glauco R. |
| spellingShingle |
Souza, Glauco R. ddc 570 bkl 44.00 misc Combinatorial targeting misc Nanotechnology misc Nanoshuttles misc Multimodal detection misc Gold nanoparticle misc Phage misc Peptide misc Fractal misc Fluorescence misc Scattering misc Direct assembly misc Angle-dependent misc Light scattering misc Au-phage misc ELISA Combinatorial targeting and nanotechnology applications |
| authorStr |
Souza, Glauco R. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)320433269 |
| format |
electronic Article |
| dewey-ones |
570 - Life sciences; biology |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1572-8781 |
| topic_title |
570 ASE 44.00 bkl Combinatorial targeting and nanotechnology applications Combinatorial targeting (dpeaa)DE-He213 Nanotechnology (dpeaa)DE-He213 Nanoshuttles (dpeaa)DE-He213 Multimodal detection (dpeaa)DE-He213 Gold nanoparticle (dpeaa)DE-He213 Phage (dpeaa)DE-He213 Peptide (dpeaa)DE-He213 Fractal (dpeaa)DE-He213 Fluorescence (dpeaa)DE-He213 Scattering (dpeaa)DE-He213 Direct assembly (dpeaa)DE-He213 Angle-dependent (dpeaa)DE-He213 Light scattering (dpeaa)DE-He213 Au-phage (dpeaa)DE-He213 ELISA (dpeaa)DE-He213 |
| topic |
ddc 570 bkl 44.00 misc Combinatorial targeting misc Nanotechnology misc Nanoshuttles misc Multimodal detection misc Gold nanoparticle misc Phage misc Peptide misc Fractal misc Fluorescence misc Scattering misc Direct assembly misc Angle-dependent misc Light scattering misc Au-phage misc ELISA |
| topic_unstemmed |
ddc 570 bkl 44.00 misc Combinatorial targeting misc Nanotechnology misc Nanoshuttles misc Multimodal detection misc Gold nanoparticle misc Phage misc Peptide misc Fractal misc Fluorescence misc Scattering misc Direct assembly misc Angle-dependent misc Light scattering misc Au-phage misc ELISA |
| topic_browse |
ddc 570 bkl 44.00 misc Combinatorial targeting misc Nanotechnology misc Nanoshuttles misc Multimodal detection misc Gold nanoparticle misc Phage misc Peptide misc Fractal misc Fluorescence misc Scattering misc Direct assembly misc Angle-dependent misc Light scattering misc Au-phage misc ELISA |
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Combinatorial targeting and nanotechnology applications |
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Combinatorial targeting and nanotechnology applications |
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Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. |
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Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. |
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Abstract The development of improved methods for targeted cell detection is of general interest in many fields of research and drug development. There are a number of well-established techniques for the study and detection of biomarkers expressed in living cells and tissues. Many of them rely on multi-step procedures that might not meet ideal assay requirements for speed, cost, sensitivity, and specificity. Here we report and further validate an approach that enables spontaneous molecular assembly to generate biologically active networks of bacteriophage (phage) assembled with gold (Au) nanoparticles (termed Au-phage nanoshuttles). Here, the nanoshuttles preserve the cell binding and internalization attributes mediated by a displayed peptide targeted to a cell surface receptor. The organization of such targeted assemblies can be further manipulated to be used as a mutimodal detection assembly, and they can be characterized as fractal nanostructures by angle-dependent light scattering fractal dimension analysis. Targeted Au-phage nanoshuttles offer multiple functionalities for nanotechnology-based sensing and reporting, including enhanced florescence and improved contrast for darkfield microscopy. |
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| score |
7.4017544 |