Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection
Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited f...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
López, Rossana Verónica Mendoza [verfasserIn] Levi, José Eduardo [verfasserIn] Eluf-Neto, José [verfasserIn] Koifman, Rosalina Jorge [verfasserIn] Koifman, Sergio [verfasserIn] Curado, Maria Paula [verfasserIn] Michaluart-Junior, Pedro [verfasserIn] Figueiredo, David Livingstone Alves [verfasserIn] Saggioro, Fabiano Pinto [verfasserIn] de Carvalho, Marcos Brasilino [verfasserIn] Kowalski, Luiz Paulo [verfasserIn] Abrahão, Márcio [verfasserIn] de Góis-Filho, Francisco [verfasserIn] Tajara, Eloiza Helena [verfasserIn] Waterboer, Tim [verfasserIn] Boffetta, Paolo [verfasserIn] Brennan, Paul [verfasserIn] Wünsch-Filho, Victor [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Cancer causes & control - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1990, 25(2014), 4 vom: 29. Jan., Seite 461-471 |
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| Übergeordnetes Werk: |
volume:25 ; year:2014 ; number:4 ; day:29 ; month:01 ; pages:461-471 |
| Links: |
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| DOI / URN: |
10.1007/s10552-014-0348-8 |
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| Katalog-ID: |
SPR01119734X |
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| 100 | 1 | |a López, Rossana Verónica Mendoza |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection |
| 264 | 1 | |c 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. | ||
| 650 | 4 | |a Human papillomavirus |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Serology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Head and neck cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prevalence |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Levi, José Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Eluf-Neto, José |e verfasserin |4 aut | |
| 700 | 1 | |a Koifman, Rosalina Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Koifman, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Curado, Maria Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Michaluart-Junior, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Figueiredo, David Livingstone Alves |e verfasserin |4 aut | |
| 700 | 1 | |a Saggioro, Fabiano Pinto |e verfasserin |4 aut | |
| 700 | 1 | |a de Carvalho, Marcos Brasilino |e verfasserin |4 aut | |
| 700 | 1 | |a Kowalski, Luiz Paulo |e verfasserin |4 aut | |
| 700 | 1 | |a Abrahão, Márcio |e verfasserin |4 aut | |
| 700 | 1 | |a de Góis-Filho, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Tajara, Eloiza Helena |e verfasserin |4 aut | |
| 700 | 1 | |a Waterboer, Tim |e verfasserin |4 aut | |
| 700 | 1 | |a Boffetta, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Brennan, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Wünsch-Filho, Victor |e verfasserin |4 aut | |
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10.1007/s10552-014-0348-8 doi (DE-627)SPR01119734X (SPR)s10552-014-0348-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl López, Rossana Verónica Mendoza verfasserin aut Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. Human papillomavirus (dpeaa)DE-He213 Serology (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Head and neck cancer (dpeaa)DE-He213 Prevalence (dpeaa)DE-He213 Levi, José Eduardo verfasserin aut Eluf-Neto, José verfasserin aut Koifman, Rosalina Jorge verfasserin aut Koifman, Sergio verfasserin aut Curado, Maria Paula verfasserin aut Michaluart-Junior, Pedro verfasserin aut Figueiredo, David Livingstone Alves verfasserin aut Saggioro, Fabiano Pinto verfasserin aut de Carvalho, Marcos Brasilino verfasserin aut Kowalski, Luiz Paulo verfasserin aut Abrahão, Márcio verfasserin aut de Góis-Filho, Francisco verfasserin aut Tajara, Eloiza Helena verfasserin aut Waterboer, Tim verfasserin aut Boffetta, Paolo verfasserin aut Brennan, Paul verfasserin aut Wünsch-Filho, Victor verfasserin aut Enthalten in Cancer causes & control Dordrecht [u.a.] : Springer Science + Business Media B.V., 1990 25(2014), 4 vom: 29. Jan., Seite 461-471 (DE-627)306324288 (DE-600)1496544-6 1573-7225 nnns volume:25 year:2014 number:4 day:29 month:01 pages:461-471 https://dx.doi.org/10.1007/s10552-014-0348-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2943 GBV_ILN_2946 GBV_ILN_2949 GBV_ILN_2951 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 25 2014 4 29 01 461-471 |
| spelling |
10.1007/s10552-014-0348-8 doi (DE-627)SPR01119734X (SPR)s10552-014-0348-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl López, Rossana Verónica Mendoza verfasserin aut Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. Human papillomavirus (dpeaa)DE-He213 Serology (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Head and neck cancer (dpeaa)DE-He213 Prevalence (dpeaa)DE-He213 Levi, José Eduardo verfasserin aut Eluf-Neto, José verfasserin aut Koifman, Rosalina Jorge verfasserin aut Koifman, Sergio verfasserin aut Curado, Maria Paula verfasserin aut Michaluart-Junior, Pedro verfasserin aut Figueiredo, David Livingstone Alves verfasserin aut Saggioro, Fabiano Pinto verfasserin aut de Carvalho, Marcos Brasilino verfasserin aut Kowalski, Luiz Paulo verfasserin aut Abrahão, Márcio verfasserin aut de Góis-Filho, Francisco verfasserin aut Tajara, Eloiza Helena verfasserin aut Waterboer, Tim verfasserin aut Boffetta, Paolo verfasserin aut Brennan, Paul verfasserin aut Wünsch-Filho, Victor verfasserin aut Enthalten in Cancer causes & control Dordrecht [u.a.] : Springer Science + Business Media B.V., 1990 25(2014), 4 vom: 29. Jan., Seite 461-471 (DE-627)306324288 (DE-600)1496544-6 1573-7225 nnns volume:25 year:2014 number:4 day:29 month:01 pages:461-471 https://dx.doi.org/10.1007/s10552-014-0348-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2943 GBV_ILN_2946 GBV_ILN_2949 GBV_ILN_2951 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 25 2014 4 29 01 461-471 |
| allfields_unstemmed |
10.1007/s10552-014-0348-8 doi (DE-627)SPR01119734X (SPR)s10552-014-0348-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl López, Rossana Verónica Mendoza verfasserin aut Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. Human papillomavirus (dpeaa)DE-He213 Serology (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Head and neck cancer (dpeaa)DE-He213 Prevalence (dpeaa)DE-He213 Levi, José Eduardo verfasserin aut Eluf-Neto, José verfasserin aut Koifman, Rosalina Jorge verfasserin aut Koifman, Sergio verfasserin aut Curado, Maria Paula verfasserin aut Michaluart-Junior, Pedro verfasserin aut Figueiredo, David Livingstone Alves verfasserin aut Saggioro, Fabiano Pinto verfasserin aut de Carvalho, Marcos Brasilino verfasserin aut Kowalski, Luiz Paulo verfasserin aut Abrahão, Márcio verfasserin aut de Góis-Filho, Francisco verfasserin aut Tajara, Eloiza Helena verfasserin aut Waterboer, Tim verfasserin aut Boffetta, Paolo verfasserin aut Brennan, Paul verfasserin aut Wünsch-Filho, Victor verfasserin aut Enthalten in Cancer causes & control Dordrecht [u.a.] : Springer Science + Business Media B.V., 1990 25(2014), 4 vom: 29. Jan., Seite 461-471 (DE-627)306324288 (DE-600)1496544-6 1573-7225 nnns volume:25 year:2014 number:4 day:29 month:01 pages:461-471 https://dx.doi.org/10.1007/s10552-014-0348-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2943 GBV_ILN_2946 GBV_ILN_2949 GBV_ILN_2951 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 25 2014 4 29 01 461-471 |
| allfieldsGer |
10.1007/s10552-014-0348-8 doi (DE-627)SPR01119734X (SPR)s10552-014-0348-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl López, Rossana Verónica Mendoza verfasserin aut Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. Human papillomavirus (dpeaa)DE-He213 Serology (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Head and neck cancer (dpeaa)DE-He213 Prevalence (dpeaa)DE-He213 Levi, José Eduardo verfasserin aut Eluf-Neto, José verfasserin aut Koifman, Rosalina Jorge verfasserin aut Koifman, Sergio verfasserin aut Curado, Maria Paula verfasserin aut Michaluart-Junior, Pedro verfasserin aut Figueiredo, David Livingstone Alves verfasserin aut Saggioro, Fabiano Pinto verfasserin aut de Carvalho, Marcos Brasilino verfasserin aut Kowalski, Luiz Paulo verfasserin aut Abrahão, Márcio verfasserin aut de Góis-Filho, Francisco verfasserin aut Tajara, Eloiza Helena verfasserin aut Waterboer, Tim verfasserin aut Boffetta, Paolo verfasserin aut Brennan, Paul verfasserin aut Wünsch-Filho, Victor verfasserin aut Enthalten in Cancer causes & control Dordrecht [u.a.] : Springer Science + Business Media B.V., 1990 25(2014), 4 vom: 29. Jan., Seite 461-471 (DE-627)306324288 (DE-600)1496544-6 1573-7225 nnns volume:25 year:2014 number:4 day:29 month:01 pages:461-471 https://dx.doi.org/10.1007/s10552-014-0348-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2943 GBV_ILN_2946 GBV_ILN_2949 GBV_ILN_2951 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 25 2014 4 29 01 461-471 |
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10.1007/s10552-014-0348-8 doi (DE-627)SPR01119734X (SPR)s10552-014-0348-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl López, Rossana Verónica Mendoza verfasserin aut Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. Human papillomavirus (dpeaa)DE-He213 Serology (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Head and neck cancer (dpeaa)DE-He213 Prevalence (dpeaa)DE-He213 Levi, José Eduardo verfasserin aut Eluf-Neto, José verfasserin aut Koifman, Rosalina Jorge verfasserin aut Koifman, Sergio verfasserin aut Curado, Maria Paula verfasserin aut Michaluart-Junior, Pedro verfasserin aut Figueiredo, David Livingstone Alves verfasserin aut Saggioro, Fabiano Pinto verfasserin aut de Carvalho, Marcos Brasilino verfasserin aut Kowalski, Luiz Paulo verfasserin aut Abrahão, Márcio verfasserin aut de Góis-Filho, Francisco verfasserin aut Tajara, Eloiza Helena verfasserin aut Waterboer, Tim verfasserin aut Boffetta, Paolo verfasserin aut Brennan, Paul verfasserin aut Wünsch-Filho, Victor verfasserin aut Enthalten in Cancer causes & control Dordrecht [u.a.] : Springer Science + Business Media B.V., 1990 25(2014), 4 vom: 29. Jan., Seite 461-471 (DE-627)306324288 (DE-600)1496544-6 1573-7225 nnns volume:25 year:2014 number:4 day:29 month:01 pages:461-471 https://dx.doi.org/10.1007/s10552-014-0348-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2943 GBV_ILN_2946 GBV_ILN_2949 GBV_ILN_2951 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 25 2014 4 29 01 461-471 |
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Enthalten in Cancer causes & control 25(2014), 4 vom: 29. Jan., Seite 461-471 volume:25 year:2014 number:4 day:29 month:01 pages:461-471 |
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López, Rossana Verónica Mendoza @@aut@@ Levi, José Eduardo @@aut@@ Eluf-Neto, José @@aut@@ Koifman, Rosalina Jorge @@aut@@ Koifman, Sergio @@aut@@ Curado, Maria Paula @@aut@@ Michaluart-Junior, Pedro @@aut@@ Figueiredo, David Livingstone Alves @@aut@@ Saggioro, Fabiano Pinto @@aut@@ de Carvalho, Marcos Brasilino @@aut@@ Kowalski, Luiz Paulo @@aut@@ Abrahão, Márcio @@aut@@ de Góis-Filho, Francisco @@aut@@ Tajara, Eloiza Helena @@aut@@ Waterboer, Tim @@aut@@ Boffetta, Paolo @@aut@@ Brennan, Paul @@aut@@ Wünsch-Filho, Victor @@aut@@ |
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We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. 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| author |
López, Rossana Verónica Mendoza |
| spellingShingle |
López, Rossana Verónica Mendoza ddc 610 bkl 44.81 misc Human papillomavirus misc Serology misc Prognosis misc Head and neck cancer misc Prevalence Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection |
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López, Rossana Verónica Mendoza |
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610 - Medicine & health |
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1573-7225 |
| topic_title |
610 ASE 44.81 bkl Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection Human papillomavirus (dpeaa)DE-He213 Serology (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Head and neck cancer (dpeaa)DE-He213 Prevalence (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.81 misc Human papillomavirus misc Serology misc Prognosis misc Head and neck cancer misc Prevalence |
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ddc 610 bkl 44.81 misc Human papillomavirus misc Serology misc Prognosis misc Head and neck cancer misc Prevalence |
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ddc 610 bkl 44.81 misc Human papillomavirus misc Serology misc Prognosis misc Head and neck cancer misc Prevalence |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Cancer causes & control |
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306324288 |
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610 - Medicine & health |
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Cancer causes & control |
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(DE-627)306324288 (DE-600)1496544-6 |
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Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection |
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(DE-627)SPR01119734X (SPR)s10552-014-0348-8-e |
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Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection |
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López, Rossana Verónica Mendoza |
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Cancer causes & control |
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Cancer causes & control |
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eng |
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600 - Technology |
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2014 |
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461 |
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López, Rossana Verónica Mendoza Levi, José Eduardo Eluf-Neto, José Koifman, Rosalina Jorge Koifman, Sergio Curado, Maria Paula Michaluart-Junior, Pedro Figueiredo, David Livingstone Alves Saggioro, Fabiano Pinto de Carvalho, Marcos Brasilino Kowalski, Luiz Paulo Abrahão, Márcio de Góis-Filho, Francisco Tajara, Eloiza Helena Waterboer, Tim Boffetta, Paolo Brennan, Paul Wünsch-Filho, Victor |
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610 ASE 44.81 bkl |
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Elektronische Aufsätze |
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López, Rossana Verónica Mendoza |
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10.1007/s10552-014-0348-8 |
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610 |
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verfasserin |
| title_sort |
human papillomavirus (hpv) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of hpv infection |
| title_auth |
Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection |
| abstract |
Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. |
| abstractGer |
Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. |
| abstract_unstemmed |
Background The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. Methods This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan–Meier method and Cox regression. Results Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Conclusion Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. |
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Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection |
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https://dx.doi.org/10.1007/s10552-014-0348-8 |
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Levi, José Eduardo Eluf-Neto, José Koifman, Rosalina Jorge Koifman, Sergio Curado, Maria Paula Michaluart-Junior, Pedro Figueiredo, David Livingstone Alves Saggioro, Fabiano Pinto de Carvalho, Marcos Brasilino Kowalski, Luiz Paulo Abrahão, Márcio de Góis-Filho, Francisco Tajara, Eloiza Helena Waterboer, Tim Boffetta, Paolo Brennan, Paul Wünsch-Filho, Victor |
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Levi, José Eduardo Eluf-Neto, José Koifman, Rosalina Jorge Koifman, Sergio Curado, Maria Paula Michaluart-Junior, Pedro Figueiredo, David Livingstone Alves Saggioro, Fabiano Pinto de Carvalho, Marcos Brasilino Kowalski, Luiz Paulo Abrahão, Márcio de Góis-Filho, Francisco Tajara, Eloiza Helena Waterboer, Tim Boffetta, Paolo Brennan, Paul Wünsch-Filho, Victor |
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10.1007/s10552-014-0348-8 |
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2024-07-03T21:06:44.139Z |
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| score |
7.3964148 |