Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging
Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, John K-J. [verfasserIn] Zhu, Ying [verfasserIn] O’Hara, Dorene [verfasserIn] Khaw, Kenneth [verfasserIn] |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Cardiovascular engineering - Dordrecht [u.a.] : Springer Science + Business Media B.V, 2001, 7(2007), 4 vom: 16. Nov., Seite 135-139 |
|---|---|
| Übergeordnetes Werk: |
volume:7 ; year:2007 ; number:4 ; day:16 ; month:11 ; pages:135-139 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10558-007-9040-x |
|---|
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SPR011291613 |
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| 520 | |a Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. | ||
| 650 | 4 | |a Systolic hypertension |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Wave reflections |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Arterial compliance |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Vascular stiffness |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Aging |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Zhu, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a O’Hara, Dorene |e verfasserin |4 aut | |
| 700 | 1 | |a Khaw, Kenneth |e verfasserin |4 aut | |
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10.1007/s10558-007-9040-x doi (DE-627)SPR011291613 (SPR)s10558-007-9040-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Li, John K-J. verfasserin aut Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. Systolic hypertension (dpeaa)DE-He213 Wave reflections (dpeaa)DE-He213 Arterial compliance (dpeaa)DE-He213 Vascular stiffness (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Zhu, Ying verfasserin aut O’Hara, Dorene verfasserin aut Khaw, Kenneth verfasserin aut Enthalten in Cardiovascular engineering Dordrecht [u.a.] : Springer Science + Business Media B.V, 2001 7(2007), 4 vom: 16. Nov., Seite 135-139 (DE-627)325609152 (DE-600)2037838-5 1573-6806 nnns volume:7 year:2007 number:4 day:16 month:11 pages:135-139 https://dx.doi.org/10.1007/s10558-007-9040-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 GBV_ILN_70 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2027 GBV_ILN_2048 GBV_ILN_2190 44.85 ASE AR 7 2007 4 16 11 135-139 |
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10.1007/s10558-007-9040-x doi (DE-627)SPR011291613 (SPR)s10558-007-9040-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Li, John K-J. verfasserin aut Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. Systolic hypertension (dpeaa)DE-He213 Wave reflections (dpeaa)DE-He213 Arterial compliance (dpeaa)DE-He213 Vascular stiffness (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Zhu, Ying verfasserin aut O’Hara, Dorene verfasserin aut Khaw, Kenneth verfasserin aut Enthalten in Cardiovascular engineering Dordrecht [u.a.] : Springer Science + Business Media B.V, 2001 7(2007), 4 vom: 16. Nov., Seite 135-139 (DE-627)325609152 (DE-600)2037838-5 1573-6806 nnns volume:7 year:2007 number:4 day:16 month:11 pages:135-139 https://dx.doi.org/10.1007/s10558-007-9040-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 GBV_ILN_70 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2027 GBV_ILN_2048 GBV_ILN_2190 44.85 ASE AR 7 2007 4 16 11 135-139 |
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10.1007/s10558-007-9040-x doi (DE-627)SPR011291613 (SPR)s10558-007-9040-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Li, John K-J. verfasserin aut Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. Systolic hypertension (dpeaa)DE-He213 Wave reflections (dpeaa)DE-He213 Arterial compliance (dpeaa)DE-He213 Vascular stiffness (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Zhu, Ying verfasserin aut O’Hara, Dorene verfasserin aut Khaw, Kenneth verfasserin aut Enthalten in Cardiovascular engineering Dordrecht [u.a.] : Springer Science + Business Media B.V, 2001 7(2007), 4 vom: 16. Nov., Seite 135-139 (DE-627)325609152 (DE-600)2037838-5 1573-6806 nnns volume:7 year:2007 number:4 day:16 month:11 pages:135-139 https://dx.doi.org/10.1007/s10558-007-9040-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 GBV_ILN_70 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2027 GBV_ILN_2048 GBV_ILN_2190 44.85 ASE AR 7 2007 4 16 11 135-139 |
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10.1007/s10558-007-9040-x doi (DE-627)SPR011291613 (SPR)s10558-007-9040-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Li, John K-J. verfasserin aut Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. Systolic hypertension (dpeaa)DE-He213 Wave reflections (dpeaa)DE-He213 Arterial compliance (dpeaa)DE-He213 Vascular stiffness (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Zhu, Ying verfasserin aut O’Hara, Dorene verfasserin aut Khaw, Kenneth verfasserin aut Enthalten in Cardiovascular engineering Dordrecht [u.a.] : Springer Science + Business Media B.V, 2001 7(2007), 4 vom: 16. Nov., Seite 135-139 (DE-627)325609152 (DE-600)2037838-5 1573-6806 nnns volume:7 year:2007 number:4 day:16 month:11 pages:135-139 https://dx.doi.org/10.1007/s10558-007-9040-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 GBV_ILN_70 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2027 GBV_ILN_2048 GBV_ILN_2190 44.85 ASE AR 7 2007 4 16 11 135-139 |
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10.1007/s10558-007-9040-x doi (DE-627)SPR011291613 (SPR)s10558-007-9040-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.85 bkl Li, John K-J. verfasserin aut Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. Systolic hypertension (dpeaa)DE-He213 Wave reflections (dpeaa)DE-He213 Arterial compliance (dpeaa)DE-He213 Vascular stiffness (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Zhu, Ying verfasserin aut O’Hara, Dorene verfasserin aut Khaw, Kenneth verfasserin aut Enthalten in Cardiovascular engineering Dordrecht [u.a.] : Springer Science + Business Media B.V, 2001 7(2007), 4 vom: 16. Nov., Seite 135-139 (DE-627)325609152 (DE-600)2037838-5 1573-6806 nnns volume:7 year:2007 number:4 day:16 month:11 pages:135-139 https://dx.doi.org/10.1007/s10558-007-9040-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 GBV_ILN_70 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2027 GBV_ILN_2048 GBV_ILN_2190 44.85 ASE AR 7 2007 4 16 11 135-139 |
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610 ASE 44.85 bkl Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging Systolic hypertension (dpeaa)DE-He213 Wave reflections (dpeaa)DE-He213 Arterial compliance (dpeaa)DE-He213 Vascular stiffness (dpeaa)DE-He213 Aging (dpeaa)DE-He213 |
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Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging |
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Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging |
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Li, John K-J. |
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Li, John K-J. Zhu, Ying O’Hara, Dorene Khaw, Kenneth |
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allometric hemodynamic analysis of isolated systolic hypertension and aging |
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Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging |
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Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. |
| abstractGer |
Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. |
| abstract_unstemmed |
Abstract Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. |
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Allometric Hemodynamic Analysis of Isolated Systolic Hypertension and Aging |
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