Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway
Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gao, Yonglin [verfasserIn] Dong, Chaohua [verfasserIn] Yin, Jungang [verfasserIn] Shen, Jingyu [verfasserIn] Tian, Jingwei [verfasserIn] Li, Chunmei [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Cellular and molecular neurobiology - Dordrecht : Springer Science + Business Media B.V, 1981, 32(2012), 4 vom: 06. Jan., Seite 523-529 |
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| Übergeordnetes Werk: |
volume:32 ; year:2012 ; number:4 ; day:06 ; month:01 ; pages:523-529 |
| Links: |
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| DOI / URN: |
10.1007/s10571-011-9792-0 |
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| Katalog-ID: |
SPR011389184 |
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| 245 | 1 | 0 | |a Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway |
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| 520 | |a Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. | ||
| 650 | 4 | |a Fucoidan |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neuroprotective effects |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oxidative stress |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Apoptosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Phosphatidylinositol-3-kinase (PI3K)/Akt |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PC12 cells |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Dong, Chaohua |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Jungang |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Jingyu |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Jingwei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chunmei |e verfasserin |4 aut | |
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10.1007/s10571-011-9792-0 doi (DE-627)SPR011389184 (SPR)s10571-011-9792-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Gao, Yonglin verfasserin aut Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. Fucoidan (dpeaa)DE-He213 Neuroprotective effects (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Phosphatidylinositol-3-kinase (PI3K)/Akt (dpeaa)DE-He213 PC12 cells (dpeaa)DE-He213 Dong, Chaohua verfasserin aut Yin, Jungang verfasserin aut Shen, Jingyu verfasserin aut Tian, Jingwei verfasserin aut Li, Chunmei verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 32(2012), 4 vom: 06. Jan., Seite 523-529 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:32 year:2012 number:4 day:06 month:01 pages:523-529 https://dx.doi.org/10.1007/s10571-011-9792-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 32 2012 4 06 01 523-529 |
| spelling |
10.1007/s10571-011-9792-0 doi (DE-627)SPR011389184 (SPR)s10571-011-9792-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Gao, Yonglin verfasserin aut Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. Fucoidan (dpeaa)DE-He213 Neuroprotective effects (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Phosphatidylinositol-3-kinase (PI3K)/Akt (dpeaa)DE-He213 PC12 cells (dpeaa)DE-He213 Dong, Chaohua verfasserin aut Yin, Jungang verfasserin aut Shen, Jingyu verfasserin aut Tian, Jingwei verfasserin aut Li, Chunmei verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 32(2012), 4 vom: 06. Jan., Seite 523-529 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:32 year:2012 number:4 day:06 month:01 pages:523-529 https://dx.doi.org/10.1007/s10571-011-9792-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 32 2012 4 06 01 523-529 |
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10.1007/s10571-011-9792-0 doi (DE-627)SPR011389184 (SPR)s10571-011-9792-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Gao, Yonglin verfasserin aut Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. Fucoidan (dpeaa)DE-He213 Neuroprotective effects (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Phosphatidylinositol-3-kinase (PI3K)/Akt (dpeaa)DE-He213 PC12 cells (dpeaa)DE-He213 Dong, Chaohua verfasserin aut Yin, Jungang verfasserin aut Shen, Jingyu verfasserin aut Tian, Jingwei verfasserin aut Li, Chunmei verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 32(2012), 4 vom: 06. Jan., Seite 523-529 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:32 year:2012 number:4 day:06 month:01 pages:523-529 https://dx.doi.org/10.1007/s10571-011-9792-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 32 2012 4 06 01 523-529 |
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10.1007/s10571-011-9792-0 doi (DE-627)SPR011389184 (SPR)s10571-011-9792-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Gao, Yonglin verfasserin aut Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. Fucoidan (dpeaa)DE-He213 Neuroprotective effects (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Phosphatidylinositol-3-kinase (PI3K)/Akt (dpeaa)DE-He213 PC12 cells (dpeaa)DE-He213 Dong, Chaohua verfasserin aut Yin, Jungang verfasserin aut Shen, Jingyu verfasserin aut Tian, Jingwei verfasserin aut Li, Chunmei verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 32(2012), 4 vom: 06. Jan., Seite 523-529 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:32 year:2012 number:4 day:06 month:01 pages:523-529 https://dx.doi.org/10.1007/s10571-011-9792-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 32 2012 4 06 01 523-529 |
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10.1007/s10571-011-9792-0 doi (DE-627)SPR011389184 (SPR)s10571-011-9792-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Gao, Yonglin verfasserin aut Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. Fucoidan (dpeaa)DE-He213 Neuroprotective effects (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Phosphatidylinositol-3-kinase (PI3K)/Akt (dpeaa)DE-He213 PC12 cells (dpeaa)DE-He213 Dong, Chaohua verfasserin aut Yin, Jungang verfasserin aut Shen, Jingyu verfasserin aut Tian, Jingwei verfasserin aut Li, Chunmei verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 32(2012), 4 vom: 06. Jan., Seite 523-529 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:32 year:2012 number:4 day:06 month:01 pages:523-529 https://dx.doi.org/10.1007/s10571-011-9792-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 32 2012 4 06 01 523-529 |
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Enthalten in Cellular and molecular neurobiology 32(2012), 4 vom: 06. Jan., Seite 523-529 volume:32 year:2012 number:4 day:06 month:01 pages:523-529 |
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Fucoidan Neuroprotective effects Oxidative stress Apoptosis Phosphatidylinositol-3-kinase (PI3K)/Akt PC12 cells |
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Gao, Yonglin @@aut@@ Dong, Chaohua @@aut@@ Yin, Jungang @@aut@@ Shen, Jingyu @@aut@@ Tian, Jingwei @@aut@@ Li, Chunmei @@aut@@ |
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|
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Gao, Yonglin |
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Gao, Yonglin ddc 610 bkl 44.90 misc Fucoidan misc Neuroprotective effects misc Oxidative stress misc Apoptosis misc Phosphatidylinositol-3-kinase (PI3K)/Akt misc PC12 cells Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway |
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610 ASE 44.90 bkl Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway Fucoidan (dpeaa)DE-He213 Neuroprotective effects (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Phosphatidylinositol-3-kinase (PI3K)/Akt (dpeaa)DE-He213 PC12 cells (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Fucoidan misc Neuroprotective effects misc Oxidative stress misc Apoptosis misc Phosphatidylinositol-3-kinase (PI3K)/Akt misc PC12 cells |
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ddc 610 bkl 44.90 misc Fucoidan misc Neuroprotective effects misc Oxidative stress misc Apoptosis misc Phosphatidylinositol-3-kinase (PI3K)/Akt misc PC12 cells |
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Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway |
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Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway |
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Gao, Yonglin Dong, Chaohua Yin, Jungang Shen, Jingyu Tian, Jingwei Li, Chunmei |
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610 ASE 44.90 bkl |
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Elektronische Aufsätze |
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Gao, Yonglin |
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10.1007/s10571-011-9792-0 |
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610 |
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verfasserin |
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neuroprotective effect of fucoidan on $ h_{2} %$ o_{2} $-induced apoptosis in pc12 cells via activation of pi3k/akt pathway |
| title_auth |
Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway |
| abstract |
Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. |
| abstractGer |
Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. |
| abstract_unstemmed |
Abstract One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on $ H_{2} %$ O_{2} $-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in $ H_{2} %$ O_{2} $-induced PC12 cells. These changes were associated with an increase in superoxide dismutase and glutathione peroxidase activity, and reduction in malondialdehyde. In addition, fucoidan treatment inhibited apoptosis in $ H_{2} %$ O_{2} $-induced PC12 cells by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing Akt phosphorylation (p-Akt). However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002. In consequence, fucoidan might protect the neurocytes against $ H_{2} %$ O_{2} $-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. |
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Neuroprotective Effect of Fucoidan on $ H_{2} %$ O_{2} $-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway |
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| score |
7.4021015 |