$ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia
Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglia...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jia, Jingjing [verfasserIn] Li, Changyan [verfasserIn] Zhang, Ting [verfasserIn] Sun, Jingjing [verfasserIn] Peng, Sijia [verfasserIn] Xie, Qizhi [verfasserIn] Huang, Yining [verfasserIn] Yi, Li [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Cellular and molecular neurobiology - Dordrecht : Springer Science + Business Media B.V, 1981, 39(2019), 8 vom: 29. Juni, Seite 1125-1137 |
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| Übergeordnetes Werk: |
volume:39 ; year:2019 ; number:8 ; day:29 ; month:06 ; pages:1125-1137 |
| Links: |
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| DOI / URN: |
10.1007/s10571-019-00707-2 |
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| Katalog-ID: |
SPR011398469 |
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| 245 | 1 | 2 | |a $ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia |
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| 520 | |a Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. | ||
| 650 | 4 | |a Cerium nanoparticles |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a LXW7 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Integrin αvβ3 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Inflammation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oxidative stress |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Li, Changyan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Jingjing |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Sijia |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Qizhi |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yining |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Li |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cellular and molecular neurobiology |d Dordrecht : Springer Science + Business Media B.V, 1981 |g 39(2019), 8 vom: 29. Juni, Seite 1125-1137 |w (DE-627)306351536 |w (DE-600)1496697-9 |x 1573-6830 |7 nnns |
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10.1007/s10571-019-00707-2 doi (DE-627)SPR011398469 (SPR)s10571-019-00707-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Jia, Jingjing verfasserin aut $ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. Cerium nanoparticles (dpeaa)DE-He213 LXW7 (dpeaa)DE-He213 Integrin αvβ3 (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Li, Changyan verfasserin aut Zhang, Ting verfasserin aut Sun, Jingjing verfasserin aut Peng, Sijia verfasserin aut Xie, Qizhi verfasserin aut Huang, Yining verfasserin aut Yi, Li verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 39(2019), 8 vom: 29. Juni, Seite 1125-1137 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:39 year:2019 number:8 day:29 month:06 pages:1125-1137 https://dx.doi.org/10.1007/s10571-019-00707-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 39 2019 8 29 06 1125-1137 |
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10.1007/s10571-019-00707-2 doi (DE-627)SPR011398469 (SPR)s10571-019-00707-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Jia, Jingjing verfasserin aut $ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. Cerium nanoparticles (dpeaa)DE-He213 LXW7 (dpeaa)DE-He213 Integrin αvβ3 (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Li, Changyan verfasserin aut Zhang, Ting verfasserin aut Sun, Jingjing verfasserin aut Peng, Sijia verfasserin aut Xie, Qizhi verfasserin aut Huang, Yining verfasserin aut Yi, Li verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 39(2019), 8 vom: 29. Juni, Seite 1125-1137 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:39 year:2019 number:8 day:29 month:06 pages:1125-1137 https://dx.doi.org/10.1007/s10571-019-00707-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 39 2019 8 29 06 1125-1137 |
| allfields_unstemmed |
10.1007/s10571-019-00707-2 doi (DE-627)SPR011398469 (SPR)s10571-019-00707-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Jia, Jingjing verfasserin aut $ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. Cerium nanoparticles (dpeaa)DE-He213 LXW7 (dpeaa)DE-He213 Integrin αvβ3 (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Li, Changyan verfasserin aut Zhang, Ting verfasserin aut Sun, Jingjing verfasserin aut Peng, Sijia verfasserin aut Xie, Qizhi verfasserin aut Huang, Yining verfasserin aut Yi, Li verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 39(2019), 8 vom: 29. Juni, Seite 1125-1137 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:39 year:2019 number:8 day:29 month:06 pages:1125-1137 https://dx.doi.org/10.1007/s10571-019-00707-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 39 2019 8 29 06 1125-1137 |
| allfieldsGer |
10.1007/s10571-019-00707-2 doi (DE-627)SPR011398469 (SPR)s10571-019-00707-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Jia, Jingjing verfasserin aut $ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. Cerium nanoparticles (dpeaa)DE-He213 LXW7 (dpeaa)DE-He213 Integrin αvβ3 (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Li, Changyan verfasserin aut Zhang, Ting verfasserin aut Sun, Jingjing verfasserin aut Peng, Sijia verfasserin aut Xie, Qizhi verfasserin aut Huang, Yining verfasserin aut Yi, Li verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 39(2019), 8 vom: 29. Juni, Seite 1125-1137 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:39 year:2019 number:8 day:29 month:06 pages:1125-1137 https://dx.doi.org/10.1007/s10571-019-00707-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 39 2019 8 29 06 1125-1137 |
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10.1007/s10571-019-00707-2 doi (DE-627)SPR011398469 (SPR)s10571-019-00707-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Jia, Jingjing verfasserin aut $ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. Cerium nanoparticles (dpeaa)DE-He213 LXW7 (dpeaa)DE-He213 Integrin αvβ3 (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Li, Changyan verfasserin aut Zhang, Ting verfasserin aut Sun, Jingjing verfasserin aut Peng, Sijia verfasserin aut Xie, Qizhi verfasserin aut Huang, Yining verfasserin aut Yi, Li verfasserin aut Enthalten in Cellular and molecular neurobiology Dordrecht : Springer Science + Business Media B.V, 1981 39(2019), 8 vom: 29. Juni, Seite 1125-1137 (DE-627)306351536 (DE-600)1496697-9 1573-6830 nnns volume:39 year:2019 number:8 day:29 month:06 pages:1125-1137 https://dx.doi.org/10.1007/s10571-019-00707-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 39 2019 8 29 06 1125-1137 |
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Enthalten in Cellular and molecular neurobiology 39(2019), 8 vom: 29. Juni, Seite 1125-1137 volume:39 year:2019 number:8 day:29 month:06 pages:1125-1137 |
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Enthalten in Cellular and molecular neurobiology 39(2019), 8 vom: 29. Juni, Seite 1125-1137 volume:39 year:2019 number:8 day:29 month:06 pages:1125-1137 |
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findex.gbv.de |
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Cerium nanoparticles LXW7 Integrin αvβ3 Inflammation Oxidative stress |
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Cellular and molecular neurobiology |
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Jia, Jingjing @@aut@@ Li, Changyan @@aut@@ Zhang, Ting @@aut@@ Sun, Jingjing @@aut@@ Peng, Sijia @@aut@@ Xie, Qizhi @@aut@@ Huang, Yining @@aut@@ Yi, Li @@aut@@ |
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2019-06-29T00:00:00Z |
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3610 |
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SPR011398469 |
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|
| author |
Jia, Jingjing |
| spellingShingle |
Jia, Jingjing ddc 610 bkl 44.90 misc Cerium nanoparticles misc LXW7 misc Integrin αvβ3 misc Inflammation misc Oxidative stress $ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia |
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Jia, Jingjing |
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1573-6830 |
| topic_title |
610 ASE 44.90 bkl $ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia Cerium nanoparticles (dpeaa)DE-He213 LXW7 (dpeaa)DE-He213 Integrin αvβ3 (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.90 misc Cerium nanoparticles misc LXW7 misc Integrin αvβ3 misc Inflammation misc Oxidative stress |
| topic_unstemmed |
ddc 610 bkl 44.90 misc Cerium nanoparticles misc LXW7 misc Integrin αvβ3 misc Inflammation misc Oxidative stress |
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ddc 610 bkl 44.90 misc Cerium nanoparticles misc LXW7 misc Integrin αvβ3 misc Inflammation misc Oxidative stress |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Cellular and molecular neurobiology |
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610 - Medicine & health |
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Cellular and molecular neurobiology |
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(DE-627)306351536 (DE-600)1496697-9 |
| title |
$ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia |
| ctrlnum |
(DE-627)SPR011398469 (SPR)s10571-019-00707-2-e |
| title_full |
$ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia |
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Jia, Jingjing |
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Cellular and molecular neurobiology |
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Cellular and molecular neurobiology |
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eng |
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600 - Technology |
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2019 |
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1125 |
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Jia, Jingjing Li, Changyan Zhang, Ting Sun, Jingjing Peng, Sijia Xie, Qizhi Huang, Yining Yi, Li |
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39 |
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610 ASE 44.90 bkl |
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Elektronische Aufsätze |
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Jia, Jingjing |
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10.1007/s10571-019-00707-2 |
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610 |
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verfasserin |
| title_sort |
ceo_{2} $paa-lxw7 attenuates lps-induced inflammation in bv2 microglia |
| title_auth |
$ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia |
| abstract |
Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. |
| abstractGer |
Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. |
| abstract_unstemmed |
Abstract Microglia are the inherent immune effector cells in the central nervous system (CNS), are activated rapidly when the CNS is stimulated by ischaemia, infection, injury, etc. and participate in and aggravate the development of inflammatory reactions in the CNS. During the process of microglial activation, inflammatory factors such as TNF-α and IL-1β and an abundance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), are released by damaged nerve cells. LXW7 is a small molecule peptide and specifically binds with integrin αvβ3. Cerium oxide nanoparticles (nanoceria) are strong free radical scavengers and are widely used in many studies. In this research, a model of inflammation was established using lipopolysaccharide (LPS) to induce BV2 microglia activation, and the effects of $ CeO_{2} $PAA (synthetic nanoscale cerium oxide particles), LXW7 and $ CeO_{2} $@PAA-LXW7 were evaluated. We detected the expression level of inflammatory factors, the release of NO in BV2 cells and the generation of intracellular ROS. The expression levels of focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) and their phosphorylated proteins were detected in BV2 microglia. We found that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 all effectively inhibited the activation of BV2 microglia, reduced the production of cytokines and the release of NO and reduced the production of intracellular ROS. The three treatments all inhibited the phosphorylation of FAK and STAT3 in BV2 microglia. Regarding these effects, $ CeO_{2} $@PAA-LXW7 was more effective than the other two monotherapies. Our data indicate that $ CeO_{2} $@PAA, LXW7 and $ CeO_{2} $@PAA-LXW7 can exert a neuroprotective function by inhibiting the inflammatory response of LPS-induced BV2 microglia. LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin αvβ3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, $ CeO_{2} $@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of $ CeO_{2} $@PAA. |
| collection_details |
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| container_issue |
8 |
| title_short |
$ CeO_{2} $PAA-LXW7 Attenuates LPS-Induced Inflammation in BV2 Microglia |
| url |
https://dx.doi.org/10.1007/s10571-019-00707-2 |
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| author2 |
Li, Changyan Zhang, Ting Sun, Jingjing Peng, Sijia Xie, Qizhi Huang, Yining Yi, Li |
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Li, Changyan Zhang, Ting Sun, Jingjing Peng, Sijia Xie, Qizhi Huang, Yining Yi, Li |
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| doi_str |
10.1007/s10571-019-00707-2 |
| up_date |
2024-07-03T22:25:22.203Z |
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| score |
7.400137 |