Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach
Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Fort...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ocean, Allyson J. [verfasserIn] Christos, Paul [verfasserIn] Sparano, Joseph A. [verfasserIn] Shah, Manish A. [verfasserIn] Yantiss, Rhonda K. [verfasserIn] Cheng, Jonathan [verfasserIn] Lin, Juan [verfasserIn] Papetti, Michael [verfasserIn] Matulich, Dan [verfasserIn] Schnoll-Sussman, Felice [verfasserIn] Besanceney-Webler, Christen [verfasserIn] Xiang, Jenny [verfasserIn] Ward, Maureen [verfasserIn] Dilts, Kaili Temple [verfasserIn] Keresztes, Roger [verfasserIn] Holloway, Shannon [verfasserIn] Chen, Eric X. [verfasserIn] Wright, John J. [verfasserIn] Lane, Maureen E. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Investigational new drugs - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983, 32(2014), 3 vom: 15. Feb., Seite 542-548 |
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| Übergeordnetes Werk: |
volume:32 ; year:2014 ; number:3 ; day:15 ; month:02 ; pages:542-548 |
| Links: |
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| DOI / URN: |
10.1007/s10637-014-0070-0 |
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| Katalog-ID: |
SPR012023582 |
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| 100 | 1 | |a Ocean, Allyson J. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach |
| 264 | 1 | |c 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. | ||
| 650 | 4 | |a Bortezomib |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Proteasome inhibitor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Irinotecan |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gastroesophageal junction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adenocarcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Combination therapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Microarray |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Christos, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Sparano, Joseph A. |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Manish A. |e verfasserin |4 aut | |
| 700 | 1 | |a Yantiss, Rhonda K. |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Papetti, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Matulich, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Schnoll-Sussman, Felice |e verfasserin |4 aut | |
| 700 | 1 | |a Besanceney-Webler, Christen |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Jenny |e verfasserin |4 aut | |
| 700 | 1 | |a Ward, Maureen |e verfasserin |4 aut | |
| 700 | 1 | |a Dilts, Kaili Temple |e verfasserin |4 aut | |
| 700 | 1 | |a Keresztes, Roger |e verfasserin |4 aut | |
| 700 | 1 | |a Holloway, Shannon |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Eric X. |e verfasserin |4 aut | |
| 700 | 1 | |a Wright, John J. |e verfasserin |4 aut | |
| 700 | 1 | |a Lane, Maureen E. |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:32 |g year:2014 |g number:3 |g day:15 |g month:02 |g pages:542-548 |
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10.1007/s10637-014-0070-0 doi (DE-627)SPR012023582 (SPR)s10637-014-0070-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Ocean, Allyson J. verfasserin aut Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. Bortezomib (dpeaa)DE-He213 Proteasome inhibitor (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Gastroesophageal junction (dpeaa)DE-He213 Adenocarcinoma (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Christos, Paul verfasserin aut Sparano, Joseph A. verfasserin aut Shah, Manish A. verfasserin aut Yantiss, Rhonda K. verfasserin aut Cheng, Jonathan verfasserin aut Lin, Juan verfasserin aut Papetti, Michael verfasserin aut Matulich, Dan verfasserin aut Schnoll-Sussman, Felice verfasserin aut Besanceney-Webler, Christen verfasserin aut Xiang, Jenny verfasserin aut Ward, Maureen verfasserin aut Dilts, Kaili Temple verfasserin aut Keresztes, Roger verfasserin aut Holloway, Shannon verfasserin aut Chen, Eric X. verfasserin aut Wright, John J. verfasserin aut Lane, Maureen E. verfasserin aut Enthalten in Investigational new drugs Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 32(2014), 3 vom: 15. Feb., Seite 542-548 (DE-627)320481492 (DE-600)2009846-7 1573-0646 nnns volume:32 year:2014 number:3 day:15 month:02 pages:542-548 https://dx.doi.org/10.1007/s10637-014-0070-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 32 2014 3 15 02 542-548 |
| spelling |
10.1007/s10637-014-0070-0 doi (DE-627)SPR012023582 (SPR)s10637-014-0070-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Ocean, Allyson J. verfasserin aut Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. Bortezomib (dpeaa)DE-He213 Proteasome inhibitor (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Gastroesophageal junction (dpeaa)DE-He213 Adenocarcinoma (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Christos, Paul verfasserin aut Sparano, Joseph A. verfasserin aut Shah, Manish A. verfasserin aut Yantiss, Rhonda K. verfasserin aut Cheng, Jonathan verfasserin aut Lin, Juan verfasserin aut Papetti, Michael verfasserin aut Matulich, Dan verfasserin aut Schnoll-Sussman, Felice verfasserin aut Besanceney-Webler, Christen verfasserin aut Xiang, Jenny verfasserin aut Ward, Maureen verfasserin aut Dilts, Kaili Temple verfasserin aut Keresztes, Roger verfasserin aut Holloway, Shannon verfasserin aut Chen, Eric X. verfasserin aut Wright, John J. verfasserin aut Lane, Maureen E. verfasserin aut Enthalten in Investigational new drugs Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 32(2014), 3 vom: 15. Feb., Seite 542-548 (DE-627)320481492 (DE-600)2009846-7 1573-0646 nnns volume:32 year:2014 number:3 day:15 month:02 pages:542-548 https://dx.doi.org/10.1007/s10637-014-0070-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 32 2014 3 15 02 542-548 |
| allfields_unstemmed |
10.1007/s10637-014-0070-0 doi (DE-627)SPR012023582 (SPR)s10637-014-0070-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Ocean, Allyson J. verfasserin aut Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. Bortezomib (dpeaa)DE-He213 Proteasome inhibitor (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Gastroesophageal junction (dpeaa)DE-He213 Adenocarcinoma (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Christos, Paul verfasserin aut Sparano, Joseph A. verfasserin aut Shah, Manish A. verfasserin aut Yantiss, Rhonda K. verfasserin aut Cheng, Jonathan verfasserin aut Lin, Juan verfasserin aut Papetti, Michael verfasserin aut Matulich, Dan verfasserin aut Schnoll-Sussman, Felice verfasserin aut Besanceney-Webler, Christen verfasserin aut Xiang, Jenny verfasserin aut Ward, Maureen verfasserin aut Dilts, Kaili Temple verfasserin aut Keresztes, Roger verfasserin aut Holloway, Shannon verfasserin aut Chen, Eric X. verfasserin aut Wright, John J. verfasserin aut Lane, Maureen E. verfasserin aut Enthalten in Investigational new drugs Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 32(2014), 3 vom: 15. Feb., Seite 542-548 (DE-627)320481492 (DE-600)2009846-7 1573-0646 nnns volume:32 year:2014 number:3 day:15 month:02 pages:542-548 https://dx.doi.org/10.1007/s10637-014-0070-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 32 2014 3 15 02 542-548 |
| allfieldsGer |
10.1007/s10637-014-0070-0 doi (DE-627)SPR012023582 (SPR)s10637-014-0070-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Ocean, Allyson J. verfasserin aut Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. Bortezomib (dpeaa)DE-He213 Proteasome inhibitor (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Gastroesophageal junction (dpeaa)DE-He213 Adenocarcinoma (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Christos, Paul verfasserin aut Sparano, Joseph A. verfasserin aut Shah, Manish A. verfasserin aut Yantiss, Rhonda K. verfasserin aut Cheng, Jonathan verfasserin aut Lin, Juan verfasserin aut Papetti, Michael verfasserin aut Matulich, Dan verfasserin aut Schnoll-Sussman, Felice verfasserin aut Besanceney-Webler, Christen verfasserin aut Xiang, Jenny verfasserin aut Ward, Maureen verfasserin aut Dilts, Kaili Temple verfasserin aut Keresztes, Roger verfasserin aut Holloway, Shannon verfasserin aut Chen, Eric X. verfasserin aut Wright, John J. verfasserin aut Lane, Maureen E. verfasserin aut Enthalten in Investigational new drugs Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 32(2014), 3 vom: 15. Feb., Seite 542-548 (DE-627)320481492 (DE-600)2009846-7 1573-0646 nnns volume:32 year:2014 number:3 day:15 month:02 pages:542-548 https://dx.doi.org/10.1007/s10637-014-0070-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 32 2014 3 15 02 542-548 |
| allfieldsSound |
10.1007/s10637-014-0070-0 doi (DE-627)SPR012023582 (SPR)s10637-014-0070-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Ocean, Allyson J. verfasserin aut Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. Bortezomib (dpeaa)DE-He213 Proteasome inhibitor (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Gastroesophageal junction (dpeaa)DE-He213 Adenocarcinoma (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Christos, Paul verfasserin aut Sparano, Joseph A. verfasserin aut Shah, Manish A. verfasserin aut Yantiss, Rhonda K. verfasserin aut Cheng, Jonathan verfasserin aut Lin, Juan verfasserin aut Papetti, Michael verfasserin aut Matulich, Dan verfasserin aut Schnoll-Sussman, Felice verfasserin aut Besanceney-Webler, Christen verfasserin aut Xiang, Jenny verfasserin aut Ward, Maureen verfasserin aut Dilts, Kaili Temple verfasserin aut Keresztes, Roger verfasserin aut Holloway, Shannon verfasserin aut Chen, Eric X. verfasserin aut Wright, John J. verfasserin aut Lane, Maureen E. verfasserin aut Enthalten in Investigational new drugs Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 32(2014), 3 vom: 15. Feb., Seite 542-548 (DE-627)320481492 (DE-600)2009846-7 1573-0646 nnns volume:32 year:2014 number:3 day:15 month:02 pages:542-548 https://dx.doi.org/10.1007/s10637-014-0070-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 32 2014 3 15 02 542-548 |
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Ocean, Allyson J. @@aut@@ Christos, Paul @@aut@@ Sparano, Joseph A. @@aut@@ Shah, Manish A. @@aut@@ Yantiss, Rhonda K. @@aut@@ Cheng, Jonathan @@aut@@ Lin, Juan @@aut@@ Papetti, Michael @@aut@@ Matulich, Dan @@aut@@ Schnoll-Sussman, Felice @@aut@@ Besanceney-Webler, Christen @@aut@@ Xiang, Jenny @@aut@@ Ward, Maureen @@aut@@ Dilts, Kaili Temple @@aut@@ Keresztes, Roger @@aut@@ Holloway, Shannon @@aut@@ Chen, Eric X. @@aut@@ Wright, John J. @@aut@@ Lane, Maureen E. @@aut@@ |
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| author |
Ocean, Allyson J. |
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Ocean, Allyson J. ddc 610 bkl 44.40 misc Bortezomib misc Proteasome inhibitor misc Irinotecan misc Gastroesophageal junction misc Adenocarcinoma misc Combination therapy misc Microarray Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach |
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610 ASE 44.40 bkl Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach Bortezomib (dpeaa)DE-He213 Proteasome inhibitor (dpeaa)DE-He213 Irinotecan (dpeaa)DE-He213 Gastroesophageal junction (dpeaa)DE-He213 Adenocarcinoma (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 |
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ddc 610 bkl 44.40 misc Bortezomib misc Proteasome inhibitor misc Irinotecan misc Gastroesophageal junction misc Adenocarcinoma misc Combination therapy misc Microarray |
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ddc 610 bkl 44.40 misc Bortezomib misc Proteasome inhibitor misc Irinotecan misc Gastroesophageal junction misc Adenocarcinoma misc Combination therapy misc Microarray |
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ddc 610 bkl 44.40 misc Bortezomib misc Proteasome inhibitor misc Irinotecan misc Gastroesophageal junction misc Adenocarcinoma misc Combination therapy misc Microarray |
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Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach |
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(DE-627)SPR012023582 (SPR)s10637-014-0070-0-e |
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Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach |
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Ocean, Allyson J. |
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2014 |
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Ocean, Allyson J. Christos, Paul Sparano, Joseph A. Shah, Manish A. Yantiss, Rhonda K. Cheng, Jonathan Lin, Juan Papetti, Michael Matulich, Dan Schnoll-Sussman, Felice Besanceney-Webler, Christen Xiang, Jenny Ward, Maureen Dilts, Kaili Temple Keresztes, Roger Holloway, Shannon Chen, Eric X. Wright, John J. Lane, Maureen E. |
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Elektronische Aufsätze |
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Ocean, Allyson J. |
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10.1007/s10637-014-0070-0 |
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610 |
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verfasserin |
| title_sort |
phase ii trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach |
| title_auth |
Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach |
| abstract |
Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. |
| abstractGer |
Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. |
| abstract_unstemmed |
Summary Purpose To determine the effectiveness of bortezomib plus irinotecan and bortezomib alone in patients with advanced gastroesophageal junction (GEJ) and gastric adenocarcinoma. We also sought to explore the effect of these therapeutics on tumor and normal gene expression in vivo. Methods Forty-one patients with advanced GEJ (89 %) or gastric (11 %) adenocarcinoma received bortezomib (1.3 mg/$ m^{2} $ days 1, 4, 8, 11) plus irinotecan (125 mg/$ m^{2} $ days 1, 8) every 21 days as first line therapy (N = 29), or bortezomib alone as second line therapy (N = 12). The trial was designed to detect a 40 % response rate for the combination, and 20 % response rate for bortezomib alone. Affymetrix HU133A gene chip arrays were used for gene expression studies. Results Objective response occurred in 3 of 29 patients (10 %, 95 % confidence intervals [CI] 2 %, 27 %) treated with bortezomib plus irinotecan, and in 1 of 12 patients (8 %, 95 % CI 0 %, 39 %) with bortezomib alone. Due to the limited number of responders, there were no significant correlations with response found in the gene expression profiles of 12 patients whose tumors were sampled before and 24 h after therapy with bortezomib alone (N = 2) or the combination (N = 10). Conclusions We conclude that bortezomib is not effective for the treatment of advanced adenocarcinoma of the GEJ or stomach, whether used alone or in combination with irinotecan, in an unselected patient population. |
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Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach |
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https://dx.doi.org/10.1007/s10637-014-0070-0 |
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Christos, Paul Sparano, Joseph A. Shah, Manish A. Yantiss, Rhonda K. Cheng, Jonathan Lin, Juan Papetti, Michael Matulich, Dan Schnoll-Sussman, Felice Besanceney-Webler, Christen Xiang, Jenny Ward, Maureen Dilts, Kaili Temple Keresztes, Roger Holloway, Shannon Chen, Eric X. Wright, John J. Lane, Maureen E. |
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Christos, Paul Sparano, Joseph A. Shah, Manish A. Yantiss, Rhonda K. Cheng, Jonathan Lin, Juan Papetti, Michael Matulich, Dan Schnoll-Sussman, Felice Besanceney-Webler, Christen Xiang, Jenny Ward, Maureen Dilts, Kaili Temple Keresztes, Roger Holloway, Shannon Chen, Eric X. Wright, John J. Lane, Maureen E. |
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10.1007/s10637-014-0070-0 |
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2024-07-04T01:26:46.618Z |
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| score |
7.3995953 |