Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma

Abstract Our preliminary study indicated that Engrailed-2 (EN2) is downregulated but also ectopically expressed in clear-cell renal cell carcinoma (CCRCC), and the absence of EN2 expression was associated with poor histological grade. However, the specific roles of EN2 in CCRCC have yet to be elucid...
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Autor*in:	Lai, Cai-yong [verfasserIn] Xu, Yin [verfasserIn] Yu, Gan-shen [verfasserIn] Wu, Xun [verfasserIn] Li, Yun-fei [verfasserIn] Pan, Bin [verfasserIn] Heng, Bao-li [verfasserIn] Xue, Yi-jun [verfasserIn] Su, Ze-xuan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Engrailed-2 Clear-cell renal cell carcinoma Anti-oncogene

Übergeordnetes Werk:	Enthalten in: The histochemical journal - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968, 47(2016), 3 vom: 07. März, Seite 229-237
Übergeordnetes Werk:	volume:47 ; year:2016 ; number:3 ; day:07 ; month:03 ; pages:229-237

Links:	Volltext

DOI / URN:	10.1007/s10735-016-9665-4

Katalog-ID:	SPR01283646X

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spelling	10.1007/s10735-016-9665-4 doi (DE-627)SPR01283646X (SPR)s10735-016-9665-4-e DE-627 ger DE-627 rakwb eng 540 610 ASE 44.35 bkl 42.15 bkl Lai, Cai-yong verfasserin aut Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Our preliminary study indicated that Engrailed-2 (EN2) is downregulated but also ectopically expressed in clear-cell renal cell carcinoma (CCRCC), and the absence of EN2 expression was associated with poor histological grade. However, the specific roles of EN2 in CCRCC have yet to be elucidated. In the present study, we examined the effects of inhibiting EN2 expression by human renal tubular epithelial cells (HK-2) and overexpressing EN2 by human clear-cell renal cells (786-O). Results showed that EN2 inhibition accelerated HK-2 cell proliferation, shortened the cell cycle, reduced apoptosis, and acted more invasively. By contrast, EN2 overexpression in 786-O cells decelerated the proliferative ability of 786-O, increased the percentage of cell apoptosis, and weakened the invasive ability. Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells. Engrailed-2 (dpeaa)DE-He213 Clear-cell renal cell carcinoma (dpeaa)DE-He213 Anti-oncogene (dpeaa)DE-He213 Xu, Yin verfasserin aut Yu, Gan-shen verfasserin aut Wu, Xun verfasserin aut Li, Yun-fei verfasserin aut Pan, Bin verfasserin aut Heng, Bao-li verfasserin aut Xue, Yi-jun verfasserin aut Su, Ze-xuan verfasserin aut Enthalten in The histochemical journal Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968 47(2016), 3 vom: 07. März, Seite 229-237 (DE-627)503327638 (DE-600)2210318-1 1573-6865 nnns volume:47 year:2016 number:3 day:07 month:03 pages:229-237 https://dx.doi.org/10.1007/s10735-016-9665-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.35 ASE 42.15 ASE AR 47 2016 3 07 03 229-237
allfields_unstemmed	10.1007/s10735-016-9665-4 doi (DE-627)SPR01283646X (SPR)s10735-016-9665-4-e DE-627 ger DE-627 rakwb eng 540 610 ASE 44.35 bkl 42.15 bkl Lai, Cai-yong verfasserin aut Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Our preliminary study indicated that Engrailed-2 (EN2) is downregulated but also ectopically expressed in clear-cell renal cell carcinoma (CCRCC), and the absence of EN2 expression was associated with poor histological grade. However, the specific roles of EN2 in CCRCC have yet to be elucidated. In the present study, we examined the effects of inhibiting EN2 expression by human renal tubular epithelial cells (HK-2) and overexpressing EN2 by human clear-cell renal cells (786-O). Results showed that EN2 inhibition accelerated HK-2 cell proliferation, shortened the cell cycle, reduced apoptosis, and acted more invasively. By contrast, EN2 overexpression in 786-O cells decelerated the proliferative ability of 786-O, increased the percentage of cell apoptosis, and weakened the invasive ability. Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells. Engrailed-2 (dpeaa)DE-He213 Clear-cell renal cell carcinoma (dpeaa)DE-He213 Anti-oncogene (dpeaa)DE-He213 Xu, Yin verfasserin aut Yu, Gan-shen verfasserin aut Wu, Xun verfasserin aut Li, Yun-fei verfasserin aut Pan, Bin verfasserin aut Heng, Bao-li verfasserin aut Xue, Yi-jun verfasserin aut Su, Ze-xuan verfasserin aut Enthalten in The histochemical journal Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968 47(2016), 3 vom: 07. März, Seite 229-237 (DE-627)503327638 (DE-600)2210318-1 1573-6865 nnns volume:47 year:2016 number:3 day:07 month:03 pages:229-237 https://dx.doi.org/10.1007/s10735-016-9665-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.35 ASE 42.15 ASE AR 47 2016 3 07 03 229-237
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allfieldsSound	10.1007/s10735-016-9665-4 doi (DE-627)SPR01283646X (SPR)s10735-016-9665-4-e DE-627 ger DE-627 rakwb eng 540 610 ASE 44.35 bkl 42.15 bkl Lai, Cai-yong verfasserin aut Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Our preliminary study indicated that Engrailed-2 (EN2) is downregulated but also ectopically expressed in clear-cell renal cell carcinoma (CCRCC), and the absence of EN2 expression was associated with poor histological grade. However, the specific roles of EN2 in CCRCC have yet to be elucidated. In the present study, we examined the effects of inhibiting EN2 expression by human renal tubular epithelial cells (HK-2) and overexpressing EN2 by human clear-cell renal cells (786-O). Results showed that EN2 inhibition accelerated HK-2 cell proliferation, shortened the cell cycle, reduced apoptosis, and acted more invasively. By contrast, EN2 overexpression in 786-O cells decelerated the proliferative ability of 786-O, increased the percentage of cell apoptosis, and weakened the invasive ability. Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells. Engrailed-2 (dpeaa)DE-He213 Clear-cell renal cell carcinoma (dpeaa)DE-He213 Anti-oncogene (dpeaa)DE-He213 Xu, Yin verfasserin aut Yu, Gan-shen verfasserin aut Wu, Xun verfasserin aut Li, Yun-fei verfasserin aut Pan, Bin verfasserin aut Heng, Bao-li verfasserin aut Xue, Yi-jun verfasserin aut Su, Ze-xuan verfasserin aut Enthalten in The histochemical journal Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968 47(2016), 3 vom: 07. März, Seite 229-237 (DE-627)503327638 (DE-600)2210318-1 1573-6865 nnns volume:47 year:2016 number:3 day:07 month:03 pages:229-237 https://dx.doi.org/10.1007/s10735-016-9665-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.35 ASE 42.15 ASE AR 47 2016 3 07 03 229-237
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source	Enthalten in The histochemical journal 47(2016), 3 vom: 07. März, Seite 229-237 volume:47 year:2016 number:3 day:07 month:03 pages:229-237
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author	Lai, Cai-yong
spellingShingle	Lai, Cai-yong ddc 540 bkl 44.35 bkl 42.15 misc Engrailed-2 misc Clear-cell renal cell carcinoma misc Anti-oncogene Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma
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topic_title	540 610 ASE 44.35 bkl 42.15 bkl Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma Engrailed-2 (dpeaa)DE-He213 Clear-cell renal cell carcinoma (dpeaa)DE-He213 Anti-oncogene (dpeaa)DE-He213
topic	ddc 540 bkl 44.35 bkl 42.15 misc Engrailed-2 misc Clear-cell renal cell carcinoma misc Anti-oncogene
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title	Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma
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title_full	Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma
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author_browse	Lai, Cai-yong Xu, Yin Yu, Gan-shen Wu, Xun Li, Yun-fei Pan, Bin Heng, Bao-li Xue, Yi-jun Su, Ze-xuan
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title_sort	engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma
title_auth	Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma
abstract	Abstract Our preliminary study indicated that Engrailed-2 (EN2) is downregulated but also ectopically expressed in clear-cell renal cell carcinoma (CCRCC), and the absence of EN2 expression was associated with poor histological grade. However, the specific roles of EN2 in CCRCC have yet to be elucidated. In the present study, we examined the effects of inhibiting EN2 expression by human renal tubular epithelial cells (HK-2) and overexpressing EN2 by human clear-cell renal cells (786-O). Results showed that EN2 inhibition accelerated HK-2 cell proliferation, shortened the cell cycle, reduced apoptosis, and acted more invasively. By contrast, EN2 overexpression in 786-O cells decelerated the proliferative ability of 786-O, increased the percentage of cell apoptosis, and weakened the invasive ability. Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells.
abstractGer	Abstract Our preliminary study indicated that Engrailed-2 (EN2) is downregulated but also ectopically expressed in clear-cell renal cell carcinoma (CCRCC), and the absence of EN2 expression was associated with poor histological grade. However, the specific roles of EN2 in CCRCC have yet to be elucidated. In the present study, we examined the effects of inhibiting EN2 expression by human renal tubular epithelial cells (HK-2) and overexpressing EN2 by human clear-cell renal cells (786-O). Results showed that EN2 inhibition accelerated HK-2 cell proliferation, shortened the cell cycle, reduced apoptosis, and acted more invasively. By contrast, EN2 overexpression in 786-O cells decelerated the proliferative ability of 786-O, increased the percentage of cell apoptosis, and weakened the invasive ability. Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells.
abstract_unstemmed	Abstract Our preliminary study indicated that Engrailed-2 (EN2) is downregulated but also ectopically expressed in clear-cell renal cell carcinoma (CCRCC), and the absence of EN2 expression was associated with poor histological grade. However, the specific roles of EN2 in CCRCC have yet to be elucidated. In the present study, we examined the effects of inhibiting EN2 expression by human renal tubular epithelial cells (HK-2) and overexpressing EN2 by human clear-cell renal cells (786-O). Results showed that EN2 inhibition accelerated HK-2 cell proliferation, shortened the cell cycle, reduced apoptosis, and acted more invasively. By contrast, EN2 overexpression in 786-O cells decelerated the proliferative ability of 786-O, increased the percentage of cell apoptosis, and weakened the invasive ability. Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells.
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title_short	Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma
url	https://dx.doi.org/10.1007/s10735-016-9665-4
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author2	Xu, Yin Yu, Gan-shen Wu, Xun Li, Yun-fei Pan, Bin Heng, Bao-li Xue, Yi-jun Su, Ze-xuan
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However, the specific roles of EN2 in CCRCC have yet to be elucidated. In the present study, we examined the effects of inhibiting EN2 expression by human renal tubular epithelial cells (HK-2) and overexpressing EN2 by human clear-cell renal cells (786-O). Results showed that EN2 inhibition accelerated HK-2 cell proliferation, shortened the cell cycle, reduced apoptosis, and acted more invasively. By contrast, EN2 overexpression in 786-O cells decelerated the proliferative ability of 786-O, increased the percentage of cell apoptosis, and weakened the invasive ability. 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Engrailed-2 might play an anti-oncogenic role in clear-cell renal cell carcinoma

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