Release of copper complexes from a nanostructured sol–gel titania for cancer treatment
Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
López, Tessy [verfasserIn] Ortiz-Islas, Emma [verfasserIn] Guevara, Patricia [verfasserIn] Rodríguez-Reinoso, Francisco [verfasserIn] Gómez, Esteban [verfasserIn] Cuevas, José Luis [verfasserIn] Novaro, Octavio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of materials science - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1966, 50(2015), 6 vom: 13. Jan., Seite 2410-2421 |
|---|---|
| Übergeordnetes Werk: |
volume:50 ; year:2015 ; number:6 ; day:13 ; month:01 ; pages:2410-2421 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10853-014-8796-9 |
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| Katalog-ID: |
SPR013907859 |
|---|
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| 520 | |a Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. | ||
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| 650 | 4 | |a Copper Complex |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Copper Compound |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nanostructured Lipid Carrier |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ortiz-Islas, Emma |e verfasserin |4 aut | |
| 700 | 1 | |a Guevara, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Reinoso, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez, Esteban |e verfasserin |4 aut | |
| 700 | 1 | |a Cuevas, José Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Novaro, Octavio |e verfasserin |4 aut | |
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10.1007/s10853-014-8796-9 doi (DE-627)SPR013907859 (SPR)s10853-014-8796-9-e DE-627 ger DE-627 rakwb eng 670 ASE 51.00 bkl López, Tessy verfasserin aut Release of copper complexes from a nanostructured sol–gel titania for cancer treatment 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. Drug Release (dpeaa)DE-He213 CuCl2 (dpeaa)DE-He213 Copper Complex (dpeaa)DE-He213 Copper Compound (dpeaa)DE-He213 Nanostructured Lipid Carrier (dpeaa)DE-He213 Ortiz-Islas, Emma verfasserin aut Guevara, Patricia verfasserin aut Rodríguez-Reinoso, Francisco verfasserin aut Gómez, Esteban verfasserin aut Cuevas, José Luis verfasserin aut Novaro, Octavio verfasserin aut Enthalten in Journal of materials science Dordrecht [u.a.] : Springer Science + Business Media B.V, 1966 50(2015), 6 vom: 13. Jan., Seite 2410-2421 (DE-627)315293969 (DE-600)2015305-3 1573-4803 nnns volume:50 year:2015 number:6 day:13 month:01 pages:2410-2421 https://dx.doi.org/10.1007/s10853-014-8796-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 ASE AR 50 2015 6 13 01 2410-2421 |
| spelling |
10.1007/s10853-014-8796-9 doi (DE-627)SPR013907859 (SPR)s10853-014-8796-9-e DE-627 ger DE-627 rakwb eng 670 ASE 51.00 bkl López, Tessy verfasserin aut Release of copper complexes from a nanostructured sol–gel titania for cancer treatment 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. Drug Release (dpeaa)DE-He213 CuCl2 (dpeaa)DE-He213 Copper Complex (dpeaa)DE-He213 Copper Compound (dpeaa)DE-He213 Nanostructured Lipid Carrier (dpeaa)DE-He213 Ortiz-Islas, Emma verfasserin aut Guevara, Patricia verfasserin aut Rodríguez-Reinoso, Francisco verfasserin aut Gómez, Esteban verfasserin aut Cuevas, José Luis verfasserin aut Novaro, Octavio verfasserin aut Enthalten in Journal of materials science Dordrecht [u.a.] : Springer Science + Business Media B.V, 1966 50(2015), 6 vom: 13. Jan., Seite 2410-2421 (DE-627)315293969 (DE-600)2015305-3 1573-4803 nnns volume:50 year:2015 number:6 day:13 month:01 pages:2410-2421 https://dx.doi.org/10.1007/s10853-014-8796-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 ASE AR 50 2015 6 13 01 2410-2421 |
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10.1007/s10853-014-8796-9 doi (DE-627)SPR013907859 (SPR)s10853-014-8796-9-e DE-627 ger DE-627 rakwb eng 670 ASE 51.00 bkl López, Tessy verfasserin aut Release of copper complexes from a nanostructured sol–gel titania for cancer treatment 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. Drug Release (dpeaa)DE-He213 CuCl2 (dpeaa)DE-He213 Copper Complex (dpeaa)DE-He213 Copper Compound (dpeaa)DE-He213 Nanostructured Lipid Carrier (dpeaa)DE-He213 Ortiz-Islas, Emma verfasserin aut Guevara, Patricia verfasserin aut Rodríguez-Reinoso, Francisco verfasserin aut Gómez, Esteban verfasserin aut Cuevas, José Luis verfasserin aut Novaro, Octavio verfasserin aut Enthalten in Journal of materials science Dordrecht [u.a.] : Springer Science + Business Media B.V, 1966 50(2015), 6 vom: 13. Jan., Seite 2410-2421 (DE-627)315293969 (DE-600)2015305-3 1573-4803 nnns volume:50 year:2015 number:6 day:13 month:01 pages:2410-2421 https://dx.doi.org/10.1007/s10853-014-8796-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 ASE AR 50 2015 6 13 01 2410-2421 |
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10.1007/s10853-014-8796-9 doi (DE-627)SPR013907859 (SPR)s10853-014-8796-9-e DE-627 ger DE-627 rakwb eng 670 ASE 51.00 bkl López, Tessy verfasserin aut Release of copper complexes from a nanostructured sol–gel titania for cancer treatment 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. Drug Release (dpeaa)DE-He213 CuCl2 (dpeaa)DE-He213 Copper Complex (dpeaa)DE-He213 Copper Compound (dpeaa)DE-He213 Nanostructured Lipid Carrier (dpeaa)DE-He213 Ortiz-Islas, Emma verfasserin aut Guevara, Patricia verfasserin aut Rodríguez-Reinoso, Francisco verfasserin aut Gómez, Esteban verfasserin aut Cuevas, José Luis verfasserin aut Novaro, Octavio verfasserin aut Enthalten in Journal of materials science Dordrecht [u.a.] : Springer Science + Business Media B.V, 1966 50(2015), 6 vom: 13. Jan., Seite 2410-2421 (DE-627)315293969 (DE-600)2015305-3 1573-4803 nnns volume:50 year:2015 number:6 day:13 month:01 pages:2410-2421 https://dx.doi.org/10.1007/s10853-014-8796-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 ASE AR 50 2015 6 13 01 2410-2421 |
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10.1007/s10853-014-8796-9 doi (DE-627)SPR013907859 (SPR)s10853-014-8796-9-e DE-627 ger DE-627 rakwb eng 670 ASE 51.00 bkl López, Tessy verfasserin aut Release of copper complexes from a nanostructured sol–gel titania for cancer treatment 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. Drug Release (dpeaa)DE-He213 CuCl2 (dpeaa)DE-He213 Copper Complex (dpeaa)DE-He213 Copper Compound (dpeaa)DE-He213 Nanostructured Lipid Carrier (dpeaa)DE-He213 Ortiz-Islas, Emma verfasserin aut Guevara, Patricia verfasserin aut Rodríguez-Reinoso, Francisco verfasserin aut Gómez, Esteban verfasserin aut Cuevas, José Luis verfasserin aut Novaro, Octavio verfasserin aut Enthalten in Journal of materials science Dordrecht [u.a.] : Springer Science + Business Media B.V, 1966 50(2015), 6 vom: 13. Jan., Seite 2410-2421 (DE-627)315293969 (DE-600)2015305-3 1573-4803 nnns volume:50 year:2015 number:6 day:13 month:01 pages:2410-2421 https://dx.doi.org/10.1007/s10853-014-8796-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 ASE AR 50 2015 6 13 01 2410-2421 |
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Enthalten in Journal of materials science 50(2015), 6 vom: 13. Jan., Seite 2410-2421 volume:50 year:2015 number:6 day:13 month:01 pages:2410-2421 |
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Drug Release CuCl2 Copper Complex Copper Compound Nanostructured Lipid Carrier |
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López, Tessy @@aut@@ Ortiz-Islas, Emma @@aut@@ Guevara, Patricia @@aut@@ Rodríguez-Reinoso, Francisco @@aut@@ Gómez, Esteban @@aut@@ Cuevas, José Luis @@aut@@ Novaro, Octavio @@aut@@ |
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The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. 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López, Tessy |
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López, Tessy ddc 670 bkl 51.00 misc Drug Release misc CuCl2 misc Copper Complex misc Copper Compound misc Nanostructured Lipid Carrier Release of copper complexes from a nanostructured sol–gel titania for cancer treatment |
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670 ASE 51.00 bkl Release of copper complexes from a nanostructured sol–gel titania for cancer treatment Drug Release (dpeaa)DE-He213 CuCl2 (dpeaa)DE-He213 Copper Complex (dpeaa)DE-He213 Copper Compound (dpeaa)DE-He213 Nanostructured Lipid Carrier (dpeaa)DE-He213 |
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Release of copper complexes from a nanostructured sol–gel titania for cancer treatment |
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López, Tessy Ortiz-Islas, Emma Guevara, Patricia Rodríguez-Reinoso, Francisco Gómez, Esteban Cuevas, José Luis Novaro, Octavio |
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López, Tessy |
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release of copper complexes from a nanostructured sol–gel titania for cancer treatment |
| title_auth |
Release of copper complexes from a nanostructured sol–gel titania for cancer treatment |
| abstract |
Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. |
| abstractGer |
Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. |
| abstract_unstemmed |
Abstract Copper complexes containing inorganic ligands were loaded on a functionalized titania (F-$ TiO_{2} $) to obtain drug delivery systems. The as-received copper complexes and those released from titania were tested as toxic agents on different cancer cell lines. The sol–gel method was used for the synthesis and surface functionalization of the titania, as well as for loading the copper complexes, all in a single step. The resultant Cu/F-$ TiO_{2} $ materials were characterized by several techniques. An “in vitro” releasing test was developed using an aqueous medium. Different concentrations (15.6–1000 µg $ mL^{−1} $) of each copper complex, those loaded on titania (Cu/F-$ TiO_{2} $), functionalized titania, and cis-Pt as a reference material, were incubated on RG2, C6, U373, and B16 cancer cell lines for 24 h. The morphology of functionalized titania and the different Cu/F-$ TiO_{2} $ materials obtained consists of aggregated nanoparticles, which generate mesopores. The amorphous phase (in dominant proportion) and the anatase phase were the structures identified through the X-ray diffraction profiles. These results agree with high-resolution transmission electron microscopy. Theoretical studies indicate that the copper compounds were released by a Fickian diffusion mechanism. It was found that independently of the copper complex and also the cell line used, low concentrations of each copper compound were sufficient to kill almost 100 % of cancer cells. When the cancer cells were treated with increasing concentrations of the Cu/F-$ TiO_{2} $ materials the number of survival cells decreased. Both copper complexes alone as well as those loaded on $ TiO_{2} $ had higher toxic effect than cis-Pt. |
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Release of copper complexes from a nanostructured sol–gel titania for cancer treatment |
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Ortiz-Islas, Emma Guevara, Patricia Rodríguez-Reinoso, Francisco Gómez, Esteban Cuevas, José Luis Novaro, Octavio |
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| score |
7.3996496 |