Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients

Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Respons...
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Autor*in:	Puri, Goverdhan D. [verfasserIn] Mathew, Preethy J. [verfasserIn] Sethu Madhavan, J. [verfasserIn] Hegde, Harihar V. [verfasserIn] Fiehn, Andreas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	anaesthesia depth anaesthetics i.v awareness entropy monitoring, bispectral index pharmacokinetics pharmacology

Übergeordnetes Werk:	Enthalten in: Journal of clinical monitoring and computing - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1985, 25(2011), 5 vom: 01. Okt.
Übergeordnetes Werk:	volume:25 ; year:2011 ; number:5 ; day:01 ; month:10

Links:	Volltext

DOI / URN:	10.1007/s10877-011-9309-x

Katalog-ID:	SPR014269910

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100	1		\|a Puri, Goverdhan D. \|e verfasserin \|4 aut
245	1	0	\|a Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients
264		1	\|c 2011
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337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established.
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700	1		\|a Mathew, Preethy J. \|e verfasserin \|4 aut
700	1		\|a Sethu Madhavan, J. \|e verfasserin \|4 aut
700	1		\|a Hegde, Harihar V. \|e verfasserin \|4 aut
700	1		\|a Fiehn, Andreas \|e verfasserin \|4 aut
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matchkey_str	article:15732614:2011----::ipcrlneetoynpeitdlsarpflocnrtosihagtoto
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bklnumber	44.09 44.66
publishDate	2011
allfields	10.1007/s10877-011-9309-x doi (DE-627)SPR014269910 (SPR)s10877-011-9309-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.09 bkl 44.66 bkl Puri, Goverdhan D. verfasserin aut Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established. anaesthesia depth (dpeaa)DE-He213 anaesthetics i.v (dpeaa)DE-He213 awareness (dpeaa)DE-He213 entropy (dpeaa)DE-He213 monitoring, bispectral index (dpeaa)DE-He213 pharmacokinetics (dpeaa)DE-He213 pharmacology (dpeaa)DE-He213 Mathew, Preethy J. verfasserin aut Sethu Madhavan, J. verfasserin aut Hegde, Harihar V. verfasserin aut Fiehn, Andreas verfasserin aut Enthalten in Journal of clinical monitoring and computing Dordrecht [u.a.] : Springer Science + Business Media B.V., 1985 25(2011), 5 vom: 01. Okt. (DE-627)320483797 (DE-600)2010139-9 1573-2614 nnns volume:25 year:2011 number:5 day:01 month:10 https://dx.doi.org/10.1007/s10877-011-9309-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.09 ASE 44.66 ASE AR 25 2011 5 01 10
spelling	10.1007/s10877-011-9309-x doi (DE-627)SPR014269910 (SPR)s10877-011-9309-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.09 bkl 44.66 bkl Puri, Goverdhan D. verfasserin aut Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established. anaesthesia depth (dpeaa)DE-He213 anaesthetics i.v (dpeaa)DE-He213 awareness (dpeaa)DE-He213 entropy (dpeaa)DE-He213 monitoring, bispectral index (dpeaa)DE-He213 pharmacokinetics (dpeaa)DE-He213 pharmacology (dpeaa)DE-He213 Mathew, Preethy J. verfasserin aut Sethu Madhavan, J. verfasserin aut Hegde, Harihar V. verfasserin aut Fiehn, Andreas verfasserin aut Enthalten in Journal of clinical monitoring and computing Dordrecht [u.a.] : Springer Science + Business Media B.V., 1985 25(2011), 5 vom: 01. Okt. (DE-627)320483797 (DE-600)2010139-9 1573-2614 nnns volume:25 year:2011 number:5 day:01 month:10 https://dx.doi.org/10.1007/s10877-011-9309-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.09 ASE 44.66 ASE AR 25 2011 5 01 10
allfields_unstemmed	10.1007/s10877-011-9309-x doi (DE-627)SPR014269910 (SPR)s10877-011-9309-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.09 bkl 44.66 bkl Puri, Goverdhan D. verfasserin aut Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established. anaesthesia depth (dpeaa)DE-He213 anaesthetics i.v (dpeaa)DE-He213 awareness (dpeaa)DE-He213 entropy (dpeaa)DE-He213 monitoring, bispectral index (dpeaa)DE-He213 pharmacokinetics (dpeaa)DE-He213 pharmacology (dpeaa)DE-He213 Mathew, Preethy J. verfasserin aut Sethu Madhavan, J. verfasserin aut Hegde, Harihar V. verfasserin aut Fiehn, Andreas verfasserin aut Enthalten in Journal of clinical monitoring and computing Dordrecht [u.a.] : Springer Science + Business Media B.V., 1985 25(2011), 5 vom: 01. Okt. (DE-627)320483797 (DE-600)2010139-9 1573-2614 nnns volume:25 year:2011 number:5 day:01 month:10 https://dx.doi.org/10.1007/s10877-011-9309-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.09 ASE 44.66 ASE AR 25 2011 5 01 10
allfieldsGer	10.1007/s10877-011-9309-x doi (DE-627)SPR014269910 (SPR)s10877-011-9309-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.09 bkl 44.66 bkl Puri, Goverdhan D. verfasserin aut Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established. anaesthesia depth (dpeaa)DE-He213 anaesthetics i.v (dpeaa)DE-He213 awareness (dpeaa)DE-He213 entropy (dpeaa)DE-He213 monitoring, bispectral index (dpeaa)DE-He213 pharmacokinetics (dpeaa)DE-He213 pharmacology (dpeaa)DE-He213 Mathew, Preethy J. verfasserin aut Sethu Madhavan, J. verfasserin aut Hegde, Harihar V. verfasserin aut Fiehn, Andreas verfasserin aut Enthalten in Journal of clinical monitoring and computing Dordrecht [u.a.] : Springer Science + Business Media B.V., 1985 25(2011), 5 vom: 01. Okt. (DE-627)320483797 (DE-600)2010139-9 1573-2614 nnns volume:25 year:2011 number:5 day:01 month:10 https://dx.doi.org/10.1007/s10877-011-9309-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.09 ASE 44.66 ASE AR 25 2011 5 01 10
allfieldsSound	10.1007/s10877-011-9309-x doi (DE-627)SPR014269910 (SPR)s10877-011-9309-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.09 bkl 44.66 bkl Puri, Goverdhan D. verfasserin aut Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established. anaesthesia depth (dpeaa)DE-He213 anaesthetics i.v (dpeaa)DE-He213 awareness (dpeaa)DE-He213 entropy (dpeaa)DE-He213 monitoring, bispectral index (dpeaa)DE-He213 pharmacokinetics (dpeaa)DE-He213 pharmacology (dpeaa)DE-He213 Mathew, Preethy J. verfasserin aut Sethu Madhavan, J. verfasserin aut Hegde, Harihar V. verfasserin aut Fiehn, Andreas verfasserin aut Enthalten in Journal of clinical monitoring and computing Dordrecht [u.a.] : Springer Science + Business Media B.V., 1985 25(2011), 5 vom: 01. Okt. (DE-627)320483797 (DE-600)2010139-9 1573-2614 nnns volume:25 year:2011 number:5 day:01 month:10 https://dx.doi.org/10.1007/s10877-011-9309-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.09 ASE 44.66 ASE AR 25 2011 5 01 10
language	English
source	Enthalten in Journal of clinical monitoring and computing 25(2011), 5 vom: 01. Okt. volume:25 year:2011 number:5 day:01 month:10
sourceStr	Enthalten in Journal of clinical monitoring and computing 25(2011), 5 vom: 01. Okt. volume:25 year:2011 number:5 day:01 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	anaesthesia depth anaesthetics i.v awareness entropy monitoring, bispectral index pharmacokinetics pharmacology
dewey-raw	610
isfreeaccess_bool	false
container_title	Journal of clinical monitoring and computing
authorswithroles_txt_mv	Puri, Goverdhan D. @@aut@@ Mathew, Preethy J. @@aut@@ Sethu Madhavan, J. @@aut@@ Hegde, Harihar V. @@aut@@ Fiehn, Andreas @@aut@@
publishDateDaySort_date	2011-10-01T00:00:00Z
hierarchy_top_id	320483797
dewey-sort	3610
id	SPR014269910
language_de	englisch
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We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. 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author	Puri, Goverdhan D.
spellingShingle	Puri, Goverdhan D. ddc 610 bkl 44.09 bkl 44.66 misc anaesthesia depth misc anaesthetics i.v misc awareness misc entropy misc monitoring, bispectral index misc pharmacokinetics misc pharmacology Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients
authorStr	Puri, Goverdhan D.
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topic_title	610 ASE 44.09 bkl 44.66 bkl Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients anaesthesia depth (dpeaa)DE-He213 anaesthetics i.v (dpeaa)DE-He213 awareness (dpeaa)DE-He213 entropy (dpeaa)DE-He213 monitoring, bispectral index (dpeaa)DE-He213 pharmacokinetics (dpeaa)DE-He213 pharmacology (dpeaa)DE-He213
topic	ddc 610 bkl 44.09 bkl 44.66 misc anaesthesia depth misc anaesthetics i.v misc awareness misc entropy misc monitoring, bispectral index misc pharmacokinetics misc pharmacology
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title	Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients
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title_full	Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients
author_sort	Puri, Goverdhan D.
journal	Journal of clinical monitoring and computing
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author_browse	Puri, Goverdhan D. Mathew, Preethy J. Sethu Madhavan, J. Hegde, Harihar V. Fiehn, Andreas
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author-letter	Puri, Goverdhan D.
doi_str_mv	10.1007/s10877-011-9309-x
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title_sort	bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in indian patients
title_auth	Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients
abstract	Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established.
abstractGer	Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established.
abstract_unstemmed	Objective Many processed electroencephalographic signals are used now to help the anaesthesiologist titrate the depth of sedation. We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. Also, the relations between target plasma concentration and objective measures of different levels of anaesthesia have been established.
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container_issue	5
title_short	Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients
url	https://dx.doi.org/10.1007/s10877-011-9309-x
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author2	Mathew, Preethy J. Sethu Madhavan, J. Hegde, Harihar V. Fiehn, Andreas
author2Str	Mathew, Preethy J. Sethu Madhavan, J. Hegde, Harihar V. Fiehn, Andreas
ppnlink	320483797
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doi_str	10.1007/s10877-011-9309-x
up_date	2024-07-04T00:57:20.651Z
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We investigated the relationship between target plasma propofol concentration and objective end-points of sedation—Bispectral Index (BIS), State Entropy (SE) and Response Entropy (RE)—at clinical end-points as assessed by Modified Observer Assessment of Alertness/sedation Scale (MOAAS) in Indian patients. Methods Eighteen ASA 1 and 2 Indian adult patients scheduled to undergo elective surgery were included. The target control infusion (TCI) of propofol was administered using ‘Diprifusor’. The level of sedation was assessed using MOAAS by the anaesthesiologist. BIS, SE, RE were recorded throughout. TCI was started at 0.5 μg/ml and increased by 0.5 μg/ml every 6 min till MOAAS scores reached 0 or there was sustained BIS value less than 30. Results The $ EC_{50} $ and $ EC_{95} $ of predicted plasma propofol concentration for loss of consciousness (assessed by loss of response to verbal command), were 2.3 and 2.8 μg/ml respectively and for loss of response to painful stimuli (trapezius squeeze) were 4.0 and 5.0 μg/ml respectively. The BIS and entropy values ($ EC_{50} $ and $ EC_{95} $) for loss of consciousness and response to painful stimuli in Indian patients were estimated. The preliminary relation of target plasma propofol concentration with BIS was found to be BIS = 100.5–16.4 × (Target concentration). Conclusions The target plasma propofol concentrations required to produce unconsciousness and loss of response to painful stimuli in Indian patients have been estimated. 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Bi-spectral index, entropy and predicted plasma propofol concentrations with target controlled infusions in Indian patients

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