The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors
Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wiczling, Paweł [verfasserIn] Bartkowska-Śniatkowska, Alicja [verfasserIn] Szerkus, Oliwia [verfasserIn] Siluk, Danuta [verfasserIn] Rosada-Kurasińska, Jowita [verfasserIn] Warzybok, Justyna [verfasserIn] Borsuk, Agnieszka [verfasserIn] Kaliszan, Roman [verfasserIn] Grześkowiak, Edmund [verfasserIn] Bienert, Agnieszka [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: Journal of Pharmacokinetics and Biopharmaceutics - Kluwer Academic Publishers-Plenum Publishers, 1973, 43(2016), 3 vom: 24. Mai, Seite 315-324 |
|---|---|
| Übergeordnetes Werk: |
volume:43 ; year:2016 ; number:3 ; day:24 ; month:05 ; pages:315-324 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10928-016-9474-0 |
|---|
| Katalog-ID: |
SPR014712547 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR014712547 | ||
| 003 | DE-627 | ||
| 005 | 20230519141612.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201006s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10928-016-9474-0 |2 doi | |
| 035 | |a (DE-627)SPR014712547 | ||
| 035 | |a (SPR)s10928-016-9474-0-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wiczling, Paweł |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. | ||
| 650 | 4 | |a Dexmedetomidine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a WinBUGS |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Population pharmacokinetics |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Informative priors |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Bartkowska-Śniatkowska, Alicja |e verfasserin |4 aut | |
| 700 | 1 | |a Szerkus, Oliwia |e verfasserin |4 aut | |
| 700 | 1 | |a Siluk, Danuta |e verfasserin |4 aut | |
| 700 | 1 | |a Rosada-Kurasińska, Jowita |e verfasserin |4 aut | |
| 700 | 1 | |a Warzybok, Justyna |e verfasserin |4 aut | |
| 700 | 1 | |a Borsuk, Agnieszka |e verfasserin |4 aut | |
| 700 | 1 | |a Kaliszan, Roman |e verfasserin |4 aut | |
| 700 | 1 | |a Grześkowiak, Edmund |e verfasserin |4 aut | |
| 700 | 1 | |a Bienert, Agnieszka |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of Pharmacokinetics and Biopharmaceutics |d Kluwer Academic Publishers-Plenum Publishers, 1973 |g 43(2016), 3 vom: 24. Mai, Seite 315-324 |w (DE-627)SPR014694166 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2016 |g number:3 |g day:24 |g month:05 |g pages:315-324 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s10928-016-9474-0 |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_40 | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2016 |e 3 |b 24 |c 05 |h 315-324 | ||
| author_variant |
p w pw a b ś abś o s os d s ds j r k jrk j w jw a b ab r k rk e g eg a b ab |
|---|---|
| matchkey_str |
wiczlingpawebartkowskaniatkowskaalicjasz:2016----:hpamckntcodxeeoiieuigogemnuinnrtclylpdarcainsbys |
| hierarchy_sort_str |
2016 |
| publishDate |
2016 |
| allfields |
10.1007/s10928-016-9474-0 doi (DE-627)SPR014712547 (SPR)s10928-016-9474-0-e DE-627 ger DE-627 rakwb eng Wiczling, Paweł verfasserin aut The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. Dexmedetomidine (dpeaa)DE-He213 WinBUGS (dpeaa)DE-He213 Population pharmacokinetics (dpeaa)DE-He213 Informative priors (dpeaa)DE-He213 Bartkowska-Śniatkowska, Alicja verfasserin aut Szerkus, Oliwia verfasserin aut Siluk, Danuta verfasserin aut Rosada-Kurasińska, Jowita verfasserin aut Warzybok, Justyna verfasserin aut Borsuk, Agnieszka verfasserin aut Kaliszan, Roman verfasserin aut Grześkowiak, Edmund verfasserin aut Bienert, Agnieszka verfasserin aut Enthalten in Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers, 1973 43(2016), 3 vom: 24. Mai, Seite 315-324 (DE-627)SPR014694166 nnns volume:43 year:2016 number:3 day:24 month:05 pages:315-324 https://dx.doi.org/10.1007/s10928-016-9474-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 AR 43 2016 3 24 05 315-324 |
| spelling |
10.1007/s10928-016-9474-0 doi (DE-627)SPR014712547 (SPR)s10928-016-9474-0-e DE-627 ger DE-627 rakwb eng Wiczling, Paweł verfasserin aut The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. Dexmedetomidine (dpeaa)DE-He213 WinBUGS (dpeaa)DE-He213 Population pharmacokinetics (dpeaa)DE-He213 Informative priors (dpeaa)DE-He213 Bartkowska-Śniatkowska, Alicja verfasserin aut Szerkus, Oliwia verfasserin aut Siluk, Danuta verfasserin aut Rosada-Kurasińska, Jowita verfasserin aut Warzybok, Justyna verfasserin aut Borsuk, Agnieszka verfasserin aut Kaliszan, Roman verfasserin aut Grześkowiak, Edmund verfasserin aut Bienert, Agnieszka verfasserin aut Enthalten in Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers, 1973 43(2016), 3 vom: 24. Mai, Seite 315-324 (DE-627)SPR014694166 nnns volume:43 year:2016 number:3 day:24 month:05 pages:315-324 https://dx.doi.org/10.1007/s10928-016-9474-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 AR 43 2016 3 24 05 315-324 |
| allfields_unstemmed |
10.1007/s10928-016-9474-0 doi (DE-627)SPR014712547 (SPR)s10928-016-9474-0-e DE-627 ger DE-627 rakwb eng Wiczling, Paweł verfasserin aut The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. Dexmedetomidine (dpeaa)DE-He213 WinBUGS (dpeaa)DE-He213 Population pharmacokinetics (dpeaa)DE-He213 Informative priors (dpeaa)DE-He213 Bartkowska-Śniatkowska, Alicja verfasserin aut Szerkus, Oliwia verfasserin aut Siluk, Danuta verfasserin aut Rosada-Kurasińska, Jowita verfasserin aut Warzybok, Justyna verfasserin aut Borsuk, Agnieszka verfasserin aut Kaliszan, Roman verfasserin aut Grześkowiak, Edmund verfasserin aut Bienert, Agnieszka verfasserin aut Enthalten in Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers, 1973 43(2016), 3 vom: 24. Mai, Seite 315-324 (DE-627)SPR014694166 nnns volume:43 year:2016 number:3 day:24 month:05 pages:315-324 https://dx.doi.org/10.1007/s10928-016-9474-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 AR 43 2016 3 24 05 315-324 |
| allfieldsGer |
10.1007/s10928-016-9474-0 doi (DE-627)SPR014712547 (SPR)s10928-016-9474-0-e DE-627 ger DE-627 rakwb eng Wiczling, Paweł verfasserin aut The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. Dexmedetomidine (dpeaa)DE-He213 WinBUGS (dpeaa)DE-He213 Population pharmacokinetics (dpeaa)DE-He213 Informative priors (dpeaa)DE-He213 Bartkowska-Śniatkowska, Alicja verfasserin aut Szerkus, Oliwia verfasserin aut Siluk, Danuta verfasserin aut Rosada-Kurasińska, Jowita verfasserin aut Warzybok, Justyna verfasserin aut Borsuk, Agnieszka verfasserin aut Kaliszan, Roman verfasserin aut Grześkowiak, Edmund verfasserin aut Bienert, Agnieszka verfasserin aut Enthalten in Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers, 1973 43(2016), 3 vom: 24. Mai, Seite 315-324 (DE-627)SPR014694166 nnns volume:43 year:2016 number:3 day:24 month:05 pages:315-324 https://dx.doi.org/10.1007/s10928-016-9474-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 AR 43 2016 3 24 05 315-324 |
| allfieldsSound |
10.1007/s10928-016-9474-0 doi (DE-627)SPR014712547 (SPR)s10928-016-9474-0-e DE-627 ger DE-627 rakwb eng Wiczling, Paweł verfasserin aut The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. Dexmedetomidine (dpeaa)DE-He213 WinBUGS (dpeaa)DE-He213 Population pharmacokinetics (dpeaa)DE-He213 Informative priors (dpeaa)DE-He213 Bartkowska-Śniatkowska, Alicja verfasserin aut Szerkus, Oliwia verfasserin aut Siluk, Danuta verfasserin aut Rosada-Kurasińska, Jowita verfasserin aut Warzybok, Justyna verfasserin aut Borsuk, Agnieszka verfasserin aut Kaliszan, Roman verfasserin aut Grześkowiak, Edmund verfasserin aut Bienert, Agnieszka verfasserin aut Enthalten in Journal of Pharmacokinetics and Biopharmaceutics Kluwer Academic Publishers-Plenum Publishers, 1973 43(2016), 3 vom: 24. Mai, Seite 315-324 (DE-627)SPR014694166 nnns volume:43 year:2016 number:3 day:24 month:05 pages:315-324 https://dx.doi.org/10.1007/s10928-016-9474-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 AR 43 2016 3 24 05 315-324 |
| language |
English |
| source |
Enthalten in Journal of Pharmacokinetics and Biopharmaceutics 43(2016), 3 vom: 24. Mai, Seite 315-324 volume:43 year:2016 number:3 day:24 month:05 pages:315-324 |
| sourceStr |
Enthalten in Journal of Pharmacokinetics and Biopharmaceutics 43(2016), 3 vom: 24. Mai, Seite 315-324 volume:43 year:2016 number:3 day:24 month:05 pages:315-324 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Dexmedetomidine WinBUGS Population pharmacokinetics Informative priors |
| isfreeaccess_bool |
true |
| container_title |
Journal of Pharmacokinetics and Biopharmaceutics |
| authorswithroles_txt_mv |
Wiczling, Paweł @@aut@@ Bartkowska-Śniatkowska, Alicja @@aut@@ Szerkus, Oliwia @@aut@@ Siluk, Danuta @@aut@@ Rosada-Kurasińska, Jowita @@aut@@ Warzybok, Justyna @@aut@@ Borsuk, Agnieszka @@aut@@ Kaliszan, Roman @@aut@@ Grześkowiak, Edmund @@aut@@ Bienert, Agnieszka @@aut@@ |
| publishDateDaySort_date |
2016-05-24T00:00:00Z |
| hierarchy_top_id |
SPR014694166 |
| id |
SPR014712547 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR014712547</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519141612.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10928-016-9474-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR014712547</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10928-016-9474-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wiczling, Paweł</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dexmedetomidine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">WinBUGS</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Population pharmacokinetics</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Informative priors</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bartkowska-Śniatkowska, Alicja</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Szerkus, Oliwia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Siluk, Danuta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rosada-Kurasińska, Jowita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Warzybok, Justyna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Borsuk, Agnieszka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kaliszan, Roman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Grześkowiak, Edmund</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bienert, Agnieszka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of Pharmacokinetics and Biopharmaceutics</subfield><subfield code="d">Kluwer Academic Publishers-Plenum Publishers, 1973</subfield><subfield code="g">43(2016), 3 vom: 24. Mai, Seite 315-324</subfield><subfield code="w">(DE-627)SPR014694166</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:43</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:3</subfield><subfield code="g">day:24</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:315-324</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s10928-016-9474-0</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">43</subfield><subfield code="j">2016</subfield><subfield code="e">3</subfield><subfield code="b">24</subfield><subfield code="c">05</subfield><subfield code="h">315-324</subfield></datafield></record></collection>
|
| author |
Wiczling, Paweł |
| spellingShingle |
Wiczling, Paweł misc Dexmedetomidine misc WinBUGS misc Population pharmacokinetics misc Informative priors The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors |
| authorStr |
Wiczling, Paweł |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)SPR014694166 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors Dexmedetomidine (dpeaa)DE-He213 WinBUGS (dpeaa)DE-He213 Population pharmacokinetics (dpeaa)DE-He213 Informative priors (dpeaa)DE-He213 |
| topic |
misc Dexmedetomidine misc WinBUGS misc Population pharmacokinetics misc Informative priors |
| topic_unstemmed |
misc Dexmedetomidine misc WinBUGS misc Population pharmacokinetics misc Informative priors |
| topic_browse |
misc Dexmedetomidine misc WinBUGS misc Population pharmacokinetics misc Informative priors |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Journal of Pharmacokinetics and Biopharmaceutics |
| hierarchy_parent_id |
SPR014694166 |
| hierarchy_top_title |
Journal of Pharmacokinetics and Biopharmaceutics |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)SPR014694166 |
| title |
The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors |
| ctrlnum |
(DE-627)SPR014712547 (SPR)s10928-016-9474-0-e |
| title_full |
The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors |
| author_sort |
Wiczling, Paweł |
| journal |
Journal of Pharmacokinetics and Biopharmaceutics |
| journalStr |
Journal of Pharmacokinetics and Biopharmaceutics |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2016 |
| contenttype_str_mv |
txt |
| container_start_page |
315 |
| author_browse |
Wiczling, Paweł Bartkowska-Śniatkowska, Alicja Szerkus, Oliwia Siluk, Danuta Rosada-Kurasińska, Jowita Warzybok, Justyna Borsuk, Agnieszka Kaliszan, Roman Grześkowiak, Edmund Bienert, Agnieszka |
| container_volume |
43 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Wiczling, Paweł |
| doi_str_mv |
10.1007/s10928-016-9474-0 |
| author2-role |
verfasserin |
| title_sort |
pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. a bayesian approach with informative priors |
| title_auth |
The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors |
| abstract |
Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. |
| abstractGer |
Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. |
| abstract_unstemmed |
Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_40 |
| container_issue |
3 |
| title_short |
The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors |
| url |
https://dx.doi.org/10.1007/s10928-016-9474-0 |
| remote_bool |
true |
| author2 |
Bartkowska-Śniatkowska, Alicja Szerkus, Oliwia Siluk, Danuta Rosada-Kurasińska, Jowita Warzybok, Justyna Borsuk, Agnieszka Kaliszan, Roman Grześkowiak, Edmund Bienert, Agnieszka |
| author2Str |
Bartkowska-Śniatkowska, Alicja Szerkus, Oliwia Siluk, Danuta Rosada-Kurasińska, Jowita Warzybok, Justyna Borsuk, Agnieszka Kaliszan, Roman Grześkowiak, Edmund Bienert, Agnieszka |
| ppnlink |
SPR014694166 |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s10928-016-9474-0 |
| up_date |
2024-07-04T02:47:18.206Z |
| _version_ |
1803614932907851776 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR014712547</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519141612.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10928-016-9474-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR014712547</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10928-016-9474-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wiczling, Paweł</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after infusion initiation and second from 0 to 8 h after infusion end. Data analysis was conducted using WinBUGS software. The prior information on dexmedetomidine pharmacokinetics was elicited from the literature study pooling results from a relatively large group of 95 children. A two compartment PK model, with allometrically scaled parameters, maturation of clearance and t-student residual distribution on a log-scale was used to describe the data. The incorporation of time-dependent (different between two occasions) PK parameters improved the model. It was observed that volume of distribution is 1.5-fold higher during the second occasion. There was also an evidence of increased (1.3-fold) clearance for the second occasion with posterior probability equal to 62 %. This work demonstrated the usefulness of Bayesian modeling with informative priors in analyzing pharmacokinetic data and comparing it with existing literature knowledge.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dexmedetomidine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">WinBUGS</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Population pharmacokinetics</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Informative priors</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bartkowska-Śniatkowska, Alicja</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Szerkus, Oliwia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Siluk, Danuta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rosada-Kurasińska, Jowita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Warzybok, Justyna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Borsuk, Agnieszka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kaliszan, Roman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Grześkowiak, Edmund</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bienert, Agnieszka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of Pharmacokinetics and Biopharmaceutics</subfield><subfield code="d">Kluwer Academic Publishers-Plenum Publishers, 1973</subfield><subfield code="g">43(2016), 3 vom: 24. Mai, Seite 315-324</subfield><subfield code="w">(DE-627)SPR014694166</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:43</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:3</subfield><subfield code="g">day:24</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:315-324</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s10928-016-9474-0</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">43</subfield><subfield code="j">2016</subfield><subfield code="e">3</subfield><subfield code="b">24</subfield><subfield code="c">05</subfield><subfield code="h">315-324</subfield></datafield></record></collection>
|
| score |
7.4000483 |