Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions
Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Eersels, J. L. H. [verfasserIn] Mertens, J. [verfasserIn] Herscheid, J. D. M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of radioanalytical and nuclear chemistry - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968, 288(2010), 1 vom: 23. Dez., Seite 291-296 |
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| Übergeordnetes Werk: |
volume:288 ; year:2010 ; number:1 ; day:23 ; month:12 ; pages:291-296 |
| Links: |
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| DOI / URN: |
10.1007/s10967-010-0956-z |
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| Katalog-ID: |
SPR015171655 |
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| 100 | 1 | |a Eersels, J. L. H. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions |
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| 520 | |a Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. | ||
| 650 | 4 | |a Radioiodination |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mixed solvent |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Acetonitrile |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Complex constant |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adjusted copper concentration |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mertens, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Herscheid, J. D. M. |e verfasserin |4 aut | |
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10.1007/s10967-010-0956-z doi (DE-627)SPR015171655 (SPR)s10967-010-0956-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.00 bkl Eersels, J. L. H. verfasserin aut Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. Radioiodination (dpeaa)DE-He213 Mixed solvent (dpeaa)DE-He213 Acetonitrile (dpeaa)DE-He213 Complex constant (dpeaa)DE-He213 Adjusted copper concentration (dpeaa)DE-He213 Mertens, J. verfasserin aut Herscheid, J. D. M. verfasserin aut Enthalten in Journal of radioanalytical and nuclear chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968 288(2010), 1 vom: 23. Dez., Seite 291-296 (DE-627)320578011 (DE-600)2017242-4 1588-2780 nnns volume:288 year:2010 number:1 day:23 month:12 pages:291-296 https://dx.doi.org/10.1007/s10967-010-0956-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 288 2010 1 23 12 291-296 |
| spelling |
10.1007/s10967-010-0956-z doi (DE-627)SPR015171655 (SPR)s10967-010-0956-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.00 bkl Eersels, J. L. H. verfasserin aut Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. Radioiodination (dpeaa)DE-He213 Mixed solvent (dpeaa)DE-He213 Acetonitrile (dpeaa)DE-He213 Complex constant (dpeaa)DE-He213 Adjusted copper concentration (dpeaa)DE-He213 Mertens, J. verfasserin aut Herscheid, J. D. M. verfasserin aut Enthalten in Journal of radioanalytical and nuclear chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968 288(2010), 1 vom: 23. Dez., Seite 291-296 (DE-627)320578011 (DE-600)2017242-4 1588-2780 nnns volume:288 year:2010 number:1 day:23 month:12 pages:291-296 https://dx.doi.org/10.1007/s10967-010-0956-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 288 2010 1 23 12 291-296 |
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10.1007/s10967-010-0956-z doi (DE-627)SPR015171655 (SPR)s10967-010-0956-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.00 bkl Eersels, J. L. H. verfasserin aut Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. Radioiodination (dpeaa)DE-He213 Mixed solvent (dpeaa)DE-He213 Acetonitrile (dpeaa)DE-He213 Complex constant (dpeaa)DE-He213 Adjusted copper concentration (dpeaa)DE-He213 Mertens, J. verfasserin aut Herscheid, J. D. M. verfasserin aut Enthalten in Journal of radioanalytical and nuclear chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968 288(2010), 1 vom: 23. Dez., Seite 291-296 (DE-627)320578011 (DE-600)2017242-4 1588-2780 nnns volume:288 year:2010 number:1 day:23 month:12 pages:291-296 https://dx.doi.org/10.1007/s10967-010-0956-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 288 2010 1 23 12 291-296 |
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10.1007/s10967-010-0956-z doi (DE-627)SPR015171655 (SPR)s10967-010-0956-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.00 bkl Eersels, J. L. H. verfasserin aut Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. Radioiodination (dpeaa)DE-He213 Mixed solvent (dpeaa)DE-He213 Acetonitrile (dpeaa)DE-He213 Complex constant (dpeaa)DE-He213 Adjusted copper concentration (dpeaa)DE-He213 Mertens, J. verfasserin aut Herscheid, J. D. M. verfasserin aut Enthalten in Journal of radioanalytical and nuclear chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968 288(2010), 1 vom: 23. Dez., Seite 291-296 (DE-627)320578011 (DE-600)2017242-4 1588-2780 nnns volume:288 year:2010 number:1 day:23 month:12 pages:291-296 https://dx.doi.org/10.1007/s10967-010-0956-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 288 2010 1 23 12 291-296 |
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10.1007/s10967-010-0956-z doi (DE-627)SPR015171655 (SPR)s10967-010-0956-z-e DE-627 ger DE-627 rakwb eng 540 ASE 35.00 bkl Eersels, J. L. H. verfasserin aut Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. Radioiodination (dpeaa)DE-He213 Mixed solvent (dpeaa)DE-He213 Acetonitrile (dpeaa)DE-He213 Complex constant (dpeaa)DE-He213 Adjusted copper concentration (dpeaa)DE-He213 Mertens, J. verfasserin aut Herscheid, J. D. M. verfasserin aut Enthalten in Journal of radioanalytical and nuclear chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1968 288(2010), 1 vom: 23. Dez., Seite 291-296 (DE-627)320578011 (DE-600)2017242-4 1588-2780 nnns volume:288 year:2010 number:1 day:23 month:12 pages:291-296 https://dx.doi.org/10.1007/s10967-010-0956-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 288 2010 1 23 12 291-296 |
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Eersels, J. L. H. @@aut@@ Mertens, J. @@aut@@ Herscheid, J. D. M. @@aut@@ |
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| author |
Eersels, J. L. H. |
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Eersels, J. L. H. ddc 540 bkl 35.00 misc Radioiodination misc Mixed solvent misc Acetonitrile misc Complex constant misc Adjusted copper concentration Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions |
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540 ASE 35.00 bkl Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions Radioiodination (dpeaa)DE-He213 Mixed solvent (dpeaa)DE-He213 Acetonitrile (dpeaa)DE-He213 Complex constant (dpeaa)DE-He213 Adjusted copper concentration (dpeaa)DE-He213 |
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ddc 540 bkl 35.00 misc Radioiodination misc Mixed solvent misc Acetonitrile misc Complex constant misc Adjusted copper concentration |
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ddc 540 bkl 35.00 misc Radioiodination misc Mixed solvent misc Acetonitrile misc Complex constant misc Adjusted copper concentration |
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ddc 540 bkl 35.00 misc Radioiodination misc Mixed solvent misc Acetonitrile misc Complex constant misc Adjusted copper concentration |
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Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions |
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(DE-627)SPR015171655 (SPR)s10967-010-0956-z-e |
| title_full |
Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions |
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Eersels, J. L. H. |
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Journal of radioanalytical and nuclear chemistry |
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Eersels, J. L. H. Mertens, J. Herscheid, J. D. M. |
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Eersels, J. L. H. |
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optimization of the labeling yield by determination of the $ cu^{+} $–acetonitrile complex constant in $ cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions |
| title_auth |
Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions |
| abstract |
Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. |
| abstractGer |
Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. |
| abstract_unstemmed |
Abstract To apply the $ Cu^{+} $-assisted nucleophilic exchange based radioiodination of aromatic compounds for more lipophilic compounds the reaction is carried out in mixed solvent conditions. Due to its physicochemical properties acetonitrile is an attractive solvent. Although acetonitrile forms complexes with $ Cu^{+} $ decreasing the labeling yield. This article describes a method for the determination of the complex constant at labeling temperature based on a Lineweaver–Burk approach, relating the reaction rate constant and the concentration of precursor in presence of different amounts of acetonitrile. The method also allows to calculate the adjusted amount of copper salt in order to obtain the same high labeling yield as obtained in absence of acetonitrile. |
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Optimization of the labeling yield by determination of the $ Cu^{+} $–acetonitrile complex constant in $ Cu^{+} $-catalyzed nucleophilic exchange reactions in mixed solvent conditions |
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https://dx.doi.org/10.1007/s10967-010-0956-z |
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Mertens, J. Herscheid, J. D. M. |
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| doi_str |
10.1007/s10967-010-0956-z |
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2024-07-03T14:24:10.655Z |
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| score |
7.4002104 |