Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids
Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Braun, Katharina [verfasserIn] Pochert, Alexander [verfasserIn] Beck, Michaela [verfasserIn] Fiedler, Richard [verfasserIn] Gruber, Jens [verfasserIn] Lindén, Mika [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of sol gel science and technology - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1993, 79(2016), 2 vom: 22. Apr., Seite 319-327 |
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| Übergeordnetes Werk: |
volume:79 ; year:2016 ; number:2 ; day:22 ; month:04 ; pages:319-327 |
| Links: |
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| DOI / URN: |
10.1007/s10971-016-4053-9 |
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SPR01526307X |
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| 520 | |a Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. | ||
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| 650 | 4 | |a Silica dissolution |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Simulated body fluids |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Pochert, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Beck, Michaela |e verfasserin |4 aut | |
| 700 | 1 | |a Fiedler, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Gruber, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Lindén, Mika |e verfasserin |4 aut | |
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10.1007/s10971-016-4053-9 doi (DE-627)SPR01526307X (SPR)s10971-016-4053-9-e DE-627 ger DE-627 rakwb eng 600 670 ASE 35.18 bkl 51.60 bkl Braun, Katharina verfasserin aut Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. Mesoporous silica (dpeaa)DE-He213 Silica dissolution (dpeaa)DE-He213 Physiological buffers (dpeaa)DE-He213 Simulated body fluids (dpeaa)DE-He213 Pochert, Alexander verfasserin aut Beck, Michaela verfasserin aut Fiedler, Richard verfasserin aut Gruber, Jens verfasserin aut Lindén, Mika verfasserin aut Enthalten in Journal of sol gel science and technology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1993 79(2016), 2 vom: 22. Apr., Seite 319-327 (DE-627)268757607 (DE-600)1472726-2 1573-4846 nnns volume:79 year:2016 number:2 day:22 month:04 pages:319-327 https://dx.doi.org/10.1007/s10971-016-4053-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 ASE 51.60 ASE AR 79 2016 2 22 04 319-327 |
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10.1007/s10971-016-4053-9 doi (DE-627)SPR01526307X (SPR)s10971-016-4053-9-e DE-627 ger DE-627 rakwb eng 600 670 ASE 35.18 bkl 51.60 bkl Braun, Katharina verfasserin aut Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. Mesoporous silica (dpeaa)DE-He213 Silica dissolution (dpeaa)DE-He213 Physiological buffers (dpeaa)DE-He213 Simulated body fluids (dpeaa)DE-He213 Pochert, Alexander verfasserin aut Beck, Michaela verfasserin aut Fiedler, Richard verfasserin aut Gruber, Jens verfasserin aut Lindén, Mika verfasserin aut Enthalten in Journal of sol gel science and technology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1993 79(2016), 2 vom: 22. Apr., Seite 319-327 (DE-627)268757607 (DE-600)1472726-2 1573-4846 nnns volume:79 year:2016 number:2 day:22 month:04 pages:319-327 https://dx.doi.org/10.1007/s10971-016-4053-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 ASE 51.60 ASE AR 79 2016 2 22 04 319-327 |
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10.1007/s10971-016-4053-9 doi (DE-627)SPR01526307X (SPR)s10971-016-4053-9-e DE-627 ger DE-627 rakwb eng 600 670 ASE 35.18 bkl 51.60 bkl Braun, Katharina verfasserin aut Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. Mesoporous silica (dpeaa)DE-He213 Silica dissolution (dpeaa)DE-He213 Physiological buffers (dpeaa)DE-He213 Simulated body fluids (dpeaa)DE-He213 Pochert, Alexander verfasserin aut Beck, Michaela verfasserin aut Fiedler, Richard verfasserin aut Gruber, Jens verfasserin aut Lindén, Mika verfasserin aut Enthalten in Journal of sol gel science and technology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1993 79(2016), 2 vom: 22. Apr., Seite 319-327 (DE-627)268757607 (DE-600)1472726-2 1573-4846 nnns volume:79 year:2016 number:2 day:22 month:04 pages:319-327 https://dx.doi.org/10.1007/s10971-016-4053-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 ASE 51.60 ASE AR 79 2016 2 22 04 319-327 |
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10.1007/s10971-016-4053-9 doi (DE-627)SPR01526307X (SPR)s10971-016-4053-9-e DE-627 ger DE-627 rakwb eng 600 670 ASE 35.18 bkl 51.60 bkl Braun, Katharina verfasserin aut Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. Mesoporous silica (dpeaa)DE-He213 Silica dissolution (dpeaa)DE-He213 Physiological buffers (dpeaa)DE-He213 Simulated body fluids (dpeaa)DE-He213 Pochert, Alexander verfasserin aut Beck, Michaela verfasserin aut Fiedler, Richard verfasserin aut Gruber, Jens verfasserin aut Lindén, Mika verfasserin aut Enthalten in Journal of sol gel science and technology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1993 79(2016), 2 vom: 22. Apr., Seite 319-327 (DE-627)268757607 (DE-600)1472726-2 1573-4846 nnns volume:79 year:2016 number:2 day:22 month:04 pages:319-327 https://dx.doi.org/10.1007/s10971-016-4053-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 ASE 51.60 ASE AR 79 2016 2 22 04 319-327 |
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10.1007/s10971-016-4053-9 doi (DE-627)SPR01526307X (SPR)s10971-016-4053-9-e DE-627 ger DE-627 rakwb eng 600 670 ASE 35.18 bkl 51.60 bkl Braun, Katharina verfasserin aut Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. Mesoporous silica (dpeaa)DE-He213 Silica dissolution (dpeaa)DE-He213 Physiological buffers (dpeaa)DE-He213 Simulated body fluids (dpeaa)DE-He213 Pochert, Alexander verfasserin aut Beck, Michaela verfasserin aut Fiedler, Richard verfasserin aut Gruber, Jens verfasserin aut Lindén, Mika verfasserin aut Enthalten in Journal of sol gel science and technology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1993 79(2016), 2 vom: 22. Apr., Seite 319-327 (DE-627)268757607 (DE-600)1472726-2 1573-4846 nnns volume:79 year:2016 number:2 day:22 month:04 pages:319-327 https://dx.doi.org/10.1007/s10971-016-4053-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 ASE 51.60 ASE AR 79 2016 2 22 04 319-327 |
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Braun, Katharina @@aut@@ Pochert, Alexander @@aut@@ Beck, Michaela @@aut@@ Fiedler, Richard @@aut@@ Gruber, Jens @@aut@@ Lindén, Mika @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR01526307X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519082904.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10971-016-4053-9</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR01526307X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s10971-016-4053-9-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">600</subfield><subfield code="a">670</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">35.18</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">51.60</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Braun, Katharina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. 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Braun, Katharina |
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Braun, Katharina ddc 600 bkl 35.18 bkl 51.60 misc Mesoporous silica misc Silica dissolution misc Physiological buffers misc Simulated body fluids Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids |
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600 670 ASE 35.18 bkl 51.60 bkl Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids Mesoporous silica (dpeaa)DE-He213 Silica dissolution (dpeaa)DE-He213 Physiological buffers (dpeaa)DE-He213 Simulated body fluids (dpeaa)DE-He213 |
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ddc 600 bkl 35.18 bkl 51.60 misc Mesoporous silica misc Silica dissolution misc Physiological buffers misc Simulated body fluids |
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ddc 600 bkl 35.18 bkl 51.60 misc Mesoporous silica misc Silica dissolution misc Physiological buffers misc Simulated body fluids |
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dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids |
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Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids |
| abstract |
Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. |
| abstractGer |
Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. |
| abstract_unstemmed |
Abstract The application of mesoporous silica nanoparticles as a platform for drug delivery and bioimaging requires a good understanding of the degradability of these particles under physiological conditions. Optimally, the degradability should be studied in vivo using relevant administration routes and dosings, but such studies are complicated and expensive. Thus, the biodegradability is often studied in vitro using simulated body fluids. However, such studies are scarce to date, and the results are partially conflicting. The aims of this study were therefore (a) to determine the influence of the composition of different simulated body fluids on the observed silica dissolution rates and (b) to establish morphological key parameters that determine the dissolution kinetics of silica nanoparticles. As dissolution media, simulated body fluid (SBF), simulated lung fluid (SLF), simulated gastric juice (SGF) and PBS buffer were used, and the silica concentration was kept below the silica saturation limit. Three mesoporous silica particles of different sizes were studied together with one non-porous Stöber-type silica particle. The observed silica dissolution rates followed the order SLF > SBF ≈ PBS ≫ SGF. Apart from general pH effects, the presence of organic acids in SLF is suggested to enhance the silica dissolution rate. The specific surface area was identified as the main parameter controlling the rate of dissolution of the different silica particles studied, while particle size influences were minor. Graphical Abstract The dissolution of mesoporous silicas with different particle sizes has been studied in four different physiological buffers. |
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| container_issue |
2 |
| title_short |
Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids |
| url |
https://dx.doi.org/10.1007/s10971-016-4053-9 |
| remote_bool |
true |
| author2 |
Pochert, Alexander Beck, Michaela Fiedler, Richard Gruber, Jens Lindén, Mika |
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Pochert, Alexander Beck, Michaela Fiedler, Richard Gruber, Jens Lindén, Mika |
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| doi_str |
10.1007/s10971-016-4053-9 |
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2024-07-03T15:02:55.659Z |
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| score |
7.3995314 |