Geometric features of the Wiseman isotherm in isothermal titration calorimetry

Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Velazquez-Campoy, Adrian [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Isothermal titration calorimetry Binding isotherm Geometric analysis Binding affinity Binding enthalpy

Übergeordnetes Werk:	Enthalten in: Journal of thermal analysis and calorimetry - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969, 122(2015), 3 vom: 02. Juli, Seite 1477-1483
Übergeordnetes Werk:	volume:122 ; year:2015 ; number:3 ; day:02 ; month:07 ; pages:1477-1483

Links:	Volltext

DOI / URN:	10.1007/s10973-015-4775-x

Katalog-ID:	SPR015530442

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520			\|a Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work.
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912			\|a GBV_ILN_170
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912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
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912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
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912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
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912			\|a GBV_ILN_2108
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912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
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912			\|a GBV_ILN_2472
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author_variant	a v c avc
matchkey_str	article:15728943:2015----::emtifaueoteieaiohriiohrat
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publishDate	2015
allfields	10.1007/s10973-015-4775-x doi (DE-627)SPR015530442 (SPR)s10973-015-4775-x-e DE-627 ger DE-627 rakwb eng 660 ASE 35.00 bkl Velazquez-Campoy, Adrian verfasserin aut Geometric features of the Wiseman isotherm in isothermal titration calorimetry 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work. Isothermal titration calorimetry (dpeaa)DE-He213 Binding isotherm (dpeaa)DE-He213 Geometric analysis (dpeaa)DE-He213 Binding affinity (dpeaa)DE-He213 Binding enthalpy (dpeaa)DE-He213 Enthalten in Journal of thermal analysis and calorimetry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 122(2015), 3 vom: 02. Juli, Seite 1477-1483 (DE-627)315295422 (DE-600)2017304-0 1572-8943 nnns volume:122 year:2015 number:3 day:02 month:07 pages:1477-1483 https://dx.doi.org/10.1007/s10973-015-4775-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 122 2015 3 02 07 1477-1483
spelling	10.1007/s10973-015-4775-x doi (DE-627)SPR015530442 (SPR)s10973-015-4775-x-e DE-627 ger DE-627 rakwb eng 660 ASE 35.00 bkl Velazquez-Campoy, Adrian verfasserin aut Geometric features of the Wiseman isotherm in isothermal titration calorimetry 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work. Isothermal titration calorimetry (dpeaa)DE-He213 Binding isotherm (dpeaa)DE-He213 Geometric analysis (dpeaa)DE-He213 Binding affinity (dpeaa)DE-He213 Binding enthalpy (dpeaa)DE-He213 Enthalten in Journal of thermal analysis and calorimetry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 122(2015), 3 vom: 02. Juli, Seite 1477-1483 (DE-627)315295422 (DE-600)2017304-0 1572-8943 nnns volume:122 year:2015 number:3 day:02 month:07 pages:1477-1483 https://dx.doi.org/10.1007/s10973-015-4775-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 122 2015 3 02 07 1477-1483
allfields_unstemmed	10.1007/s10973-015-4775-x doi (DE-627)SPR015530442 (SPR)s10973-015-4775-x-e DE-627 ger DE-627 rakwb eng 660 ASE 35.00 bkl Velazquez-Campoy, Adrian verfasserin aut Geometric features of the Wiseman isotherm in isothermal titration calorimetry 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work. Isothermal titration calorimetry (dpeaa)DE-He213 Binding isotherm (dpeaa)DE-He213 Geometric analysis (dpeaa)DE-He213 Binding affinity (dpeaa)DE-He213 Binding enthalpy (dpeaa)DE-He213 Enthalten in Journal of thermal analysis and calorimetry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 122(2015), 3 vom: 02. Juli, Seite 1477-1483 (DE-627)315295422 (DE-600)2017304-0 1572-8943 nnns volume:122 year:2015 number:3 day:02 month:07 pages:1477-1483 https://dx.doi.org/10.1007/s10973-015-4775-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 122 2015 3 02 07 1477-1483
allfieldsGer	10.1007/s10973-015-4775-x doi (DE-627)SPR015530442 (SPR)s10973-015-4775-x-e DE-627 ger DE-627 rakwb eng 660 ASE 35.00 bkl Velazquez-Campoy, Adrian verfasserin aut Geometric features of the Wiseman isotherm in isothermal titration calorimetry 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work. Isothermal titration calorimetry (dpeaa)DE-He213 Binding isotherm (dpeaa)DE-He213 Geometric analysis (dpeaa)DE-He213 Binding affinity (dpeaa)DE-He213 Binding enthalpy (dpeaa)DE-He213 Enthalten in Journal of thermal analysis and calorimetry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 122(2015), 3 vom: 02. Juli, Seite 1477-1483 (DE-627)315295422 (DE-600)2017304-0 1572-8943 nnns volume:122 year:2015 number:3 day:02 month:07 pages:1477-1483 https://dx.doi.org/10.1007/s10973-015-4775-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 122 2015 3 02 07 1477-1483
allfieldsSound	10.1007/s10973-015-4775-x doi (DE-627)SPR015530442 (SPR)s10973-015-4775-x-e DE-627 ger DE-627 rakwb eng 660 ASE 35.00 bkl Velazquez-Campoy, Adrian verfasserin aut Geometric features of the Wiseman isotherm in isothermal titration calorimetry 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work. Isothermal titration calorimetry (dpeaa)DE-He213 Binding isotherm (dpeaa)DE-He213 Geometric analysis (dpeaa)DE-He213 Binding affinity (dpeaa)DE-He213 Binding enthalpy (dpeaa)DE-He213 Enthalten in Journal of thermal analysis and calorimetry Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 122(2015), 3 vom: 02. Juli, Seite 1477-1483 (DE-627)315295422 (DE-600)2017304-0 1572-8943 nnns volume:122 year:2015 number:3 day:02 month:07 pages:1477-1483 https://dx.doi.org/10.1007/s10973-015-4775-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 ASE AR 122 2015 3 02 07 1477-1483
language	English
source	Enthalten in Journal of thermal analysis and calorimetry 122(2015), 3 vom: 02. Juli, Seite 1477-1483 volume:122 year:2015 number:3 day:02 month:07 pages:1477-1483
sourceStr	Enthalten in Journal of thermal analysis and calorimetry 122(2015), 3 vom: 02. Juli, Seite 1477-1483 volume:122 year:2015 number:3 day:02 month:07 pages:1477-1483
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Isothermal titration calorimetry Binding isotherm Geometric analysis Binding affinity Binding enthalpy
dewey-raw	660
isfreeaccess_bool	false
container_title	Journal of thermal analysis and calorimetry
authorswithroles_txt_mv	Velazquez-Campoy, Adrian @@aut@@
publishDateDaySort_date	2015-07-02T00:00:00Z
hierarchy_top_id	315295422
dewey-sort	3660
id	SPR015530442
language_de	englisch
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author	Velazquez-Campoy, Adrian
spellingShingle	Velazquez-Campoy, Adrian ddc 660 bkl 35.00 misc Isothermal titration calorimetry misc Binding isotherm misc Geometric analysis misc Binding affinity misc Binding enthalpy Geometric features of the Wiseman isotherm in isothermal titration calorimetry
authorStr	Velazquez-Campoy, Adrian
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topic_title	660 ASE 35.00 bkl Geometric features of the Wiseman isotherm in isothermal titration calorimetry Isothermal titration calorimetry (dpeaa)DE-He213 Binding isotherm (dpeaa)DE-He213 Geometric analysis (dpeaa)DE-He213 Binding affinity (dpeaa)DE-He213 Binding enthalpy (dpeaa)DE-He213
topic	ddc 660 bkl 35.00 misc Isothermal titration calorimetry misc Binding isotherm misc Geometric analysis misc Binding affinity misc Binding enthalpy
topic_unstemmed	ddc 660 bkl 35.00 misc Isothermal titration calorimetry misc Binding isotherm misc Geometric analysis misc Binding affinity misc Binding enthalpy
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title	Geometric features of the Wiseman isotherm in isothermal titration calorimetry
ctrlnum	(DE-627)SPR015530442 (SPR)s10973-015-4775-x-e
title_full	Geometric features of the Wiseman isotherm in isothermal titration calorimetry
author_sort	Velazquez-Campoy, Adrian
journal	Journal of thermal analysis and calorimetry
journalStr	Journal of thermal analysis and calorimetry
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title_sort	geometric features of the wiseman isotherm in isothermal titration calorimetry
title_auth	Geometric features of the Wiseman isotherm in isothermal titration calorimetry
abstract	Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work.
abstractGer	Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work.
abstract_unstemmed	Abstract Isothermal titration calorimetry (ITC) has become a standard and preferred technique for studying intermolecular interactions. ITC is the only technique that allows determining the binding affinity, the binding enthalpy, and the stoichiometry in a single experiment. With a practical window of more than five orders of magnitude for reliable binding affinity determination (Kd range from millimolar to nanomolar) and its high sensitivity for measuring small heats of reaction (<1 µJ), it is especially suited for characterizing non-covalent interactions typical from biomacromolecular interactions. The Wiseman isotherm represents the usual way of presenting and analyzing the calorimetric binding data. A geometric analysis of the binding isotherm reveals important connections between certain geometric points in the isotherm and the binding parameters. Thus, although the binding parameters (in particular, affinity and enthalpy) must always be estimated through nonlinear analysis of the binding isotherm, it is also possible to easily obtain estimates of those binding parameters through the relationships presented in this work.
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container_issue	3
title_short	Geometric features of the Wiseman isotherm in isothermal titration calorimetry
url	https://dx.doi.org/10.1007/s10973-015-4775-x
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doi_str	10.1007/s10973-015-4775-x
up_date	2024-07-03T16:50:44.772Z
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Geometric features of the Wiseman isotherm in isothermal titration calorimetry

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