New tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics
Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to hetero...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pulka, Karolina [verfasserIn] Feytens, Debby [verfasserIn] Misicka, Aleksandra [verfasserIn] Tourwé, Dirk [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Molecular diversity - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995, 14(2009), 1 vom: 16. Juni, Seite 97-108 |
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| Übergeordnetes Werk: |
volume:14 ; year:2009 ; number:1 ; day:16 ; month:06 ; pages:97-108 |
| Links: |
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| DOI / URN: |
10.1007/s11030-009-9151-y |
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| Katalog-ID: |
SPR015828042 |
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| 520 | |a Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics. | ||
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| 700 | 1 | |a Misicka, Aleksandra |e verfasserin |4 aut | |
| 700 | 1 | |a Tourwé, Dirk |e verfasserin |4 aut | |
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| allfields |
10.1007/s11030-009-9151-y doi (DE-627)SPR015828042 (SPR)s11030-009-9151-y-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Pulka, Karolina verfasserin aut New tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics. Peptidomimetics (dpeaa)DE-He213 Cyclization (dpeaa)DE-He213 Fused ring system (dpeaa)DE-He213 Imidazolidin-2-ones (dpeaa)DE-He213 Imidazolidines (dpeaa)DE-He213 Piperazin-2-ones (dpeaa)DE-He213 Feytens, Debby verfasserin aut Misicka, Aleksandra verfasserin aut Tourwé, Dirk verfasserin aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 14(2009), 1 vom: 16. Juni, Seite 97-108 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:14 year:2009 number:1 day:16 month:06 pages:97-108 https://dx.doi.org/10.1007/s11030-009-9151-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 14 2009 1 16 06 97-108 |
| spelling |
10.1007/s11030-009-9151-y doi (DE-627)SPR015828042 (SPR)s11030-009-9151-y-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Pulka, Karolina verfasserin aut New tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics. Peptidomimetics (dpeaa)DE-He213 Cyclization (dpeaa)DE-He213 Fused ring system (dpeaa)DE-He213 Imidazolidin-2-ones (dpeaa)DE-He213 Imidazolidines (dpeaa)DE-He213 Piperazin-2-ones (dpeaa)DE-He213 Feytens, Debby verfasserin aut Misicka, Aleksandra verfasserin aut Tourwé, Dirk verfasserin aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 14(2009), 1 vom: 16. Juni, Seite 97-108 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:14 year:2009 number:1 day:16 month:06 pages:97-108 https://dx.doi.org/10.1007/s11030-009-9151-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 14 2009 1 16 06 97-108 |
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10.1007/s11030-009-9151-y doi (DE-627)SPR015828042 (SPR)s11030-009-9151-y-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Pulka, Karolina verfasserin aut New tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics. Peptidomimetics (dpeaa)DE-He213 Cyclization (dpeaa)DE-He213 Fused ring system (dpeaa)DE-He213 Imidazolidin-2-ones (dpeaa)DE-He213 Imidazolidines (dpeaa)DE-He213 Piperazin-2-ones (dpeaa)DE-He213 Feytens, Debby verfasserin aut Misicka, Aleksandra verfasserin aut Tourwé, Dirk verfasserin aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 14(2009), 1 vom: 16. Juni, Seite 97-108 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:14 year:2009 number:1 day:16 month:06 pages:97-108 https://dx.doi.org/10.1007/s11030-009-9151-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 14 2009 1 16 06 97-108 |
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10.1007/s11030-009-9151-y doi (DE-627)SPR015828042 (SPR)s11030-009-9151-y-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Pulka, Karolina verfasserin aut New tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics. Peptidomimetics (dpeaa)DE-He213 Cyclization (dpeaa)DE-He213 Fused ring system (dpeaa)DE-He213 Imidazolidin-2-ones (dpeaa)DE-He213 Imidazolidines (dpeaa)DE-He213 Piperazin-2-ones (dpeaa)DE-He213 Feytens, Debby verfasserin aut Misicka, Aleksandra verfasserin aut Tourwé, Dirk verfasserin aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 14(2009), 1 vom: 16. Juni, Seite 97-108 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:14 year:2009 number:1 day:16 month:06 pages:97-108 https://dx.doi.org/10.1007/s11030-009-9151-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 14 2009 1 16 06 97-108 |
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Enthalten in Molecular diversity 14(2009), 1 vom: 16. Juni, Seite 97-108 volume:14 year:2009 number:1 day:16 month:06 pages:97-108 |
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Peptidomimetics Cyclization Fused ring system Imidazolidin-2-ones Imidazolidines Piperazin-2-ones |
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Molecular diversity |
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Pulka, Karolina @@aut@@ Feytens, Debby @@aut@@ Misicka, Aleksandra @@aut@@ Tourwé, Dirk @@aut@@ |
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2009-06-16T00:00:00Z |
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Pulka, Karolina |
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570 ASE 42.00 bkl New tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics Peptidomimetics (dpeaa)DE-He213 Cyclization (dpeaa)DE-He213 Fused ring system (dpeaa)DE-He213 Imidazolidin-2-ones (dpeaa)DE-He213 Imidazolidines (dpeaa)DE-He213 Piperazin-2-ones (dpeaa)DE-He213 |
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new tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics |
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New tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics |
| abstract |
Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics. |
| abstractGer |
Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics. |
| abstract_unstemmed |
Abstract The Pictet–Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters with 1-(1′-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics. |
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New tetracyclic tetrahydro-β-carbolines as tryptophan-derived peptidomimetics |
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https://dx.doi.org/10.1007/s11030-009-9151-y |
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Feytens, Debby Misicka, Aleksandra Tourwé, Dirk |
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| doi_str |
10.1007/s11030-009-9151-y |
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2024-07-03T18:50:19.992Z |
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code="d">14</subfield><subfield code="j">2009</subfield><subfield code="e">1</subfield><subfield code="b">16</subfield><subfield code="c">06</subfield><subfield code="h">97-108</subfield></datafield></record></collection>
|
| score |
7.40125 |