Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits
Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 loc...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
An, Xiaopeng [verfasserIn] Wang, Lixin [verfasserIn] Hou, Jinxing [verfasserIn] Li, Guang [verfasserIn] Song, Yuxuan [verfasserIn] Wang, Jiangang [verfasserIn] Yang, Mingming [verfasserIn] Cui, Yihong [verfasserIn] Cao, Binyun [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Molecular biology reports - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1973, 38(2010), 6 vom: 25. Nov., Seite 4037-4043 |
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| Übergeordnetes Werk: |
volume:38 ; year:2010 ; number:6 ; day:25 ; month:11 ; pages:4037-4043 |
| Links: |
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| DOI / URN: |
10.1007/s11033-010-0522-3 |
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| Katalog-ID: |
SPR015879755 |
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| 520 | |a Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. | ||
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| 650 | 4 | |a Growth traits |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Goat |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Wang, Lixin |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Jinxing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Guang |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Yuxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jiangang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Mingming |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Yihong |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Binyun |e verfasserin |4 aut | |
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10.1007/s11033-010-0522-3 doi (DE-627)SPR015879755 (SPR)s11033-010-0522-3-e DE-627 ger DE-627 rakwb eng 570 ASE 42.13 bkl An, Xiaopeng verfasserin aut Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. gene (dpeaa)DE-He213 gene (dpeaa)DE-He213 Polymorphisms (dpeaa)DE-He213 Growth traits (dpeaa)DE-He213 Goat (dpeaa)DE-He213 Wang, Lixin verfasserin aut Hou, Jinxing verfasserin aut Li, Guang verfasserin aut Song, Yuxuan verfasserin aut Wang, Jiangang verfasserin aut Yang, Mingming verfasserin aut Cui, Yihong verfasserin aut Cao, Binyun verfasserin aut Enthalten in Molecular biology reports Dordrecht [u.a.] : Springer Science + Business Media B.V, 1973 38(2010), 6 vom: 25. Nov., Seite 4037-4043 (DE-627)270930639 (DE-600)1478217-0 1573-4978 nnns volume:38 year:2010 number:6 day:25 month:11 pages:4037-4043 https://dx.doi.org/10.1007/s11033-010-0522-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 ASE AR 38 2010 6 25 11 4037-4043 |
| spelling |
10.1007/s11033-010-0522-3 doi (DE-627)SPR015879755 (SPR)s11033-010-0522-3-e DE-627 ger DE-627 rakwb eng 570 ASE 42.13 bkl An, Xiaopeng verfasserin aut Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. gene (dpeaa)DE-He213 gene (dpeaa)DE-He213 Polymorphisms (dpeaa)DE-He213 Growth traits (dpeaa)DE-He213 Goat (dpeaa)DE-He213 Wang, Lixin verfasserin aut Hou, Jinxing verfasserin aut Li, Guang verfasserin aut Song, Yuxuan verfasserin aut Wang, Jiangang verfasserin aut Yang, Mingming verfasserin aut Cui, Yihong verfasserin aut Cao, Binyun verfasserin aut Enthalten in Molecular biology reports Dordrecht [u.a.] : Springer Science + Business Media B.V, 1973 38(2010), 6 vom: 25. Nov., Seite 4037-4043 (DE-627)270930639 (DE-600)1478217-0 1573-4978 nnns volume:38 year:2010 number:6 day:25 month:11 pages:4037-4043 https://dx.doi.org/10.1007/s11033-010-0522-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 ASE AR 38 2010 6 25 11 4037-4043 |
| allfields_unstemmed |
10.1007/s11033-010-0522-3 doi (DE-627)SPR015879755 (SPR)s11033-010-0522-3-e DE-627 ger DE-627 rakwb eng 570 ASE 42.13 bkl An, Xiaopeng verfasserin aut Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. gene (dpeaa)DE-He213 gene (dpeaa)DE-He213 Polymorphisms (dpeaa)DE-He213 Growth traits (dpeaa)DE-He213 Goat (dpeaa)DE-He213 Wang, Lixin verfasserin aut Hou, Jinxing verfasserin aut Li, Guang verfasserin aut Song, Yuxuan verfasserin aut Wang, Jiangang verfasserin aut Yang, Mingming verfasserin aut Cui, Yihong verfasserin aut Cao, Binyun verfasserin aut Enthalten in Molecular biology reports Dordrecht [u.a.] : Springer Science + Business Media B.V, 1973 38(2010), 6 vom: 25. Nov., Seite 4037-4043 (DE-627)270930639 (DE-600)1478217-0 1573-4978 nnns volume:38 year:2010 number:6 day:25 month:11 pages:4037-4043 https://dx.doi.org/10.1007/s11033-010-0522-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 ASE AR 38 2010 6 25 11 4037-4043 |
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10.1007/s11033-010-0522-3 doi (DE-627)SPR015879755 (SPR)s11033-010-0522-3-e DE-627 ger DE-627 rakwb eng 570 ASE 42.13 bkl An, Xiaopeng verfasserin aut Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. gene (dpeaa)DE-He213 gene (dpeaa)DE-He213 Polymorphisms (dpeaa)DE-He213 Growth traits (dpeaa)DE-He213 Goat (dpeaa)DE-He213 Wang, Lixin verfasserin aut Hou, Jinxing verfasserin aut Li, Guang verfasserin aut Song, Yuxuan verfasserin aut Wang, Jiangang verfasserin aut Yang, Mingming verfasserin aut Cui, Yihong verfasserin aut Cao, Binyun verfasserin aut Enthalten in Molecular biology reports Dordrecht [u.a.] : Springer Science + Business Media B.V, 1973 38(2010), 6 vom: 25. Nov., Seite 4037-4043 (DE-627)270930639 (DE-600)1478217-0 1573-4978 nnns volume:38 year:2010 number:6 day:25 month:11 pages:4037-4043 https://dx.doi.org/10.1007/s11033-010-0522-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 ASE AR 38 2010 6 25 11 4037-4043 |
| allfieldsSound |
10.1007/s11033-010-0522-3 doi (DE-627)SPR015879755 (SPR)s11033-010-0522-3-e DE-627 ger DE-627 rakwb eng 570 ASE 42.13 bkl An, Xiaopeng verfasserin aut Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. gene (dpeaa)DE-He213 gene (dpeaa)DE-He213 Polymorphisms (dpeaa)DE-He213 Growth traits (dpeaa)DE-He213 Goat (dpeaa)DE-He213 Wang, Lixin verfasserin aut Hou, Jinxing verfasserin aut Li, Guang verfasserin aut Song, Yuxuan verfasserin aut Wang, Jiangang verfasserin aut Yang, Mingming verfasserin aut Cui, Yihong verfasserin aut Cao, Binyun verfasserin aut Enthalten in Molecular biology reports Dordrecht [u.a.] : Springer Science + Business Media B.V, 1973 38(2010), 6 vom: 25. Nov., Seite 4037-4043 (DE-627)270930639 (DE-600)1478217-0 1573-4978 nnns volume:38 year:2010 number:6 day:25 month:11 pages:4037-4043 https://dx.doi.org/10.1007/s11033-010-0522-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.13 ASE AR 38 2010 6 25 11 4037-4043 |
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English |
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Enthalten in Molecular biology reports 38(2010), 6 vom: 25. Nov., Seite 4037-4043 volume:38 year:2010 number:6 day:25 month:11 pages:4037-4043 |
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Enthalten in Molecular biology reports 38(2010), 6 vom: 25. Nov., Seite 4037-4043 volume:38 year:2010 number:6 day:25 month:11 pages:4037-4043 |
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An, Xiaopeng @@aut@@ Wang, Lixin @@aut@@ Hou, Jinxing @@aut@@ Li, Guang @@aut@@ Song, Yuxuan @@aut@@ Wang, Jiangang @@aut@@ Yang, Mingming @@aut@@ Cui, Yihong @@aut@@ Cao, Binyun @@aut@@ |
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2010-11-25T00:00:00Z |
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Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. 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|
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An, Xiaopeng |
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An, Xiaopeng ddc 570 bkl 42.13 misc gene misc Polymorphisms misc Growth traits misc Goat Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits |
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570 ASE 42.13 bkl Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits gene (dpeaa)DE-He213 Polymorphisms (dpeaa)DE-He213 Growth traits (dpeaa)DE-He213 Goat (dpeaa)DE-He213 |
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ddc 570 bkl 42.13 misc gene misc Polymorphisms misc Growth traits misc Goat |
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ddc 570 bkl 42.13 misc gene misc Polymorphisms misc Growth traits misc Goat |
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Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits |
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Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits |
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An, Xiaopeng |
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Molecular biology reports |
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An, Xiaopeng Wang, Lixin Hou, Jinxing Li, Guang Song, Yuxuan Wang, Jiangang Yang, Mingming Cui, Yihong Cao, Binyun |
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10.1007/s11033-010-0522-3 |
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| title_sort |
novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits |
| title_auth |
Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits |
| abstract |
Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. |
| abstractGer |
Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. |
| abstract_unstemmed |
Abstract In this study, the polymorphisms of growth hormone (GH) gene 5′ promoter region and intron 8, exons 4 and 10 of growth hormone receptor (GHR) gene were analyzed in Xinong Saanen goats (SG) and Boer goats (BG). Two alleles (A and B) and three genotypes (AA, AB and BB) were detected at P1 locus of GH gene, and two alleles (G and T) and two genotypes (GG and GT) were detected at P4 locus of GHR gene by PCR-SSCP analysis. In addition, two single nucleotide polymorphisms (SNPs)-A73C (P1 locus) and G114T (P4 locus), were identified by DNA sequencing. The frequencies of alleles A and B in the two goat breeds were 0.61–0.62, and 0.39–0.38, respectively, and the frequencies of alleles G and T in the two goat breeds were 0.82–0.86, and 0.18–0.14, respectively. The SNP loci were in Hardy–Weinberg disequilibrium in both goat breeds (P < 0.05). Polymorphisms of GH and GHR genes were shown to be associated with growth traits in BG breed. AA and GG genotypes were associated with superior growth traits in 1-, 2- and 3-month old individuals. Hence, AA and GG genotypes are suggested to be a molecular marker for superior growth traits in BG breed. |
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Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits |
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Wang, Lixin Hou, Jinxing Li, Guang Song, Yuxuan Wang, Jiangang Yang, Mingming Cui, Yihong Cao, Binyun |
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| score |
7.4006147 |