Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats
A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors – vascular endothelia growth factor (VEGF) and fibroblast growth fa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Shaimardanova, G. F. [verfasserIn] Mukhamedshina, Ya. O. [verfasserIn] Rizvanov, A. A. [verfasserIn] Salafutdinov, I. I. [verfasserIn] Chelyshev, Yu. A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Neuroscience and behavioral physiology - New York, NY : Consultants Bureau, 1967, 43(2013), 5 vom: Juni, Seite 597-601 |
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| Übergeordnetes Werk: |
volume:43 ; year:2013 ; number:5 ; month:06 ; pages:597-601 |
| Links: |
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| DOI / URN: |
10.1007/s11055-013-9778-0 |
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| Katalog-ID: |
SPR016117654 |
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| 245 | 1 | 0 | |a Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats |
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| 520 | |a A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors – vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) – into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%. By this time, the outer areas of the white matter in animals of this group, 1.5 cm from the trauma epicenter, showed an average 30% increase in the number of perivascular cells expressing platelet-derived growth factor β receptors (PDGFβR). Addition of therapeutic genes VEGF an FGF2 to the trauma injury zone and their expression in carrier cells stimulated vascularization and post-traumatic regeneration of the spinal cord. | ||
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| 650 | 4 | |a cord blood cells |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a VEGF |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a FGF2 |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mukhamedshina, Ya. O. |e verfasserin |4 aut | |
| 700 | 1 | |a Rizvanov, A. A. |e verfasserin |4 aut | |
| 700 | 1 | |a Salafutdinov, I. I. |e verfasserin |4 aut | |
| 700 | 1 | |a Chelyshev, Yu. A. |e verfasserin |4 aut | |
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10.1007/s11055-013-9778-0 doi (DE-627)SPR016117654 (SPR)s11055-013-9778-0-e DE-627 ger DE-627 rakwb eng 570 610 ASE 44.90 bkl Shaimardanova, G. F. verfasserin aut Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors – vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) – into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%. By this time, the outer areas of the white matter in animals of this group, 1.5 cm from the trauma epicenter, showed an average 30% increase in the number of perivascular cells expressing platelet-derived growth factor β receptors (PDGFβR). Addition of therapeutic genes VEGF an FGF2 to the trauma injury zone and their expression in carrier cells stimulated vascularization and post-traumatic regeneration of the spinal cord. spinal cord (dpeaa)DE-He213 regeneration (dpeaa)DE-He213 cord blood cells (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 FGF2 (dpeaa)DE-He213 Mukhamedshina, Ya. O. verfasserin aut Rizvanov, A. A. verfasserin aut Salafutdinov, I. I. verfasserin aut Chelyshev, Yu. A. verfasserin aut Enthalten in Neuroscience and behavioral physiology New York, NY : Consultants Bureau, 1967 43(2013), 5 vom: Juni, Seite 597-601 (DE-627)325573425 (DE-600)2037678-9 1573-899X nnns volume:43 year:2013 number:5 month:06 pages:597-601 https://dx.doi.org/10.1007/s11055-013-9778-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 43 2013 5 06 597-601 |
| spelling |
10.1007/s11055-013-9778-0 doi (DE-627)SPR016117654 (SPR)s11055-013-9778-0-e DE-627 ger DE-627 rakwb eng 570 610 ASE 44.90 bkl Shaimardanova, G. F. verfasserin aut Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors – vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) – into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%. By this time, the outer areas of the white matter in animals of this group, 1.5 cm from the trauma epicenter, showed an average 30% increase in the number of perivascular cells expressing platelet-derived growth factor β receptors (PDGFβR). Addition of therapeutic genes VEGF an FGF2 to the trauma injury zone and their expression in carrier cells stimulated vascularization and post-traumatic regeneration of the spinal cord. spinal cord (dpeaa)DE-He213 regeneration (dpeaa)DE-He213 cord blood cells (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 FGF2 (dpeaa)DE-He213 Mukhamedshina, Ya. O. verfasserin aut Rizvanov, A. A. verfasserin aut Salafutdinov, I. I. verfasserin aut Chelyshev, Yu. A. verfasserin aut Enthalten in Neuroscience and behavioral physiology New York, NY : Consultants Bureau, 1967 43(2013), 5 vom: Juni, Seite 597-601 (DE-627)325573425 (DE-600)2037678-9 1573-899X nnns volume:43 year:2013 number:5 month:06 pages:597-601 https://dx.doi.org/10.1007/s11055-013-9778-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 43 2013 5 06 597-601 |
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10.1007/s11055-013-9778-0 doi (DE-627)SPR016117654 (SPR)s11055-013-9778-0-e DE-627 ger DE-627 rakwb eng 570 610 ASE 44.90 bkl Shaimardanova, G. F. verfasserin aut Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors – vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) – into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%. By this time, the outer areas of the white matter in animals of this group, 1.5 cm from the trauma epicenter, showed an average 30% increase in the number of perivascular cells expressing platelet-derived growth factor β receptors (PDGFβR). Addition of therapeutic genes VEGF an FGF2 to the trauma injury zone and their expression in carrier cells stimulated vascularization and post-traumatic regeneration of the spinal cord. spinal cord (dpeaa)DE-He213 regeneration (dpeaa)DE-He213 cord blood cells (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 FGF2 (dpeaa)DE-He213 Mukhamedshina, Ya. O. verfasserin aut Rizvanov, A. A. verfasserin aut Salafutdinov, I. I. verfasserin aut Chelyshev, Yu. A. verfasserin aut Enthalten in Neuroscience and behavioral physiology New York, NY : Consultants Bureau, 1967 43(2013), 5 vom: Juni, Seite 597-601 (DE-627)325573425 (DE-600)2037678-9 1573-899X nnns volume:43 year:2013 number:5 month:06 pages:597-601 https://dx.doi.org/10.1007/s11055-013-9778-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 43 2013 5 06 597-601 |
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Enthalten in Neuroscience and behavioral physiology 43(2013), 5 vom: Juni, Seite 597-601 volume:43 year:2013 number:5 month:06 pages:597-601 |
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Enthalten in Neuroscience and behavioral physiology 43(2013), 5 vom: Juni, Seite 597-601 volume:43 year:2013 number:5 month:06 pages:597-601 |
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Neuroscience and behavioral physiology |
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Shaimardanova, G. F. @@aut@@ Mukhamedshina, Ya. O. @@aut@@ Rizvanov, A. A. @@aut@@ Salafutdinov, I. I. @@aut@@ Chelyshev, Yu. A. @@aut@@ |
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Shaimardanova, G. F. |
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Shaimardanova, G. F. ddc 570 bkl 44.90 misc spinal cord misc regeneration misc cord blood cells misc VEGF misc FGF2 Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats |
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570 610 ASE 44.90 bkl Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats spinal cord (dpeaa)DE-He213 regeneration (dpeaa)DE-He213 cord blood cells (dpeaa)DE-He213 VEGF (dpeaa)DE-He213 FGF2 (dpeaa)DE-He213 |
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ddc 570 bkl 44.90 misc spinal cord misc regeneration misc cord blood cells misc VEGF misc FGF2 |
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ddc 570 bkl 44.90 misc spinal cord misc regeneration misc cord blood cells misc VEGF misc FGF2 |
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Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats |
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Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats |
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Shaimardanova, G. F. |
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Neuroscience and behavioral physiology |
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Shaimardanova, G. F. Mukhamedshina, Ya. O. Rizvanov, A. A. Salafutdinov, I. I. Chelyshev, Yu. A. |
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effects of transplantation of human cord blood mononuclear cells expressing the recombinant vegf and fgf2 genes into spinal cord traumatic injury sites in rats |
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Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats |
| abstract |
A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors – vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) – into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%. By this time, the outer areas of the white matter in animals of this group, 1.5 cm from the trauma epicenter, showed an average 30% increase in the number of perivascular cells expressing platelet-derived growth factor β receptors (PDGFβR). Addition of therapeutic genes VEGF an FGF2 to the trauma injury zone and their expression in carrier cells stimulated vascularization and post-traumatic regeneration of the spinal cord. |
| abstractGer |
A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors – vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) – into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%. By this time, the outer areas of the white matter in animals of this group, 1.5 cm from the trauma epicenter, showed an average 30% increase in the number of perivascular cells expressing platelet-derived growth factor β receptors (PDGFβR). Addition of therapeutic genes VEGF an FGF2 to the trauma injury zone and their expression in carrier cells stimulated vascularization and post-traumatic regeneration of the spinal cord. |
| abstract_unstemmed |
A model of dosed TVIII spinal cord contusion trauma in rats was used to study the effects of immediate single-dose transplantation of human cord blood mononuclear cells transformed with the recombinant genes for neurotrophic factors – vascular endothelia growth factor (VEGF) and fibroblast growth factor 2 (FGF2) – into the injury zone. A further group of animals, in the same conditions, received the same cells transfected with plasmid pEGFP-N2. EGFP-labeled cells were detected in the white matter for 21 days after transplantation at distances of at least 10 mm in the rostral and caudal directions from the administration point. By 30 days after transplantation with cells transfected with plasmid pBud-VEGF-FGF2, the area of intact gray matter 3 mm from the trauma epicenter increased by more than 60%. By this time, the outer areas of the white matter in animals of this group, 1.5 cm from the trauma epicenter, showed an average 30% increase in the number of perivascular cells expressing platelet-derived growth factor β receptors (PDGFβR). Addition of therapeutic genes VEGF an FGF2 to the trauma injury zone and their expression in carrier cells stimulated vascularization and post-traumatic regeneration of the spinal cord. |
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| title_short |
Effects of Transplantation of Human Cord Blood Mononuclear Cells Expressing the Recombinant VEGF and FGF2 Genes into Spinal Cord Traumatic Injury Sites in Rats |
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https://dx.doi.org/10.1007/s11055-013-9778-0 |
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Mukhamedshina, Ya. O. Rizvanov, A. A. Salafutdinov, I. I. Chelyshev, Yu. A. |
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| doi_str |
10.1007/s11055-013-9778-0 |
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2024-07-03T20:55:13.486Z |
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| score |
7.401602 |