Treatment options in childhood pontine gliomas
Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database we...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wagner, Sabine [verfasserIn] Warmuth-Metz, Monika [verfasserIn] Emser, Angela [verfasserIn] Gnekow, Astrid-K. [verfasserIn] Sträter, Ronald [verfasserIn] Rutkowski, Stefan [verfasserIn] Jorch, Norbert [verfasserIn] Schmid, Hans-J. [verfasserIn] Berthold, Frank [verfasserIn] Graf, Norbert [verfasserIn] Kortmann, Rolf-D. [verfasserIn] Pietsch, Thorsten [verfasserIn] Sörensen, Norbert [verfasserIn] Peters, Ove [verfasserIn] Wolff, Johannes E.A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2006 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neuro-oncology - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983, 79(2006), 3 vom: 06. Apr., Seite 281-287 |
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| Übergeordnetes Werk: |
volume:79 ; year:2006 ; number:3 ; day:06 ; month:04 ; pages:281-287 |
| Links: |
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| DOI / URN: |
10.1007/s11060-006-9133-1 |
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| Katalog-ID: |
SPR016155920 |
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| 245 | 1 | 0 | |a Treatment options in childhood pontine gliomas |
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| 520 | |a Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. | ||
| 650 | 4 | |a chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a children |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a irradiation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a pontine glioma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a survival |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Warmuth-Metz, Monika |e verfasserin |4 aut | |
| 700 | 1 | |a Emser, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Gnekow, Astrid-K. |e verfasserin |4 aut | |
| 700 | 1 | |a Sträter, Ronald |e verfasserin |4 aut | |
| 700 | 1 | |a Rutkowski, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Jorch, Norbert |e verfasserin |4 aut | |
| 700 | 1 | |a Schmid, Hans-J. |e verfasserin |4 aut | |
| 700 | 1 | |a Berthold, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Graf, Norbert |e verfasserin |4 aut | |
| 700 | 1 | |a Kortmann, Rolf-D. |e verfasserin |4 aut | |
| 700 | 1 | |a Pietsch, Thorsten |e verfasserin |4 aut | |
| 700 | 1 | |a Sörensen, Norbert |e verfasserin |4 aut | |
| 700 | 1 | |a Peters, Ove |e verfasserin |4 aut | |
| 700 | 1 | |a Wolff, Johannes E.A. |e verfasserin |4 aut | |
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10.1007/s11060-006-9133-1 doi (DE-627)SPR016155920 (SPR)s11060-006-9133-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wagner, Sabine verfasserin aut Treatment options in childhood pontine gliomas 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. chemotherapy (dpeaa)DE-He213 children (dpeaa)DE-He213 irradiation (dpeaa)DE-He213 pontine glioma (dpeaa)DE-He213 survival (dpeaa)DE-He213 Warmuth-Metz, Monika verfasserin aut Emser, Angela verfasserin aut Gnekow, Astrid-K. verfasserin aut Sträter, Ronald verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Schmid, Hans-J. verfasserin aut Berthold, Frank verfasserin aut Graf, Norbert verfasserin aut Kortmann, Rolf-D. verfasserin aut Pietsch, Thorsten verfasserin aut Sörensen, Norbert verfasserin aut Peters, Ove verfasserin aut Wolff, Johannes E.A. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 06. Apr., Seite 281-287 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:06 month:04 pages:281-287 https://dx.doi.org/10.1007/s11060-006-9133-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 06 04 281-287 |
| spelling |
10.1007/s11060-006-9133-1 doi (DE-627)SPR016155920 (SPR)s11060-006-9133-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wagner, Sabine verfasserin aut Treatment options in childhood pontine gliomas 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. chemotherapy (dpeaa)DE-He213 children (dpeaa)DE-He213 irradiation (dpeaa)DE-He213 pontine glioma (dpeaa)DE-He213 survival (dpeaa)DE-He213 Warmuth-Metz, Monika verfasserin aut Emser, Angela verfasserin aut Gnekow, Astrid-K. verfasserin aut Sträter, Ronald verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Schmid, Hans-J. verfasserin aut Berthold, Frank verfasserin aut Graf, Norbert verfasserin aut Kortmann, Rolf-D. verfasserin aut Pietsch, Thorsten verfasserin aut Sörensen, Norbert verfasserin aut Peters, Ove verfasserin aut Wolff, Johannes E.A. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 06. Apr., Seite 281-287 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:06 month:04 pages:281-287 https://dx.doi.org/10.1007/s11060-006-9133-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 06 04 281-287 |
| allfields_unstemmed |
10.1007/s11060-006-9133-1 doi (DE-627)SPR016155920 (SPR)s11060-006-9133-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wagner, Sabine verfasserin aut Treatment options in childhood pontine gliomas 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. chemotherapy (dpeaa)DE-He213 children (dpeaa)DE-He213 irradiation (dpeaa)DE-He213 pontine glioma (dpeaa)DE-He213 survival (dpeaa)DE-He213 Warmuth-Metz, Monika verfasserin aut Emser, Angela verfasserin aut Gnekow, Astrid-K. verfasserin aut Sträter, Ronald verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Schmid, Hans-J. verfasserin aut Berthold, Frank verfasserin aut Graf, Norbert verfasserin aut Kortmann, Rolf-D. verfasserin aut Pietsch, Thorsten verfasserin aut Sörensen, Norbert verfasserin aut Peters, Ove verfasserin aut Wolff, Johannes E.A. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 06. Apr., Seite 281-287 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:06 month:04 pages:281-287 https://dx.doi.org/10.1007/s11060-006-9133-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 06 04 281-287 |
| allfieldsGer |
10.1007/s11060-006-9133-1 doi (DE-627)SPR016155920 (SPR)s11060-006-9133-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wagner, Sabine verfasserin aut Treatment options in childhood pontine gliomas 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. chemotherapy (dpeaa)DE-He213 children (dpeaa)DE-He213 irradiation (dpeaa)DE-He213 pontine glioma (dpeaa)DE-He213 survival (dpeaa)DE-He213 Warmuth-Metz, Monika verfasserin aut Emser, Angela verfasserin aut Gnekow, Astrid-K. verfasserin aut Sträter, Ronald verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Schmid, Hans-J. verfasserin aut Berthold, Frank verfasserin aut Graf, Norbert verfasserin aut Kortmann, Rolf-D. verfasserin aut Pietsch, Thorsten verfasserin aut Sörensen, Norbert verfasserin aut Peters, Ove verfasserin aut Wolff, Johannes E.A. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 06. Apr., Seite 281-287 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:06 month:04 pages:281-287 https://dx.doi.org/10.1007/s11060-006-9133-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 06 04 281-287 |
| allfieldsSound |
10.1007/s11060-006-9133-1 doi (DE-627)SPR016155920 (SPR)s11060-006-9133-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wagner, Sabine verfasserin aut Treatment options in childhood pontine gliomas 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. chemotherapy (dpeaa)DE-He213 children (dpeaa)DE-He213 irradiation (dpeaa)DE-He213 pontine glioma (dpeaa)DE-He213 survival (dpeaa)DE-He213 Warmuth-Metz, Monika verfasserin aut Emser, Angela verfasserin aut Gnekow, Astrid-K. verfasserin aut Sträter, Ronald verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Schmid, Hans-J. verfasserin aut Berthold, Frank verfasserin aut Graf, Norbert verfasserin aut Kortmann, Rolf-D. verfasserin aut Pietsch, Thorsten verfasserin aut Sörensen, Norbert verfasserin aut Peters, Ove verfasserin aut Wolff, Johannes E.A. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 06. Apr., Seite 281-287 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:06 month:04 pages:281-287 https://dx.doi.org/10.1007/s11060-006-9133-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 06 04 281-287 |
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Enthalten in Journal of neuro-oncology 79(2006), 3 vom: 06. Apr., Seite 281-287 volume:79 year:2006 number:3 day:06 month:04 pages:281-287 |
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Wagner, Sabine @@aut@@ Warmuth-Metz, Monika @@aut@@ Emser, Angela @@aut@@ Gnekow, Astrid-K. @@aut@@ Sträter, Ronald @@aut@@ Rutkowski, Stefan @@aut@@ Jorch, Norbert @@aut@@ Schmid, Hans-J. @@aut@@ Berthold, Frank @@aut@@ Graf, Norbert @@aut@@ Kortmann, Rolf-D. @@aut@@ Pietsch, Thorsten @@aut@@ Sörensen, Norbert @@aut@@ Peters, Ove @@aut@@ Wolff, Johannes E.A. @@aut@@ |
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Wagner, Sabine |
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Wagner, Sabine ddc 610 bkl 44.81 bkl 44.90 misc chemotherapy misc children misc irradiation misc pontine glioma misc survival Treatment options in childhood pontine gliomas |
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610 ASE 44.81 bkl 44.90 bkl Treatment options in childhood pontine gliomas chemotherapy (dpeaa)DE-He213 children (dpeaa)DE-He213 irradiation (dpeaa)DE-He213 pontine glioma (dpeaa)DE-He213 survival (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 bkl 44.90 misc chemotherapy misc children misc irradiation misc pontine glioma misc survival |
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ddc 610 bkl 44.81 bkl 44.90 misc chemotherapy misc children misc irradiation misc pontine glioma misc survival |
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Journal of neuro-oncology |
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Treatment options in childhood pontine gliomas |
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Treatment options in childhood pontine gliomas |
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Wagner, Sabine |
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Journal of neuro-oncology |
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Wagner, Sabine Warmuth-Metz, Monika Emser, Angela Gnekow, Astrid-K. Sträter, Ronald Rutkowski, Stefan Jorch, Norbert Schmid, Hans-J. Berthold, Frank Graf, Norbert Kortmann, Rolf-D. Pietsch, Thorsten Sörensen, Norbert Peters, Ove Wolff, Johannes E.A. |
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Wagner, Sabine |
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10.1007/s11060-006-9133-1 |
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treatment options in childhood pontine gliomas |
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Treatment options in childhood pontine gliomas |
| abstract |
Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. |
| abstractGer |
Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. |
| abstract_unstemmed |
Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. Intensive chemotherapy seems to be important in achieving a better OS. |
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Treatment options in childhood pontine gliomas |
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Warmuth-Metz, Monika Emser, Angela Gnekow, Astrid-K. Sträter, Ronald Rutkowski, Stefan Jorch, Norbert Schmid, Hans-J. Berthold, Frank Graf, Norbert Kortmann, Rolf-D. Pietsch, Thorsten Sörensen, Norbert Peters, Ove Wolff, Johannes E.A. |
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Warmuth-Metz, Monika Emser, Angela Gnekow, Astrid-K. Sträter, Ronald Rutkowski, Stefan Jorch, Norbert Schmid, Hans-J. Berthold, Frank Graf, Norbert Kortmann, Rolf-D. Pietsch, Thorsten Sörensen, Norbert Peters, Ove Wolff, Johannes E.A. |
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2024-07-03T21:10:21.929Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR016155920</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519174050.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2006 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s11060-006-9133-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR016155920</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s11060-006-9133-1-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.81</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.90</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wagner, Sabine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Treatment options in childhood pontine gliomas</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2006</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed. Patients and methods Data of children with pontine gliomas treated in different prospective multi-center studies who were registered in the HIT-GBM database were pooled and analyzed addressing prognostic factors and the relevance of intensive treatment using contingency tables, Kaplan–Meier curves and Cox regression analyses. Results From 1983 to 2001, 153 patients (74 males, 79 females, mean age: 8.1 years) with pontine gliomas were registered. Twenty-one tumors were low-grade and 60 were high-grade gliomas (72 undefined histology: 67 no surgery, 5 incomplete data). Sixteen tumors were partially resected, and 125 were irradiated. Ninety children received chemotherapy according to the “HIT-GBM” protocols (“Hirntumor-Glioblastoma multiforme”). The one-year overall survival rate (1YOS) of all patients with pontine glioma was 39.9±4.3%. None of the surviving patients had an observation time longer than 3.9 years. Favorable prognostic factors seemed to be age younger than 4 years, low-grade histology and smaller tumor. All three major treatment modalities including resection, irradiation and chemotherapy had prognostic relevance in univariable analysis. Chemotherapy remained beneficial, even if the analysis was restricted to the subgroup of irradiated tumors (1YOS 45.8±5.4% vs. 34.4±13.5%, P=0.030). Conclusion Irradiation is an effective element for the treatment of pontine gliomas. 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