Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma
Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous ra...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wolff, Johannes E. A. [verfasserIn] Wagner, Sabine [verfasserIn] Reinert, Christiane [verfasserIn] Gnekow, Astrid [verfasserIn] Kortmann, R. -D. [verfasserIn] Kühl, Joachim [verfasserIn] Van Gool, Stefaan W. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2006 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neuro-oncology - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983, 79(2006), 3 vom: 28. Apr., Seite 315-321 |
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| Übergeordnetes Werk: |
volume:79 ; year:2006 ; number:3 ; day:28 ; month:04 ; pages:315-321 |
| Links: |
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| DOI / URN: |
10.1007/s11060-006-9147-8 |
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| Katalog-ID: |
SPR01615603X |
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| 245 | 1 | 0 | |a Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma |
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| 520 | |a Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. | ||
| 650 | 4 | |a IFN-γ |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Children |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Glioma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cyclophosphamide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pons |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Wagner, Sabine |e verfasserin |4 aut | |
| 700 | 1 | |a Reinert, Christiane |e verfasserin |4 aut | |
| 700 | 1 | |a Gnekow, Astrid |e verfasserin |4 aut | |
| 700 | 1 | |a Kortmann, R. -D. |e verfasserin |4 aut | |
| 700 | 1 | |a Kühl, Joachim |e verfasserin |4 aut | |
| 700 | 1 | |a Van Gool, Stefaan W. |e verfasserin |4 aut | |
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10.1007/s11060-006-9147-8 doi (DE-627)SPR01615603X (SPR)s11060-006-9147-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. IFN-γ (dpeaa)DE-He213 Children (dpeaa)DE-He213 Glioma (dpeaa)DE-He213 Cyclophosphamide (dpeaa)DE-He213 Pons (dpeaa)DE-He213 Wagner, Sabine verfasserin aut Reinert, Christiane verfasserin aut Gnekow, Astrid verfasserin aut Kortmann, R. -D. verfasserin aut Kühl, Joachim verfasserin aut Van Gool, Stefaan W. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 28. Apr., Seite 315-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:28 month:04 pages:315-321 https://dx.doi.org/10.1007/s11060-006-9147-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 28 04 315-321 |
| spelling |
10.1007/s11060-006-9147-8 doi (DE-627)SPR01615603X (SPR)s11060-006-9147-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. IFN-γ (dpeaa)DE-He213 Children (dpeaa)DE-He213 Glioma (dpeaa)DE-He213 Cyclophosphamide (dpeaa)DE-He213 Pons (dpeaa)DE-He213 Wagner, Sabine verfasserin aut Reinert, Christiane verfasserin aut Gnekow, Astrid verfasserin aut Kortmann, R. -D. verfasserin aut Kühl, Joachim verfasserin aut Van Gool, Stefaan W. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 28. Apr., Seite 315-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:28 month:04 pages:315-321 https://dx.doi.org/10.1007/s11060-006-9147-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 28 04 315-321 |
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10.1007/s11060-006-9147-8 doi (DE-627)SPR01615603X (SPR)s11060-006-9147-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. IFN-γ (dpeaa)DE-He213 Children (dpeaa)DE-He213 Glioma (dpeaa)DE-He213 Cyclophosphamide (dpeaa)DE-He213 Pons (dpeaa)DE-He213 Wagner, Sabine verfasserin aut Reinert, Christiane verfasserin aut Gnekow, Astrid verfasserin aut Kortmann, R. -D. verfasserin aut Kühl, Joachim verfasserin aut Van Gool, Stefaan W. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 28. Apr., Seite 315-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:28 month:04 pages:315-321 https://dx.doi.org/10.1007/s11060-006-9147-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 28 04 315-321 |
| allfieldsGer |
10.1007/s11060-006-9147-8 doi (DE-627)SPR01615603X (SPR)s11060-006-9147-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. IFN-γ (dpeaa)DE-He213 Children (dpeaa)DE-He213 Glioma (dpeaa)DE-He213 Cyclophosphamide (dpeaa)DE-He213 Pons (dpeaa)DE-He213 Wagner, Sabine verfasserin aut Reinert, Christiane verfasserin aut Gnekow, Astrid verfasserin aut Kortmann, R. -D. verfasserin aut Kühl, Joachim verfasserin aut Van Gool, Stefaan W. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 28. Apr., Seite 315-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:28 month:04 pages:315-321 https://dx.doi.org/10.1007/s11060-006-9147-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 28 04 315-321 |
| allfieldsSound |
10.1007/s11060-006-9147-8 doi (DE-627)SPR01615603X (SPR)s11060-006-9147-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. IFN-γ (dpeaa)DE-He213 Children (dpeaa)DE-He213 Glioma (dpeaa)DE-He213 Cyclophosphamide (dpeaa)DE-He213 Pons (dpeaa)DE-He213 Wagner, Sabine verfasserin aut Reinert, Christiane verfasserin aut Gnekow, Astrid verfasserin aut Kortmann, R. -D. verfasserin aut Kühl, Joachim verfasserin aut Van Gool, Stefaan W. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 79(2006), 3 vom: 28. Apr., Seite 315-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:79 year:2006 number:3 day:28 month:04 pages:315-321 https://dx.doi.org/10.1007/s11060-006-9147-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 79 2006 3 28 04 315-321 |
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English |
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Enthalten in Journal of neuro-oncology 79(2006), 3 vom: 28. Apr., Seite 315-321 volume:79 year:2006 number:3 day:28 month:04 pages:315-321 |
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Enthalten in Journal of neuro-oncology 79(2006), 3 vom: 28. Apr., Seite 315-321 volume:79 year:2006 number:3 day:28 month:04 pages:315-321 |
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IFN-γ Children Glioma Cyclophosphamide Pons |
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Wolff, Johannes E. A. @@aut@@ Wagner, Sabine @@aut@@ Reinert, Christiane @@aut@@ Gnekow, Astrid @@aut@@ Kortmann, R. -D. @@aut@@ Kühl, Joachim @@aut@@ Van Gool, Stefaan W. @@aut@@ |
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A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2006</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). 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Wolff, Johannes E. A. |
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Wolff, Johannes E. A. ddc 610 bkl 44.81 bkl 44.90 misc IFN-γ misc Children misc Glioma misc Cyclophosphamide misc Pons Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma |
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610 ASE 44.81 bkl 44.90 bkl Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma IFN-γ (dpeaa)DE-He213 Children (dpeaa)DE-He213 Glioma (dpeaa)DE-He213 Cyclophosphamide (dpeaa)DE-He213 Pons (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 bkl 44.90 misc IFN-γ misc Children misc Glioma misc Cyclophosphamide misc Pons |
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Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma |
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Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma |
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Wolff, Johannes E. A. |
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Wolff, Johannes E. A. Wagner, Sabine Reinert, Christiane Gnekow, Astrid Kortmann, R. -D. Kühl, Joachim Van Gool, Stefaan W. |
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Wolff, Johannes E. A. |
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maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma |
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Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma |
| abstract |
Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. |
| abstractGer |
Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. |
| abstract_unstemmed |
Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-γ) doses starting from 25 µg/$ m^{2} $/d s.c. increasing up to a maximum of 175 µg/$ m^{2} $/d within 7 weeks. Cyclophosphamide was given at 300 mg/$ m^{2} $ i.v. every 21 days. Forty pediatric glioma patients were enrolled (median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex (n = 8), basal ganglia (n = 4), brainstem (n = 24), cerebellum (n = 3), spinal cord (n = 1). Histologies were GBM (n = 14), AA (n = 14), LGG (n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous (2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival (1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol (n.s.). Conclusion Maintenance treatment with IFN-γ and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma. |
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| score |
7.400383 |