Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma
Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wolff, Johannes E. A. [verfasserIn] Kramm, Christof [verfasserIn] Kortmann, Rolf-Dieter [verfasserIn] Pietsch, Torsten [verfasserIn] Rutkowski, Stefan [verfasserIn] Jorch, Norbert [verfasserIn] Gnekow, Astrid [verfasserIn] Driever, Pablo Hernáiz [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neuro-oncology - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983, 90(2008), 3 vom: 05. Aug. |
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| Übergeordnetes Werk: |
volume:90 ; year:2008 ; number:3 ; day:05 ; month:08 |
| Links: |
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| DOI / URN: |
10.1007/s11060-008-9662-x |
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| Katalog-ID: |
SPR016161157 |
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| 245 | 1 | 0 | |a Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma |
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| 520 | |a Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols. | ||
| 650 | 4 | |a Valproic acid |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Glioblastoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anaplastic astrocytomas |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pontine glioma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Child |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adolescent |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kramm, Christof |e verfasserin |4 aut | |
| 700 | 1 | |a Kortmann, Rolf-Dieter |e verfasserin |4 aut | |
| 700 | 1 | |a Pietsch, Torsten |e verfasserin |4 aut | |
| 700 | 1 | |a Rutkowski, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Jorch, Norbert |e verfasserin |4 aut | |
| 700 | 1 | |a Gnekow, Astrid |e verfasserin |4 aut | |
| 700 | 1 | |a Driever, Pablo Hernáiz |e verfasserin |4 aut | |
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2008 |
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10.1007/s11060-008-9662-x doi (DE-627)SPR016161157 (SPR)s11060-008-9662-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols. Valproic acid (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 Anaplastic astrocytomas (dpeaa)DE-He213 Pontine glioma (dpeaa)DE-He213 Child (dpeaa)DE-He213 Adolescent (dpeaa)DE-He213 Kramm, Christof verfasserin aut Kortmann, Rolf-Dieter verfasserin aut Pietsch, Torsten verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Gnekow, Astrid verfasserin aut Driever, Pablo Hernáiz verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 90(2008), 3 vom: 05. Aug. (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:90 year:2008 number:3 day:05 month:08 https://dx.doi.org/10.1007/s11060-008-9662-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 90 2008 3 05 08 |
| spelling |
10.1007/s11060-008-9662-x doi (DE-627)SPR016161157 (SPR)s11060-008-9662-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols. Valproic acid (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 Anaplastic astrocytomas (dpeaa)DE-He213 Pontine glioma (dpeaa)DE-He213 Child (dpeaa)DE-He213 Adolescent (dpeaa)DE-He213 Kramm, Christof verfasserin aut Kortmann, Rolf-Dieter verfasserin aut Pietsch, Torsten verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Gnekow, Astrid verfasserin aut Driever, Pablo Hernáiz verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 90(2008), 3 vom: 05. Aug. (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:90 year:2008 number:3 day:05 month:08 https://dx.doi.org/10.1007/s11060-008-9662-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 90 2008 3 05 08 |
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10.1007/s11060-008-9662-x doi (DE-627)SPR016161157 (SPR)s11060-008-9662-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols. Valproic acid (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 Anaplastic astrocytomas (dpeaa)DE-He213 Pontine glioma (dpeaa)DE-He213 Child (dpeaa)DE-He213 Adolescent (dpeaa)DE-He213 Kramm, Christof verfasserin aut Kortmann, Rolf-Dieter verfasserin aut Pietsch, Torsten verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Gnekow, Astrid verfasserin aut Driever, Pablo Hernáiz verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 90(2008), 3 vom: 05. Aug. (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:90 year:2008 number:3 day:05 month:08 https://dx.doi.org/10.1007/s11060-008-9662-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 90 2008 3 05 08 |
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10.1007/s11060-008-9662-x doi (DE-627)SPR016161157 (SPR)s11060-008-9662-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Wolff, Johannes E. A. verfasserin aut Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols. Valproic acid (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 Anaplastic astrocytomas (dpeaa)DE-He213 Pontine glioma (dpeaa)DE-He213 Child (dpeaa)DE-He213 Adolescent (dpeaa)DE-He213 Kramm, Christof verfasserin aut Kortmann, Rolf-Dieter verfasserin aut Pietsch, Torsten verfasserin aut Rutkowski, Stefan verfasserin aut Jorch, Norbert verfasserin aut Gnekow, Astrid verfasserin aut Driever, Pablo Hernáiz verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 90(2008), 3 vom: 05. Aug. (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:90 year:2008 number:3 day:05 month:08 https://dx.doi.org/10.1007/s11060-008-9662-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 90 2008 3 05 08 |
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Enthalten in Journal of neuro-oncology 90(2008), 3 vom: 05. Aug. volume:90 year:2008 number:3 day:05 month:08 |
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Enthalten in Journal of neuro-oncology 90(2008), 3 vom: 05. Aug. volume:90 year:2008 number:3 day:05 month:08 |
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Valproic acid Glioblastoma Anaplastic astrocytomas Pontine glioma Child Adolescent |
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Wolff, Johannes E. A. @@aut@@ Kramm, Christof @@aut@@ Kortmann, Rolf-Dieter @@aut@@ Pietsch, Torsten @@aut@@ Rutkowski, Stefan @@aut@@ Jorch, Norbert @@aut@@ Gnekow, Astrid @@aut@@ Driever, Pablo Hernáiz @@aut@@ |
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| author |
Wolff, Johannes E. A. |
| spellingShingle |
Wolff, Johannes E. A. ddc 610 bkl 44.81 bkl 44.90 misc Valproic acid misc Glioblastoma misc Anaplastic astrocytomas misc Pontine glioma misc Child misc Adolescent Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma |
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610 ASE 44.81 bkl 44.90 bkl Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma Valproic acid (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 Anaplastic astrocytomas (dpeaa)DE-He213 Pontine glioma (dpeaa)DE-He213 Child (dpeaa)DE-He213 Adolescent (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 bkl 44.90 misc Valproic acid misc Glioblastoma misc Anaplastic astrocytomas misc Pontine glioma misc Child misc Adolescent |
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ddc 610 bkl 44.81 bkl 44.90 misc Valproic acid misc Glioblastoma misc Anaplastic astrocytomas misc Pontine glioma misc Child misc Adolescent |
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ddc 610 bkl 44.81 bkl 44.90 misc Valproic acid misc Glioblastoma misc Anaplastic astrocytomas misc Pontine glioma misc Child misc Adolescent |
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Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma |
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Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma |
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Wolff, Johannes E. A. |
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Journal of neuro-oncology |
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Wolff, Johannes E. A. Kramm, Christof Kortmann, Rolf-Dieter Pietsch, Torsten Rutkowski, Stefan Jorch, Norbert Gnekow, Astrid Driever, Pablo Hernáiz |
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valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma |
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Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma |
| abstract |
Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols. |
| abstractGer |
Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols. |
| abstract_unstemmed |
Abstract Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols. |
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3 |
| title_short |
Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma |
| url |
https://dx.doi.org/10.1007/s11060-008-9662-x |
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| author2 |
Kramm, Christof Kortmann, Rolf-Dieter Pietsch, Torsten Rutkowski, Stefan Jorch, Norbert Gnekow, Astrid Driever, Pablo Hernáiz |
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Kramm, Christof Kortmann, Rolf-Dieter Pietsch, Torsten Rutkowski, Stefan Jorch, Norbert Gnekow, Astrid Driever, Pablo Hernáiz |
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| doi_str |
10.1007/s11060-008-9662-x |
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2024-07-03T21:12:46.079Z |
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| score |
7.400387 |