Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas
Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Severa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ahluwalia, Manmeet S. [verfasserIn] Patton, Carol [verfasserIn] Stevens, Glen [verfasserIn] Tekautz, Tanya [verfasserIn] Angelov, Lilyana [verfasserIn] Vogelbaum, Michael A. [verfasserIn] Weil, Robert J. [verfasserIn] Chao, Sam [verfasserIn] Elson, Paul [verfasserIn] Suh, John H. [verfasserIn] Barnett, Gene H. [verfasserIn] Peereboom, David M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neuro-oncology - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983, 102(2010), 2 vom: 04. Aug., Seite 317-321 |
|---|---|
| Übergeordnetes Werk: |
volume:102 ; year:2010 ; number:2 ; day:04 ; month:08 ; pages:317-321 |
| Links: |
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| DOI / URN: |
10.1007/s11060-010-0325-3 |
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| Katalog-ID: |
SPR016167848 |
|---|
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| 245 | 1 | 0 | |a Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas |
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| 520 | |a Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. | ||
| 650 | 4 | |a Glioblastoma multiforme |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HIV protease inhibitors |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Matrix metalloproteases |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ritonavir/lopinavir |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Efficacy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Phase II |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Patton, Carol |e verfasserin |4 aut | |
| 700 | 1 | |a Stevens, Glen |e verfasserin |4 aut | |
| 700 | 1 | |a Tekautz, Tanya |e verfasserin |4 aut | |
| 700 | 1 | |a Angelov, Lilyana |e verfasserin |4 aut | |
| 700 | 1 | |a Vogelbaum, Michael A. |e verfasserin |4 aut | |
| 700 | 1 | |a Weil, Robert J. |e verfasserin |4 aut | |
| 700 | 1 | |a Chao, Sam |e verfasserin |4 aut | |
| 700 | 1 | |a Elson, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Suh, John H. |e verfasserin |4 aut | |
| 700 | 1 | |a Barnett, Gene H. |e verfasserin |4 aut | |
| 700 | 1 | |a Peereboom, David M. |e verfasserin |4 aut | |
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10.1007/s11060-010-0325-3 doi (DE-627)SPR016167848 (SPR)s11060-010-0325-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Ahluwalia, Manmeet S. verfasserin aut Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. Glioblastoma multiforme (dpeaa)DE-He213 HIV protease inhibitors (dpeaa)DE-He213 Matrix metalloproteases (dpeaa)DE-He213 Ritonavir/lopinavir (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Phase II (dpeaa)DE-He213 Patton, Carol verfasserin aut Stevens, Glen verfasserin aut Tekautz, Tanya verfasserin aut Angelov, Lilyana verfasserin aut Vogelbaum, Michael A. verfasserin aut Weil, Robert J. verfasserin aut Chao, Sam verfasserin aut Elson, Paul verfasserin aut Suh, John H. verfasserin aut Barnett, Gene H. verfasserin aut Peereboom, David M. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 102(2010), 2 vom: 04. Aug., Seite 317-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:102 year:2010 number:2 day:04 month:08 pages:317-321 https://dx.doi.org/10.1007/s11060-010-0325-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 102 2010 2 04 08 317-321 |
| spelling |
10.1007/s11060-010-0325-3 doi (DE-627)SPR016167848 (SPR)s11060-010-0325-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Ahluwalia, Manmeet S. verfasserin aut Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. Glioblastoma multiforme (dpeaa)DE-He213 HIV protease inhibitors (dpeaa)DE-He213 Matrix metalloproteases (dpeaa)DE-He213 Ritonavir/lopinavir (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Phase II (dpeaa)DE-He213 Patton, Carol verfasserin aut Stevens, Glen verfasserin aut Tekautz, Tanya verfasserin aut Angelov, Lilyana verfasserin aut Vogelbaum, Michael A. verfasserin aut Weil, Robert J. verfasserin aut Chao, Sam verfasserin aut Elson, Paul verfasserin aut Suh, John H. verfasserin aut Barnett, Gene H. verfasserin aut Peereboom, David M. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 102(2010), 2 vom: 04. Aug., Seite 317-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:102 year:2010 number:2 day:04 month:08 pages:317-321 https://dx.doi.org/10.1007/s11060-010-0325-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 102 2010 2 04 08 317-321 |
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10.1007/s11060-010-0325-3 doi (DE-627)SPR016167848 (SPR)s11060-010-0325-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Ahluwalia, Manmeet S. verfasserin aut Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. Glioblastoma multiforme (dpeaa)DE-He213 HIV protease inhibitors (dpeaa)DE-He213 Matrix metalloproteases (dpeaa)DE-He213 Ritonavir/lopinavir (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Phase II (dpeaa)DE-He213 Patton, Carol verfasserin aut Stevens, Glen verfasserin aut Tekautz, Tanya verfasserin aut Angelov, Lilyana verfasserin aut Vogelbaum, Michael A. verfasserin aut Weil, Robert J. verfasserin aut Chao, Sam verfasserin aut Elson, Paul verfasserin aut Suh, John H. verfasserin aut Barnett, Gene H. verfasserin aut Peereboom, David M. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 102(2010), 2 vom: 04. Aug., Seite 317-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:102 year:2010 number:2 day:04 month:08 pages:317-321 https://dx.doi.org/10.1007/s11060-010-0325-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 102 2010 2 04 08 317-321 |
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10.1007/s11060-010-0325-3 doi (DE-627)SPR016167848 (SPR)s11060-010-0325-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Ahluwalia, Manmeet S. verfasserin aut Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. Glioblastoma multiforme (dpeaa)DE-He213 HIV protease inhibitors (dpeaa)DE-He213 Matrix metalloproteases (dpeaa)DE-He213 Ritonavir/lopinavir (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Phase II (dpeaa)DE-He213 Patton, Carol verfasserin aut Stevens, Glen verfasserin aut Tekautz, Tanya verfasserin aut Angelov, Lilyana verfasserin aut Vogelbaum, Michael A. verfasserin aut Weil, Robert J. verfasserin aut Chao, Sam verfasserin aut Elson, Paul verfasserin aut Suh, John H. verfasserin aut Barnett, Gene H. verfasserin aut Peereboom, David M. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 102(2010), 2 vom: 04. Aug., Seite 317-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:102 year:2010 number:2 day:04 month:08 pages:317-321 https://dx.doi.org/10.1007/s11060-010-0325-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 102 2010 2 04 08 317-321 |
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10.1007/s11060-010-0325-3 doi (DE-627)SPR016167848 (SPR)s11060-010-0325-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Ahluwalia, Manmeet S. verfasserin aut Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. Glioblastoma multiforme (dpeaa)DE-He213 HIV protease inhibitors (dpeaa)DE-He213 Matrix metalloproteases (dpeaa)DE-He213 Ritonavir/lopinavir (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Phase II (dpeaa)DE-He213 Patton, Carol verfasserin aut Stevens, Glen verfasserin aut Tekautz, Tanya verfasserin aut Angelov, Lilyana verfasserin aut Vogelbaum, Michael A. verfasserin aut Weil, Robert J. verfasserin aut Chao, Sam verfasserin aut Elson, Paul verfasserin aut Suh, John H. verfasserin aut Barnett, Gene H. verfasserin aut Peereboom, David M. verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 102(2010), 2 vom: 04. Aug., Seite 317-321 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:102 year:2010 number:2 day:04 month:08 pages:317-321 https://dx.doi.org/10.1007/s11060-010-0325-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 102 2010 2 04 08 317-321 |
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Enthalten in Journal of neuro-oncology 102(2010), 2 vom: 04. Aug., Seite 317-321 volume:102 year:2010 number:2 day:04 month:08 pages:317-321 |
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Enthalten in Journal of neuro-oncology 102(2010), 2 vom: 04. Aug., Seite 317-321 volume:102 year:2010 number:2 day:04 month:08 pages:317-321 |
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Glioblastoma multiforme HIV protease inhibitors Matrix metalloproteases Ritonavir/lopinavir Efficacy Phase II |
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Ahluwalia, Manmeet S. @@aut@@ Patton, Carol @@aut@@ Stevens, Glen @@aut@@ Tekautz, Tanya @@aut@@ Angelov, Lilyana @@aut@@ Vogelbaum, Michael A. @@aut@@ Weil, Robert J. @@aut@@ Chao, Sam @@aut@@ Elson, Paul @@aut@@ Suh, John H. @@aut@@ Barnett, Gene H. @@aut@@ Peereboom, David M. @@aut@@ |
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Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. 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|
| author |
Ahluwalia, Manmeet S. |
| spellingShingle |
Ahluwalia, Manmeet S. ddc 610 bkl 44.81 bkl 44.90 misc Glioblastoma multiforme misc HIV protease inhibitors misc Matrix metalloproteases misc Ritonavir/lopinavir misc Efficacy misc Phase II Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas |
| authorStr |
Ahluwalia, Manmeet S. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)32046122X |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut aut aut aut aut |
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springer |
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true |
| illustrated |
Not Illustrated |
| issn |
1573-7373 |
| topic_title |
610 ASE 44.81 bkl 44.90 bkl Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas Glioblastoma multiforme (dpeaa)DE-He213 HIV protease inhibitors (dpeaa)DE-He213 Matrix metalloproteases (dpeaa)DE-He213 Ritonavir/lopinavir (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Phase II (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.81 bkl 44.90 misc Glioblastoma multiforme misc HIV protease inhibitors misc Matrix metalloproteases misc Ritonavir/lopinavir misc Efficacy misc Phase II |
| topic_unstemmed |
ddc 610 bkl 44.81 bkl 44.90 misc Glioblastoma multiforme misc HIV protease inhibitors misc Matrix metalloproteases misc Ritonavir/lopinavir misc Efficacy misc Phase II |
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Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas |
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Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas |
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Ahluwalia, Manmeet S. |
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Ahluwalia, Manmeet S. Patton, Carol Stevens, Glen Tekautz, Tanya Angelov, Lilyana Vogelbaum, Michael A. Weil, Robert J. Chao, Sam Elson, Paul Suh, John H. Barnett, Gene H. Peereboom, David M. |
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Ahluwalia, Manmeet S. |
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10.1007/s11060-010-0325-3 |
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phase ii trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas |
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Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas |
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Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. |
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Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. |
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Abstract Current therapies for recurrent or progressive high-grade gliomas (HGG, WHO grade 3–4) produce a 6-month progression-free survival of only 10–25%. Migration and invasion by HGG is mediated in part by matrix metalloproteases (MMPs) which promote remodeling of the extracellular matrix. Several HIV protease inhibitors (HIVPI) decrease the expression of MMPs in astrocytes and microglia. Given these mechanisms of antitumor activity of HIVPI, we evaluated the efficacy of ritonavir/lopinavir, a combination HIVPI, in patients with progressive or recurrent HGG in an open label phase II trial. Nineteen patients were treated in this study. Patients received ritonavir/lopinavir (400 mg/100 mg) orally twice daily. All patients were treated until progression of disease or unacceptable toxicity. A complete response was seen in one patient (5%). Three patients (16%) had stable disease as the best response. Fifteen patients (79%) had progressive disease. The 6-month progression free survival ($ PFS_{6} $) was 11% (2 of 19 patients). Ritonavir/lopinavir was well tolerated in patients with heavily pretreated refractory HGG, and no grade 3 or 4 toxicity was seen. The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint. |
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| score |
7.4000845 |