A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study
Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Robins, H. Ian [verfasserIn] Zhang, Peixin [verfasserIn] Gilbert, Mark R. [verfasserIn] Chakravarti, Arnab [verfasserIn] de Groot, John F. [verfasserIn] Grimm, Sean A. [verfasserIn] Wang, Fen [verfasserIn] Lieberman, Frank S. [verfasserIn] Krauze, Andra [verfasserIn] Trotti, Andy M. [verfasserIn] Mohile, Nimish [verfasserIn] Kee, Andrew Y. J. [verfasserIn] Colman, Howard [verfasserIn] Cavaliere, Robert [verfasserIn] Kesari, Santosh [verfasserIn] Chmura, Steven J. [verfasserIn] Mehta, Minesh [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neuro-oncology - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983, 126(2015), 2 vom: 27. Okt., Seite 309-316 |
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| Übergeordnetes Werk: |
volume:126 ; year:2015 ; number:2 ; day:27 ; month:10 ; pages:309-316 |
| Links: |
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| DOI / URN: |
10.1007/s11060-015-1966-z |
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| Katalog-ID: |
SPR016184009 |
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| 100 | 1 | |a Robins, H. Ian |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study |
| 264 | 1 | |c 2015 | |
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| 520 | |a Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). | ||
| 650 | 4 | |a Glioblastoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a ABT-888 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Temozolomide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Velparib |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Zhang, Peixin |e verfasserin |4 aut | |
| 700 | 1 | |a Gilbert, Mark R. |e verfasserin |4 aut | |
| 700 | 1 | |a Chakravarti, Arnab |e verfasserin |4 aut | |
| 700 | 1 | |a de Groot, John F. |e verfasserin |4 aut | |
| 700 | 1 | |a Grimm, Sean A. |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Fen |e verfasserin |4 aut | |
| 700 | 1 | |a Lieberman, Frank S. |e verfasserin |4 aut | |
| 700 | 1 | |a Krauze, Andra |e verfasserin |4 aut | |
| 700 | 1 | |a Trotti, Andy M. |e verfasserin |4 aut | |
| 700 | 1 | |a Mohile, Nimish |e verfasserin |4 aut | |
| 700 | 1 | |a Kee, Andrew Y. J. |e verfasserin |4 aut | |
| 700 | 1 | |a Colman, Howard |e verfasserin |4 aut | |
| 700 | 1 | |a Cavaliere, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Kesari, Santosh |e verfasserin |4 aut | |
| 700 | 1 | |a Chmura, Steven J. |e verfasserin |4 aut | |
| 700 | 1 | |a Mehta, Minesh |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuro-oncology |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 |g 126(2015), 2 vom: 27. Okt., Seite 309-316 |w (DE-627)32046122X |w (DE-600)2007293-4 |x 1573-7373 |7 nnns |
| 773 | 1 | 8 | |g volume:126 |g year:2015 |g number:2 |g day:27 |g month:10 |g pages:309-316 |
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10.1007/s11060-015-1966-z doi (DE-627)SPR016184009 (SPR)s11060-015-1966-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Robins, H. Ian verfasserin aut A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). Glioblastoma (dpeaa)DE-He213 ABT-888 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Velparib (dpeaa)DE-He213 Zhang, Peixin verfasserin aut Gilbert, Mark R. verfasserin aut Chakravarti, Arnab verfasserin aut de Groot, John F. verfasserin aut Grimm, Sean A. verfasserin aut Wang, Fen verfasserin aut Lieberman, Frank S. verfasserin aut Krauze, Andra verfasserin aut Trotti, Andy M. verfasserin aut Mohile, Nimish verfasserin aut Kee, Andrew Y. J. verfasserin aut Colman, Howard verfasserin aut Cavaliere, Robert verfasserin aut Kesari, Santosh verfasserin aut Chmura, Steven J. verfasserin aut Mehta, Minesh verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 126(2015), 2 vom: 27. Okt., Seite 309-316 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:126 year:2015 number:2 day:27 month:10 pages:309-316 https://dx.doi.org/10.1007/s11060-015-1966-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 126 2015 2 27 10 309-316 |
| spelling |
10.1007/s11060-015-1966-z doi (DE-627)SPR016184009 (SPR)s11060-015-1966-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Robins, H. Ian verfasserin aut A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). Glioblastoma (dpeaa)DE-He213 ABT-888 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Velparib (dpeaa)DE-He213 Zhang, Peixin verfasserin aut Gilbert, Mark R. verfasserin aut Chakravarti, Arnab verfasserin aut de Groot, John F. verfasserin aut Grimm, Sean A. verfasserin aut Wang, Fen verfasserin aut Lieberman, Frank S. verfasserin aut Krauze, Andra verfasserin aut Trotti, Andy M. verfasserin aut Mohile, Nimish verfasserin aut Kee, Andrew Y. J. verfasserin aut Colman, Howard verfasserin aut Cavaliere, Robert verfasserin aut Kesari, Santosh verfasserin aut Chmura, Steven J. verfasserin aut Mehta, Minesh verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 126(2015), 2 vom: 27. Okt., Seite 309-316 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:126 year:2015 number:2 day:27 month:10 pages:309-316 https://dx.doi.org/10.1007/s11060-015-1966-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 126 2015 2 27 10 309-316 |
| allfields_unstemmed |
10.1007/s11060-015-1966-z doi (DE-627)SPR016184009 (SPR)s11060-015-1966-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Robins, H. Ian verfasserin aut A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). Glioblastoma (dpeaa)DE-He213 ABT-888 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Velparib (dpeaa)DE-He213 Zhang, Peixin verfasserin aut Gilbert, Mark R. verfasserin aut Chakravarti, Arnab verfasserin aut de Groot, John F. verfasserin aut Grimm, Sean A. verfasserin aut Wang, Fen verfasserin aut Lieberman, Frank S. verfasserin aut Krauze, Andra verfasserin aut Trotti, Andy M. verfasserin aut Mohile, Nimish verfasserin aut Kee, Andrew Y. J. verfasserin aut Colman, Howard verfasserin aut Cavaliere, Robert verfasserin aut Kesari, Santosh verfasserin aut Chmura, Steven J. verfasserin aut Mehta, Minesh verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 126(2015), 2 vom: 27. Okt., Seite 309-316 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:126 year:2015 number:2 day:27 month:10 pages:309-316 https://dx.doi.org/10.1007/s11060-015-1966-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 126 2015 2 27 10 309-316 |
| allfieldsGer |
10.1007/s11060-015-1966-z doi (DE-627)SPR016184009 (SPR)s11060-015-1966-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Robins, H. Ian verfasserin aut A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). Glioblastoma (dpeaa)DE-He213 ABT-888 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Velparib (dpeaa)DE-He213 Zhang, Peixin verfasserin aut Gilbert, Mark R. verfasserin aut Chakravarti, Arnab verfasserin aut de Groot, John F. verfasserin aut Grimm, Sean A. verfasserin aut Wang, Fen verfasserin aut Lieberman, Frank S. verfasserin aut Krauze, Andra verfasserin aut Trotti, Andy M. verfasserin aut Mohile, Nimish verfasserin aut Kee, Andrew Y. J. verfasserin aut Colman, Howard verfasserin aut Cavaliere, Robert verfasserin aut Kesari, Santosh verfasserin aut Chmura, Steven J. verfasserin aut Mehta, Minesh verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 126(2015), 2 vom: 27. Okt., Seite 309-316 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:126 year:2015 number:2 day:27 month:10 pages:309-316 https://dx.doi.org/10.1007/s11060-015-1966-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 126 2015 2 27 10 309-316 |
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10.1007/s11060-015-1966-z doi (DE-627)SPR016184009 (SPR)s11060-015-1966-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl 44.90 bkl Robins, H. Ian verfasserin aut A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). Glioblastoma (dpeaa)DE-He213 ABT-888 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Velparib (dpeaa)DE-He213 Zhang, Peixin verfasserin aut Gilbert, Mark R. verfasserin aut Chakravarti, Arnab verfasserin aut de Groot, John F. verfasserin aut Grimm, Sean A. verfasserin aut Wang, Fen verfasserin aut Lieberman, Frank S. verfasserin aut Krauze, Andra verfasserin aut Trotti, Andy M. verfasserin aut Mohile, Nimish verfasserin aut Kee, Andrew Y. J. verfasserin aut Colman, Howard verfasserin aut Cavaliere, Robert verfasserin aut Kesari, Santosh verfasserin aut Chmura, Steven J. verfasserin aut Mehta, Minesh verfasserin aut Enthalten in Journal of neuro-oncology Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 126(2015), 2 vom: 27. Okt., Seite 309-316 (DE-627)32046122X (DE-600)2007293-4 1573-7373 nnns volume:126 year:2015 number:2 day:27 month:10 pages:309-316 https://dx.doi.org/10.1007/s11060-015-1966-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.90 ASE AR 126 2015 2 27 10 309-316 |
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Enthalten in Journal of neuro-oncology 126(2015), 2 vom: 27. Okt., Seite 309-316 volume:126 year:2015 number:2 day:27 month:10 pages:309-316 |
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Enthalten in Journal of neuro-oncology 126(2015), 2 vom: 27. Okt., Seite 309-316 volume:126 year:2015 number:2 day:27 month:10 pages:309-316 |
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Glioblastoma ABT-888 Temozolomide Velparib |
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Robins, H. Ian @@aut@@ Zhang, Peixin @@aut@@ Gilbert, Mark R. @@aut@@ Chakravarti, Arnab @@aut@@ de Groot, John F. @@aut@@ Grimm, Sean A. @@aut@@ Wang, Fen @@aut@@ Lieberman, Frank S. @@aut@@ Krauze, Andra @@aut@@ Trotti, Andy M. @@aut@@ Mohile, Nimish @@aut@@ Kee, Andrew Y. J. @@aut@@ Colman, Howard @@aut@@ Cavaliere, Robert @@aut@@ Kesari, Santosh @@aut@@ Chmura, Steven J. @@aut@@ Mehta, Minesh @@aut@@ |
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2015-10-27T00:00:00Z |
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| author |
Robins, H. Ian |
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Robins, H. Ian ddc 610 bkl 44.81 bkl 44.90 misc Glioblastoma misc ABT-888 misc Temozolomide misc Velparib A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study |
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610 ASE 44.81 bkl 44.90 bkl A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study Glioblastoma (dpeaa)DE-He213 ABT-888 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Velparib (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 bkl 44.90 misc Glioblastoma misc ABT-888 misc Temozolomide misc Velparib |
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ddc 610 bkl 44.81 bkl 44.90 misc Glioblastoma misc ABT-888 misc Temozolomide misc Velparib |
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ddc 610 bkl 44.81 bkl 44.90 misc Glioblastoma misc ABT-888 misc Temozolomide misc Velparib |
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A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study |
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A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study |
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Robins, H. Ian |
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Robins, H. Ian Zhang, Peixin Gilbert, Mark R. Chakravarti, Arnab de Groot, John F. Grimm, Sean A. Wang, Fen Lieberman, Frank S. Krauze, Andra Trotti, Andy M. Mohile, Nimish Kee, Andrew Y. J. Colman, Howard Cavaliere, Robert Kesari, Santosh Chmura, Steven J. Mehta, Minesh |
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Robins, H. Ian |
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10.1007/s11060-015-1966-z |
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verfasserin |
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randomized phase i/ii study of abt-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an nrg oncology rtog group study |
| title_auth |
A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study |
| abstract |
Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). |
| abstractGer |
Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). |
| abstract_unstemmed |
Abstract This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the primary endpoint. The maximum tolerated dose (MTD) for TMZ using the 21 day of 28 TMZ schedule, in concert with 40 mg BID ABT-888 was determined in a phase I portion of this study, and previously reported to be 75 mg/$ m^{2} $ (arm1). The MTD for ABT-888 (40 mg BID) and the 5 of 28 day TMZ (150–200 mg/$ m^{2} $) schedule was known from prior trials (arm2). Two cohorts were studied: bevacizumab (BEV) naïve (n = 151), and BEV refractory (n = 74). Overall ten patients were ineligible. The incidence rate of grade 3/4 myelosuppression over all was 20.0 %. For the BEV refractory cohort, the PFS 6 was 4.4 %; for the BEV naïve cohort, PFS6 was 17 %. Overall survival was similar for both arms in both the BEV naïve [median survival time (MST) 10.3 M; 95 % CI 8.4–12] and BEV refractory cohort (MST 4.7 M; 95 %CI 3.5–5.6). The median PFS was essentially the same for both arms and both cohorts at ~2.0 M (95 % CI 1.9–2.1). |
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A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study |
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https://dx.doi.org/10.1007/s11060-015-1966-z |
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Zhang, Peixin Gilbert, Mark R. Chakravarti, Arnab de Groot, John F. Grimm, Sean A. Wang, Fen Lieberman, Frank S. Krauze, Andra Trotti, Andy M. Mohile, Nimish Kee, Andrew Y. J. Colman, Howard Cavaliere, Robert Kesari, Santosh Chmura, Steven J. Mehta, Minesh |
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Zhang, Peixin Gilbert, Mark R. Chakravarti, Arnab de Groot, John F. Grimm, Sean A. Wang, Fen Lieberman, Frank S. Krauze, Andra Trotti, Andy M. Mohile, Nimish Kee, Andrew Y. J. Colman, Howard Cavaliere, Robert Kesari, Santosh Chmura, Steven J. Mehta, Minesh |
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| doi_str |
10.1007/s11060-015-1966-z |
| up_date |
2024-07-03T21:23:48.520Z |
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| score |
7.400194 |