Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC
The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sergeeva, M. S. [verfasserIn] Grushevskaya, L. N. [verfasserIn] Avdyunina, N. I. [verfasserIn] Pyatin, B. M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Übergeordnetes Werk: |
Enthalten in: Pharmaceutical chemistry journal - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967, 45(2012), 11 vom: Feb., Seite 701-704 |
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| Übergeordnetes Werk: |
volume:45 ; year:2012 ; number:11 ; month:02 ; pages:701-704 |
| Links: |
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| DOI / URN: |
10.1007/s11094-012-0704-5 |
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| Katalog-ID: |
SPR016531973 |
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| 520 | |a The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. | ||
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| 700 | 1 | |a Pyatin, B. M. |e verfasserin |4 aut | |
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10.1007/s11094-012-0704-5 doi (DE-627)SPR016531973 (SPR)s11094-012-0704-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Sergeeva, M. S. verfasserin aut Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. Grushevskaya, L. N. verfasserin aut Avdyunina, N. I. verfasserin aut Pyatin, B. M. verfasserin aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 45(2012), 11 vom: Feb., Seite 701-704 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:45 year:2012 number:11 month:02 pages:701-704 https://dx.doi.org/10.1007/s11094-012-0704-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 45 2012 11 02 701-704 |
| spelling |
10.1007/s11094-012-0704-5 doi (DE-627)SPR016531973 (SPR)s11094-012-0704-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Sergeeva, M. S. verfasserin aut Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. Grushevskaya, L. N. verfasserin aut Avdyunina, N. I. verfasserin aut Pyatin, B. M. verfasserin aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 45(2012), 11 vom: Feb., Seite 701-704 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:45 year:2012 number:11 month:02 pages:701-704 https://dx.doi.org/10.1007/s11094-012-0704-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 45 2012 11 02 701-704 |
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10.1007/s11094-012-0704-5 doi (DE-627)SPR016531973 (SPR)s11094-012-0704-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Sergeeva, M. S. verfasserin aut Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. Grushevskaya, L. N. verfasserin aut Avdyunina, N. I. verfasserin aut Pyatin, B. M. verfasserin aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 45(2012), 11 vom: Feb., Seite 701-704 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:45 year:2012 number:11 month:02 pages:701-704 https://dx.doi.org/10.1007/s11094-012-0704-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 45 2012 11 02 701-704 |
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10.1007/s11094-012-0704-5 doi (DE-627)SPR016531973 (SPR)s11094-012-0704-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Sergeeva, M. S. verfasserin aut Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. Grushevskaya, L. N. verfasserin aut Avdyunina, N. I. verfasserin aut Pyatin, B. M. verfasserin aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 45(2012), 11 vom: Feb., Seite 701-704 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:45 year:2012 number:11 month:02 pages:701-704 https://dx.doi.org/10.1007/s11094-012-0704-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 45 2012 11 02 701-704 |
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10.1007/s11094-012-0704-5 doi (DE-627)SPR016531973 (SPR)s11094-012-0704-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Sergeeva, M. S. verfasserin aut Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. Grushevskaya, L. N. verfasserin aut Avdyunina, N. I. verfasserin aut Pyatin, B. M. verfasserin aut Enthalten in Pharmaceutical chemistry journal Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967 45(2012), 11 vom: Feb., Seite 701-704 (DE-627)325700621 (DE-600)2039418-4 1573-9031 nnns volume:45 year:2012 number:11 month:02 pages:701-704 https://dx.doi.org/10.1007/s11094-012-0704-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 45 2012 11 02 701-704 |
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Sergeeva, M. S. |
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610 ASE 44.40 bkl Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC |
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Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC |
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studies of the stability of cardiocyclide in substance and a solid dosage form by hplc |
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Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC |
| abstract |
The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. |
| abstractGer |
The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. |
| abstract_unstemmed |
The aim of the present work was to assess the specificity of an HPLC method developed for analysis of the purity of cardiocyclide within the framework of a study of the stability of cardiocyclide as substance and as a solid dosage formulation. Studies were performed using a liquid chromatograph with a spectrophotometric detector at a wavelength of 210 nm with a linear gradient using two mobile phases (MP): 0.02 M phosphate buffer pH 3.3 (MP A) and a mixture of acetonitrile, methanol, and 0.02 Mphosphate buffer pH 3.3 (50:50:20) (MP B). The gradient regime was: MP A/MP B from 35:65 to 0:100 over 15 min. The chromatography column was of size 150 × 4.6 mm, the sorbent was Luna C18(2), particle size 5 μm. This HPLC method allowed separation of cardiocyclide and its most likely contaminants - the intermediate products of the last two synthesis stages, some of which are also products of hydrolysis, as well as a series of unidentified contaminants in substance and the solid dosage formulation as released. The method also allows other contaminants to be detected, i.e., cardiocyclide degradation products forming on exposure to aggressive environmental factors. The method thus yields data on the stability of the substance and medicinal formulation both at the preparation stages and after incorrect storage. |
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Studies of the stability of cardiocyclide in substance and a solid dosage form by HPLC |
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https://dx.doi.org/10.1007/s11094-012-0704-5 |
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Grushevskaya, L. N. Avdyunina, N. I. Pyatin, B. M. |
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10.1007/s11094-012-0704-5 |
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2024-07-03T23:35:48.118Z |
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| score |
7.3982096 |