Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer
Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovar...
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Gespeichert in:
| Autor*in: |
King, Madeleine T. [verfasserIn] Stockler, Martin R. [verfasserIn] O’Connell, Rachel L. [verfasserIn] Buizen, Luke [verfasserIn] Joly, Florence [verfasserIn] Lanceley, Anne [verfasserIn] Hilpert, Felix [verfasserIn] Okamoto, Aikou [verfasserIn] Aotani, Eriko [verfasserIn] Bryce, Jane [verfasserIn] Donnellan, Paul [verfasserIn] Oza, Amit [verfasserIn] Avall-Lundqvist, Elisabeth [verfasserIn] Berek, Jonathan S. [verfasserIn] Sehouli, Jalid [verfasserIn] Feeney, Amanda [verfasserIn] Berton-Rigaud, Dominique [verfasserIn] Costa, Daniel S. J. [verfasserIn] Friedlander, Michael L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
Patient-reported outcome measure |
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| Übergeordnetes Werk: |
Enthalten in: Quality of life research - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1992, 27(2017), 1 vom: 16. Dez., Seite 59-74 |
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| Übergeordnetes Werk: |
volume:27 ; year:2017 ; number:1 ; day:16 ; month:12 ; pages:59-74 |
| Links: |
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| DOI / URN: |
10.1007/s11136-017-1729-8 |
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| Katalog-ID: |
SPR017001803 |
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| 245 | 1 | 0 | |a Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer |
| 264 | 1 | |c 2017 | |
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| 520 | |a Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. | ||
| 650 | 4 | |a Ovarian cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Recurrent ovarian cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Platinum sensitive |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Platinum resistant |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Platinum refractory |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Symptom burden |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Symptom benefit |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Magnitude of clinical benefit |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Net health benefit |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Patient-reported outcome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PRO |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Patient-reported outcome measure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PROM |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Quality of life |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a QOL |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Health-related quality of life |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HRQOL |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HRQL |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Stockler, Martin R. |e verfasserin |4 aut | |
| 700 | 1 | |a O’Connell, Rachel L. |e verfasserin |4 aut | |
| 700 | 1 | |a Buizen, Luke |e verfasserin |4 aut | |
| 700 | 1 | |a Joly, Florence |e verfasserin |4 aut | |
| 700 | 1 | |a Lanceley, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Hilpert, Felix |e verfasserin |4 aut | |
| 700 | 1 | |a Okamoto, Aikou |e verfasserin |4 aut | |
| 700 | 1 | |a Aotani, Eriko |e verfasserin |4 aut | |
| 700 | 1 | |a Bryce, Jane |e verfasserin |4 aut | |
| 700 | 1 | |a Donnellan, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Oza, Amit |e verfasserin |4 aut | |
| 700 | 1 | |a Avall-Lundqvist, Elisabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Berek, Jonathan S. |e verfasserin |4 aut | |
| 700 | 1 | |a Sehouli, Jalid |e verfasserin |4 aut | |
| 700 | 1 | |a Feeney, Amanda |e verfasserin |4 aut | |
| 700 | 1 | |a Berton-Rigaud, Dominique |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Daniel S. J. |e verfasserin |4 aut | |
| 700 | 1 | |a Friedlander, Michael L. |e verfasserin |4 aut | |
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10.1007/s11136-017-1729-8 doi (DE-627)SPR017001803 (SPR)s11136-017-1729-8-e DE-627 ger DE-627 rakwb eng 100 ASE 44.52 bkl King, Madeleine T. verfasserin aut Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. Ovarian cancer (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Platinum sensitive (dpeaa)DE-He213 Platinum resistant (dpeaa)DE-He213 Platinum refractory (dpeaa)DE-He213 Symptom burden (dpeaa)DE-He213 Symptom benefit (dpeaa)DE-He213 Magnitude of clinical benefit (dpeaa)DE-He213 Net health benefit (dpeaa)DE-He213 Patient-reported outcome (dpeaa)DE-He213 PRO (dpeaa)DE-He213 Patient-reported outcome measure (dpeaa)DE-He213 PROM (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 QOL (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 HRQOL (dpeaa)DE-He213 HRQL (dpeaa)DE-He213 Stockler, Martin R. verfasserin aut O’Connell, Rachel L. verfasserin aut Buizen, Luke verfasserin aut Joly, Florence verfasserin aut Lanceley, Anne verfasserin aut Hilpert, Felix verfasserin aut Okamoto, Aikou verfasserin aut Aotani, Eriko verfasserin aut Bryce, Jane verfasserin aut Donnellan, Paul verfasserin aut Oza, Amit verfasserin aut Avall-Lundqvist, Elisabeth verfasserin aut Berek, Jonathan S. verfasserin aut Sehouli, Jalid verfasserin aut Feeney, Amanda verfasserin aut Berton-Rigaud, Dominique verfasserin aut Costa, Daniel S. J. verfasserin aut Friedlander, Michael L. verfasserin aut Enthalten in Quality of life research Dordrecht [u.a.] : Springer Science + Business Media B.V, 1992 27(2017), 1 vom: 16. Dez., Seite 59-74 (DE-627)320474399 (DE-600)2008960-0 1573-2649 nnns volume:27 year:2017 number:1 day:16 month:12 pages:59-74 https://dx.doi.org/10.1007/s11136-017-1729-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2938 GBV_ILN_2949 GBV_ILN_2950 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4392 GBV_ILN_4393 GBV_ILN_4700 44.52 ASE AR 27 2017 1 16 12 59-74 |
| spelling |
10.1007/s11136-017-1729-8 doi (DE-627)SPR017001803 (SPR)s11136-017-1729-8-e DE-627 ger DE-627 rakwb eng 100 ASE 44.52 bkl King, Madeleine T. verfasserin aut Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. Ovarian cancer (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Platinum sensitive (dpeaa)DE-He213 Platinum resistant (dpeaa)DE-He213 Platinum refractory (dpeaa)DE-He213 Symptom burden (dpeaa)DE-He213 Symptom benefit (dpeaa)DE-He213 Magnitude of clinical benefit (dpeaa)DE-He213 Net health benefit (dpeaa)DE-He213 Patient-reported outcome (dpeaa)DE-He213 PRO (dpeaa)DE-He213 Patient-reported outcome measure (dpeaa)DE-He213 PROM (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 QOL (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 HRQOL (dpeaa)DE-He213 HRQL (dpeaa)DE-He213 Stockler, Martin R. verfasserin aut O’Connell, Rachel L. verfasserin aut Buizen, Luke verfasserin aut Joly, Florence verfasserin aut Lanceley, Anne verfasserin aut Hilpert, Felix verfasserin aut Okamoto, Aikou verfasserin aut Aotani, Eriko verfasserin aut Bryce, Jane verfasserin aut Donnellan, Paul verfasserin aut Oza, Amit verfasserin aut Avall-Lundqvist, Elisabeth verfasserin aut Berek, Jonathan S. verfasserin aut Sehouli, Jalid verfasserin aut Feeney, Amanda verfasserin aut Berton-Rigaud, Dominique verfasserin aut Costa, Daniel S. J. verfasserin aut Friedlander, Michael L. verfasserin aut Enthalten in Quality of life research Dordrecht [u.a.] : Springer Science + Business Media B.V, 1992 27(2017), 1 vom: 16. Dez., Seite 59-74 (DE-627)320474399 (DE-600)2008960-0 1573-2649 nnns volume:27 year:2017 number:1 day:16 month:12 pages:59-74 https://dx.doi.org/10.1007/s11136-017-1729-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2938 GBV_ILN_2949 GBV_ILN_2950 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4392 GBV_ILN_4393 GBV_ILN_4700 44.52 ASE AR 27 2017 1 16 12 59-74 |
| allfields_unstemmed |
10.1007/s11136-017-1729-8 doi (DE-627)SPR017001803 (SPR)s11136-017-1729-8-e DE-627 ger DE-627 rakwb eng 100 ASE 44.52 bkl King, Madeleine T. verfasserin aut Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. Ovarian cancer (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Platinum sensitive (dpeaa)DE-He213 Platinum resistant (dpeaa)DE-He213 Platinum refractory (dpeaa)DE-He213 Symptom burden (dpeaa)DE-He213 Symptom benefit (dpeaa)DE-He213 Magnitude of clinical benefit (dpeaa)DE-He213 Net health benefit (dpeaa)DE-He213 Patient-reported outcome (dpeaa)DE-He213 PRO (dpeaa)DE-He213 Patient-reported outcome measure (dpeaa)DE-He213 PROM (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 QOL (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 HRQOL (dpeaa)DE-He213 HRQL (dpeaa)DE-He213 Stockler, Martin R. verfasserin aut O’Connell, Rachel L. verfasserin aut Buizen, Luke verfasserin aut Joly, Florence verfasserin aut Lanceley, Anne verfasserin aut Hilpert, Felix verfasserin aut Okamoto, Aikou verfasserin aut Aotani, Eriko verfasserin aut Bryce, Jane verfasserin aut Donnellan, Paul verfasserin aut Oza, Amit verfasserin aut Avall-Lundqvist, Elisabeth verfasserin aut Berek, Jonathan S. verfasserin aut Sehouli, Jalid verfasserin aut Feeney, Amanda verfasserin aut Berton-Rigaud, Dominique verfasserin aut Costa, Daniel S. J. verfasserin aut Friedlander, Michael L. verfasserin aut Enthalten in Quality of life research Dordrecht [u.a.] : Springer Science + Business Media B.V, 1992 27(2017), 1 vom: 16. Dez., Seite 59-74 (DE-627)320474399 (DE-600)2008960-0 1573-2649 nnns volume:27 year:2017 number:1 day:16 month:12 pages:59-74 https://dx.doi.org/10.1007/s11136-017-1729-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2938 GBV_ILN_2949 GBV_ILN_2950 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4392 GBV_ILN_4393 GBV_ILN_4700 44.52 ASE AR 27 2017 1 16 12 59-74 |
| allfieldsGer |
10.1007/s11136-017-1729-8 doi (DE-627)SPR017001803 (SPR)s11136-017-1729-8-e DE-627 ger DE-627 rakwb eng 100 ASE 44.52 bkl King, Madeleine T. verfasserin aut Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. Ovarian cancer (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Platinum sensitive (dpeaa)DE-He213 Platinum resistant (dpeaa)DE-He213 Platinum refractory (dpeaa)DE-He213 Symptom burden (dpeaa)DE-He213 Symptom benefit (dpeaa)DE-He213 Magnitude of clinical benefit (dpeaa)DE-He213 Net health benefit (dpeaa)DE-He213 Patient-reported outcome (dpeaa)DE-He213 PRO (dpeaa)DE-He213 Patient-reported outcome measure (dpeaa)DE-He213 PROM (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 QOL (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 HRQOL (dpeaa)DE-He213 HRQL (dpeaa)DE-He213 Stockler, Martin R. verfasserin aut O’Connell, Rachel L. verfasserin aut Buizen, Luke verfasserin aut Joly, Florence verfasserin aut Lanceley, Anne verfasserin aut Hilpert, Felix verfasserin aut Okamoto, Aikou verfasserin aut Aotani, Eriko verfasserin aut Bryce, Jane verfasserin aut Donnellan, Paul verfasserin aut Oza, Amit verfasserin aut Avall-Lundqvist, Elisabeth verfasserin aut Berek, Jonathan S. verfasserin aut Sehouli, Jalid verfasserin aut Feeney, Amanda verfasserin aut Berton-Rigaud, Dominique verfasserin aut Costa, Daniel S. J. verfasserin aut Friedlander, Michael L. verfasserin aut Enthalten in Quality of life research Dordrecht [u.a.] : Springer Science + Business Media B.V, 1992 27(2017), 1 vom: 16. Dez., Seite 59-74 (DE-627)320474399 (DE-600)2008960-0 1573-2649 nnns volume:27 year:2017 number:1 day:16 month:12 pages:59-74 https://dx.doi.org/10.1007/s11136-017-1729-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2938 GBV_ILN_2949 GBV_ILN_2950 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4392 GBV_ILN_4393 GBV_ILN_4700 44.52 ASE AR 27 2017 1 16 12 59-74 |
| allfieldsSound |
10.1007/s11136-017-1729-8 doi (DE-627)SPR017001803 (SPR)s11136-017-1729-8-e DE-627 ger DE-627 rakwb eng 100 ASE 44.52 bkl King, Madeleine T. verfasserin aut Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. Ovarian cancer (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Platinum sensitive (dpeaa)DE-He213 Platinum resistant (dpeaa)DE-He213 Platinum refractory (dpeaa)DE-He213 Symptom burden (dpeaa)DE-He213 Symptom benefit (dpeaa)DE-He213 Magnitude of clinical benefit (dpeaa)DE-He213 Net health benefit (dpeaa)DE-He213 Patient-reported outcome (dpeaa)DE-He213 PRO (dpeaa)DE-He213 Patient-reported outcome measure (dpeaa)DE-He213 PROM (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 QOL (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 HRQOL (dpeaa)DE-He213 HRQL (dpeaa)DE-He213 Stockler, Martin R. verfasserin aut O’Connell, Rachel L. verfasserin aut Buizen, Luke verfasserin aut Joly, Florence verfasserin aut Lanceley, Anne verfasserin aut Hilpert, Felix verfasserin aut Okamoto, Aikou verfasserin aut Aotani, Eriko verfasserin aut Bryce, Jane verfasserin aut Donnellan, Paul verfasserin aut Oza, Amit verfasserin aut Avall-Lundqvist, Elisabeth verfasserin aut Berek, Jonathan S. verfasserin aut Sehouli, Jalid verfasserin aut Feeney, Amanda verfasserin aut Berton-Rigaud, Dominique verfasserin aut Costa, Daniel S. J. verfasserin aut Friedlander, Michael L. verfasserin aut Enthalten in Quality of life research Dordrecht [u.a.] : Springer Science + Business Media B.V, 1992 27(2017), 1 vom: 16. Dez., Seite 59-74 (DE-627)320474399 (DE-600)2008960-0 1573-2649 nnns volume:27 year:2017 number:1 day:16 month:12 pages:59-74 https://dx.doi.org/10.1007/s11136-017-1729-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_2938 GBV_ILN_2949 GBV_ILN_2950 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4392 GBV_ILN_4393 GBV_ILN_4700 44.52 ASE AR 27 2017 1 16 12 59-74 |
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Enthalten in Quality of life research 27(2017), 1 vom: 16. Dez., Seite 59-74 volume:27 year:2017 number:1 day:16 month:12 pages:59-74 |
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Enthalten in Quality of life research 27(2017), 1 vom: 16. Dez., Seite 59-74 volume:27 year:2017 number:1 day:16 month:12 pages:59-74 |
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Ovarian cancer Recurrent ovarian cancer Platinum sensitive Platinum resistant Platinum refractory Symptom burden Symptom benefit Magnitude of clinical benefit Net health benefit Patient-reported outcome PRO Patient-reported outcome measure PROM Quality of life QOL Health-related quality of life HRQOL HRQL |
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King, Madeleine T. @@aut@@ Stockler, Martin R. @@aut@@ O’Connell, Rachel L. @@aut@@ Buizen, Luke @@aut@@ Joly, Florence @@aut@@ Lanceley, Anne @@aut@@ Hilpert, Felix @@aut@@ Okamoto, Aikou @@aut@@ Aotani, Eriko @@aut@@ Bryce, Jane @@aut@@ Donnellan, Paul @@aut@@ Oza, Amit @@aut@@ Avall-Lundqvist, Elisabeth @@aut@@ Berek, Jonathan S. @@aut@@ Sehouli, Jalid @@aut@@ Feeney, Amanda @@aut@@ Berton-Rigaud, Dominique @@aut@@ Costa, Daniel S. J. @@aut@@ Friedlander, Michael L. @@aut@@ |
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2017-12-16T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR017001803</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520002936.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s11136-017-1729-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR017001803</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s11136-017-1729-8-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">100</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.52</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">King, Madeleine T.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. 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King, Madeleine T. |
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King, Madeleine T. ddc 100 bkl 44.52 misc Ovarian cancer misc Recurrent ovarian cancer misc Platinum sensitive misc Platinum resistant misc Platinum refractory misc Symptom burden misc Symptom benefit misc Magnitude of clinical benefit misc Net health benefit misc Patient-reported outcome misc PRO misc Patient-reported outcome measure misc PROM misc Quality of life misc QOL misc Health-related quality of life misc HRQOL misc HRQL Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer |
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100 ASE 44.52 bkl Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer Ovarian cancer (dpeaa)DE-He213 Recurrent ovarian cancer (dpeaa)DE-He213 Platinum sensitive (dpeaa)DE-He213 Platinum resistant (dpeaa)DE-He213 Platinum refractory (dpeaa)DE-He213 Symptom burden (dpeaa)DE-He213 Symptom benefit (dpeaa)DE-He213 Magnitude of clinical benefit (dpeaa)DE-He213 Net health benefit (dpeaa)DE-He213 Patient-reported outcome (dpeaa)DE-He213 PRO (dpeaa)DE-He213 Patient-reported outcome measure (dpeaa)DE-He213 PROM (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 QOL (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 HRQOL (dpeaa)DE-He213 HRQL (dpeaa)DE-He213 |
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ddc 100 bkl 44.52 misc Ovarian cancer misc Recurrent ovarian cancer misc Platinum sensitive misc Platinum resistant misc Platinum refractory misc Symptom burden misc Symptom benefit misc Magnitude of clinical benefit misc Net health benefit misc Patient-reported outcome misc PRO misc Patient-reported outcome measure misc PROM misc Quality of life misc QOL misc Health-related quality of life misc HRQOL misc HRQL |
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ddc 100 bkl 44.52 misc Ovarian cancer misc Recurrent ovarian cancer misc Platinum sensitive misc Platinum resistant misc Platinum refractory misc Symptom burden misc Symptom benefit misc Magnitude of clinical benefit misc Net health benefit misc Patient-reported outcome misc PRO misc Patient-reported outcome measure misc PROM misc Quality of life misc QOL misc Health-related quality of life misc HRQOL misc HRQL |
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ddc 100 bkl 44.52 misc Ovarian cancer misc Recurrent ovarian cancer misc Platinum sensitive misc Platinum resistant misc Platinum refractory misc Symptom burden misc Symptom benefit misc Magnitude of clinical benefit misc Net health benefit misc Patient-reported outcome misc PRO misc Patient-reported outcome measure misc PROM misc Quality of life misc QOL misc Health-related quality of life misc HRQOL misc HRQL |
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Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer |
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Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer |
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King, Madeleine T. |
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King, Madeleine T. Stockler, Martin R. O’Connell, Rachel L. Buizen, Luke Joly, Florence Lanceley, Anne Hilpert, Felix Okamoto, Aikou Aotani, Eriko Bryce, Jane Donnellan, Paul Oza, Amit Avall-Lundqvist, Elisabeth Berek, Jonathan S. Sehouli, Jalid Feeney, Amanda Berton-Rigaud, Dominique Costa, Daniel S. J. Friedlander, Michael L. |
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King, Madeleine T. |
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measuring what matters most: validation of the measure of ovarian symptoms and treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer |
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Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer |
| abstract |
Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. |
| abstractGer |
Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. |
| abstract_unstemmed |
Purpose Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test–retest reliability. |
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Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer |
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Stockler, Martin R. O’Connell, Rachel L. Buizen, Luke Joly, Florence Lanceley, Anne Hilpert, Felix Okamoto, Aikou Aotani, Eriko Bryce, Jane Donnellan, Paul Oza, Amit Avall-Lundqvist, Elisabeth Berek, Jonathan S. Sehouli, Jalid Feeney, Amanda Berton-Rigaud, Dominique Costa, Daniel S. J. Friedlander, Michael L. |
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Stockler, Martin R. O’Connell, Rachel L. Buizen, Luke Joly, Florence Lanceley, Anne Hilpert, Felix Okamoto, Aikou Aotani, Eriko Bryce, Jane Donnellan, Paul Oza, Amit Avall-Lundqvist, Elisabeth Berek, Jonathan S. Sehouli, Jalid Feeney, Amanda Berton-Rigaud, Dominique Costa, Daniel S. J. Friedlander, Michael L. |
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| doi_str |
10.1007/s11136-017-1729-8 |
| up_date |
2024-07-04T01:49:25.175Z |
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Methods GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients’ cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearman’s correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Results Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC ≥ 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. Conclusions The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. 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| score |
7.3989286 |