Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol
Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-in...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Khusnutdinova, E. F. [verfasserIn] Petrova, A. V. [verfasserIn] Apryshko, G. N. [verfasserIn] Kukovinets, O. S. [verfasserIn] Kazakova, O. B. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Russian journal of bioorganic chemistry - Moscow : MAIK Nauka/Interperiodica Publ., 2000, 44(2018), 3 vom: Mai, Seite 322-329 |
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| Übergeordnetes Werk: |
volume:44 ; year:2018 ; number:3 ; month:05 ; pages:322-329 |
| Links: |
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| DOI / URN: |
10.1134/S1068162018030081 |
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| Katalog-ID: |
SPR017269814 |
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| 100 | 1 | |a Khusnutdinova, E. F. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol |
| 264 | 1 | |c 2018 | |
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| 520 | |a Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. | ||
| 650 | 4 | |a triterpenoids |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a betulin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a erythrodiol |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a uvaol |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a cytotoxicity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a indole-fused triterpenoids |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a synthesis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Petrova, A. V. |e verfasserin |4 aut | |
| 700 | 1 | |a Apryshko, G. N. |e verfasserin |4 aut | |
| 700 | 1 | |a Kukovinets, O. S. |e verfasserin |4 aut | |
| 700 | 1 | |a Kazakova, O. B. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Russian journal of bioorganic chemistry |d Moscow : MAIK Nauka/Interperiodica Publ., 2000 |g 44(2018), 3 vom: Mai, Seite 322-329 |w (DE-627)334712912 |w (DE-600)2058156-7 |x 1573-9163 |7 nnns |
| 773 | 1 | 8 | |g volume:44 |g year:2018 |g number:3 |g month:05 |g pages:322-329 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1134/S1068162018030081 |z lizenzpflichtig |3 Volltext |
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10.1134/S1068162018030081 doi (DE-627)SPR017269814 (SPR)S1068162018030081-e DE-627 ger DE-627 rakwb eng 540 ASE 35.70 bkl Khusnutdinova, E. F. verfasserin aut Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. triterpenoids (dpeaa)DE-He213 betulin (dpeaa)DE-He213 erythrodiol (dpeaa)DE-He213 uvaol (dpeaa)DE-He213 cytotoxicity (dpeaa)DE-He213 indole-fused triterpenoids (dpeaa)DE-He213 synthesis (dpeaa)DE-He213 Petrova, A. V. verfasserin aut Apryshko, G. N. verfasserin aut Kukovinets, O. S. verfasserin aut Kazakova, O. B. verfasserin aut Enthalten in Russian journal of bioorganic chemistry Moscow : MAIK Nauka/Interperiodica Publ., 2000 44(2018), 3 vom: Mai, Seite 322-329 (DE-627)334712912 (DE-600)2058156-7 1573-9163 nnns volume:44 year:2018 number:3 month:05 pages:322-329 https://dx.doi.org/10.1134/S1068162018030081 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.70 ASE AR 44 2018 3 05 322-329 |
| spelling |
10.1134/S1068162018030081 doi (DE-627)SPR017269814 (SPR)S1068162018030081-e DE-627 ger DE-627 rakwb eng 540 ASE 35.70 bkl Khusnutdinova, E. F. verfasserin aut Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. triterpenoids (dpeaa)DE-He213 betulin (dpeaa)DE-He213 erythrodiol (dpeaa)DE-He213 uvaol (dpeaa)DE-He213 cytotoxicity (dpeaa)DE-He213 indole-fused triterpenoids (dpeaa)DE-He213 synthesis (dpeaa)DE-He213 Petrova, A. V. verfasserin aut Apryshko, G. N. verfasserin aut Kukovinets, O. S. verfasserin aut Kazakova, O. B. verfasserin aut Enthalten in Russian journal of bioorganic chemistry Moscow : MAIK Nauka/Interperiodica Publ., 2000 44(2018), 3 vom: Mai, Seite 322-329 (DE-627)334712912 (DE-600)2058156-7 1573-9163 nnns volume:44 year:2018 number:3 month:05 pages:322-329 https://dx.doi.org/10.1134/S1068162018030081 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.70 ASE AR 44 2018 3 05 322-329 |
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10.1134/S1068162018030081 doi (DE-627)SPR017269814 (SPR)S1068162018030081-e DE-627 ger DE-627 rakwb eng 540 ASE 35.70 bkl Khusnutdinova, E. F. verfasserin aut Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. triterpenoids (dpeaa)DE-He213 betulin (dpeaa)DE-He213 erythrodiol (dpeaa)DE-He213 uvaol (dpeaa)DE-He213 cytotoxicity (dpeaa)DE-He213 indole-fused triterpenoids (dpeaa)DE-He213 synthesis (dpeaa)DE-He213 Petrova, A. V. verfasserin aut Apryshko, G. N. verfasserin aut Kukovinets, O. S. verfasserin aut Kazakova, O. B. verfasserin aut Enthalten in Russian journal of bioorganic chemistry Moscow : MAIK Nauka/Interperiodica Publ., 2000 44(2018), 3 vom: Mai, Seite 322-329 (DE-627)334712912 (DE-600)2058156-7 1573-9163 nnns volume:44 year:2018 number:3 month:05 pages:322-329 https://dx.doi.org/10.1134/S1068162018030081 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.70 ASE AR 44 2018 3 05 322-329 |
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10.1134/S1068162018030081 doi (DE-627)SPR017269814 (SPR)S1068162018030081-e DE-627 ger DE-627 rakwb eng 540 ASE 35.70 bkl Khusnutdinova, E. F. verfasserin aut Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. triterpenoids (dpeaa)DE-He213 betulin (dpeaa)DE-He213 erythrodiol (dpeaa)DE-He213 uvaol (dpeaa)DE-He213 cytotoxicity (dpeaa)DE-He213 indole-fused triterpenoids (dpeaa)DE-He213 synthesis (dpeaa)DE-He213 Petrova, A. V. verfasserin aut Apryshko, G. N. verfasserin aut Kukovinets, O. S. verfasserin aut Kazakova, O. B. verfasserin aut Enthalten in Russian journal of bioorganic chemistry Moscow : MAIK Nauka/Interperiodica Publ., 2000 44(2018), 3 vom: Mai, Seite 322-329 (DE-627)334712912 (DE-600)2058156-7 1573-9163 nnns volume:44 year:2018 number:3 month:05 pages:322-329 https://dx.doi.org/10.1134/S1068162018030081 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.70 ASE AR 44 2018 3 05 322-329 |
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10.1134/S1068162018030081 doi (DE-627)SPR017269814 (SPR)S1068162018030081-e DE-627 ger DE-627 rakwb eng 540 ASE 35.70 bkl Khusnutdinova, E. F. verfasserin aut Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. triterpenoids (dpeaa)DE-He213 betulin (dpeaa)DE-He213 erythrodiol (dpeaa)DE-He213 uvaol (dpeaa)DE-He213 cytotoxicity (dpeaa)DE-He213 indole-fused triterpenoids (dpeaa)DE-He213 synthesis (dpeaa)DE-He213 Petrova, A. V. verfasserin aut Apryshko, G. N. verfasserin aut Kukovinets, O. S. verfasserin aut Kazakova, O. B. verfasserin aut Enthalten in Russian journal of bioorganic chemistry Moscow : MAIK Nauka/Interperiodica Publ., 2000 44(2018), 3 vom: Mai, Seite 322-329 (DE-627)334712912 (DE-600)2058156-7 1573-9163 nnns volume:44 year:2018 number:3 month:05 pages:322-329 https://dx.doi.org/10.1134/S1068162018030081 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.70 ASE AR 44 2018 3 05 322-329 |
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Enthalten in Russian journal of bioorganic chemistry 44(2018), 3 vom: Mai, Seite 322-329 volume:44 year:2018 number:3 month:05 pages:322-329 |
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Russian journal of bioorganic chemistry |
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Khusnutdinova, E. F. @@aut@@ Petrova, A. V. @@aut@@ Apryshko, G. N. @@aut@@ Kukovinets, O. S. @@aut@@ Kazakova, O. B. @@aut@@ |
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It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. 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| author |
Khusnutdinova, E. F. |
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Khusnutdinova, E. F. ddc 540 bkl 35.70 misc triterpenoids misc betulin misc erythrodiol misc uvaol misc cytotoxicity misc indole-fused triterpenoids misc synthesis Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol |
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540 ASE 35.70 bkl Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol triterpenoids (dpeaa)DE-He213 betulin (dpeaa)DE-He213 erythrodiol (dpeaa)DE-He213 uvaol (dpeaa)DE-He213 cytotoxicity (dpeaa)DE-He213 indole-fused triterpenoids (dpeaa)DE-He213 synthesis (dpeaa)DE-He213 |
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ddc 540 bkl 35.70 misc triterpenoids misc betulin misc erythrodiol misc uvaol misc cytotoxicity misc indole-fused triterpenoids misc synthesis |
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ddc 540 bkl 35.70 misc triterpenoids misc betulin misc erythrodiol misc uvaol misc cytotoxicity misc indole-fused triterpenoids misc synthesis |
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Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol |
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Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol |
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Khusnutdinova, E. F. |
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Russian journal of bioorganic chemistry |
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Khusnutdinova, E. F. Petrova, A. V. Apryshko, G. N. Kukovinets, O. S. Kazakova, O. B. |
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Khusnutdinova, E. F. |
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synthesis and cytotoxicity of indole derivatives of betulin, erythrodiol, and uvaol |
| title_auth |
Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol |
| abstract |
Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. |
| abstractGer |
Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. |
| abstract_unstemmed |
Abstract 2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents. |
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| title_short |
Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol |
| url |
https://dx.doi.org/10.1134/S1068162018030081 |
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Petrova, A. V. Apryshko, G. N. Kukovinets, O. S. Kazakova, O. B. |
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Petrova, A. V. Apryshko, G. N. Kukovinets, O. S. Kazakova, O. B. |
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| doi_str |
10.1134/S1068162018030081 |
| up_date |
2024-07-04T02:47:47.694Z |
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| score |
7.401106 |