Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid
Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted tr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fu, Hai-Jian [verfasserIn] Chen, Qiu-Yun [verfasserIn] Huang, Jun [verfasserIn] Zhang, Rong-Xia [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Transition metal chemistry - Dordrecht [u.a.] : Springer Science + Business Media B.V, 1975, 35(2009), 1 vom: 10. Nov., Seite 103-109 |
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| Übergeordnetes Werk: |
volume:35 ; year:2009 ; number:1 ; day:10 ; month:11 ; pages:103-109 |
| Links: |
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| DOI / URN: |
10.1007/s11243-009-9301-1 |
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| Katalog-ID: |
SPR018092276 |
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| 100 | 1 | |a Fu, Hai-Jian |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid |
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| 520 | |a Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. | ||
| 650 | 4 | |a CoCl |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ethidium Bromide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Salen |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pyridyl Ring |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Human Lung Adenocarcinoma A549 Cell |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Chen, Qiu-Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Rong-Xia |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Transition metal chemistry |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1975 |g 35(2009), 1 vom: 10. Nov., Seite 103-109 |w (DE-627)306713632 |w (DE-600)1501083-1 |x 1572-901X |7 nnns |
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| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
| 912 | |a GBV_ILN_2108 | ||
| 912 | |a GBV_ILN_2110 | ||
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| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
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| 912 | |a GBV_ILN_2147 | ||
| 912 | |a GBV_ILN_2148 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
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10.1007/s11243-009-9301-1 doi (DE-627)SPR018092276 (SPR)s11243-009-9301-1-e DE-627 ger DE-627 rakwb eng 660 ASE 58.00 bkl Fu, Hai-Jian verfasserin aut Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. CoCl (dpeaa)DE-He213 Ethidium Bromide (dpeaa)DE-He213 Salen (dpeaa)DE-He213 Pyridyl Ring (dpeaa)DE-He213 Human Lung Adenocarcinoma A549 Cell (dpeaa)DE-He213 Chen, Qiu-Yun verfasserin aut Huang, Jun verfasserin aut Zhang, Rong-Xia verfasserin aut Enthalten in Transition metal chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V, 1975 35(2009), 1 vom: 10. Nov., Seite 103-109 (DE-627)306713632 (DE-600)1501083-1 1572-901X nnns volume:35 year:2009 number:1 day:10 month:11 pages:103-109 https://dx.doi.org/10.1007/s11243-009-9301-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.00 ASE AR 35 2009 1 10 11 103-109 |
| spelling |
10.1007/s11243-009-9301-1 doi (DE-627)SPR018092276 (SPR)s11243-009-9301-1-e DE-627 ger DE-627 rakwb eng 660 ASE 58.00 bkl Fu, Hai-Jian verfasserin aut Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. CoCl (dpeaa)DE-He213 Ethidium Bromide (dpeaa)DE-He213 Salen (dpeaa)DE-He213 Pyridyl Ring (dpeaa)DE-He213 Human Lung Adenocarcinoma A549 Cell (dpeaa)DE-He213 Chen, Qiu-Yun verfasserin aut Huang, Jun verfasserin aut Zhang, Rong-Xia verfasserin aut Enthalten in Transition metal chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V, 1975 35(2009), 1 vom: 10. Nov., Seite 103-109 (DE-627)306713632 (DE-600)1501083-1 1572-901X nnns volume:35 year:2009 number:1 day:10 month:11 pages:103-109 https://dx.doi.org/10.1007/s11243-009-9301-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.00 ASE AR 35 2009 1 10 11 103-109 |
| allfields_unstemmed |
10.1007/s11243-009-9301-1 doi (DE-627)SPR018092276 (SPR)s11243-009-9301-1-e DE-627 ger DE-627 rakwb eng 660 ASE 58.00 bkl Fu, Hai-Jian verfasserin aut Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. CoCl (dpeaa)DE-He213 Ethidium Bromide (dpeaa)DE-He213 Salen (dpeaa)DE-He213 Pyridyl Ring (dpeaa)DE-He213 Human Lung Adenocarcinoma A549 Cell (dpeaa)DE-He213 Chen, Qiu-Yun verfasserin aut Huang, Jun verfasserin aut Zhang, Rong-Xia verfasserin aut Enthalten in Transition metal chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V, 1975 35(2009), 1 vom: 10. Nov., Seite 103-109 (DE-627)306713632 (DE-600)1501083-1 1572-901X nnns volume:35 year:2009 number:1 day:10 month:11 pages:103-109 https://dx.doi.org/10.1007/s11243-009-9301-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.00 ASE AR 35 2009 1 10 11 103-109 |
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10.1007/s11243-009-9301-1 doi (DE-627)SPR018092276 (SPR)s11243-009-9301-1-e DE-627 ger DE-627 rakwb eng 660 ASE 58.00 bkl Fu, Hai-Jian verfasserin aut Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. CoCl (dpeaa)DE-He213 Ethidium Bromide (dpeaa)DE-He213 Salen (dpeaa)DE-He213 Pyridyl Ring (dpeaa)DE-He213 Human Lung Adenocarcinoma A549 Cell (dpeaa)DE-He213 Chen, Qiu-Yun verfasserin aut Huang, Jun verfasserin aut Zhang, Rong-Xia verfasserin aut Enthalten in Transition metal chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V, 1975 35(2009), 1 vom: 10. Nov., Seite 103-109 (DE-627)306713632 (DE-600)1501083-1 1572-901X nnns volume:35 year:2009 number:1 day:10 month:11 pages:103-109 https://dx.doi.org/10.1007/s11243-009-9301-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.00 ASE AR 35 2009 1 10 11 103-109 |
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10.1007/s11243-009-9301-1 doi (DE-627)SPR018092276 (SPR)s11243-009-9301-1-e DE-627 ger DE-627 rakwb eng 660 ASE 58.00 bkl Fu, Hai-Jian verfasserin aut Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. CoCl (dpeaa)DE-He213 Ethidium Bromide (dpeaa)DE-He213 Salen (dpeaa)DE-He213 Pyridyl Ring (dpeaa)DE-He213 Human Lung Adenocarcinoma A549 Cell (dpeaa)DE-He213 Chen, Qiu-Yun verfasserin aut Huang, Jun verfasserin aut Zhang, Rong-Xia verfasserin aut Enthalten in Transition metal chemistry Dordrecht [u.a.] : Springer Science + Business Media B.V, 1975 35(2009), 1 vom: 10. Nov., Seite 103-109 (DE-627)306713632 (DE-600)1501083-1 1572-901X nnns volume:35 year:2009 number:1 day:10 month:11 pages:103-109 https://dx.doi.org/10.1007/s11243-009-9301-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.00 ASE AR 35 2009 1 10 11 103-109 |
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Enthalten in Transition metal chemistry 35(2009), 1 vom: 10. Nov., Seite 103-109 volume:35 year:2009 number:1 day:10 month:11 pages:103-109 |
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CoCl Ethidium Bromide Salen Pyridyl Ring Human Lung Adenocarcinoma A549 Cell |
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Transition metal chemistry |
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Fu, Hai-Jian @@aut@@ Chen, Qiu-Yun @@aut@@ Huang, Jun @@aut@@ Zhang, Rong-Xia @@aut@@ |
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2009-11-10T00:00:00Z |
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Fu, Hai-Jian |
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Fu, Hai-Jian ddc 660 bkl 58.00 misc CoCl misc Ethidium Bromide misc Salen misc Pyridyl Ring misc Human Lung Adenocarcinoma A549 Cell Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid |
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660 ASE 58.00 bkl Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid CoCl (dpeaa)DE-He213 Ethidium Bromide (dpeaa)DE-He213 Salen (dpeaa)DE-He213 Pyridyl Ring (dpeaa)DE-He213 Human Lung Adenocarcinoma A549 Cell (dpeaa)DE-He213 |
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Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid |
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Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid |
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Fu, Hai-Jian Chen, Qiu-Yun Huang, Jun Zhang, Rong-Xia |
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synthesis, dna interaction and antitumor activities of cobalt(ii) and iron(iii) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid |
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Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid |
| abstract |
Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. |
| abstractGer |
Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. |
| abstract_unstemmed |
Abstract Three complexes with 2-[bis(2-pyridylmethyl)amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)$ FeCl_{2} $] (2) and [(Adpa)Fe($ H_{2} $O)2] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) > (2) ≫ (1), which is in correlation with their DNA-binding properties. |
| collection_details |
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| container_issue |
1 |
| title_short |
Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid |
| url |
https://dx.doi.org/10.1007/s11243-009-9301-1 |
| remote_bool |
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| author2 |
Chen, Qiu-Yun Huang, Jun Zhang, Rong-Xia |
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Chen, Qiu-Yun Huang, Jun Zhang, Rong-Xia |
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| doi_str |
10.1007/s11243-009-9301-1 |
| up_date |
2024-07-03T17:18:16.042Z |
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| score |
7.4011145 |