Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma

Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ather, M. Hammad [verfasserIn] Nazim, Syed M. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Renal Cell Carcinoma Partial Nephrectomy Radical Cystectomy Obesity Class Microscopic Vascular Invasion

Übergeordnetes Werk:	Enthalten in: International urology and nephrology - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969, 42(2009), 2 vom: 28. Aug., Seite 299-303
Übergeordnetes Werk:	volume:42 ; year:2009 ; number:2 ; day:28 ; month:08 ; pages:299-303

Links:	Volltext

DOI / URN:	10.1007/s11255-009-9636-8

Katalog-ID:	SPR018245463

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245	1	0	\|a Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma
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520			\|a Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival.
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700	1		\|a Nazim, Syed M. \|e verfasserin \|4 aut
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allfields	10.1007/s11255-009-9636-8 doi (DE-627)SPR018245463 (SPR)s11255-009-9636-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl Ather, M. Hammad verfasserin aut Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival. Renal Cell Carcinoma (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Radical Cystectomy (dpeaa)DE-He213 Obesity Class (dpeaa)DE-He213 Microscopic Vascular Invasion (dpeaa)DE-He213 Nazim, Syed M. verfasserin aut Enthalten in International urology and nephrology Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 42(2009), 2 vom: 28. Aug., Seite 299-303 (DE-627)320529134 (DE-600)2015547-5 1573-2584 nnns volume:42 year:2009 number:2 day:28 month:08 pages:299-303 https://dx.doi.org/10.1007/s11255-009-9636-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 42 2009 2 28 08 299-303
spelling	10.1007/s11255-009-9636-8 doi (DE-627)SPR018245463 (SPR)s11255-009-9636-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl Ather, M. Hammad verfasserin aut Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival. Renal Cell Carcinoma (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Radical Cystectomy (dpeaa)DE-He213 Obesity Class (dpeaa)DE-He213 Microscopic Vascular Invasion (dpeaa)DE-He213 Nazim, Syed M. verfasserin aut Enthalten in International urology and nephrology Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 42(2009), 2 vom: 28. Aug., Seite 299-303 (DE-627)320529134 (DE-600)2015547-5 1573-2584 nnns volume:42 year:2009 number:2 day:28 month:08 pages:299-303 https://dx.doi.org/10.1007/s11255-009-9636-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 42 2009 2 28 08 299-303
allfields_unstemmed	10.1007/s11255-009-9636-8 doi (DE-627)SPR018245463 (SPR)s11255-009-9636-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl Ather, M. Hammad verfasserin aut Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival. Renal Cell Carcinoma (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Radical Cystectomy (dpeaa)DE-He213 Obesity Class (dpeaa)DE-He213 Microscopic Vascular Invasion (dpeaa)DE-He213 Nazim, Syed M. verfasserin aut Enthalten in International urology and nephrology Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 42(2009), 2 vom: 28. Aug., Seite 299-303 (DE-627)320529134 (DE-600)2015547-5 1573-2584 nnns volume:42 year:2009 number:2 day:28 month:08 pages:299-303 https://dx.doi.org/10.1007/s11255-009-9636-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 42 2009 2 28 08 299-303
allfieldsGer	10.1007/s11255-009-9636-8 doi (DE-627)SPR018245463 (SPR)s11255-009-9636-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl Ather, M. Hammad verfasserin aut Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival. Renal Cell Carcinoma (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Radical Cystectomy (dpeaa)DE-He213 Obesity Class (dpeaa)DE-He213 Microscopic Vascular Invasion (dpeaa)DE-He213 Nazim, Syed M. verfasserin aut Enthalten in International urology and nephrology Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 42(2009), 2 vom: 28. Aug., Seite 299-303 (DE-627)320529134 (DE-600)2015547-5 1573-2584 nnns volume:42 year:2009 number:2 day:28 month:08 pages:299-303 https://dx.doi.org/10.1007/s11255-009-9636-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 42 2009 2 28 08 299-303
allfieldsSound	10.1007/s11255-009-9636-8 doi (DE-627)SPR018245463 (SPR)s11255-009-9636-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.88 bkl Ather, M. Hammad verfasserin aut Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival. Renal Cell Carcinoma (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Radical Cystectomy (dpeaa)DE-He213 Obesity Class (dpeaa)DE-He213 Microscopic Vascular Invasion (dpeaa)DE-He213 Nazim, Syed M. verfasserin aut Enthalten in International urology and nephrology Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 42(2009), 2 vom: 28. Aug., Seite 299-303 (DE-627)320529134 (DE-600)2015547-5 1573-2584 nnns volume:42 year:2009 number:2 day:28 month:08 pages:299-303 https://dx.doi.org/10.1007/s11255-009-9636-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.88 ASE AR 42 2009 2 28 08 299-303
language	English
source	Enthalten in International urology and nephrology 42(2009), 2 vom: 28. Aug., Seite 299-303 volume:42 year:2009 number:2 day:28 month:08 pages:299-303
sourceStr	Enthalten in International urology and nephrology 42(2009), 2 vom: 28. Aug., Seite 299-303 volume:42 year:2009 number:2 day:28 month:08 pages:299-303
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Renal Cell Carcinoma Partial Nephrectomy Radical Cystectomy Obesity Class Microscopic Vascular Invasion
dewey-raw	610
isfreeaccess_bool	false
container_title	International urology and nephrology
authorswithroles_txt_mv	Ather, M. Hammad @@aut@@ Nazim, Syed M. @@aut@@
publishDateDaySort_date	2009-08-28T00:00:00Z
hierarchy_top_id	320529134
dewey-sort	3610
id	SPR018245463
language_de	englisch
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Hammad</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2009</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. 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author	Ather, M. Hammad
spellingShingle	Ather, M. Hammad ddc 610 bkl 44.88 misc Renal Cell Carcinoma misc Partial Nephrectomy misc Radical Cystectomy misc Obesity Class misc Microscopic Vascular Invasion Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma
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topic_title	610 ASE 44.88 bkl Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma Renal Cell Carcinoma (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Radical Cystectomy (dpeaa)DE-He213 Obesity Class (dpeaa)DE-He213 Microscopic Vascular Invasion (dpeaa)DE-He213
topic	ddc 610 bkl 44.88 misc Renal Cell Carcinoma misc Partial Nephrectomy misc Radical Cystectomy misc Obesity Class misc Microscopic Vascular Invasion
topic_unstemmed	ddc 610 bkl 44.88 misc Renal Cell Carcinoma misc Partial Nephrectomy misc Radical Cystectomy misc Obesity Class misc Microscopic Vascular Invasion
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title	Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma
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title_full	Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma
author_sort	Ather, M. Hammad
journal	International urology and nephrology
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author_browse	Ather, M. Hammad Nazim, Syed M.
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title_sort	impact of charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma
title_auth	Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma
abstract	Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival.
abstractGer	Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival.
abstract_unstemmed	Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson’s index has a significant predictive value on overall survival.
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title_short	Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma
url	https://dx.doi.org/10.1007/s11255-009-9636-8
remote_bool	true
author2	Nazim, Syed M.
author2Str	Nazim, Syed M.
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doi_str	10.1007/s11255-009-9636-8
up_date	2024-07-03T18:24:10.714Z
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Hammad</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2009</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective To study the impact of Charlson’s comorbidity index on overall survival following radical and partial nephrectomy performed for renal cell carcinoma (RCC). Methods Patients with primary RCC treated by tumor nephrectomy with at least 1 year of follow-up were included. The outcome parameters assessed were overall survival, impact of surgery on quality of life of patients using Karnofsky’s index and correlation of survival with respect to comorbid conditions, using Charlson’s index comorbidity score, grade and stage of disease. Results A total of 214 tumor nephrectomies were performed during study period, of which 157 (73%) fulfilling the criteria were included in the final analysis. The mean age at presentation was 57 ± 12 years. The mean Charlson’s index was 2.89 ± 2.22. Tumor stages were I–IV in 33, 30, 16 and 21%, respectively. The overall survival was 65% at a mean follow-up of 39 ± 5 months. The mean pre op Karnofsky’s index was 79.5 ± 7.13 and at follow-up it was 95.41 ± 10.65 (P < .001). The difference in functional status of patient (Karnofsky’s Index) for every stage including Stage-IV was statistically significant (P 0.01). Survival analysis showed a significant differences in overall survival according to stage (P 0.001), grade (P 0.001), size of tumor (P 0.001) and Charlson’s index (P = 0.05). Conclusions There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. 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Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma

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