Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases
Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to ea...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Takayasu, Tatsunori [verfasserIn] Ishida, Yuko [verfasserIn] Kimura, Akihiko [verfasserIn] Nosaka, Mizuho [verfasserIn] Kuninaka, Yumi [verfasserIn] Kawaguchi, Mariko [verfasserIn] Kondo, Toshikazu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Forensic toxicology - Berlin : Springer, 2006, 28(2010), 2 vom: 22. Juni, Seite 124-128 |
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| Übergeordnetes Werk: |
volume:28 ; year:2010 ; number:2 ; day:22 ; month:06 ; pages:124-128 |
| Links: |
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| DOI / URN: |
10.1007/s11419-010-0095-9 |
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| Katalog-ID: |
SPR019077831 |
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| 245 | 1 | 0 | |a Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases |
| 264 | 1 | |c 2010 | |
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| 520 | |a Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. | ||
| 650 | 4 | |a Carbamazepine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Carbamazepine-10,11-epoxide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Iminostilbene |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a GC-MS |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tissue distribution |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Human |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ishida, Yuko |e verfasserin |4 aut | |
| 700 | 1 | |a Kimura, Akihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Nosaka, Mizuho |e verfasserin |4 aut | |
| 700 | 1 | |a Kuninaka, Yumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kawaguchi, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Kondo, Toshikazu |e verfasserin |4 aut | |
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10.1007/s11419-010-0095-9 doi (DE-627)SPR019077831 (SPR)s11419-010-0095-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Takayasu, Tatsunori verfasserin aut Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. Carbamazepine (dpeaa)DE-He213 Carbamazepine-10,11-epoxide (dpeaa)DE-He213 Iminostilbene (dpeaa)DE-He213 GC-MS (dpeaa)DE-He213 Tissue distribution (dpeaa)DE-He213 Human (dpeaa)DE-He213 Ishida, Yuko verfasserin aut Kimura, Akihiko verfasserin aut Nosaka, Mizuho verfasserin aut Kuninaka, Yumi verfasserin aut Kawaguchi, Mariko verfasserin aut Kondo, Toshikazu verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 28(2010), 2 vom: 22. Juni, Seite 124-128 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:28 year:2010 number:2 day:22 month:06 pages:124-128 https://dx.doi.org/10.1007/s11419-010-0095-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 28 2010 2 22 06 124-128 |
| spelling |
10.1007/s11419-010-0095-9 doi (DE-627)SPR019077831 (SPR)s11419-010-0095-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Takayasu, Tatsunori verfasserin aut Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. Carbamazepine (dpeaa)DE-He213 Carbamazepine-10,11-epoxide (dpeaa)DE-He213 Iminostilbene (dpeaa)DE-He213 GC-MS (dpeaa)DE-He213 Tissue distribution (dpeaa)DE-He213 Human (dpeaa)DE-He213 Ishida, Yuko verfasserin aut Kimura, Akihiko verfasserin aut Nosaka, Mizuho verfasserin aut Kuninaka, Yumi verfasserin aut Kawaguchi, Mariko verfasserin aut Kondo, Toshikazu verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 28(2010), 2 vom: 22. Juni, Seite 124-128 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:28 year:2010 number:2 day:22 month:06 pages:124-128 https://dx.doi.org/10.1007/s11419-010-0095-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 28 2010 2 22 06 124-128 |
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10.1007/s11419-010-0095-9 doi (DE-627)SPR019077831 (SPR)s11419-010-0095-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Takayasu, Tatsunori verfasserin aut Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. Carbamazepine (dpeaa)DE-He213 Carbamazepine-10,11-epoxide (dpeaa)DE-He213 Iminostilbene (dpeaa)DE-He213 GC-MS (dpeaa)DE-He213 Tissue distribution (dpeaa)DE-He213 Human (dpeaa)DE-He213 Ishida, Yuko verfasserin aut Kimura, Akihiko verfasserin aut Nosaka, Mizuho verfasserin aut Kuninaka, Yumi verfasserin aut Kawaguchi, Mariko verfasserin aut Kondo, Toshikazu verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 28(2010), 2 vom: 22. Juni, Seite 124-128 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:28 year:2010 number:2 day:22 month:06 pages:124-128 https://dx.doi.org/10.1007/s11419-010-0095-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 28 2010 2 22 06 124-128 |
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10.1007/s11419-010-0095-9 doi (DE-627)SPR019077831 (SPR)s11419-010-0095-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Takayasu, Tatsunori verfasserin aut Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. Carbamazepine (dpeaa)DE-He213 Carbamazepine-10,11-epoxide (dpeaa)DE-He213 Iminostilbene (dpeaa)DE-He213 GC-MS (dpeaa)DE-He213 Tissue distribution (dpeaa)DE-He213 Human (dpeaa)DE-He213 Ishida, Yuko verfasserin aut Kimura, Akihiko verfasserin aut Nosaka, Mizuho verfasserin aut Kuninaka, Yumi verfasserin aut Kawaguchi, Mariko verfasserin aut Kondo, Toshikazu verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 28(2010), 2 vom: 22. Juni, Seite 124-128 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:28 year:2010 number:2 day:22 month:06 pages:124-128 https://dx.doi.org/10.1007/s11419-010-0095-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 28 2010 2 22 06 124-128 |
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10.1007/s11419-010-0095-9 doi (DE-627)SPR019077831 (SPR)s11419-010-0095-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Takayasu, Tatsunori verfasserin aut Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. Carbamazepine (dpeaa)DE-He213 Carbamazepine-10,11-epoxide (dpeaa)DE-He213 Iminostilbene (dpeaa)DE-He213 GC-MS (dpeaa)DE-He213 Tissue distribution (dpeaa)DE-He213 Human (dpeaa)DE-He213 Ishida, Yuko verfasserin aut Kimura, Akihiko verfasserin aut Nosaka, Mizuho verfasserin aut Kuninaka, Yumi verfasserin aut Kawaguchi, Mariko verfasserin aut Kondo, Toshikazu verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 28(2010), 2 vom: 22. Juni, Seite 124-128 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:28 year:2010 number:2 day:22 month:06 pages:124-128 https://dx.doi.org/10.1007/s11419-010-0095-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 28 2010 2 22 06 124-128 |
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Enthalten in Forensic toxicology 28(2010), 2 vom: 22. Juni, Seite 124-128 volume:28 year:2010 number:2 day:22 month:06 pages:124-128 |
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Enthalten in Forensic toxicology 28(2010), 2 vom: 22. Juni, Seite 124-128 volume:28 year:2010 number:2 day:22 month:06 pages:124-128 |
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Carbamazepine Carbamazepine-10,11-epoxide Iminostilbene GC-MS Tissue distribution Human |
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Forensic toxicology |
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Takayasu, Tatsunori @@aut@@ Ishida, Yuko @@aut@@ Kimura, Akihiko @@aut@@ Nosaka, Mizuho @@aut@@ Kuninaka, Yumi @@aut@@ Kawaguchi, Mariko @@aut@@ Kondo, Toshikazu @@aut@@ |
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2010-06-22T00:00:00Z |
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Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. 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|
| author |
Takayasu, Tatsunori |
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Takayasu, Tatsunori ddc 610 bkl 44.39 bkl 44.72 misc Carbamazepine misc Carbamazepine-10,11-epoxide misc Iminostilbene misc GC-MS misc Tissue distribution misc Human Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases |
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610 ASE 44.39 bkl 44.72 bkl Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases Carbamazepine (dpeaa)DE-He213 Carbamazepine-10,11-epoxide (dpeaa)DE-He213 Iminostilbene (dpeaa)DE-He213 GC-MS (dpeaa)DE-He213 Tissue distribution (dpeaa)DE-He213 Human (dpeaa)DE-He213 |
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ddc 610 bkl 44.39 bkl 44.72 misc Carbamazepine misc Carbamazepine-10,11-epoxide misc Iminostilbene misc GC-MS misc Tissue distribution misc Human |
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ddc 610 bkl 44.39 bkl 44.72 misc Carbamazepine misc Carbamazepine-10,11-epoxide misc Iminostilbene misc GC-MS misc Tissue distribution misc Human |
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Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases |
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(DE-627)SPR019077831 (SPR)s11419-010-0095-9-e |
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Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases |
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Takayasu, Tatsunori |
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Forensic toxicology |
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Forensic toxicology |
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eng |
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600 - Technology |
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2010 |
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Takayasu, Tatsunori Ishida, Yuko Kimura, Akihiko Nosaka, Mizuho Kuninaka, Yumi Kawaguchi, Mariko Kondo, Toshikazu |
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28 |
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610 ASE 44.39 bkl 44.72 bkl |
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Elektronische Aufsätze |
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Takayasu, Tatsunori |
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10.1007/s11419-010-0095-9 |
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610 |
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verfasserin |
| title_sort |
distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases |
| title_auth |
Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases |
| abstract |
Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. |
| abstractGer |
Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. |
| abstract_unstemmed |
Abstract Carbamazepine (CMZ) and its metabolites, carbamazepine-10,11-epoxide (CMZepo) and 2,2’-iminostilbene (Imi), were simultaneously assayed by gas chromatography-mass spectrometry (GC-MS) in body fluids and organ tissues taken from victims in five autopsy cases. Clomipramine-HCl was added to each specimen as internal standard (IS); target compounds and IS were simultaneously extracted with an Extrelut NT column before analysis by GC-MS. The concentrations of CMZ were generally much higher in organ tissues than in blood and urine, and were higher in the liver than in the lung in three cases. The concentrations of metabolites CMZepo and Imi were lower than those of CMZ in all body fl uid and organ tissue specimens; the Imi concentrations in the brain were higher than CMZepo concentrations in four cases. Imi concentrations in the kidney, however, were lower than those of CMZepo in four cases. In the lung and liver, the concentrations of Imi did not show a consistent trend; those of Imi were higher or lower than those of CMZepo, but both metabolites were not at negligible levels. To our knowledge, this is the fi rst demonstration of the distribution of Imi among human body fluids and tissues. |
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2 |
| title_short |
Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases |
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https://dx.doi.org/10.1007/s11419-010-0095-9 |
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Ishida, Yuko Kimura, Akihiko Nosaka, Mizuho Kuninaka, Yumi Kawaguchi, Mariko Kondo, Toshikazu |
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Ishida, Yuko Kimura, Akihiko Nosaka, Mizuho Kuninaka, Yumi Kawaguchi, Mariko Kondo, Toshikazu |
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2024-07-04T00:03:26.095Z |
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| score |
7.4018345 |