Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration?
Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Moosmann, Bjoern [verfasserIn] Valcheva, Tsvetelina [verfasserIn] Neukamm, Merja A. [verfasserIn] Angerer, Verena [verfasserIn] Auwärter, Volker [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Forensic toxicology - Berlin : Springer, 2006, 33(2014), 1 vom: 07. Okt., Seite 37-44 |
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| Übergeordnetes Werk: |
volume:33 ; year:2014 ; number:1 ; day:07 ; month:10 ; pages:37-44 |
| Links: |
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| DOI / URN: |
10.1007/s11419-014-0244-7 |
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| Katalog-ID: |
SPR019079478 |
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| 520 | |a Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. | ||
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| 650 | 4 | |a Hair analysis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a External contamination |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Neukamm, Merja A. |e verfasserin |4 aut | |
| 700 | 1 | |a Angerer, Verena |e verfasserin |4 aut | |
| 700 | 1 | |a Auwärter, Volker |e verfasserin |4 aut | |
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10.1007/s11419-014-0244-7 doi (DE-627)SPR019079478 (SPR)s11419-014-0244-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Moosmann, Bjoern verfasserin aut Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. Synthetic cannabinoid (dpeaa)DE-He213 Legal highs (dpeaa)DE-He213 Hair analysis (dpeaa)DE-He213 External contamination (dpeaa)DE-He213 LC–MS–MS (dpeaa)DE-He213 Laboratory staff (dpeaa)DE-He213 Valcheva, Tsvetelina verfasserin aut Neukamm, Merja A. verfasserin aut Angerer, Verena verfasserin aut Auwärter, Volker verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 33(2014), 1 vom: 07. Okt., Seite 37-44 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:33 year:2014 number:1 day:07 month:10 pages:37-44 https://dx.doi.org/10.1007/s11419-014-0244-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 33 2014 1 07 10 37-44 |
| spelling |
10.1007/s11419-014-0244-7 doi (DE-627)SPR019079478 (SPR)s11419-014-0244-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Moosmann, Bjoern verfasserin aut Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. Synthetic cannabinoid (dpeaa)DE-He213 Legal highs (dpeaa)DE-He213 Hair analysis (dpeaa)DE-He213 External contamination (dpeaa)DE-He213 LC–MS–MS (dpeaa)DE-He213 Laboratory staff (dpeaa)DE-He213 Valcheva, Tsvetelina verfasserin aut Neukamm, Merja A. verfasserin aut Angerer, Verena verfasserin aut Auwärter, Volker verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 33(2014), 1 vom: 07. Okt., Seite 37-44 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:33 year:2014 number:1 day:07 month:10 pages:37-44 https://dx.doi.org/10.1007/s11419-014-0244-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 33 2014 1 07 10 37-44 |
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10.1007/s11419-014-0244-7 doi (DE-627)SPR019079478 (SPR)s11419-014-0244-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Moosmann, Bjoern verfasserin aut Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. Synthetic cannabinoid (dpeaa)DE-He213 Legal highs (dpeaa)DE-He213 Hair analysis (dpeaa)DE-He213 External contamination (dpeaa)DE-He213 LC–MS–MS (dpeaa)DE-He213 Laboratory staff (dpeaa)DE-He213 Valcheva, Tsvetelina verfasserin aut Neukamm, Merja A. verfasserin aut Angerer, Verena verfasserin aut Auwärter, Volker verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 33(2014), 1 vom: 07. Okt., Seite 37-44 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:33 year:2014 number:1 day:07 month:10 pages:37-44 https://dx.doi.org/10.1007/s11419-014-0244-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 33 2014 1 07 10 37-44 |
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10.1007/s11419-014-0244-7 doi (DE-627)SPR019079478 (SPR)s11419-014-0244-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Moosmann, Bjoern verfasserin aut Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. Synthetic cannabinoid (dpeaa)DE-He213 Legal highs (dpeaa)DE-He213 Hair analysis (dpeaa)DE-He213 External contamination (dpeaa)DE-He213 LC–MS–MS (dpeaa)DE-He213 Laboratory staff (dpeaa)DE-He213 Valcheva, Tsvetelina verfasserin aut Neukamm, Merja A. verfasserin aut Angerer, Verena verfasserin aut Auwärter, Volker verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 33(2014), 1 vom: 07. Okt., Seite 37-44 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:33 year:2014 number:1 day:07 month:10 pages:37-44 https://dx.doi.org/10.1007/s11419-014-0244-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 33 2014 1 07 10 37-44 |
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10.1007/s11419-014-0244-7 doi (DE-627)SPR019079478 (SPR)s11419-014-0244-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Moosmann, Bjoern verfasserin aut Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. Synthetic cannabinoid (dpeaa)DE-He213 Legal highs (dpeaa)DE-He213 Hair analysis (dpeaa)DE-He213 External contamination (dpeaa)DE-He213 LC–MS–MS (dpeaa)DE-He213 Laboratory staff (dpeaa)DE-He213 Valcheva, Tsvetelina verfasserin aut Neukamm, Merja A. verfasserin aut Angerer, Verena verfasserin aut Auwärter, Volker verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 33(2014), 1 vom: 07. Okt., Seite 37-44 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:33 year:2014 number:1 day:07 month:10 pages:37-44 https://dx.doi.org/10.1007/s11419-014-0244-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 33 2014 1 07 10 37-44 |
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English |
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Enthalten in Forensic toxicology 33(2014), 1 vom: 07. Okt., Seite 37-44 volume:33 year:2014 number:1 day:07 month:10 pages:37-44 |
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Enthalten in Forensic toxicology 33(2014), 1 vom: 07. Okt., Seite 37-44 volume:33 year:2014 number:1 day:07 month:10 pages:37-44 |
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Synthetic cannabinoid Legal highs Hair analysis External contamination LC–MS–MS Laboratory staff |
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Moosmann, Bjoern @@aut@@ Valcheva, Tsvetelina @@aut@@ Neukamm, Merja A. @@aut@@ Angerer, Verena @@aut@@ Auwärter, Volker @@aut@@ |
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However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. 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Moosmann, Bjoern |
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Moosmann, Bjoern ddc 610 bkl 44.39 bkl 44.72 misc Synthetic cannabinoid misc Legal highs misc Hair analysis misc External contamination misc LC–MS–MS misc Laboratory staff Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? |
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610 ASE 44.39 bkl 44.72 bkl Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? Synthetic cannabinoid (dpeaa)DE-He213 Legal highs (dpeaa)DE-He213 Hair analysis (dpeaa)DE-He213 External contamination (dpeaa)DE-He213 LC–MS–MS (dpeaa)DE-He213 Laboratory staff (dpeaa)DE-He213 |
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ddc 610 bkl 44.39 bkl 44.72 misc Synthetic cannabinoid misc Legal highs misc Hair analysis misc External contamination misc LC–MS–MS misc Laboratory staff |
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Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? |
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Moosmann, Bjoern Valcheva, Tsvetelina Neukamm, Merja A. Angerer, Verena Auwärter, Volker |
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hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? |
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Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? |
| abstract |
Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. |
| abstractGer |
Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. |
| abstract_unstemmed |
Abstract When narcotics police officers or other persons handling drug materials at work are suspected of consuming drugs, hair analysis may be useful to prove or refute such suspicion. However, it is known for many drugs that differentiation between actual drug use and external contamination can be challenging or sometimes impossible. This study evaluated the extent of external contamination caused by handling of synthetic cannabinoid-containing materials under realistic conditions in a forensic laboratory. Hair samples of laboratory staff were systematically analyzed for synthetic cannabinoids with a validated liquid chromatography–tandem mass spectrometry method after a large quantity of seized “legal high” products was analyzed in our laboratory. Furthermore, hair samples of laboratory staff not directly in contact with the drug materials and close relatives of exposed subjects were analyzed to check for cross contamination. All samples of persons who were in direct contact with drug materials tested positive for at least one synthetic cannabinoid. Concentrations ranged from trace amounts up to a maximum of 170 pg/mg (JWH-210), and roughly reflected the duration and intensity of exposure. Unexpectedly, subjects without direct contact with drug material also showed measurable concentrations of synthetic cannabinoids in hair. Concentrations caused by contamination were within the typical range found in known users of these drugs and could lead to false positive results and incorrect conclusions. Therefore, we recommend that body fluids should be simultaneously analyzed to unambiguously prove use of these drugs. |
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Hair analysis of synthetic cannabinoids: does the handling of herbal mixtures affect the analyst’s hair concentration? |
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| score |
7.400137 |