Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8
Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results T...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Iwamuro, Yoshiaki [verfasserIn] Murakami, Takaya [verfasserIn] Ishimaru, Reiko [verfasserIn] Chinaka, Satoshi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Forensic toxicology - Berlin : Springer, 2006, 37(2018), 1 vom: 06. Sept., Seite 250-253 |
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| Übergeordnetes Werk: |
volume:37 ; year:2018 ; number:1 ; day:06 ; month:09 ; pages:250-253 |
| Links: |
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| DOI / URN: |
10.1007/s11419-018-0441-x |
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| Katalog-ID: |
SPR01908160X |
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| 100 | 1 | |a Iwamuro, Yoshiaki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 |
| 264 | 1 | |c 2018 | |
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| 520 | |a Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. | ||
| 650 | 4 | |a Muscle relaxant |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Rocuronium |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Muscle relaxant reversal agent |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sugammadex |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a LC/MS |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Murakami, Takaya |e verfasserin |4 aut | |
| 700 | 1 | |a Ishimaru, Reiko |e verfasserin |4 aut | |
| 700 | 1 | |a Chinaka, Satoshi |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Forensic toxicology |d Berlin : Springer, 2006 |g 37(2018), 1 vom: 06. Sept., Seite 250-253 |w (DE-627)511915527 |w (DE-600)2234828-1 |x 1860-8973 |7 nnns |
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10.1007/s11419-018-0441-x doi (DE-627)SPR01908160X (SPR)s11419-018-0441-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Iwamuro, Yoshiaki verfasserin aut Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. Muscle relaxant (dpeaa)DE-He213 Rocuronium (dpeaa)DE-He213 Muscle relaxant reversal agent (dpeaa)DE-He213 Sugammadex (dpeaa)DE-He213 LC/MS (dpeaa)DE-He213 Murakami, Takaya verfasserin aut Ishimaru, Reiko verfasserin aut Chinaka, Satoshi verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 37(2018), 1 vom: 06. Sept., Seite 250-253 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:37 year:2018 number:1 day:06 month:09 pages:250-253 https://dx.doi.org/10.1007/s11419-018-0441-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 37 2018 1 06 09 250-253 |
| spelling |
10.1007/s11419-018-0441-x doi (DE-627)SPR01908160X (SPR)s11419-018-0441-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Iwamuro, Yoshiaki verfasserin aut Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. Muscle relaxant (dpeaa)DE-He213 Rocuronium (dpeaa)DE-He213 Muscle relaxant reversal agent (dpeaa)DE-He213 Sugammadex (dpeaa)DE-He213 LC/MS (dpeaa)DE-He213 Murakami, Takaya verfasserin aut Ishimaru, Reiko verfasserin aut Chinaka, Satoshi verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 37(2018), 1 vom: 06. Sept., Seite 250-253 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:37 year:2018 number:1 day:06 month:09 pages:250-253 https://dx.doi.org/10.1007/s11419-018-0441-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 37 2018 1 06 09 250-253 |
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10.1007/s11419-018-0441-x doi (DE-627)SPR01908160X (SPR)s11419-018-0441-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Iwamuro, Yoshiaki verfasserin aut Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. Muscle relaxant (dpeaa)DE-He213 Rocuronium (dpeaa)DE-He213 Muscle relaxant reversal agent (dpeaa)DE-He213 Sugammadex (dpeaa)DE-He213 LC/MS (dpeaa)DE-He213 Murakami, Takaya verfasserin aut Ishimaru, Reiko verfasserin aut Chinaka, Satoshi verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 37(2018), 1 vom: 06. Sept., Seite 250-253 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:37 year:2018 number:1 day:06 month:09 pages:250-253 https://dx.doi.org/10.1007/s11419-018-0441-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 37 2018 1 06 09 250-253 |
| allfieldsGer |
10.1007/s11419-018-0441-x doi (DE-627)SPR01908160X (SPR)s11419-018-0441-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Iwamuro, Yoshiaki verfasserin aut Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. Muscle relaxant (dpeaa)DE-He213 Rocuronium (dpeaa)DE-He213 Muscle relaxant reversal agent (dpeaa)DE-He213 Sugammadex (dpeaa)DE-He213 LC/MS (dpeaa)DE-He213 Murakami, Takaya verfasserin aut Ishimaru, Reiko verfasserin aut Chinaka, Satoshi verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 37(2018), 1 vom: 06. Sept., Seite 250-253 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:37 year:2018 number:1 day:06 month:09 pages:250-253 https://dx.doi.org/10.1007/s11419-018-0441-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 37 2018 1 06 09 250-253 |
| allfieldsSound |
10.1007/s11419-018-0441-x doi (DE-627)SPR01908160X (SPR)s11419-018-0441-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.39 bkl 44.72 bkl Iwamuro, Yoshiaki verfasserin aut Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. Muscle relaxant (dpeaa)DE-He213 Rocuronium (dpeaa)DE-He213 Muscle relaxant reversal agent (dpeaa)DE-He213 Sugammadex (dpeaa)DE-He213 LC/MS (dpeaa)DE-He213 Murakami, Takaya verfasserin aut Ishimaru, Reiko verfasserin aut Chinaka, Satoshi verfasserin aut Enthalten in Forensic toxicology Berlin : Springer, 2006 37(2018), 1 vom: 06. Sept., Seite 250-253 (DE-627)511915527 (DE-600)2234828-1 1860-8973 nnns volume:37 year:2018 number:1 day:06 month:09 pages:250-253 https://dx.doi.org/10.1007/s11419-018-0441-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.39 ASE 44.72 ASE AR 37 2018 1 06 09 250-253 |
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Enthalten in Forensic toxicology 37(2018), 1 vom: 06. Sept., Seite 250-253 volume:37 year:2018 number:1 day:06 month:09 pages:250-253 |
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Muscle relaxant Rocuronium Muscle relaxant reversal agent Sugammadex LC/MS |
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Iwamuro, Yoshiaki @@aut@@ Murakami, Takaya @@aut@@ Ishimaru, Reiko @@aut@@ Chinaka, Satoshi @@aut@@ |
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2018-09-06T00:00:00Z |
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Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. 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|
| author |
Iwamuro, Yoshiaki |
| spellingShingle |
Iwamuro, Yoshiaki ddc 610 bkl 44.39 bkl 44.72 misc Muscle relaxant misc Rocuronium misc Muscle relaxant reversal agent misc Sugammadex misc LC/MS Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 |
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610 ASE 44.39 bkl 44.72 bkl Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 Muscle relaxant (dpeaa)DE-He213 Rocuronium (dpeaa)DE-He213 Muscle relaxant reversal agent (dpeaa)DE-He213 Sugammadex (dpeaa)DE-He213 LC/MS (dpeaa)DE-He213 |
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ddc 610 bkl 44.39 bkl 44.72 misc Muscle relaxant misc Rocuronium misc Muscle relaxant reversal agent misc Sugammadex misc LC/MS |
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ddc 610 bkl 44.39 bkl 44.72 misc Muscle relaxant misc Rocuronium misc Muscle relaxant reversal agent misc Sugammadex misc LC/MS |
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ddc 610 bkl 44.39 bkl 44.72 misc Muscle relaxant misc Rocuronium misc Muscle relaxant reversal agent misc Sugammadex misc LC/MS |
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Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 |
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Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 |
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Iwamuro, Yoshiaki |
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Iwamuro, Yoshiaki Murakami, Takaya Ishimaru, Reiko Chinaka, Satoshi |
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postmortem detection of rocuronium and sugammadex by lc/ms in the blood of a patient who died on postoperative day 8 |
| title_auth |
Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 |
| abstract |
Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. |
| abstractGer |
Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. |
| abstract_unstemmed |
Purpose This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. Methods The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). Results The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. Conclusions When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated. |
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1 |
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Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8 |
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https://dx.doi.org/10.1007/s11419-018-0441-x |
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Murakami, Takaya Ishimaru, Reiko Chinaka, Satoshi |
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Murakami, Takaya Ishimaru, Reiko Chinaka, Satoshi |
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| doi_str |
10.1007/s11419-018-0441-x |
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2024-07-04T00:04:45.914Z |
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| score |
7.3998203 |