Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging
Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Ying [verfasserIn] Liu, Gang [verfasserIn] Lou, Xin [verfasserIn] Chen, Zhiye [verfasserIn] Ma, Lin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Science in China - Heidelberg : Springer, 1997, 60(2017), 1 vom: Jan., Seite 11-15 |
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| Übergeordnetes Werk: |
volume:60 ; year:2017 ; number:1 ; month:01 ; pages:11-15 |
| Links: |
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| DOI / URN: |
10.1007/s11427-016-0386-2 |
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| Katalog-ID: |
SPR019200706 |
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| 520 | |a Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. | ||
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| 700 | 1 | |a Ma, Lin |e verfasserin |4 aut | |
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10.1007/s11427-016-0386-2 doi (DE-627)SPR019200706 (SPR)s11427-016-0386-2-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Li, Ying verfasserin aut Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. dynamic contrast enhanced MR (dpeaa)DE-He213 Gd-DTPA-BMA (dpeaa)DE-He213 Gd-DTPA (dpeaa)DE-He213 ionic (dpeaa)DE-He213 non-ionic (dpeaa)DE-He213 Liu, Gang verfasserin aut Lou, Xin verfasserin aut Chen, Zhiye verfasserin aut Ma, Lin verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 60(2017), 1 vom: Jan., Seite 11-15 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:60 year:2017 number:1 month:01 pages:11-15 https://dx.doi.org/10.1007/s11427-016-0386-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 60 2017 1 01 11-15 |
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10.1007/s11427-016-0386-2 doi (DE-627)SPR019200706 (SPR)s11427-016-0386-2-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Li, Ying verfasserin aut Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. dynamic contrast enhanced MR (dpeaa)DE-He213 Gd-DTPA-BMA (dpeaa)DE-He213 Gd-DTPA (dpeaa)DE-He213 ionic (dpeaa)DE-He213 non-ionic (dpeaa)DE-He213 Liu, Gang verfasserin aut Lou, Xin verfasserin aut Chen, Zhiye verfasserin aut Ma, Lin verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 60(2017), 1 vom: Jan., Seite 11-15 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:60 year:2017 number:1 month:01 pages:11-15 https://dx.doi.org/10.1007/s11427-016-0386-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 60 2017 1 01 11-15 |
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10.1007/s11427-016-0386-2 doi (DE-627)SPR019200706 (SPR)s11427-016-0386-2-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Li, Ying verfasserin aut Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. dynamic contrast enhanced MR (dpeaa)DE-He213 Gd-DTPA-BMA (dpeaa)DE-He213 Gd-DTPA (dpeaa)DE-He213 ionic (dpeaa)DE-He213 non-ionic (dpeaa)DE-He213 Liu, Gang verfasserin aut Lou, Xin verfasserin aut Chen, Zhiye verfasserin aut Ma, Lin verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 60(2017), 1 vom: Jan., Seite 11-15 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:60 year:2017 number:1 month:01 pages:11-15 https://dx.doi.org/10.1007/s11427-016-0386-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 60 2017 1 01 11-15 |
| allfieldsGer |
10.1007/s11427-016-0386-2 doi (DE-627)SPR019200706 (SPR)s11427-016-0386-2-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Li, Ying verfasserin aut Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. dynamic contrast enhanced MR (dpeaa)DE-He213 Gd-DTPA-BMA (dpeaa)DE-He213 Gd-DTPA (dpeaa)DE-He213 ionic (dpeaa)DE-He213 non-ionic (dpeaa)DE-He213 Liu, Gang verfasserin aut Lou, Xin verfasserin aut Chen, Zhiye verfasserin aut Ma, Lin verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 60(2017), 1 vom: Jan., Seite 11-15 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:60 year:2017 number:1 month:01 pages:11-15 https://dx.doi.org/10.1007/s11427-016-0386-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 60 2017 1 01 11-15 |
| allfieldsSound |
10.1007/s11427-016-0386-2 doi (DE-627)SPR019200706 (SPR)s11427-016-0386-2-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Li, Ying verfasserin aut Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. dynamic contrast enhanced MR (dpeaa)DE-He213 Gd-DTPA-BMA (dpeaa)DE-He213 Gd-DTPA (dpeaa)DE-He213 ionic (dpeaa)DE-He213 non-ionic (dpeaa)DE-He213 Liu, Gang verfasserin aut Lou, Xin verfasserin aut Chen, Zhiye verfasserin aut Ma, Lin verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 60(2017), 1 vom: Jan., Seite 11-15 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:60 year:2017 number:1 month:01 pages:11-15 https://dx.doi.org/10.1007/s11427-016-0386-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 60 2017 1 01 11-15 |
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English |
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Enthalten in Science in China 60(2017), 1 vom: Jan., Seite 11-15 volume:60 year:2017 number:1 month:01 pages:11-15 |
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Enthalten in Science in China 60(2017), 1 vom: Jan., Seite 11-15 volume:60 year:2017 number:1 month:01 pages:11-15 |
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dynamic contrast enhanced MR Gd-DTPA-BMA Gd-DTPA ionic non-ionic |
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Li, Ying @@aut@@ Liu, Gang @@aut@@ Lou, Xin @@aut@@ Chen, Zhiye @@aut@@ Ma, Lin @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR019200706</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519173634.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s11427-016-0386-2</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR019200706</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s11427-016-0386-2-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Li, Ying</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P&lt;0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P&gt;0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P&gt;0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. 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Li, Ying |
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Li, Ying ddc 570 bkl 42.00 misc dynamic contrast enhanced MR misc Gd-DTPA-BMA misc Gd-DTPA misc ionic misc non-ionic Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging |
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570 ASE 42.00 bkl Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging dynamic contrast enhanced MR (dpeaa)DE-He213 Gd-DTPA-BMA (dpeaa)DE-He213 Gd-DTPA (dpeaa)DE-He213 ionic (dpeaa)DE-He213 non-ionic (dpeaa)DE-He213 |
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ddc 570 bkl 42.00 misc dynamic contrast enhanced MR misc Gd-DTPA-BMA misc Gd-DTPA misc ionic misc non-ionic |
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Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging |
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Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging |
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Li, Ying Liu, Gang Lou, Xin Chen, Zhiye Ma, Lin |
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intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of c6 glioma with dynamic contrast-enhanced magnetic resonance imaging |
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Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging |
| abstract |
Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. |
| abstractGer |
Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. |
| abstract_unstemmed |
Abstract This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0.2 mL $ s^{−1} $) of GBCA at 0.4 mmol $ kg^{−1} $ were performed. Each rat received two DCE-MRI scans, 24 h apart. The first and second scans were performed using Gd-DTPA-BMA and Gd-DTPA, respectively. Image data were processed using the Patlak model. Both Ktrans and Vp maps were generated. Tumors were manually segmented on all 3D Ktrans and Vp maps. Pixel counts and mean values were recorded for use in a paired t-test. Three radiologists independently performed the tumor segmentation and value calculation. The agreements from different observers were subjective to the intra-class correlation coefficient (ICC). Readers demonstrated that the pixel counts of tumors in Ktrans maps were higher with Gd-DTPA-BMA than with Gd-DTPA (P<0.001, all readers). Although the Ktrans values were higher with Gd-DTPA-BMA than with Gd-DTPA, there was no statistical significance (P>0.05, all readers). The pixel counts of tumors in Vp maps, as well as Vp values, showed no obvious difference between the two agents (P>0.05, all readers). Excellent interobserver measurement reproducibility and reliability were demonstrated in the ICC tests. The Gd-DTPA-BMA contrast agent had significantly higher pixel counts of glioma in the Ktrans maps, and an increased tendency for average Ktrans values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma. |
| collection_details |
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| container_issue |
1 |
| title_short |
Intra-individual comparison of different gadolinium-based contrast agents in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging |
| url |
https://dx.doi.org/10.1007/s11427-016-0386-2 |
| remote_bool |
true |
| author2 |
Liu, Gang Lou, Xin Chen, Zhiye Ma, Lin |
| author2Str |
Liu, Gang Lou, Xin Chen, Zhiye Ma, Lin |
| ppnlink |
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| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s11427-016-0386-2 |
| up_date |
2024-07-04T00:36:06.643Z |
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| score |
7.3983727 |