Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing
Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gu, Yunhao [verfasserIn] Huang, Yixin [verfasserIn] Qiu, Zhiyue [verfasserIn] Xu, Zhuobin [verfasserIn] Li, Dandan [verfasserIn] Chen, Lei [verfasserIn] Jiang, Jing [verfasserIn] Gao, Lizeng [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Science in China - Heidelberg : Springer, 1997, 63(2019), 1 vom: 26. Aug., Seite 68-79 |
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| Übergeordnetes Werk: |
volume:63 ; year:2019 ; number:1 ; day:26 ; month:08 ; pages:68-79 |
| Links: |
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| DOI / URN: |
10.1007/s11427-019-9590-6 |
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| Katalog-ID: |
SPR01920759X |
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| 520 | |a Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. | ||
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10.1007/s11427-019-9590-6 doi (DE-627)SPR01920759X (SPR)s11427-019-9590-6-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Gu, Yunhao verfasserin aut Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. iron oxide nanozymes (dpeaa)DE-He213 vitamin B (dpeaa)DE-He213 ROS scavenging (dpeaa)DE-He213 mouth ulcer (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 Huang, Yixin verfasserin aut Qiu, Zhiyue verfasserin aut Xu, Zhuobin verfasserin aut Li, Dandan verfasserin aut Chen, Lei verfasserin aut Jiang, Jing verfasserin aut Gao, Lizeng verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2019), 1 vom: 26. Aug., Seite 68-79 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:63 year:2019 number:1 day:26 month:08 pages:68-79 https://dx.doi.org/10.1007/s11427-019-9590-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 63 2019 1 26 08 68-79 |
| spelling |
10.1007/s11427-019-9590-6 doi (DE-627)SPR01920759X (SPR)s11427-019-9590-6-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Gu, Yunhao verfasserin aut Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. iron oxide nanozymes (dpeaa)DE-He213 vitamin B (dpeaa)DE-He213 ROS scavenging (dpeaa)DE-He213 mouth ulcer (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 Huang, Yixin verfasserin aut Qiu, Zhiyue verfasserin aut Xu, Zhuobin verfasserin aut Li, Dandan verfasserin aut Chen, Lei verfasserin aut Jiang, Jing verfasserin aut Gao, Lizeng verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2019), 1 vom: 26. Aug., Seite 68-79 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:63 year:2019 number:1 day:26 month:08 pages:68-79 https://dx.doi.org/10.1007/s11427-019-9590-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 63 2019 1 26 08 68-79 |
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10.1007/s11427-019-9590-6 doi (DE-627)SPR01920759X (SPR)s11427-019-9590-6-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Gu, Yunhao verfasserin aut Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. iron oxide nanozymes (dpeaa)DE-He213 vitamin B (dpeaa)DE-He213 ROS scavenging (dpeaa)DE-He213 mouth ulcer (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 Huang, Yixin verfasserin aut Qiu, Zhiyue verfasserin aut Xu, Zhuobin verfasserin aut Li, Dandan verfasserin aut Chen, Lei verfasserin aut Jiang, Jing verfasserin aut Gao, Lizeng verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2019), 1 vom: 26. Aug., Seite 68-79 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:63 year:2019 number:1 day:26 month:08 pages:68-79 https://dx.doi.org/10.1007/s11427-019-9590-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 63 2019 1 26 08 68-79 |
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10.1007/s11427-019-9590-6 doi (DE-627)SPR01920759X (SPR)s11427-019-9590-6-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Gu, Yunhao verfasserin aut Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. iron oxide nanozymes (dpeaa)DE-He213 vitamin B (dpeaa)DE-He213 ROS scavenging (dpeaa)DE-He213 mouth ulcer (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 Huang, Yixin verfasserin aut Qiu, Zhiyue verfasserin aut Xu, Zhuobin verfasserin aut Li, Dandan verfasserin aut Chen, Lei verfasserin aut Jiang, Jing verfasserin aut Gao, Lizeng verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2019), 1 vom: 26. Aug., Seite 68-79 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:63 year:2019 number:1 day:26 month:08 pages:68-79 https://dx.doi.org/10.1007/s11427-019-9590-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 63 2019 1 26 08 68-79 |
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10.1007/s11427-019-9590-6 doi (DE-627)SPR01920759X (SPR)s11427-019-9590-6-e DE-627 ger DE-627 rakwb eng 570 ASE 42.00 bkl Gu, Yunhao verfasserin aut Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. iron oxide nanozymes (dpeaa)DE-He213 vitamin B (dpeaa)DE-He213 ROS scavenging (dpeaa)DE-He213 mouth ulcer (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 Huang, Yixin verfasserin aut Qiu, Zhiyue verfasserin aut Xu, Zhuobin verfasserin aut Li, Dandan verfasserin aut Chen, Lei verfasserin aut Jiang, Jing verfasserin aut Gao, Lizeng verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2019), 1 vom: 26. Aug., Seite 68-79 (DE-627)377758779 (DE-600)2133225-3 1862-2798 nnns volume:63 year:2019 number:1 day:26 month:08 pages:68-79 https://dx.doi.org/10.1007/s11427-019-9590-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 ASE AR 63 2019 1 26 08 68-79 |
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Enthalten in Science in China 63(2019), 1 vom: 26. Aug., Seite 68-79 volume:63 year:2019 number:1 day:26 month:08 pages:68-79 |
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Gu, Yunhao @@aut@@ Huang, Yixin @@aut@@ Qiu, Zhiyue @@aut@@ Xu, Zhuobin @@aut@@ Li, Dandan @@aut@@ Chen, Lei @@aut@@ Jiang, Jing @@aut@@ Gao, Lizeng @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR01920759X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519094151.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s11427-019-9590-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR01920759X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s11427-019-9590-6-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Gu, Yunhao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">iron oxide nanozymes</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">vitamin B</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ROS scavenging</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mouth ulcer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">anti-inflammation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Huang, Yixin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Qiu, Zhiyue</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xu, Zhuobin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Dandan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Lei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jiang, Jing</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gao, Lizeng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Science in China</subfield><subfield code="d">Heidelberg : Springer, 1997</subfield><subfield code="g">63(2019), 1 vom: 26. 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Gu, Yunhao |
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Gu, Yunhao ddc 570 bkl 42.00 misc iron oxide nanozymes misc vitamin B misc ROS scavenging misc mouth ulcer misc anti-inflammation Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing |
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570 ASE 42.00 bkl Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing iron oxide nanozymes (dpeaa)DE-He213 vitamin B (dpeaa)DE-He213 ROS scavenging (dpeaa)DE-He213 mouth ulcer (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 |
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Gu, Yunhao Huang, Yixin Qiu, Zhiyue Xu, Zhuobin Li, Dandan Chen, Lei Jiang, Jing Gao, Lizeng |
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Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing |
| abstract |
Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. |
| abstractGer |
Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. |
| abstract_unstemmed |
Abstract Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient’s condition. Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin $ B_{2} $ ($ VB_{2} $) modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities, acting as typical iron oxide nanozymes (IONzymes) with triad activities. In particular, $ VB_{2} $ modification significantly improved the SOD-like activity, thus providing a reactive oxygen species (ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin $ B_{2} $ modified IONzymes ($ VB_{2} $-IONzymes) protect human oral keratinocytes (HOK) and BALB/3T3 cells from hydrogen peroxide ($ H_{2} %$ O_{2} $), and these cells have high biocompatibility to eukaryotic cells. In addition, $ VB_{2} $-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, $ VB_{2} $-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin $ B_{2} $ modification endows iron oxide nanoparticles with enhanced enzyme-like activities and $ VB_{2} $-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. |
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| container_issue |
1 |
| title_short |
Vitamin $ B_{2} $ functionalized iron oxide nanozymes for mouth ulcer healing |
| url |
https://dx.doi.org/10.1007/s11427-019-9590-6 |
| remote_bool |
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| author2 |
Huang, Yixin Qiu, Zhiyue Xu, Zhuobin Li, Dandan Chen, Lei Jiang, Jing Gao, Lizeng |
| author2Str |
Huang, Yixin Qiu, Zhiyue Xu, Zhuobin Li, Dandan Chen, Lei Jiang, Jing Gao, Lizeng |
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| doi_str |
10.1007/s11427-019-9590-6 |
| up_date |
2024-07-04T00:38:12.732Z |
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|
| score |
7.399721 |