The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro

Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related...
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Autor*in:	Snigireva, A. V. [verfasserIn] Vrublevskaya, V. V. [verfasserIn] Zhmurina, M. A. [verfasserIn] Skarga, Y. Y. [verfasserIn] Morenkov, O. S. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	Enthalten in: Biophysics - Moscow : Maik Nauka/Interperiodica, 1995, 63(2018), 6 vom: Nov., Seite 931-939
Übergeordnetes Werk:	volume:63 ; year:2018 ; number:6 ; month:11 ; pages:931-939

Links:	Volltext

DOI / URN:	10.1134/S0006350918060258

Katalog-ID:	SPR019701845

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520			\|a Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro.
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allfields	10.1134/S0006350918060258 doi (DE-627)SPR019701845 (SPR)S0006350918060258-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl Snigireva, A. V. verfasserin aut The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro. Vrublevskaya, V. V. verfasserin aut Zhmurina, M. A. verfasserin aut Skarga, Y. Y. verfasserin aut Morenkov, O. S. verfasserin aut Enthalten in Biophysics Moscow : Maik Nauka/Interperiodica, 1995 63(2018), 6 vom: Nov., Seite 931-939 (DE-627)32063955X (DE-600)2024886-6 1555-6654 nnns volume:63 year:2018 number:6 month:11 pages:931-939 https://dx.doi.org/10.1134/S0006350918060258 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE AR 63 2018 6 11 931-939
spelling	10.1134/S0006350918060258 doi (DE-627)SPR019701845 (SPR)S0006350918060258-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl Snigireva, A. V. verfasserin aut The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro. Vrublevskaya, V. V. verfasserin aut Zhmurina, M. A. verfasserin aut Skarga, Y. Y. verfasserin aut Morenkov, O. S. verfasserin aut Enthalten in Biophysics Moscow : Maik Nauka/Interperiodica, 1995 63(2018), 6 vom: Nov., Seite 931-939 (DE-627)32063955X (DE-600)2024886-6 1555-6654 nnns volume:63 year:2018 number:6 month:11 pages:931-939 https://dx.doi.org/10.1134/S0006350918060258 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE AR 63 2018 6 11 931-939
allfields_unstemmed	10.1134/S0006350918060258 doi (DE-627)SPR019701845 (SPR)S0006350918060258-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl Snigireva, A. V. verfasserin aut The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro. Vrublevskaya, V. V. verfasserin aut Zhmurina, M. A. verfasserin aut Skarga, Y. Y. verfasserin aut Morenkov, O. S. verfasserin aut Enthalten in Biophysics Moscow : Maik Nauka/Interperiodica, 1995 63(2018), 6 vom: Nov., Seite 931-939 (DE-627)32063955X (DE-600)2024886-6 1555-6654 nnns volume:63 year:2018 number:6 month:11 pages:931-939 https://dx.doi.org/10.1134/S0006350918060258 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE AR 63 2018 6 11 931-939
allfieldsGer	10.1134/S0006350918060258 doi (DE-627)SPR019701845 (SPR)S0006350918060258-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl Snigireva, A. V. verfasserin aut The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro. Vrublevskaya, V. V. verfasserin aut Zhmurina, M. A. verfasserin aut Skarga, Y. Y. verfasserin aut Morenkov, O. S. verfasserin aut Enthalten in Biophysics Moscow : Maik Nauka/Interperiodica, 1995 63(2018), 6 vom: Nov., Seite 931-939 (DE-627)32063955X (DE-600)2024886-6 1555-6654 nnns volume:63 year:2018 number:6 month:11 pages:931-939 https://dx.doi.org/10.1134/S0006350918060258 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE AR 63 2018 6 11 931-939
allfieldsSound	10.1134/S0006350918060258 doi (DE-627)SPR019701845 (SPR)S0006350918060258-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl Snigireva, A. V. verfasserin aut The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro. Vrublevskaya, V. V. verfasserin aut Zhmurina, M. A. verfasserin aut Skarga, Y. Y. verfasserin aut Morenkov, O. S. verfasserin aut Enthalten in Biophysics Moscow : Maik Nauka/Interperiodica, 1995 63(2018), 6 vom: Nov., Seite 931-939 (DE-627)32063955X (DE-600)2024886-6 1555-6654 nnns volume:63 year:2018 number:6 month:11 pages:931-939 https://dx.doi.org/10.1134/S0006350918060258 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE AR 63 2018 6 11 931-939
language	English
source	Enthalten in Biophysics 63(2018), 6 vom: Nov., Seite 931-939 volume:63 year:2018 number:6 month:11 pages:931-939
sourceStr	Enthalten in Biophysics 63(2018), 6 vom: Nov., Seite 931-939 volume:63 year:2018 number:6 month:11 pages:931-939
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container_title	Biophysics
authorswithroles_txt_mv	Snigireva, A. V. @@aut@@ Vrublevskaya, V. V. @@aut@@ Zhmurina, M. A. @@aut@@ Skarga, Y. Y. @@aut@@ Morenkov, O. S. @@aut@@
publishDateDaySort_date	2018-11-01T00:00:00Z
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author	Snigireva, A. V.
spellingShingle	Snigireva, A. V. ddc 570 bkl 42.12 The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro
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topic_title	570 530 ASE 42.12 bkl The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro
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title	The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro
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title_full	The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro
author_sort	Snigireva, A. V.
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author_browse	Snigireva, A. V. Vrublevskaya, V. V. Zhmurina, M. A. Skarga, Y. Y. Morenkov, O. S.
container_volume	63
class	570 530 ASE 42.12 bkl
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author-letter	Snigireva, A. V.
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title_sort	mechanisms of stimulation of migration and invasion of tumor cells by extracellular heat shock protein 90 (ehsp90) in vitro
title_auth	The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro
abstract	Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro.
abstractGer	Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro.
abstract_unstemmed	Abstract Extracellular heat shock protein 90 (eHsp90) plays an important role in cell motility, invasion, and metastasis of tumor cells. eHsp90 stimulates migration and invasion of cells via interaction with surface receptors, which is accompanied by the activation of multiple cell motility-related signaling pathways. In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro.
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title_short	The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro
url	https://dx.doi.org/10.1134/S0006350918060258
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author2	Vrublevskaya, V. V. Zhmurina, M. A. Skarga, Y. Y. Morenkov, O. S.
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doi_str	10.1134/S0006350918060258
up_date	2024-07-04T02:37:49.293Z
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In addition, еHsp90 promotes cell invasion by the activation of extracellular matrix metalloproteinases. The role of different receptors, intracellular signaling pathways, and matrix metalloproteinases in the еHsp90-dependent migration and invasion of different types of cells has been investigated insufficiently. In this study, we demonstrated that HER2 is involved in the еHsp90-mediated stimulation of migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells in vitro. eHsp90-induced migration and invasion of cells are accompanied by the activation of ERK1/2-, IKK/NF-κB-, FAK-, ROCK1- and Src-mediated signaling pathways and by the limited activation of JNK, while the p38-mediated signaling cascade is not activated. eHsp90 also stimulates PI3K-Akt signaling pathway in А-172 cells, while in НТ1080 cells Akt is activated regardless of PI3K. It has been established that matrix metalloproteinases are involved in the eHsp90-dependent stimulation of invasion of А-172 and НТ1080 cells in vitro.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vrublevskaya, V. V.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhmurina, M. A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Skarga, Y. Y.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Morenkov, O. 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The Mechanisms of Stimulation of Migration and Invasion of Tumor Cells by Extracellular Heat Shock Protein 90 (eHsp90) in vitro

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