Neurexins and neuroligins: new partners for $ GABA_{A} $ receptors at synapses
Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information proce...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wu, Bei [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Anmerkung: |
© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 |
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| Übergeordnetes Werk: |
Enthalten in: Frontiers of biology in China - Berlin : Springer, 2006, 6(2011), 3 vom: 05. Juni |
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| Übergeordnetes Werk: |
volume:6 ; year:2011 ; number:3 ; day:05 ; month:06 |
| Links: |
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| DOI / URN: |
10.1007/s11515-011-1020-2 |
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| 520 | |a Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. | ||
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10.1007/s11515-011-1020-2 doi (DE-627)SPR020485204 (SPR)s11515-011-1020-2-e DE-627 ger DE-627 rakwb eng Wu, Bei verfasserin aut Neurexins and neuroligins: new partners for $ GABA_{A} $ receptors at synapses 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. GABA (dpeaa)DE-He213 receptors (dpeaa)DE-He213 synapses (dpeaa)DE-He213 neurexins (dpeaa)DE-He213 neuroligins (dpeaa)DE-He213 Zhang, Chen aut Enthalten in Frontiers of biology in China Berlin : Springer, 2006 6(2011), 3 vom: 05. Juni (DE-627)510109896 (DE-600)2229527-6 1673-3622 nnns volume:6 year:2011 number:3 day:05 month:06 https://dx.doi.org/10.1007/s11515-011-1020-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 6 2011 3 05 06 |
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10.1007/s11515-011-1020-2 doi (DE-627)SPR020485204 (SPR)s11515-011-1020-2-e DE-627 ger DE-627 rakwb eng Wu, Bei verfasserin aut Neurexins and neuroligins: new partners for $ GABA_{A} $ receptors at synapses 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. GABA (dpeaa)DE-He213 receptors (dpeaa)DE-He213 synapses (dpeaa)DE-He213 neurexins (dpeaa)DE-He213 neuroligins (dpeaa)DE-He213 Zhang, Chen aut Enthalten in Frontiers of biology in China Berlin : Springer, 2006 6(2011), 3 vom: 05. Juni (DE-627)510109896 (DE-600)2229527-6 1673-3622 nnns volume:6 year:2011 number:3 day:05 month:06 https://dx.doi.org/10.1007/s11515-011-1020-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 6 2011 3 05 06 |
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10.1007/s11515-011-1020-2 doi (DE-627)SPR020485204 (SPR)s11515-011-1020-2-e DE-627 ger DE-627 rakwb eng Wu, Bei verfasserin aut Neurexins and neuroligins: new partners for $ GABA_{A} $ receptors at synapses 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. GABA (dpeaa)DE-He213 receptors (dpeaa)DE-He213 synapses (dpeaa)DE-He213 neurexins (dpeaa)DE-He213 neuroligins (dpeaa)DE-He213 Zhang, Chen aut Enthalten in Frontiers of biology in China Berlin : Springer, 2006 6(2011), 3 vom: 05. Juni (DE-627)510109896 (DE-600)2229527-6 1673-3622 nnns volume:6 year:2011 number:3 day:05 month:06 https://dx.doi.org/10.1007/s11515-011-1020-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 6 2011 3 05 06 |
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10.1007/s11515-011-1020-2 doi (DE-627)SPR020485204 (SPR)s11515-011-1020-2-e DE-627 ger DE-627 rakwb eng Wu, Bei verfasserin aut Neurexins and neuroligins: new partners for $ GABA_{A} $ receptors at synapses 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. GABA (dpeaa)DE-He213 receptors (dpeaa)DE-He213 synapses (dpeaa)DE-He213 neurexins (dpeaa)DE-He213 neuroligins (dpeaa)DE-He213 Zhang, Chen aut Enthalten in Frontiers of biology in China Berlin : Springer, 2006 6(2011), 3 vom: 05. Juni (DE-627)510109896 (DE-600)2229527-6 1673-3622 nnns volume:6 year:2011 number:3 day:05 month:06 https://dx.doi.org/10.1007/s11515-011-1020-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 6 2011 3 05 06 |
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10.1007/s11515-011-1020-2 doi (DE-627)SPR020485204 (SPR)s11515-011-1020-2-e DE-627 ger DE-627 rakwb eng Wu, Bei verfasserin aut Neurexins and neuroligins: new partners for $ GABA_{A} $ receptors at synapses 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. GABA (dpeaa)DE-He213 receptors (dpeaa)DE-He213 synapses (dpeaa)DE-He213 neurexins (dpeaa)DE-He213 neuroligins (dpeaa)DE-He213 Zhang, Chen aut Enthalten in Frontiers of biology in China Berlin : Springer, 2006 6(2011), 3 vom: 05. Juni (DE-627)510109896 (DE-600)2229527-6 1673-3622 nnns volume:6 year:2011 number:3 day:05 month:06 https://dx.doi.org/10.1007/s11515-011-1020-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 6 2011 3 05 06 |
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Neurexins and neuroligins: new partners for $ GABA_{A} $ receptors at synapses |
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Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 |
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Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 |
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Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. As one of several types of endogenous receptors, $ GABA_{A} $ receptors have been shown to be essential in most, if not all, aspects of brain functioning, including neural development and information processing. Mutations in genes encoding $ GABA_{A} $ receptors and alterations in the function of $ GABA_{A} $ receptors are associated with many neurologic diseases, and $ GABA_{A} $ receptors have been clinically targeted by many drugs, such as benzodiazepines and general anesthetics. Extensive studies have revealed a number of intracellular chaperons/interactions for $ GABA_{A} $ receptors, providing a protein-protein network in regulating the trafficking and location of $ GABA_{A} $ receptors in the brain. Recently, neurexins and neuroligins, two families of transmembrane proteins present at neurological synapses, are implicated as new partners to $ GABA_{A} $ receptors. These works shed new light on the synaptic regulation of $ GABA_{A} $ receptor activity. Here, we summarized the proteins that were implicated in the function of $ GABA_{A} $ receptors, including neurexins and neuroligins. © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011 |
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