Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report
Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of th...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Schettino, Clorinda [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2007 |
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| Übergeordnetes Werk: |
Enthalten in: Targeted oncology - Paris : Springer Verlag France S.A.R.L., 2006, 2(2007), 4 vom: 05. Sept., Seite 253-257 |
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| Übergeordnetes Werk: |
volume:2 ; year:2007 ; number:4 ; day:05 ; month:09 ; pages:253-257 |
| Links: |
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| DOI / URN: |
10.1007/s11523-007-0061-6 |
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| Katalog-ID: |
SPR020528833 |
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| 100 | 1 | |a Schettino, Clorinda |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report |
| 264 | 1 | |c 2007 | |
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| 520 | |a Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of the EGFR on the tumor cell, thereby inhibiting receptor-associated tyrosine kinase activation. Two randomized phase III clinical trials have recently demonstrated that cetuximab increases the activity of radiotherapy in the treatment of locally advanced SCCHN and of platinum-based chemotherapy in the treatment of metastatic SCCHN. Here we report the clinical case of a long-lasting complete response in a 57-year-old male, who was a current smoker and had a history of alcohol abuse, affected by recurrent locally advanced SCCHN after failure of radiotherapy and of platinum-based chemotherapy. | ||
| 650 | 4 | |a Head and neck cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cetuximab |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Monoclonal antibodies (MAbs) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Epidermal growth factor receptor (EGFR) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antitumor activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Case report |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Bareschino, Maria Anna |4 aut | |
| 700 | 1 | |a Monaco, Katia |4 aut | |
| 700 | 1 | |a Orditura, Michele |4 aut | |
| 700 | 1 | |a De Vita, Ferdinando |4 aut | |
| 700 | 1 | |a Ciardiello, Fortunato |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Targeted oncology |d Paris : Springer Verlag France S.A.R.L., 2006 |g 2(2007), 4 vom: 05. Sept., Seite 253-257 |w (DE-627)507903838 |w (DE-600)2222136-0 |x 1776-260X |7 nnns |
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10.1007/s11523-007-0061-6 doi (DE-627)SPR020528833 (SPR)s11523-007-0061-6-e DE-627 ger DE-627 rakwb eng Schettino, Clorinda verfasserin aut Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of the EGFR on the tumor cell, thereby inhibiting receptor-associated tyrosine kinase activation. Two randomized phase III clinical trials have recently demonstrated that cetuximab increases the activity of radiotherapy in the treatment of locally advanced SCCHN and of platinum-based chemotherapy in the treatment of metastatic SCCHN. Here we report the clinical case of a long-lasting complete response in a 57-year-old male, who was a current smoker and had a history of alcohol abuse, affected by recurrent locally advanced SCCHN after failure of radiotherapy and of platinum-based chemotherapy. Head and neck cancer (dpeaa)DE-He213 Cetuximab (dpeaa)DE-He213 Monoclonal antibodies (MAbs) (dpeaa)DE-He213 Epidermal growth factor receptor (EGFR) (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Bareschino, Maria Anna aut Monaco, Katia aut Orditura, Michele aut De Vita, Ferdinando aut Ciardiello, Fortunato aut Enthalten in Targeted oncology Paris : Springer Verlag France S.A.R.L., 2006 2(2007), 4 vom: 05. Sept., Seite 253-257 (DE-627)507903838 (DE-600)2222136-0 1776-260X nnns volume:2 year:2007 number:4 day:05 month:09 pages:253-257 https://dx.doi.org/10.1007/s11523-007-0061-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2007 4 05 09 253-257 |
| spelling |
10.1007/s11523-007-0061-6 doi (DE-627)SPR020528833 (SPR)s11523-007-0061-6-e DE-627 ger DE-627 rakwb eng Schettino, Clorinda verfasserin aut Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of the EGFR on the tumor cell, thereby inhibiting receptor-associated tyrosine kinase activation. Two randomized phase III clinical trials have recently demonstrated that cetuximab increases the activity of radiotherapy in the treatment of locally advanced SCCHN and of platinum-based chemotherapy in the treatment of metastatic SCCHN. Here we report the clinical case of a long-lasting complete response in a 57-year-old male, who was a current smoker and had a history of alcohol abuse, affected by recurrent locally advanced SCCHN after failure of radiotherapy and of platinum-based chemotherapy. Head and neck cancer (dpeaa)DE-He213 Cetuximab (dpeaa)DE-He213 Monoclonal antibodies (MAbs) (dpeaa)DE-He213 Epidermal growth factor receptor (EGFR) (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Bareschino, Maria Anna aut Monaco, Katia aut Orditura, Michele aut De Vita, Ferdinando aut Ciardiello, Fortunato aut Enthalten in Targeted oncology Paris : Springer Verlag France S.A.R.L., 2006 2(2007), 4 vom: 05. Sept., Seite 253-257 (DE-627)507903838 (DE-600)2222136-0 1776-260X nnns volume:2 year:2007 number:4 day:05 month:09 pages:253-257 https://dx.doi.org/10.1007/s11523-007-0061-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2007 4 05 09 253-257 |
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10.1007/s11523-007-0061-6 doi (DE-627)SPR020528833 (SPR)s11523-007-0061-6-e DE-627 ger DE-627 rakwb eng Schettino, Clorinda verfasserin aut Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of the EGFR on the tumor cell, thereby inhibiting receptor-associated tyrosine kinase activation. Two randomized phase III clinical trials have recently demonstrated that cetuximab increases the activity of radiotherapy in the treatment of locally advanced SCCHN and of platinum-based chemotherapy in the treatment of metastatic SCCHN. Here we report the clinical case of a long-lasting complete response in a 57-year-old male, who was a current smoker and had a history of alcohol abuse, affected by recurrent locally advanced SCCHN after failure of radiotherapy and of platinum-based chemotherapy. Head and neck cancer (dpeaa)DE-He213 Cetuximab (dpeaa)DE-He213 Monoclonal antibodies (MAbs) (dpeaa)DE-He213 Epidermal growth factor receptor (EGFR) (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Bareschino, Maria Anna aut Monaco, Katia aut Orditura, Michele aut De Vita, Ferdinando aut Ciardiello, Fortunato aut Enthalten in Targeted oncology Paris : Springer Verlag France S.A.R.L., 2006 2(2007), 4 vom: 05. Sept., Seite 253-257 (DE-627)507903838 (DE-600)2222136-0 1776-260X nnns volume:2 year:2007 number:4 day:05 month:09 pages:253-257 https://dx.doi.org/10.1007/s11523-007-0061-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2007 4 05 09 253-257 |
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10.1007/s11523-007-0061-6 doi (DE-627)SPR020528833 (SPR)s11523-007-0061-6-e DE-627 ger DE-627 rakwb eng Schettino, Clorinda verfasserin aut Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2007 Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of the EGFR on the tumor cell, thereby inhibiting receptor-associated tyrosine kinase activation. Two randomized phase III clinical trials have recently demonstrated that cetuximab increases the activity of radiotherapy in the treatment of locally advanced SCCHN and of platinum-based chemotherapy in the treatment of metastatic SCCHN. Here we report the clinical case of a long-lasting complete response in a 57-year-old male, who was a current smoker and had a history of alcohol abuse, affected by recurrent locally advanced SCCHN after failure of radiotherapy and of platinum-based chemotherapy. Head and neck cancer (dpeaa)DE-He213 Cetuximab (dpeaa)DE-He213 Monoclonal antibodies (MAbs) (dpeaa)DE-He213 Epidermal growth factor receptor (EGFR) (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Bareschino, Maria Anna aut Monaco, Katia aut Orditura, Michele aut De Vita, Ferdinando aut Ciardiello, Fortunato aut Enthalten in Targeted oncology Paris : Springer Verlag France S.A.R.L., 2006 2(2007), 4 vom: 05. Sept., Seite 253-257 (DE-627)507903838 (DE-600)2222136-0 1776-260X nnns volume:2 year:2007 number:4 day:05 month:09 pages:253-257 https://dx.doi.org/10.1007/s11523-007-0061-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2007 4 05 09 253-257 |
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Enthalten in Targeted oncology 2(2007), 4 vom: 05. Sept., Seite 253-257 volume:2 year:2007 number:4 day:05 month:09 pages:253-257 |
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Enthalten in Targeted oncology 2(2007), 4 vom: 05. Sept., Seite 253-257 volume:2 year:2007 number:4 day:05 month:09 pages:253-257 |
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Head and neck cancer Cetuximab Monoclonal antibodies (MAbs) Epidermal growth factor receptor (EGFR) Antitumor activity Case report |
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Schettino, Clorinda @@aut@@ Bareschino, Maria Anna @@aut@@ Monaco, Katia @@aut@@ Orditura, Michele @@aut@@ De Vita, Ferdinando @@aut@@ Ciardiello, Fortunato @@aut@@ |
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2007-09-05T00:00:00Z |
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Schettino, Clorinda |
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Schettino, Clorinda misc Head and neck cancer misc Cetuximab misc Monoclonal antibodies (MAbs) misc Epidermal growth factor receptor (EGFR) misc Antitumor activity misc Case report Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report |
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Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report Head and neck cancer (dpeaa)DE-He213 Cetuximab (dpeaa)DE-He213 Monoclonal antibodies (MAbs) (dpeaa)DE-He213 Epidermal growth factor receptor (EGFR) (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Case report (dpeaa)DE-He213 |
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misc Head and neck cancer misc Cetuximab misc Monoclonal antibodies (MAbs) misc Epidermal growth factor receptor (EGFR) misc Antitumor activity misc Case report |
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misc Head and neck cancer misc Cetuximab misc Monoclonal antibodies (MAbs) misc Epidermal growth factor receptor (EGFR) misc Antitumor activity misc Case report |
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Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report |
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Schettino, Clorinda Bareschino, Maria Anna Monaco, Katia Orditura, Michele De Vita, Ferdinando Ciardiello, Fortunato |
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effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (scchn): a case report |
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Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report |
| abstract |
Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of the EGFR on the tumor cell, thereby inhibiting receptor-associated tyrosine kinase activation. Two randomized phase III clinical trials have recently demonstrated that cetuximab increases the activity of radiotherapy in the treatment of locally advanced SCCHN and of platinum-based chemotherapy in the treatment of metastatic SCCHN. Here we report the clinical case of a long-lasting complete response in a 57-year-old male, who was a current smoker and had a history of alcohol abuse, affected by recurrent locally advanced SCCHN after failure of radiotherapy and of platinum-based chemotherapy. © Springer-Verlag 2007 |
| abstractGer |
Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of the EGFR on the tumor cell, thereby inhibiting receptor-associated tyrosine kinase activation. Two randomized phase III clinical trials have recently demonstrated that cetuximab increases the activity of radiotherapy in the treatment of locally advanced SCCHN and of platinum-based chemotherapy in the treatment of metastatic SCCHN. Here we report the clinical case of a long-lasting complete response in a 57-year-old male, who was a current smoker and had a history of alcohol abuse, affected by recurrent locally advanced SCCHN after failure of radiotherapy and of platinum-based chemotherapy. © Springer-Verlag 2007 |
| abstract_unstemmed |
Abstract The epidermal growth factor receptor (EGFR) is frequently overexpressed in squamous cell carcinoma of head and neck (SCCHN). Different strategies to target the activated EGFR have reached the clinic. Cetuximab is a monoclonal antibody that selectively binds to the extracellular domain of the EGFR on the tumor cell, thereby inhibiting receptor-associated tyrosine kinase activation. Two randomized phase III clinical trials have recently demonstrated that cetuximab increases the activity of radiotherapy in the treatment of locally advanced SCCHN and of platinum-based chemotherapy in the treatment of metastatic SCCHN. Here we report the clinical case of a long-lasting complete response in a 57-year-old male, who was a current smoker and had a history of alcohol abuse, affected by recurrent locally advanced SCCHN after failure of radiotherapy and of platinum-based chemotherapy. © Springer-Verlag 2007 |
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Effect of cetuximab in recurrent and refractory squamous cell carcinoma of the head and neck (SCCHN): a case report |
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https://dx.doi.org/10.1007/s11523-007-0061-6 |
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Bareschino, Maria Anna Monaco, Katia Orditura, Michele De Vita, Ferdinando Ciardiello, Fortunato |
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Bareschino, Maria Anna Monaco, Katia Orditura, Michele De Vita, Ferdinando Ciardiello, Fortunato |
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10.1007/s11523-007-0061-6 |
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2024-07-03T16:37:51.922Z |
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| score |
7.4004097 |