Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids

Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Al-Ghannam, Sheikha M. [verfasserIn] Al-Olyan, Abeer M.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Spectrofluorometric determination Pharmaceutical preparations Biological fluids

Anmerkung:	© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008

Übergeordnetes Werk:	Enthalten in: Central European journal of chemistry - Warsaw : Central European Science Journals, 2003, 6(2008), 2 vom: 14. März, Seite 222-228
Übergeordnetes Werk:	volume:6 ; year:2008 ; number:2 ; day:14 ; month:03 ; pages:222-228

Links:	Volltext

DOI / URN:	10.2478/s11532-008-0011-x

Katalog-ID:	SPR02060193X

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520			\|a Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedipine and isradipine with Zn/HCl and measuring the fluorescence intensity obtained ($ λ_{em} $/$ λ_{ex} $) at 460/364, 450/393 and 446/360 nm, respectively. The factors affecting the development of the fluorophore and its stability were studied and optimized. The effect of some surfactants such as β-cyclodextrin (βCD), carboxymethylcelullose (CMC), sodium dodecyl sulphate (SDS) and triton X-100, on the fluorescence intensity was studied. The fluorescence intensity-concentration plots of nicardipine, nifedipine and isradipine were rectilinear over the ranges 0.4–6.0, 0.2–4.0 and 0.1–9.0 μg $ ml^{−1} $ with detection limits of 0.0028, 0.017 and 0.016 μg $ ml^{−1} $, respectively. The proposed method was successfully applied to commercial tablets containing the compounds; the percentage recovery agreed well with those obtained using the official methods. The method was further extended to the in vitro determination of the compounds in spiked human plasma and urine samples. A proposal of the reduction reaction pathway was postulated.
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spelling	10.2478/s11532-008-0011-x doi (DE-627)SPR02060193X (SPR)s11532-008-0011-x-e DE-627 ger DE-627 rakwb eng Al-Ghannam, Sheikha M. verfasserin aut Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008 Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedipine and isradipine with Zn/HCl and measuring the fluorescence intensity obtained ($ λ_{em} $/$ λ_{ex} $) at 460/364, 450/393 and 446/360 nm, respectively. The factors affecting the development of the fluorophore and its stability were studied and optimized. The effect of some surfactants such as β-cyclodextrin (βCD), carboxymethylcelullose (CMC), sodium dodecyl sulphate (SDS) and triton X-100, on the fluorescence intensity was studied. The fluorescence intensity-concentration plots of nicardipine, nifedipine and isradipine were rectilinear over the ranges 0.4–6.0, 0.2–4.0 and 0.1–9.0 μg $ ml^{−1} $ with detection limits of 0.0028, 0.017 and 0.016 μg $ ml^{−1} $, respectively. The proposed method was successfully applied to commercial tablets containing the compounds; the percentage recovery agreed well with those obtained using the official methods. The method was further extended to the in vitro determination of the compounds in spiked human plasma and urine samples. A proposal of the reduction reaction pathway was postulated. Spectrofluorometric determination (dpeaa)DE-He213 Pharmaceutical preparations (dpeaa)DE-He213 Biological fluids (dpeaa)DE-He213 Al-Olyan, Abeer M. aut Enthalten in Central European journal of chemistry Warsaw : Central European Science Journals, 2003 6(2008), 2 vom: 14. März, Seite 222-228 (DE-627)358627516 (DE-600)2097193-X 1644-3624 nnns volume:6 year:2008 number:2 day:14 month:03 pages:222-228 https://dx.doi.org/10.2478/s11532-008-0011-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2008 2 14 03 222-228
allfields_unstemmed	10.2478/s11532-008-0011-x doi (DE-627)SPR02060193X (SPR)s11532-008-0011-x-e DE-627 ger DE-627 rakwb eng Al-Ghannam, Sheikha M. verfasserin aut Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008 Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedipine and isradipine with Zn/HCl and measuring the fluorescence intensity obtained ($ λ_{em} $/$ λ_{ex} $) at 460/364, 450/393 and 446/360 nm, respectively. The factors affecting the development of the fluorophore and its stability were studied and optimized. The effect of some surfactants such as β-cyclodextrin (βCD), carboxymethylcelullose (CMC), sodium dodecyl sulphate (SDS) and triton X-100, on the fluorescence intensity was studied. The fluorescence intensity-concentration plots of nicardipine, nifedipine and isradipine were rectilinear over the ranges 0.4–6.0, 0.2–4.0 and 0.1–9.0 μg $ ml^{−1} $ with detection limits of 0.0028, 0.017 and 0.016 μg $ ml^{−1} $, respectively. The proposed method was successfully applied to commercial tablets containing the compounds; the percentage recovery agreed well with those obtained using the official methods. The method was further extended to the in vitro determination of the compounds in spiked human plasma and urine samples. A proposal of the reduction reaction pathway was postulated. Spectrofluorometric determination (dpeaa)DE-He213 Pharmaceutical preparations (dpeaa)DE-He213 Biological fluids (dpeaa)DE-He213 Al-Olyan, Abeer M. aut Enthalten in Central European journal of chemistry Warsaw : Central European Science Journals, 2003 6(2008), 2 vom: 14. März, Seite 222-228 (DE-627)358627516 (DE-600)2097193-X 1644-3624 nnns volume:6 year:2008 number:2 day:14 month:03 pages:222-228 https://dx.doi.org/10.2478/s11532-008-0011-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2008 2 14 03 222-228
allfieldsGer	10.2478/s11532-008-0011-x doi (DE-627)SPR02060193X (SPR)s11532-008-0011-x-e DE-627 ger DE-627 rakwb eng Al-Ghannam, Sheikha M. verfasserin aut Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008 Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedipine and isradipine with Zn/HCl and measuring the fluorescence intensity obtained ($ λ_{em} $/$ λ_{ex} $) at 460/364, 450/393 and 446/360 nm, respectively. The factors affecting the development of the fluorophore and its stability were studied and optimized. The effect of some surfactants such as β-cyclodextrin (βCD), carboxymethylcelullose (CMC), sodium dodecyl sulphate (SDS) and triton X-100, on the fluorescence intensity was studied. The fluorescence intensity-concentration plots of nicardipine, nifedipine and isradipine were rectilinear over the ranges 0.4–6.0, 0.2–4.0 and 0.1–9.0 μg $ ml^{−1} $ with detection limits of 0.0028, 0.017 and 0.016 μg $ ml^{−1} $, respectively. The proposed method was successfully applied to commercial tablets containing the compounds; the percentage recovery agreed well with those obtained using the official methods. The method was further extended to the in vitro determination of the compounds in spiked human plasma and urine samples. A proposal of the reduction reaction pathway was postulated. Spectrofluorometric determination (dpeaa)DE-He213 Pharmaceutical preparations (dpeaa)DE-He213 Biological fluids (dpeaa)DE-He213 Al-Olyan, Abeer M. aut Enthalten in Central European journal of chemistry Warsaw : Central European Science Journals, 2003 6(2008), 2 vom: 14. März, Seite 222-228 (DE-627)358627516 (DE-600)2097193-X 1644-3624 nnns volume:6 year:2008 number:2 day:14 month:03 pages:222-228 https://dx.doi.org/10.2478/s11532-008-0011-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2008 2 14 03 222-228
allfieldsSound	10.2478/s11532-008-0011-x doi (DE-627)SPR02060193X (SPR)s11532-008-0011-x-e DE-627 ger DE-627 rakwb eng Al-Ghannam, Sheikha M. verfasserin aut Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008 Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedipine and isradipine with Zn/HCl and measuring the fluorescence intensity obtained ($ λ_{em} $/$ λ_{ex} $) at 460/364, 450/393 and 446/360 nm, respectively. The factors affecting the development of the fluorophore and its stability were studied and optimized. The effect of some surfactants such as β-cyclodextrin (βCD), carboxymethylcelullose (CMC), sodium dodecyl sulphate (SDS) and triton X-100, on the fluorescence intensity was studied. The fluorescence intensity-concentration plots of nicardipine, nifedipine and isradipine were rectilinear over the ranges 0.4–6.0, 0.2–4.0 and 0.1–9.0 μg $ ml^{−1} $ with detection limits of 0.0028, 0.017 and 0.016 μg $ ml^{−1} $, respectively. The proposed method was successfully applied to commercial tablets containing the compounds; the percentage recovery agreed well with those obtained using the official methods. The method was further extended to the in vitro determination of the compounds in spiked human plasma and urine samples. A proposal of the reduction reaction pathway was postulated. Spectrofluorometric determination (dpeaa)DE-He213 Pharmaceutical preparations (dpeaa)DE-He213 Biological fluids (dpeaa)DE-He213 Al-Olyan, Abeer M. aut Enthalten in Central European journal of chemistry Warsaw : Central European Science Journals, 2003 6(2008), 2 vom: 14. März, Seite 222-228 (DE-627)358627516 (DE-600)2097193-X 1644-3624 nnns volume:6 year:2008 number:2 day:14 month:03 pages:222-228 https://dx.doi.org/10.2478/s11532-008-0011-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2008 2 14 03 222-228
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author	Al-Ghannam, Sheikha M.
spellingShingle	Al-Ghannam, Sheikha M. misc Spectrofluorometric determination misc Pharmaceutical preparations misc Biological fluids Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids
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topic_title	Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids Spectrofluorometric determination (dpeaa)DE-He213 Pharmaceutical preparations (dpeaa)DE-He213 Biological fluids (dpeaa)DE-He213
topic	misc Spectrofluorometric determination misc Pharmaceutical preparations misc Biological fluids
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title	Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids
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title_full	Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids
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title_sort	spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids
title_auth	Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids
abstract	Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedipine and isradipine with Zn/HCl and measuring the fluorescence intensity obtained ($ λ_{em} $/$ λ_{ex} $) at 460/364, 450/393 and 446/360 nm, respectively. The factors affecting the development of the fluorophore and its stability were studied and optimized. The effect of some surfactants such as β-cyclodextrin (βCD), carboxymethylcelullose (CMC), sodium dodecyl sulphate (SDS) and triton X-100, on the fluorescence intensity was studied. The fluorescence intensity-concentration plots of nicardipine, nifedipine and isradipine were rectilinear over the ranges 0.4–6.0, 0.2–4.0 and 0.1–9.0 μg $ ml^{−1} $ with detection limits of 0.0028, 0.017 and 0.016 μg $ ml^{−1} $, respectively. The proposed method was successfully applied to commercial tablets containing the compounds; the percentage recovery agreed well with those obtained using the official methods. The method was further extended to the in vitro determination of the compounds in spiked human plasma and urine samples. A proposal of the reduction reaction pathway was postulated. © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008
abstractGer	Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedipine and isradipine with Zn/HCl and measuring the fluorescence intensity obtained ($ λ_{em} $/$ λ_{ex} $) at 460/364, 450/393 and 446/360 nm, respectively. The factors affecting the development of the fluorophore and its stability were studied and optimized. The effect of some surfactants such as β-cyclodextrin (βCD), carboxymethylcelullose (CMC), sodium dodecyl sulphate (SDS) and triton X-100, on the fluorescence intensity was studied. The fluorescence intensity-concentration plots of nicardipine, nifedipine and isradipine were rectilinear over the ranges 0.4–6.0, 0.2–4.0 and 0.1–9.0 μg $ ml^{−1} $ with detection limits of 0.0028, 0.017 and 0.016 μg $ ml^{−1} $, respectively. The proposed method was successfully applied to commercial tablets containing the compounds; the percentage recovery agreed well with those obtained using the official methods. The method was further extended to the in vitro determination of the compounds in spiked human plasma and urine samples. A proposal of the reduction reaction pathway was postulated. © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008
abstract_unstemmed	Abstract A simple and highly sensitive spectrofluorometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids. The method is based on the reduction of nicardipine, nifedipine and isradipine with Zn/HCl and measuring the fluorescence intensity obtained ($ λ_{em} $/$ λ_{ex} $) at 460/364, 450/393 and 446/360 nm, respectively. The factors affecting the development of the fluorophore and its stability were studied and optimized. The effect of some surfactants such as β-cyclodextrin (βCD), carboxymethylcelullose (CMC), sodium dodecyl sulphate (SDS) and triton X-100, on the fluorescence intensity was studied. The fluorescence intensity-concentration plots of nicardipine, nifedipine and isradipine were rectilinear over the ranges 0.4–6.0, 0.2–4.0 and 0.1–9.0 μg $ ml^{−1} $ with detection limits of 0.0028, 0.017 and 0.016 μg $ ml^{−1} $, respectively. The proposed method was successfully applied to commercial tablets containing the compounds; the percentage recovery agreed well with those obtained using the official methods. The method was further extended to the in vitro determination of the compounds in spiked human plasma and urine samples. A proposal of the reduction reaction pathway was postulated. © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008
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title_short	Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids
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Spectrofluorometric determination of nicardipine, nifedipine and isradipine in pharmaceutical preparations and biological fluids

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