Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience

Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Bonomo, Pierluigi [verfasserIn] Livi, Lorenzo Rampini, Andrea Meattini, Icro Agresti, Benedetta Simontacchi, Gabriele Paiar, Fabiola Mangoni, Monica Bonucci, Ivano Greto, Daniela Masi, Laura Doro, Raffaella Marrazzo, Livia Biti, Giampaolo

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Cardiac metastases Paracardiac metastases Oligometastases Stereotactic body radiotherapy Radiotherapy

Anmerkung:	© Springer-Verlag Italia 2013

Übergeordnetes Werk:	Enthalten in: La Radiologia medica - Milan : Springer Milan, 2006, 118(2013), 6 vom: 28. Mai, Seite 1055-1065
Übergeordnetes Werk:	volume:118 ; year:2013 ; number:6 ; day:28 ; month:05 ; pages:1055-1065

Links:	Volltext

DOI / URN:	10.1007/s11547-013-0932-0

Katalog-ID:	SPR020683723

Internformat


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100	1		\|a Bonomo, Pierluigi \|e verfasserin \|4 aut
245	1	0	\|a Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience
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520			\|a Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases.
650		4	\|a Cardiac metastases \|7 (dpeaa)DE-He213
650		4	\|a Paracardiac metastases \|7 (dpeaa)DE-He213
650		4	\|a Oligometastases \|7 (dpeaa)DE-He213
650		4	\|a Stereotactic body radiotherapy \|7 (dpeaa)DE-He213
650		4	\|a Radiotherapy \|7 (dpeaa)DE-He213
700	1		\|a Livi, Lorenzo \|4 aut
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700	1		\|a Meattini, Icro \|4 aut
700	1		\|a Agresti, Benedetta \|4 aut
700	1		\|a Simontacchi, Gabriele \|4 aut
700	1		\|a Paiar, Fabiola \|4 aut
700	1		\|a Mangoni, Monica \|4 aut
700	1		\|a Bonucci, Ivano \|4 aut
700	1		\|a Greto, Daniela \|4 aut
700	1		\|a Masi, Laura \|4 aut
700	1		\|a Doro, Raffaella \|4 aut
700	1		\|a Marrazzo, Livia \|4 aut
700	1		\|a Biti, Giampaolo \|4 aut
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912			\|a GBV_ILN_138
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912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
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publishDate	2013
allfields	10.1007/s11547-013-0932-0 doi (DE-627)SPR020683723 (SPR)s11547-013-0932-0-e DE-627 ger DE-627 rakwb eng Bonomo, Pierluigi verfasserin aut Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Italia 2013 Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. Cardiac metastases (dpeaa)DE-He213 Paracardiac metastases (dpeaa)DE-He213 Oligometastases (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Livi, Lorenzo aut Rampini, Andrea aut Meattini, Icro aut Agresti, Benedetta aut Simontacchi, Gabriele aut Paiar, Fabiola aut Mangoni, Monica aut Bonucci, Ivano aut Greto, Daniela aut Masi, Laura aut Doro, Raffaella aut Marrazzo, Livia aut Biti, Giampaolo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 118(2013), 6 vom: 28. Mai, Seite 1055-1065 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:118 year:2013 number:6 day:28 month:05 pages:1055-1065 https://dx.doi.org/10.1007/s11547-013-0932-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 118 2013 6 28 05 1055-1065
spelling	10.1007/s11547-013-0932-0 doi (DE-627)SPR020683723 (SPR)s11547-013-0932-0-e DE-627 ger DE-627 rakwb eng Bonomo, Pierluigi verfasserin aut Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Italia 2013 Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. Cardiac metastases (dpeaa)DE-He213 Paracardiac metastases (dpeaa)DE-He213 Oligometastases (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Livi, Lorenzo aut Rampini, Andrea aut Meattini, Icro aut Agresti, Benedetta aut Simontacchi, Gabriele aut Paiar, Fabiola aut Mangoni, Monica aut Bonucci, Ivano aut Greto, Daniela aut Masi, Laura aut Doro, Raffaella aut Marrazzo, Livia aut Biti, Giampaolo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 118(2013), 6 vom: 28. Mai, Seite 1055-1065 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:118 year:2013 number:6 day:28 month:05 pages:1055-1065 https://dx.doi.org/10.1007/s11547-013-0932-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 118 2013 6 28 05 1055-1065
allfields_unstemmed	10.1007/s11547-013-0932-0 doi (DE-627)SPR020683723 (SPR)s11547-013-0932-0-e DE-627 ger DE-627 rakwb eng Bonomo, Pierluigi verfasserin aut Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Italia 2013 Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. Cardiac metastases (dpeaa)DE-He213 Paracardiac metastases (dpeaa)DE-He213 Oligometastases (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Livi, Lorenzo aut Rampini, Andrea aut Meattini, Icro aut Agresti, Benedetta aut Simontacchi, Gabriele aut Paiar, Fabiola aut Mangoni, Monica aut Bonucci, Ivano aut Greto, Daniela aut Masi, Laura aut Doro, Raffaella aut Marrazzo, Livia aut Biti, Giampaolo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 118(2013), 6 vom: 28. Mai, Seite 1055-1065 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:118 year:2013 number:6 day:28 month:05 pages:1055-1065 https://dx.doi.org/10.1007/s11547-013-0932-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 118 2013 6 28 05 1055-1065
allfieldsGer	10.1007/s11547-013-0932-0 doi (DE-627)SPR020683723 (SPR)s11547-013-0932-0-e DE-627 ger DE-627 rakwb eng Bonomo, Pierluigi verfasserin aut Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Italia 2013 Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. Cardiac metastases (dpeaa)DE-He213 Paracardiac metastases (dpeaa)DE-He213 Oligometastases (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Livi, Lorenzo aut Rampini, Andrea aut Meattini, Icro aut Agresti, Benedetta aut Simontacchi, Gabriele aut Paiar, Fabiola aut Mangoni, Monica aut Bonucci, Ivano aut Greto, Daniela aut Masi, Laura aut Doro, Raffaella aut Marrazzo, Livia aut Biti, Giampaolo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 118(2013), 6 vom: 28. Mai, Seite 1055-1065 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:118 year:2013 number:6 day:28 month:05 pages:1055-1065 https://dx.doi.org/10.1007/s11547-013-0932-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 118 2013 6 28 05 1055-1065
allfieldsSound	10.1007/s11547-013-0932-0 doi (DE-627)SPR020683723 (SPR)s11547-013-0932-0-e DE-627 ger DE-627 rakwb eng Bonomo, Pierluigi verfasserin aut Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Italia 2013 Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. Cardiac metastases (dpeaa)DE-He213 Paracardiac metastases (dpeaa)DE-He213 Oligometastases (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Livi, Lorenzo aut Rampini, Andrea aut Meattini, Icro aut Agresti, Benedetta aut Simontacchi, Gabriele aut Paiar, Fabiola aut Mangoni, Monica aut Bonucci, Ivano aut Greto, Daniela aut Masi, Laura aut Doro, Raffaella aut Marrazzo, Livia aut Biti, Giampaolo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 118(2013), 6 vom: 28. Mai, Seite 1055-1065 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:118 year:2013 number:6 day:28 month:05 pages:1055-1065 https://dx.doi.org/10.1007/s11547-013-0932-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 118 2013 6 28 05 1055-1065
language	English
source	Enthalten in La Radiologia medica 118(2013), 6 vom: 28. Mai, Seite 1055-1065 volume:118 year:2013 number:6 day:28 month:05 pages:1055-1065
sourceStr	Enthalten in La Radiologia medica 118(2013), 6 vom: 28. Mai, Seite 1055-1065 volume:118 year:2013 number:6 day:28 month:05 pages:1055-1065
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cardiac metastases Paracardiac metastases Oligometastases Stereotactic body radiotherapy Radiotherapy
isfreeaccess_bool	false
container_title	La Radiologia medica
authorswithroles_txt_mv	Bonomo, Pierluigi @@aut@@ Livi, Lorenzo @@aut@@ Rampini, Andrea @@aut@@ Meattini, Icro @@aut@@ Agresti, Benedetta @@aut@@ Simontacchi, Gabriele @@aut@@ Paiar, Fabiola @@aut@@ Mangoni, Monica @@aut@@ Bonucci, Ivano @@aut@@ Greto, Daniela @@aut@@ Masi, Laura @@aut@@ Doro, Raffaella @@aut@@ Marrazzo, Livia @@aut@@ Biti, Giampaolo @@aut@@
publishDateDaySort_date	2013-05-28T00:00:00Z
hierarchy_top_id	50900623X
id	SPR020683723
language_de	englisch
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author	Bonomo, Pierluigi
spellingShingle	Bonomo, Pierluigi misc Cardiac metastases misc Paracardiac metastases misc Oligometastases misc Stereotactic body radiotherapy misc Radiotherapy Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience
authorStr	Bonomo, Pierluigi
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topic_title	Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience Cardiac metastases (dpeaa)DE-He213 Paracardiac metastases (dpeaa)DE-He213 Oligometastases (dpeaa)DE-He213 Stereotactic body radiotherapy (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213
topic	misc Cardiac metastases misc Paracardiac metastases misc Oligometastases misc Stereotactic body radiotherapy misc Radiotherapy
topic_unstemmed	misc Cardiac metastases misc Paracardiac metastases misc Oligometastases misc Stereotactic body radiotherapy misc Radiotherapy
topic_browse	misc Cardiac metastases misc Paracardiac metastases misc Oligometastases misc Stereotactic body radiotherapy misc Radiotherapy
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title	Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience
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title_full	Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience
author_sort	Bonomo, Pierluigi
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author_browse	Bonomo, Pierluigi Livi, Lorenzo Rampini, Andrea Meattini, Icro Agresti, Benedetta Simontacchi, Gabriele Paiar, Fabiola Mangoni, Monica Bonucci, Ivano Greto, Daniela Masi, Laura Doro, Raffaella Marrazzo, Livia Biti, Giampaolo
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doi_str_mv	10.1007/s11547-013-0932-0
title_sort	stereotactic body radiotherapy for cardiac and paracardiac metastases: university of florence experience
title_auth	Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience
abstract	Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. © Springer-Verlag Italia 2013
abstractGer	Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. © Springer-Verlag Italia 2013
abstract_unstemmed	Purpose This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy (SBRT) for paracardiac and cardiac metastatic lesions, defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchyma. Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. Conclusions Results of our retrospective study indicate that SBRT represents a safe and effective treatment option for patients with cardiac and paracardiac metastases. © Springer-Verlag Italia 2013
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title_short	Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience
url	https://dx.doi.org/10.1007/s11547-013-0932-0
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author2	Livi, Lorenzo Rampini, Andrea Meattini, Icro Agresti, Benedetta Simontacchi, Gabriele Paiar, Fabiola Mangoni, Monica Bonucci, Ivano Greto, Daniela Masi, Laura Doro, Raffaella Marrazzo, Livia Biti, Giampaolo
author2Str	Livi, Lorenzo Rampini, Andrea Meattini, Icro Agresti, Benedetta Simontacchi, Gabriele Paiar, Fabiola Mangoni, Monica Bonucci, Ivano Greto, Daniela Masi, Laura Doro, Raffaella Marrazzo, Livia Biti, Giampaolo
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up_date	2024-07-03T17:34:32.134Z
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Materials and methods Between January 2009 and May 2011, 16 patients with paracardiac and cardiac lesions were treated with SBRT. For dose specification, in 15 of 16 patients, the prescription dosage was 36 Gy in three fractions (70% isodose). In one patient, the target lesion was inside the heart, and the prescription dosage was 30 Gy in three fractions (70% isodose). Results Regarding response to stereotactic radiotherapy, we recorded one (6%) complete response (CR), six (37%) partial responses (PR), five (32%) stable disease (SD) and four (25%) local failures. Median interval to local failure was 5.2 (range, 3–12) months. The cause of death was distant progression of disease in all four patients. Compliance to treatment was excellent; no patient developed cardiological symptoms or electrocardiographic abnormalities, even months after SBRT. 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Stereotactic body radiotherapy for cardiac and paracardiac metastases: University of Florence experience

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