Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost
Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 201...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fiorentino, Alba [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Anmerkung: |
© Italian Society of Medical Radiology 2017 |
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| Übergeordnetes Werk: |
Enthalten in: La Radiologia medica - Milan : Springer Milan, 2006, 122(2017), 6 vom: 21. Feb., Seite 464-471 |
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| Übergeordnetes Werk: |
volume:122 ; year:2017 ; number:6 ; day:21 ; month:02 ; pages:464-471 |
| Links: |
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| DOI / URN: |
10.1007/s11547-017-0741-y |
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| Katalog-ID: |
SPR020689403 |
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| 100 | 1 | |a Fiorentino, Alba |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost |
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| 520 | |a Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. | ||
| 650 | 4 | |a Breast radiotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Bilateral breast cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Simultaneous integrated boost |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nodal irradiation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a VMAT |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mazzola, Rosario |4 aut | |
| 700 | 1 | |a Naccarato, Stefania |4 aut | |
| 700 | 1 | |a Giaj-Levra, Niccolò |4 aut | |
| 700 | 1 | |a Fersino, Sergio |4 aut | |
| 700 | 1 | |a Sicignano, Gianluisa |4 aut | |
| 700 | 1 | |a Tebano, Umberto |4 aut | |
| 700 | 1 | |a Ricchetti, Francesco |4 aut | |
| 700 | 1 | |a Ruggieri, Ruggero |4 aut | |
| 700 | 1 | |a Alongi, Filippo |4 aut | |
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10.1007/s11547-017-0741-y doi (DE-627)SPR020689403 (SPR)s11547-017-0741-y-e DE-627 ger DE-627 rakwb eng Fiorentino, Alba verfasserin aut Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Medical Radiology 2017 Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. Breast radiotherapy (dpeaa)DE-He213 Bilateral breast cancer (dpeaa)DE-He213 Simultaneous integrated boost (dpeaa)DE-He213 Nodal irradiation (dpeaa)DE-He213 VMAT (dpeaa)DE-He213 Mazzola, Rosario aut Naccarato, Stefania aut Giaj-Levra, Niccolò aut Fersino, Sergio aut Sicignano, Gianluisa aut Tebano, Umberto aut Ricchetti, Francesco aut Ruggieri, Ruggero aut Alongi, Filippo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 122(2017), 6 vom: 21. Feb., Seite 464-471 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:122 year:2017 number:6 day:21 month:02 pages:464-471 https://dx.doi.org/10.1007/s11547-017-0741-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 122 2017 6 21 02 464-471 |
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10.1007/s11547-017-0741-y doi (DE-627)SPR020689403 (SPR)s11547-017-0741-y-e DE-627 ger DE-627 rakwb eng Fiorentino, Alba verfasserin aut Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Medical Radiology 2017 Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. Breast radiotherapy (dpeaa)DE-He213 Bilateral breast cancer (dpeaa)DE-He213 Simultaneous integrated boost (dpeaa)DE-He213 Nodal irradiation (dpeaa)DE-He213 VMAT (dpeaa)DE-He213 Mazzola, Rosario aut Naccarato, Stefania aut Giaj-Levra, Niccolò aut Fersino, Sergio aut Sicignano, Gianluisa aut Tebano, Umberto aut Ricchetti, Francesco aut Ruggieri, Ruggero aut Alongi, Filippo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 122(2017), 6 vom: 21. Feb., Seite 464-471 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:122 year:2017 number:6 day:21 month:02 pages:464-471 https://dx.doi.org/10.1007/s11547-017-0741-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 122 2017 6 21 02 464-471 |
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10.1007/s11547-017-0741-y doi (DE-627)SPR020689403 (SPR)s11547-017-0741-y-e DE-627 ger DE-627 rakwb eng Fiorentino, Alba verfasserin aut Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Medical Radiology 2017 Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. Breast radiotherapy (dpeaa)DE-He213 Bilateral breast cancer (dpeaa)DE-He213 Simultaneous integrated boost (dpeaa)DE-He213 Nodal irradiation (dpeaa)DE-He213 VMAT (dpeaa)DE-He213 Mazzola, Rosario aut Naccarato, Stefania aut Giaj-Levra, Niccolò aut Fersino, Sergio aut Sicignano, Gianluisa aut Tebano, Umberto aut Ricchetti, Francesco aut Ruggieri, Ruggero aut Alongi, Filippo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 122(2017), 6 vom: 21. Feb., Seite 464-471 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:122 year:2017 number:6 day:21 month:02 pages:464-471 https://dx.doi.org/10.1007/s11547-017-0741-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 122 2017 6 21 02 464-471 |
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10.1007/s11547-017-0741-y doi (DE-627)SPR020689403 (SPR)s11547-017-0741-y-e DE-627 ger DE-627 rakwb eng Fiorentino, Alba verfasserin aut Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Medical Radiology 2017 Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. Breast radiotherapy (dpeaa)DE-He213 Bilateral breast cancer (dpeaa)DE-He213 Simultaneous integrated boost (dpeaa)DE-He213 Nodal irradiation (dpeaa)DE-He213 VMAT (dpeaa)DE-He213 Mazzola, Rosario aut Naccarato, Stefania aut Giaj-Levra, Niccolò aut Fersino, Sergio aut Sicignano, Gianluisa aut Tebano, Umberto aut Ricchetti, Francesco aut Ruggieri, Ruggero aut Alongi, Filippo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 122(2017), 6 vom: 21. Feb., Seite 464-471 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:122 year:2017 number:6 day:21 month:02 pages:464-471 https://dx.doi.org/10.1007/s11547-017-0741-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 122 2017 6 21 02 464-471 |
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10.1007/s11547-017-0741-y doi (DE-627)SPR020689403 (SPR)s11547-017-0741-y-e DE-627 ger DE-627 rakwb eng Fiorentino, Alba verfasserin aut Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Society of Medical Radiology 2017 Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. Breast radiotherapy (dpeaa)DE-He213 Bilateral breast cancer (dpeaa)DE-He213 Simultaneous integrated boost (dpeaa)DE-He213 Nodal irradiation (dpeaa)DE-He213 VMAT (dpeaa)DE-He213 Mazzola, Rosario aut Naccarato, Stefania aut Giaj-Levra, Niccolò aut Fersino, Sergio aut Sicignano, Gianluisa aut Tebano, Umberto aut Ricchetti, Francesco aut Ruggieri, Ruggero aut Alongi, Filippo aut Enthalten in La Radiologia medica Milan : Springer Milan, 2006 122(2017), 6 vom: 21. Feb., Seite 464-471 (DE-627)50900623X (DE-600)2225828-0 1826-6983 nnns volume:122 year:2017 number:6 day:21 month:02 pages:464-471 https://dx.doi.org/10.1007/s11547-017-0741-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 122 2017 6 21 02 464-471 |
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Enthalten in La Radiologia medica 122(2017), 6 vom: 21. Feb., Seite 464-471 volume:122 year:2017 number:6 day:21 month:02 pages:464-471 |
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Enthalten in La Radiologia medica 122(2017), 6 vom: 21. Feb., Seite 464-471 volume:122 year:2017 number:6 day:21 month:02 pages:464-471 |
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Breast radiotherapy Bilateral breast cancer Simultaneous integrated boost Nodal irradiation VMAT |
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Fiorentino, Alba @@aut@@ Mazzola, Rosario @@aut@@ Naccarato, Stefania @@aut@@ Giaj-Levra, Niccolò @@aut@@ Fersino, Sergio @@aut@@ Sicignano, Gianluisa @@aut@@ Tebano, Umberto @@aut@@ Ricchetti, Francesco @@aut@@ Ruggieri, Ruggero @@aut@@ Alongi, Filippo @@aut@@ |
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Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. 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Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost Breast radiotherapy (dpeaa)DE-He213 Bilateral breast cancer (dpeaa)DE-He213 Simultaneous integrated boost (dpeaa)DE-He213 Nodal irradiation (dpeaa)DE-He213 VMAT (dpeaa)DE-He213 |
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Fiorentino, Alba Mazzola, Rosario Naccarato, Stefania Giaj-Levra, Niccolò Fersino, Sergio Sicignano, Gianluisa Tebano, Umberto Ricchetti, Francesco Ruggieri, Ruggero Alongi, Filippo |
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Fiorentino, Alba |
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10.1007/s11547-017-0741-y |
| title_sort |
synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost |
| title_auth |
Synchronous bilateral breast cancer irradiation: clinical and dosimetrical issues using volumetric modulated arc therapy and simultaneous integrated boost |
| abstract |
Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. © Italian Society of Medical Radiology 2017 |
| abstractGer |
Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. © Italian Society of Medical Radiology 2017 |
| abstract_unstemmed |
Objectives The aim of the present retrospective analysis was to evaluate dosimetric parameters, feasibility and outcome for Synchronous Bilateral Breast Cancer (SBBC) patients treated with adjuvant radiotherapy (RT) by Volumetric Modulated Arc Therapy (VMAT). Methods From September 2011 to April 2016, 1100 Breast Cancer (BC) patients were referred to our institution to receive adjuvant breast RT, and those with SBBC were selected for the present analysis. A total of 16 patients were identified. A total dose of 50 Gy in 25 fractions was prescribed to the Planning Target Volume of the whole bilateral breast ($ PTV_{BN} $) with or without the supraclavicular and infraclavicular nodes, while a total dose of 60 Gy in 25 fractions was prescribed to the surgical bed ($ PTV_{boost} $). Several VxGy and Dx% parameters were analyzed for the PTVs, together with Conformity and Homogeneity indexes (CI, HI), and for the critical Organs at risk (OARs), lungs and heart first. Results With a median follow-up of 24 months, no acute or late side effects more than grade 2 were observed. All patients are alive without any sign of disease. For target dose coverage, our observed inter-patients averages (±1 sd) were V95% Dp = 96.7 ± 1.6% (96.3 ± 1.8%) to the left (right) $ PTV_{BN} $, V95% Dp = 98.6 ± 2.7% (99.4 ± 0.9%) to the left (right) $ PTV_{boost} $, and D2% = 64.4 ± 1.8 Gy (65.0 ± 2.0 Gy) to the left (right) $ PTV_{boost} $, respectively. With regard to the heart, the inter-patient average of Dmean was 8.3 ± 3.3 Gy. For the lungs, the inter-patient average of Dmean, V5 Gy and V20 Gy were 11.8 ± 2.3 Gy, 78.9 ± 15.3% and 15.7 ± 5%, respectively. Conclusions The present retrospective analysis showed the feasibility, tolerability and safety of VMAT in the treatment of SBBC patients. Further studies are necessary to confirm these preliminary data. © Italian Society of Medical Radiology 2017 |
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Mazzola, Rosario Naccarato, Stefania Giaj-Levra, Niccolò Fersino, Sergio Sicignano, Gianluisa Tebano, Umberto Ricchetti, Francesco Ruggieri, Ruggero Alongi, Filippo |
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Mazzola, Rosario Naccarato, Stefania Giaj-Levra, Niccolò Fersino, Sergio Sicignano, Gianluisa Tebano, Umberto Ricchetti, Francesco Ruggieri, Ruggero Alongi, Filippo |
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| score |
7.4013615 |