Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair
Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic compo...
Ausführliche Beschreibung
Autor*in: |
Belcarz, Anna [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2013 |
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Anmerkung: |
© Versita Warsaw and Springer-Verlag Wien 2013 |
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Übergeordnetes Werk: |
Enthalten in: Central European journal of biology - Warsaw : Central European Science Journals, 2006, 8(2013), 6 vom: 16. März, Seite 534-548 |
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Übergeordnetes Werk: |
volume:8 ; year:2013 ; number:6 ; day:16 ; month:03 ; pages:534-548 |
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DOI / URN: |
10.2478/s11535-013-0169-2 |
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Katalog-ID: |
SPR020835477 |
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520 | |a Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. | ||
650 | 4 | |a Hydroxyapatite ceramics |7 (dpeaa)DE-He213 | |
650 | 4 | |a Bone filler |7 (dpeaa)DE-He213 | |
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700 | 1 | |a Ginalska, Grażyna |4 aut | |
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700 | 1 | |a Piekarczyk, Wojciech |4 aut | |
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10.2478/s11535-013-0169-2 doi (DE-627)SPR020835477 (SPR)s11535-013-0169-2-e DE-627 ger DE-627 rakwb eng Belcarz, Anna verfasserin aut Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Versita Warsaw and Springer-Verlag Wien 2013 Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. Hydroxyapatite ceramics (dpeaa)DE-He213 Bone filler (dpeaa)DE-He213 Sorption index (dpeaa)DE-He213 Sterility (dpeaa)DE-He213 Bioactivity (dpeaa)DE-He213 Ginalska, Grażyna aut Pycka, Teodozja aut Zima, Aneta aut Ślósarczyk, Anna aut Polkowska, Izabela aut Paszkiewicz, Zofia aut Piekarczyk, Wojciech aut Enthalten in Central European journal of biology Warsaw : Central European Science Journals, 2006 8(2013), 6 vom: 16. März, Seite 534-548 (DE-627)511641087 (DE-600)2234099-3 1644-3632 nnns volume:8 year:2013 number:6 day:16 month:03 pages:534-548 https://dx.doi.org/10.2478/s11535-013-0169-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6 16 03 534-548 |
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10.2478/s11535-013-0169-2 doi (DE-627)SPR020835477 (SPR)s11535-013-0169-2-e DE-627 ger DE-627 rakwb eng Belcarz, Anna verfasserin aut Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Versita Warsaw and Springer-Verlag Wien 2013 Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. Hydroxyapatite ceramics (dpeaa)DE-He213 Bone filler (dpeaa)DE-He213 Sorption index (dpeaa)DE-He213 Sterility (dpeaa)DE-He213 Bioactivity (dpeaa)DE-He213 Ginalska, Grażyna aut Pycka, Teodozja aut Zima, Aneta aut Ślósarczyk, Anna aut Polkowska, Izabela aut Paszkiewicz, Zofia aut Piekarczyk, Wojciech aut Enthalten in Central European journal of biology Warsaw : Central European Science Journals, 2006 8(2013), 6 vom: 16. März, Seite 534-548 (DE-627)511641087 (DE-600)2234099-3 1644-3632 nnns volume:8 year:2013 number:6 day:16 month:03 pages:534-548 https://dx.doi.org/10.2478/s11535-013-0169-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6 16 03 534-548 |
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10.2478/s11535-013-0169-2 doi (DE-627)SPR020835477 (SPR)s11535-013-0169-2-e DE-627 ger DE-627 rakwb eng Belcarz, Anna verfasserin aut Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Versita Warsaw and Springer-Verlag Wien 2013 Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. Hydroxyapatite ceramics (dpeaa)DE-He213 Bone filler (dpeaa)DE-He213 Sorption index (dpeaa)DE-He213 Sterility (dpeaa)DE-He213 Bioactivity (dpeaa)DE-He213 Ginalska, Grażyna aut Pycka, Teodozja aut Zima, Aneta aut Ślósarczyk, Anna aut Polkowska, Izabela aut Paszkiewicz, Zofia aut Piekarczyk, Wojciech aut Enthalten in Central European journal of biology Warsaw : Central European Science Journals, 2006 8(2013), 6 vom: 16. März, Seite 534-548 (DE-627)511641087 (DE-600)2234099-3 1644-3632 nnns volume:8 year:2013 number:6 day:16 month:03 pages:534-548 https://dx.doi.org/10.2478/s11535-013-0169-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6 16 03 534-548 |
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10.2478/s11535-013-0169-2 doi (DE-627)SPR020835477 (SPR)s11535-013-0169-2-e DE-627 ger DE-627 rakwb eng Belcarz, Anna verfasserin aut Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Versita Warsaw and Springer-Verlag Wien 2013 Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. Hydroxyapatite ceramics (dpeaa)DE-He213 Bone filler (dpeaa)DE-He213 Sorption index (dpeaa)DE-He213 Sterility (dpeaa)DE-He213 Bioactivity (dpeaa)DE-He213 Ginalska, Grażyna aut Pycka, Teodozja aut Zima, Aneta aut Ślósarczyk, Anna aut Polkowska, Izabela aut Paszkiewicz, Zofia aut Piekarczyk, Wojciech aut Enthalten in Central European journal of biology Warsaw : Central European Science Journals, 2006 8(2013), 6 vom: 16. März, Seite 534-548 (DE-627)511641087 (DE-600)2234099-3 1644-3632 nnns volume:8 year:2013 number:6 day:16 month:03 pages:534-548 https://dx.doi.org/10.2478/s11535-013-0169-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6 16 03 534-548 |
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10.2478/s11535-013-0169-2 doi (DE-627)SPR020835477 (SPR)s11535-013-0169-2-e DE-627 ger DE-627 rakwb eng Belcarz, Anna verfasserin aut Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Versita Warsaw and Springer-Verlag Wien 2013 Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. Hydroxyapatite ceramics (dpeaa)DE-He213 Bone filler (dpeaa)DE-He213 Sorption index (dpeaa)DE-He213 Sterility (dpeaa)DE-He213 Bioactivity (dpeaa)DE-He213 Ginalska, Grażyna aut Pycka, Teodozja aut Zima, Aneta aut Ślósarczyk, Anna aut Polkowska, Izabela aut Paszkiewicz, Zofia aut Piekarczyk, Wojciech aut Enthalten in Central European journal of biology Warsaw : Central European Science Journals, 2006 8(2013), 6 vom: 16. März, Seite 534-548 (DE-627)511641087 (DE-600)2234099-3 1644-3632 nnns volume:8 year:2013 number:6 day:16 month:03 pages:534-548 https://dx.doi.org/10.2478/s11535-013-0169-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6 16 03 534-548 |
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application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair |
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Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair |
abstract |
Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. © Versita Warsaw and Springer-Verlag Wien 2013 |
abstractGer |
Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. © Versita Warsaw and Springer-Verlag Wien 2013 |
abstract_unstemmed |
Background Unsatisfactory surgical handiness is a commonly known disadvantage of implantable granular bioceramics. To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. Promising results of pilot clinical experiment suggest that further in vivo experiments should be performed. © Versita Warsaw and Springer-Verlag Wien 2013 |
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To overcome this problem, β-1,3-glucan, biotechnologically derived polysaccharide, has been proposed as a joining agent to combine granular ceramics into novel compact and elastic composite. Hydroxyapatite/glucan elastic material was processed and evaluated as a potential bone void filler. Methodology The procedure of composite formation was based on gelling properties of glucan. Its properties were studied using X-ray microtomography, SEM-EDS, FTIR spectroscopy, compression test and ultrasonic method. Sorption index was determined in phosphate buffered saline; bioactivity in simulated body fluid; sterility in growth broth and human blood plasma; implantation procedure in dog model. Results HAp/glucan composite is sterilizable, flexible and self-adapting to defect shape. It exhibits bioactivity, good surgical handiness, high sorption index and profitable mechanical properties, resembling those of spongy bone. Results of pilot clinical experiment on animal (dog) patients of a local clinic of animal surgery suggested good healing properties of the composite and its transformation into new bone tissue within critical-size defect. Conclusions The results obtained in this study confirm that flexible HAp/glucan composite has potential as a bone-substituting material. 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