Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine

Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Antonenko, Kate O. [verfasserIn] Kresyun, Valentin I. Antonenko, Peter B.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Drug-resistance M.tuberculosis katG rpoB

Anmerkung:	© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009

Übergeordnetes Werk:	Enthalten in: Central European journal of medicine - Warsaw : Central European Science Journals, 2006, 5(2009), 1 vom: 20. Nov., Seite 30-35
Übergeordnetes Werk:	volume:5 ; year:2009 ; number:1 ; day:20 ; month:11 ; pages:30-35

Links:	Volltext

DOI / URN:	10.2478/s11536-009-0114-6

Katalog-ID:	SPR020871317

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allfields	10.2478/s11536-009-0114-6 doi (DE-627)SPR020871317 (SPR)s11536-009-0114-6-e DE-627 ger DE-627 rakwb eng Antonenko, Kate O. verfasserin aut Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009 Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these mutations in different groups of patients with tuberculosis. An extremely high level of primary and acquired resistance of M. tuberculosis to first-line antituberculosis drugs has been found in the Southwest region of Ukraine. The PCR method has proved to have high sensitivity in the detection of mutations in katG and rpoB genes. The data showed significant spreading of M. tuberculosis strains with mutations in katG and rpoB genes in penitentiaries and an increased level of these mutations during tuberculosis treatment. The presence of mutations in rpoB and katG genes was associated with a more severe course of tuberculosis, increased risk of treatment default, persistence of positive smears on microscopy at discharge, and poor closing of tuberculous cavities. Extremely high level of mutations in the rpoB and katG genes of M. tuberculosis was observed in Beijing family strains. Our findings support the capability of the PCR method to detect M. tuberculosis that is resistant to drugs such as isoniazid and rifampicin. Drug-resistance (dpeaa)DE-He213 M.tuberculosis (dpeaa)DE-He213 katG (dpeaa)DE-He213 rpoB (dpeaa)DE-He213 Kresyun, Valentin I. aut Antonenko, Peter B. aut Enthalten in Central European journal of medicine Warsaw : Central European Science Journals, 2006 5(2009), 1 vom: 20. Nov., Seite 30-35 (DE-627)511914962 (DE-600)2234698-3 1644-3640 nnns volume:5 year:2009 number:1 day:20 month:11 pages:30-35 https://dx.doi.org/10.2478/s11536-009-0114-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 20 11 30-35
spelling	10.2478/s11536-009-0114-6 doi (DE-627)SPR020871317 (SPR)s11536-009-0114-6-e DE-627 ger DE-627 rakwb eng Antonenko, Kate O. verfasserin aut Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009 Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these mutations in different groups of patients with tuberculosis. An extremely high level of primary and acquired resistance of M. tuberculosis to first-line antituberculosis drugs has been found in the Southwest region of Ukraine. The PCR method has proved to have high sensitivity in the detection of mutations in katG and rpoB genes. The data showed significant spreading of M. tuberculosis strains with mutations in katG and rpoB genes in penitentiaries and an increased level of these mutations during tuberculosis treatment. The presence of mutations in rpoB and katG genes was associated with a more severe course of tuberculosis, increased risk of treatment default, persistence of positive smears on microscopy at discharge, and poor closing of tuberculous cavities. Extremely high level of mutations in the rpoB and katG genes of M. tuberculosis was observed in Beijing family strains. Our findings support the capability of the PCR method to detect M. tuberculosis that is resistant to drugs such as isoniazid and rifampicin. Drug-resistance (dpeaa)DE-He213 M.tuberculosis (dpeaa)DE-He213 katG (dpeaa)DE-He213 rpoB (dpeaa)DE-He213 Kresyun, Valentin I. aut Antonenko, Peter B. aut Enthalten in Central European journal of medicine Warsaw : Central European Science Journals, 2006 5(2009), 1 vom: 20. Nov., Seite 30-35 (DE-627)511914962 (DE-600)2234698-3 1644-3640 nnns volume:5 year:2009 number:1 day:20 month:11 pages:30-35 https://dx.doi.org/10.2478/s11536-009-0114-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 20 11 30-35
allfields_unstemmed	10.2478/s11536-009-0114-6 doi (DE-627)SPR020871317 (SPR)s11536-009-0114-6-e DE-627 ger DE-627 rakwb eng Antonenko, Kate O. verfasserin aut Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009 Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these mutations in different groups of patients with tuberculosis. An extremely high level of primary and acquired resistance of M. tuberculosis to first-line antituberculosis drugs has been found in the Southwest region of Ukraine. The PCR method has proved to have high sensitivity in the detection of mutations in katG and rpoB genes. The data showed significant spreading of M. tuberculosis strains with mutations in katG and rpoB genes in penitentiaries and an increased level of these mutations during tuberculosis treatment. The presence of mutations in rpoB and katG genes was associated with a more severe course of tuberculosis, increased risk of treatment default, persistence of positive smears on microscopy at discharge, and poor closing of tuberculous cavities. Extremely high level of mutations in the rpoB and katG genes of M. tuberculosis was observed in Beijing family strains. Our findings support the capability of the PCR method to detect M. tuberculosis that is resistant to drugs such as isoniazid and rifampicin. Drug-resistance (dpeaa)DE-He213 M.tuberculosis (dpeaa)DE-He213 katG (dpeaa)DE-He213 rpoB (dpeaa)DE-He213 Kresyun, Valentin I. aut Antonenko, Peter B. aut Enthalten in Central European journal of medicine Warsaw : Central European Science Journals, 2006 5(2009), 1 vom: 20. Nov., Seite 30-35 (DE-627)511914962 (DE-600)2234698-3 1644-3640 nnns volume:5 year:2009 number:1 day:20 month:11 pages:30-35 https://dx.doi.org/10.2478/s11536-009-0114-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 20 11 30-35
allfieldsGer	10.2478/s11536-009-0114-6 doi (DE-627)SPR020871317 (SPR)s11536-009-0114-6-e DE-627 ger DE-627 rakwb eng Antonenko, Kate O. verfasserin aut Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009 Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these mutations in different groups of patients with tuberculosis. An extremely high level of primary and acquired resistance of M. tuberculosis to first-line antituberculosis drugs has been found in the Southwest region of Ukraine. The PCR method has proved to have high sensitivity in the detection of mutations in katG and rpoB genes. The data showed significant spreading of M. tuberculosis strains with mutations in katG and rpoB genes in penitentiaries and an increased level of these mutations during tuberculosis treatment. The presence of mutations in rpoB and katG genes was associated with a more severe course of tuberculosis, increased risk of treatment default, persistence of positive smears on microscopy at discharge, and poor closing of tuberculous cavities. Extremely high level of mutations in the rpoB and katG genes of M. tuberculosis was observed in Beijing family strains. Our findings support the capability of the PCR method to detect M. tuberculosis that is resistant to drugs such as isoniazid and rifampicin. Drug-resistance (dpeaa)DE-He213 M.tuberculosis (dpeaa)DE-He213 katG (dpeaa)DE-He213 rpoB (dpeaa)DE-He213 Kresyun, Valentin I. aut Antonenko, Peter B. aut Enthalten in Central European journal of medicine Warsaw : Central European Science Journals, 2006 5(2009), 1 vom: 20. Nov., Seite 30-35 (DE-627)511914962 (DE-600)2234698-3 1644-3640 nnns volume:5 year:2009 number:1 day:20 month:11 pages:30-35 https://dx.doi.org/10.2478/s11536-009-0114-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 20 11 30-35
allfieldsSound	10.2478/s11536-009-0114-6 doi (DE-627)SPR020871317 (SPR)s11536-009-0114-6-e DE-627 ger DE-627 rakwb eng Antonenko, Kate O. verfasserin aut Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009 Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these mutations in different groups of patients with tuberculosis. An extremely high level of primary and acquired resistance of M. tuberculosis to first-line antituberculosis drugs has been found in the Southwest region of Ukraine. The PCR method has proved to have high sensitivity in the detection of mutations in katG and rpoB genes. The data showed significant spreading of M. tuberculosis strains with mutations in katG and rpoB genes in penitentiaries and an increased level of these mutations during tuberculosis treatment. The presence of mutations in rpoB and katG genes was associated with a more severe course of tuberculosis, increased risk of treatment default, persistence of positive smears on microscopy at discharge, and poor closing of tuberculous cavities. Extremely high level of mutations in the rpoB and katG genes of M. tuberculosis was observed in Beijing family strains. Our findings support the capability of the PCR method to detect M. tuberculosis that is resistant to drugs such as isoniazid and rifampicin. Drug-resistance (dpeaa)DE-He213 M.tuberculosis (dpeaa)DE-He213 katG (dpeaa)DE-He213 rpoB (dpeaa)DE-He213 Kresyun, Valentin I. aut Antonenko, Peter B. aut Enthalten in Central European journal of medicine Warsaw : Central European Science Journals, 2006 5(2009), 1 vom: 20. Nov., Seite 30-35 (DE-627)511914962 (DE-600)2234698-3 1644-3640 nnns volume:5 year:2009 number:1 day:20 month:11 pages:30-35 https://dx.doi.org/10.2478/s11536-009-0114-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 20 11 30-35
language	English
source	Enthalten in Central European journal of medicine 5(2009), 1 vom: 20. Nov., Seite 30-35 volume:5 year:2009 number:1 day:20 month:11 pages:30-35
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topic_facet	Drug-resistance M.tuberculosis katG rpoB
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container_title	Central European journal of medicine
authorswithroles_txt_mv	Antonenko, Kate O. @@aut@@ Kresyun, Valentin I. @@aut@@ Antonenko, Peter B. @@aut@@
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author	Antonenko, Kate O.
spellingShingle	Antonenko, Kate O. misc Drug-resistance misc M.tuberculosis misc katG misc rpoB Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine
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topic_title	Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine Drug-resistance (dpeaa)DE-He213 M.tuberculosis (dpeaa)DE-He213 katG (dpeaa)DE-He213 rpoB (dpeaa)DE-He213
topic	misc Drug-resistance misc M.tuberculosis misc katG misc rpoB
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title	Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine
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title_full	Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine
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title_sort	mutations leading to drug-resistant mycobacterium tuberculosis infection in ukraine
title_auth	Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine
abstract	Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these mutations in different groups of patients with tuberculosis. An extremely high level of primary and acquired resistance of M. tuberculosis to first-line antituberculosis drugs has been found in the Southwest region of Ukraine. The PCR method has proved to have high sensitivity in the detection of mutations in katG and rpoB genes. The data showed significant spreading of M. tuberculosis strains with mutations in katG and rpoB genes in penitentiaries and an increased level of these mutations during tuberculosis treatment. The presence of mutations in rpoB and katG genes was associated with a more severe course of tuberculosis, increased risk of treatment default, persistence of positive smears on microscopy at discharge, and poor closing of tuberculous cavities. Extremely high level of mutations in the rpoB and katG genes of M. tuberculosis was observed in Beijing family strains. Our findings support the capability of the PCR method to detect M. tuberculosis that is resistant to drugs such as isoniazid and rifampicin. © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009
abstractGer	Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these mutations in different groups of patients with tuberculosis. An extremely high level of primary and acquired resistance of M. tuberculosis to first-line antituberculosis drugs has been found in the Southwest region of Ukraine. The PCR method has proved to have high sensitivity in the detection of mutations in katG and rpoB genes. The data showed significant spreading of M. tuberculosis strains with mutations in katG and rpoB genes in penitentiaries and an increased level of these mutations during tuberculosis treatment. The presence of mutations in rpoB and katG genes was associated with a more severe course of tuberculosis, increased risk of treatment default, persistence of positive smears on microscopy at discharge, and poor closing of tuberculous cavities. Extremely high level of mutations in the rpoB and katG genes of M. tuberculosis was observed in Beijing family strains. Our findings support the capability of the PCR method to detect M. tuberculosis that is resistant to drugs such as isoniazid and rifampicin. © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009
abstract_unstemmed	Abstract The goal of this research was detection of the drug-resistance level of Mycobacterium tuberculosis infection in the Odesa region of Southwest Ukraine, investigation of the level of mutation in katG and rpoB genes for M. tuberculosis with polymerase chain reaction (PCR), and spread of these mutations in different groups of patients with tuberculosis. An extremely high level of primary and acquired resistance of M. tuberculosis to first-line antituberculosis drugs has been found in the Southwest region of Ukraine. The PCR method has proved to have high sensitivity in the detection of mutations in katG and rpoB genes. The data showed significant spreading of M. tuberculosis strains with mutations in katG and rpoB genes in penitentiaries and an increased level of these mutations during tuberculosis treatment. The presence of mutations in rpoB and katG genes was associated with a more severe course of tuberculosis, increased risk of treatment default, persistence of positive smears on microscopy at discharge, and poor closing of tuberculous cavities. Extremely high level of mutations in the rpoB and katG genes of M. tuberculosis was observed in Beijing family strains. Our findings support the capability of the PCR method to detect M. tuberculosis that is resistant to drugs such as isoniazid and rifampicin. © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009
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title_short	Mutations leading to drug-resistant Mycobacterium tuberculosis infection in Ukraine
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