Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography

Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 week...
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Autor*in:	Tachibana, Atsushi [verfasserIn] Nagasawa, Ayumu Kitamura, Akihiro Miyazaki, Shohei Murase, Kenya

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Anmerkung:	© Japan Radiological Society 2010

Übergeordnetes Werk:	Enthalten in: Radiation medicine - Tokyo : Springer, 1999, 28(2010), 2 vom: Feb., Seite 123-131
Übergeordnetes Werk:	volume:28 ; year:2010 ; number:2 ; month:02 ; pages:123-131

Links:	Volltext

DOI / URN:	10.1007/s11604-009-0396-2

Katalog-ID:	SPR021030707

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allfields	10.1007/s11604-009-0396-2 doi (DE-627)SPR021030707 (SPR)s11604-009-0396-2-e DE-627 ger DE-627 rakwb eng Tachibana, Atsushi verfasserin aut Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2010 Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 weeks (n = 5) on days 0, 2, 4, and 7. The rats were given intraperitoneally cisplatin 3.6 mg/kg body weight (BW) on day 0. The contrast clearance per unit renal volume (K1) was estimated using the Patlak model, and that of the entire kidney (K) was obtained by multiplying K1 by the renal volume (V). Results On day 0, the K1 value increased up to 8 weeks and dropped thereafter. The V and K values increased with age. The K value per unit BW was maximum at 4 weeks, remained relatively unchanged between 6 and 8 weeks, and dropped thereafter. The BW, K1, and K values normalized by those on day 0 became lower in old rats than in young ones, and the differences among rats of different ages became greater with days after cisplatin injection, indicating that the cisplatin-induced nephrotoxicity becomes more severe with age. Conclusion This study demonstrated the existence of age-dependent difference in cisplatin-induced nephrotoxicity in rats. Nagasawa, Ayumu aut Kitamura, Akihiro aut Miyazaki, Shohei aut Murase, Kenya aut Enthalten in Radiation medicine Tokyo : Springer, 1999 28(2010), 2 vom: Feb., Seite 123-131 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:28 year:2010 number:2 month:02 pages:123-131 https://dx.doi.org/10.1007/s11604-009-0396-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2010 2 02 123-131
spelling	10.1007/s11604-009-0396-2 doi (DE-627)SPR021030707 (SPR)s11604-009-0396-2-e DE-627 ger DE-627 rakwb eng Tachibana, Atsushi verfasserin aut Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2010 Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 weeks (n = 5) on days 0, 2, 4, and 7. The rats were given intraperitoneally cisplatin 3.6 mg/kg body weight (BW) on day 0. The contrast clearance per unit renal volume (K1) was estimated using the Patlak model, and that of the entire kidney (K) was obtained by multiplying K1 by the renal volume (V). Results On day 0, the K1 value increased up to 8 weeks and dropped thereafter. The V and K values increased with age. The K value per unit BW was maximum at 4 weeks, remained relatively unchanged between 6 and 8 weeks, and dropped thereafter. The BW, K1, and K values normalized by those on day 0 became lower in old rats than in young ones, and the differences among rats of different ages became greater with days after cisplatin injection, indicating that the cisplatin-induced nephrotoxicity becomes more severe with age. Conclusion This study demonstrated the existence of age-dependent difference in cisplatin-induced nephrotoxicity in rats. Nagasawa, Ayumu aut Kitamura, Akihiro aut Miyazaki, Shohei aut Murase, Kenya aut Enthalten in Radiation medicine Tokyo : Springer, 1999 28(2010), 2 vom: Feb., Seite 123-131 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:28 year:2010 number:2 month:02 pages:123-131 https://dx.doi.org/10.1007/s11604-009-0396-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2010 2 02 123-131
allfields_unstemmed	10.1007/s11604-009-0396-2 doi (DE-627)SPR021030707 (SPR)s11604-009-0396-2-e DE-627 ger DE-627 rakwb eng Tachibana, Atsushi verfasserin aut Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2010 Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 weeks (n = 5) on days 0, 2, 4, and 7. The rats were given intraperitoneally cisplatin 3.6 mg/kg body weight (BW) on day 0. The contrast clearance per unit renal volume (K1) was estimated using the Patlak model, and that of the entire kidney (K) was obtained by multiplying K1 by the renal volume (V). Results On day 0, the K1 value increased up to 8 weeks and dropped thereafter. The V and K values increased with age. The K value per unit BW was maximum at 4 weeks, remained relatively unchanged between 6 and 8 weeks, and dropped thereafter. The BW, K1, and K values normalized by those on day 0 became lower in old rats than in young ones, and the differences among rats of different ages became greater with days after cisplatin injection, indicating that the cisplatin-induced nephrotoxicity becomes more severe with age. Conclusion This study demonstrated the existence of age-dependent difference in cisplatin-induced nephrotoxicity in rats. Nagasawa, Ayumu aut Kitamura, Akihiro aut Miyazaki, Shohei aut Murase, Kenya aut Enthalten in Radiation medicine Tokyo : Springer, 1999 28(2010), 2 vom: Feb., Seite 123-131 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:28 year:2010 number:2 month:02 pages:123-131 https://dx.doi.org/10.1007/s11604-009-0396-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2010 2 02 123-131
allfieldsGer	10.1007/s11604-009-0396-2 doi (DE-627)SPR021030707 (SPR)s11604-009-0396-2-e DE-627 ger DE-627 rakwb eng Tachibana, Atsushi verfasserin aut Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2010 Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 weeks (n = 5) on days 0, 2, 4, and 7. The rats were given intraperitoneally cisplatin 3.6 mg/kg body weight (BW) on day 0. The contrast clearance per unit renal volume (K1) was estimated using the Patlak model, and that of the entire kidney (K) was obtained by multiplying K1 by the renal volume (V). Results On day 0, the K1 value increased up to 8 weeks and dropped thereafter. The V and K values increased with age. The K value per unit BW was maximum at 4 weeks, remained relatively unchanged between 6 and 8 weeks, and dropped thereafter. The BW, K1, and K values normalized by those on day 0 became lower in old rats than in young ones, and the differences among rats of different ages became greater with days after cisplatin injection, indicating that the cisplatin-induced nephrotoxicity becomes more severe with age. Conclusion This study demonstrated the existence of age-dependent difference in cisplatin-induced nephrotoxicity in rats. Nagasawa, Ayumu aut Kitamura, Akihiro aut Miyazaki, Shohei aut Murase, Kenya aut Enthalten in Radiation medicine Tokyo : Springer, 1999 28(2010), 2 vom: Feb., Seite 123-131 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:28 year:2010 number:2 month:02 pages:123-131 https://dx.doi.org/10.1007/s11604-009-0396-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2010 2 02 123-131
allfieldsSound	10.1007/s11604-009-0396-2 doi (DE-627)SPR021030707 (SPR)s11604-009-0396-2-e DE-627 ger DE-627 rakwb eng Tachibana, Atsushi verfasserin aut Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2010 Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 weeks (n = 5) on days 0, 2, 4, and 7. The rats were given intraperitoneally cisplatin 3.6 mg/kg body weight (BW) on day 0. The contrast clearance per unit renal volume (K1) was estimated using the Patlak model, and that of the entire kidney (K) was obtained by multiplying K1 by the renal volume (V). Results On day 0, the K1 value increased up to 8 weeks and dropped thereafter. The V and K values increased with age. The K value per unit BW was maximum at 4 weeks, remained relatively unchanged between 6 and 8 weeks, and dropped thereafter. The BW, K1, and K values normalized by those on day 0 became lower in old rats than in young ones, and the differences among rats of different ages became greater with days after cisplatin injection, indicating that the cisplatin-induced nephrotoxicity becomes more severe with age. Conclusion This study demonstrated the existence of age-dependent difference in cisplatin-induced nephrotoxicity in rats. Nagasawa, Ayumu aut Kitamura, Akihiro aut Miyazaki, Shohei aut Murase, Kenya aut Enthalten in Radiation medicine Tokyo : Springer, 1999 28(2010), 2 vom: Feb., Seite 123-131 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:28 year:2010 number:2 month:02 pages:123-131 https://dx.doi.org/10.1007/s11604-009-0396-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 28 2010 2 02 123-131
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author	Tachibana, Atsushi
spellingShingle	Tachibana, Atsushi Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography
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topic_title	Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography
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title	Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography
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title_full	Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography
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author_browse	Tachibana, Atsushi Nagasawa, Ayumu Kitamura, Akihiro Miyazaki, Shohei Murase, Kenya
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title_sort	experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography
title_auth	Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography
abstract	Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 weeks (n = 5) on days 0, 2, 4, and 7. The rats were given intraperitoneally cisplatin 3.6 mg/kg body weight (BW) on day 0. The contrast clearance per unit renal volume (K1) was estimated using the Patlak model, and that of the entire kidney (K) was obtained by multiplying K1 by the renal volume (V). Results On day 0, the K1 value increased up to 8 weeks and dropped thereafter. The V and K values increased with age. The K value per unit BW was maximum at 4 weeks, remained relatively unchanged between 6 and 8 weeks, and dropped thereafter. The BW, K1, and K values normalized by those on day 0 became lower in old rats than in young ones, and the differences among rats of different ages became greater with days after cisplatin injection, indicating that the cisplatin-induced nephrotoxicity becomes more severe with age. Conclusion This study demonstrated the existence of age-dependent difference in cisplatin-induced nephrotoxicity in rats. © Japan Radiological Society 2010
abstractGer	Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 weeks (n = 5) on days 0, 2, 4, and 7. The rats were given intraperitoneally cisplatin 3.6 mg/kg body weight (BW) on day 0. The contrast clearance per unit renal volume (K1) was estimated using the Patlak model, and that of the entire kidney (K) was obtained by multiplying K1 by the renal volume (V). Results On day 0, the K1 value increased up to 8 weeks and dropped thereafter. The V and K values increased with age. The K value per unit BW was maximum at 4 weeks, remained relatively unchanged between 6 and 8 weeks, and dropped thereafter. The BW, K1, and K values normalized by those on day 0 became lower in old rats than in young ones, and the differences among rats of different ages became greater with days after cisplatin injection, indicating that the cisplatin-induced nephrotoxicity becomes more severe with age. Conclusion This study demonstrated the existence of age-dependent difference in cisplatin-induced nephrotoxicity in rats. © Japan Radiological Society 2010
abstract_unstemmed	Purpose The aim of this study was to investigate age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography (DCE-CT). Materials and methods The DCE-CT studies were performed in 23 rats aged 4 weeks (n = 6), 6 weeks (n = 6), 8 weeks (n = 6), and 24 weeks (n = 5) on days 0, 2, 4, and 7. The rats were given intraperitoneally cisplatin 3.6 mg/kg body weight (BW) on day 0. The contrast clearance per unit renal volume (K1) was estimated using the Patlak model, and that of the entire kidney (K) was obtained by multiplying K1 by the renal volume (V). Results On day 0, the K1 value increased up to 8 weeks and dropped thereafter. The V and K values increased with age. The K value per unit BW was maximum at 4 weeks, remained relatively unchanged between 6 and 8 weeks, and dropped thereafter. The BW, K1, and K values normalized by those on day 0 became lower in old rats than in young ones, and the differences among rats of different ages became greater with days after cisplatin injection, indicating that the cisplatin-induced nephrotoxicity becomes more severe with age. Conclusion This study demonstrated the existence of age-dependent difference in cisplatin-induced nephrotoxicity in rats. © Japan Radiological Society 2010
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title_short	Experimental verification of age-dependent cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced computed tomography
url	https://dx.doi.org/10.1007/s11604-009-0396-2
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author2	Nagasawa, Ayumu Kitamura, Akihiro Miyazaki, Shohei Murase, Kenya
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up_date	2024-07-03T19:51:53.283Z
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